AR101984A1 - Anticuerpos de alta afinidad y resistencia a la agregación basados en dominios vl variables y derivados vhh - Google Patents

Anticuerpos de alta afinidad y resistencia a la agregación basados en dominios vl variables y derivados vhh

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Publication number
AR101984A1
AR101984A1 ARP150103033A ARP150103033A AR101984A1 AR 101984 A1 AR101984 A1 AR 101984A1 AR P150103033 A ARP150103033 A AR P150103033A AR P150103033 A ARP150103033 A AR P150103033A AR 101984 A1 AR101984 A1 AR 101984A1
Authority
AR
Argentina
Prior art keywords
variable domains
high affinity
antibodies
antibodies based
aggregation resistance
Prior art date
Application number
ARP150103033A
Other languages
English (en)
Inventor
Yurevich Ustyugov Yakov
Vladimirovna Sofronova Ekaterina
Mikhailovna Ekimova Victoria
Valentinovich Morozov Dmitriy
Alexeevich IVANOV Roman
Aleksandrovich Nemankin Timothy
Veniaminovna Chernovskaya Tatyana
Valerievich KORZHAVIN Dmitriy
Vladimirovna Goncharova Olga
Sergeevna Chernyh Yulia
Borisovich ULITIN Andrey
Rudolfovich EVDOKIMOV Stanislav
Vladimirovich Soloviev Valeriy
Original Assignee
Biocad Cjsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Cjsc filed Critical Biocad Cjsc
Publication of AR101984A1 publication Critical patent/AR101984A1/es

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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

Los anticuerpos monoclonales del tipo IgG se sugirieron incluyendo dominios variables representados por una combinación de un derivado VHH con un dominio variable de la cadena ligera VL. Tales anticuerpos pueden incluir sustituciones de aminoácidos en posiciones 44 y 45 (numeración Kabat) o combinaciones de las mismas. Los anticuerpos de la presente poseen una afinidad aumentada y estabilidad de agregación mejorada.
ARP150103033A 2014-09-26 2015-09-18 Anticuerpos de alta afinidad y resistencia a la agregación basados en dominios vl variables y derivados vhh AR101984A1 (es)

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JP7122672B2 (ja) * 2018-06-08 2022-08-22 パナソニックＩｐマネジメント株式会社 Ｖｈｈ抗体
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EP3689907A1 (en) 2019-01-31 2020-08-05 Numab Therapeutics AG Antibodies targeting il-17a and methods of use thereof
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EP3199550A4 (en) 2018-09-26
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MX2016012769A (es) 2017-05-11
CA2941656A1 (en) 2016-03-31
US10442869B2 (en) 2019-10-15
JP2017538656A (ja) 2017-12-28
US20200031952A1 (en) 2020-01-30
CN107001458B (zh) 2022-02-18
IL244762A0 (en) 2016-07-31
SG11201607283RA (en) 2017-04-27
MY192853A (en) 2022-09-13
AU2015322141A1 (en) 2016-09-29
CL2016001028A1 (es) 2016-12-16
ZA201605265B (en) 2017-11-29
JP7206303B2 (ja) 2023-01-17
PH12016501391A1 (en) 2016-08-15
UY36319A (es) 2016-04-29
JP2021072810A (ja) 2021-05-13
US11447574B2 (en) 2022-09-20
CN107001458A (zh) 2017-08-01
KR102600823B1 (ko) 2023-11-10
TW201620935A (zh) 2016-06-16
EP3199550A1 (en) 2017-08-02
UA125111C2 (uk) 2022-01-12
MA39254A1 (fr) 2018-05-31
CA2941656C (en) 2022-03-08
NZ724306A (en) 2018-10-26
US20170066843A1 (en) 2017-03-09
RU2014138740A (ru) 2016-04-20
WO2016048188A1 (ru) 2016-03-31
AU2015322141B2 (en) 2018-12-20
RU2609627C2 (ru) 2017-02-02
EA201600277A1 (ru) 2017-08-31
BR112016015867A2 (pt) 2018-06-05
GEP20217311B (en) 2021-11-10
WO2016048188A8 (ru) 2016-09-22
EA037090B1 (ru) 2021-02-04
KR20170063424A (ko) 2017-06-08

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