EA201600277A1 - Высокоаффиные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh - Google Patents
Высокоаффиные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhhInfo
- Publication number
- EA201600277A1 EA201600277A1 EA201600277A EA201600277A EA201600277A1 EA 201600277 A1 EA201600277 A1 EA 201600277A1 EA 201600277 A EA201600277 A EA 201600277A EA 201600277 A EA201600277 A EA 201600277A EA 201600277 A1 EA201600277 A1 EA 201600277A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vhh
- derivative
- domains
- aggregation
- variable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K39/39591—Stabilisation, fragmentation
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
Предложены моноклональные антитела типа IgG, содержащие вариабельные домены в виде комбинации производного VHH с вариабельным доменом легкой цепи V. Указанные антитела могут содержать замены аминокислот в позициях 44 и/или 45 (по нумерации по Kabat) или их комбинации. Описанные антитела обладают повышенной аффинностью и улучшенной агрегационной стабильностью.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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RU2014138740A RU2609627C2 (ru) | 2014-09-26 | 2014-09-26 | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
PCT/RU2015/000163 WO2016048188A1 (ru) | 2014-09-26 | 2015-03-23 | Высокоаффиные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
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EA201600277A1 true EA201600277A1 (ru) | 2017-08-31 |
EA037090B1 EA037090B1 (ru) | 2021-02-04 |
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US (2) | US10442869B2 (ru) |
EP (1) | EP3199550A4 (ru) |
JP (2) | JP2017538656A (ru) |
KR (1) | KR102600823B1 (ru) |
CN (1) | CN107001458B (ru) |
AR (1) | AR101984A1 (ru) |
AU (1) | AU2015322141B2 (ru) |
BR (1) | BR112016015867A2 (ru) |
CA (1) | CA2941656C (ru) |
CL (1) | CL2016001028A1 (ru) |
EA (1) | EA037090B1 (ru) |
GE (1) | GEP20217311B (ru) |
IL (1) | IL244762A0 (ru) |
MA (2) | MA40763A (ru) |
MX (1) | MX2016012769A (ru) |
MY (1) | MY192853A (ru) |
NZ (1) | NZ724306A (ru) |
PH (1) | PH12016501391A1 (ru) |
RU (1) | RU2609627C2 (ru) |
SG (1) | SG11201607283RA (ru) |
TW (1) | TWI585104B (ru) |
UA (1) | UA125111C2 (ru) |
UY (1) | UY36319A (ru) |
WO (1) | WO2016048188A1 (ru) |
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RU2680011C2 (ru) * | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
JP7122672B2 (ja) * | 2018-06-08 | 2022-08-22 | パナソニックIpマネジメント株式会社 | Vhh抗体 |
KR20210122243A (ko) | 2019-01-31 | 2021-10-08 | 누맙 세러퓨틱스 아게 | TNFα 및 IL-17A에 대한 특이성을 가지는 다중 특이적 항체, IL-17A를 표적화하는 항체, 그리고 이의 사용 방법 |
EP3689907A1 (en) | 2019-01-31 | 2020-08-05 | Numab Therapeutics AG | Antibodies targeting il-17a and methods of use thereof |
RU2754760C2 (ru) * | 2019-04-02 | 2021-09-07 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция анти-il17a антитела и ее применение |
CN112239501B (zh) * | 2020-10-29 | 2022-01-07 | 东莞市朋志生物科技有限公司 | 抗新型冠状病毒的抗体、检测新型冠状病毒试剂和试剂盒 |
CN114920838B (zh) * | 2022-03-25 | 2023-11-24 | 南京融捷康生物科技有限公司 | 一种抗il-17a的单域抗体及其用途 |
CN114380917B (zh) * | 2022-03-25 | 2022-06-14 | 南京融捷康生物科技有限公司 | 针对IL-17A和TNFα的双特异性单域抗体及其用途 |
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JP2005289809A (ja) * | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
FR2879605B1 (fr) * | 2004-12-16 | 2008-10-17 | Centre Nat Rech Scient Cnrse | Production de formats d'anticorps et applications immunologiques de ces formats |
US8211648B2 (en) * | 2005-07-22 | 2012-07-03 | Kalobios Pharmaceuticals, Inc. | Secretion of antibodies without signal peptides from bacteria |
EP2016101A2 (en) * | 2006-05-09 | 2009-01-21 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
EP2215123A1 (en) * | 2007-11-27 | 2010-08-11 | Ablynx N.V. | Immunoglobulin constructs |
UY31504A1 (es) * | 2007-11-30 | 2009-07-17 | Construcciones de union de antigenos | |
CN103772502B (zh) * | 2007-12-07 | 2017-03-29 | 津莫吉尼蒂克斯公司 | 抗人il‑21单克隆抗体 |
GB2461546B (en) | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
WO2010130832A2 (en) * | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
EP2699597B1 (en) * | 2011-04-21 | 2016-06-01 | Garvan Institute of Medical Research | Modified variable domain molecules and methods for producing and using them b |
UA117218C2 (uk) * | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
SG10201705698PA (en) * | 2012-01-13 | 2017-08-30 | Apo-T B V | Aberrant Cell-Restricted Immunoglobulins Provided With A Toxic Moiety |
IL291571B1 (en) * | 2012-02-27 | 2024-04-01 | Ablynx Nv | CX3CR1 binding polypeptides |
CA2897997A1 (en) * | 2013-01-21 | 2014-07-24 | Abbvie Inc. | Anti-tnf and anti-il17 combination therapy biomarkers for inflammatory disease |
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