|
US9458450B2
(en)
|
2012-03-15 |
2016-10-04 |
Flodesign Sonics, Inc. |
Acoustophoretic separation technology using multi-dimensional standing waves
|
|
US9950282B2
(en)
|
2012-03-15 |
2018-04-24 |
Flodesign Sonics, Inc. |
Electronic configuration and control for acoustic standing wave generation
|
|
US9745548B2
(en)
|
2012-03-15 |
2017-08-29 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9752113B2
(en)
|
2012-03-15 |
2017-09-05 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US10322949B2
(en)
|
2012-03-15 |
2019-06-18 |
Flodesign Sonics, Inc. |
Transducer and reflector configurations for an acoustophoretic device
|
|
US10689609B2
(en)
|
2012-03-15 |
2020-06-23 |
Flodesign Sonics, Inc. |
Acoustic bioreactor processes
|
|
US10967298B2
(en)
|
2012-03-15 |
2021-04-06 |
Flodesign Sonics, Inc. |
Driver and control for variable impedence load
|
|
US10737953B2
(en)
|
2012-04-20 |
2020-08-11 |
Flodesign Sonics, Inc. |
Acoustophoretic method for use in bioreactors
|
|
EP2934532B1
(en)
|
2012-12-20 |
2019-10-23 |
Purdue Research Foundation |
Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
|
|
EP2997134B1
(en)
|
2013-05-14 |
2020-06-24 |
Board of Regents, The University of Texas System |
Human application of engineered chimeric antigen receptor (car) t-cells
|
|
CA2913052A1
(en)
|
2013-05-24 |
2014-11-27 |
Board Of Regents, The University Of Texas System |
Chimeric antigen receptor-targeting monoclonal antibodies
|
|
US9745569B2
(en)
|
2013-09-13 |
2017-08-29 |
Flodesign Sonics, Inc. |
System for generating high concentration factors for low cell density suspensions
|
|
CN105939767B
(zh)
|
2014-01-08 |
2018-04-06 |
弗洛设计声能学公司 |
具有双声电泳腔的声电泳装置
|
|
DK3105335T3
(da)
|
2014-02-14 |
2020-01-13 |
Univ Texas |
Kimære antigenreceptorer og fremgangsmåder til fremstilling heraf
|
|
IL292038B2
(en)
|
2014-04-23 |
2024-12-01 |
Juno Therapeutics Inc |
Methods for enriching or producing immune cell populations for adoptive therapy
|
|
US9744483B2
(en)
|
2014-07-02 |
2017-08-29 |
Flodesign Sonics, Inc. |
Large scale acoustic separation device
|
|
GB201506423D0
(en)
|
2015-04-15 |
2015-05-27 |
Tc Biopharm Ltd |
Gamma delta T cells and uses thereof
|
|
FR3026744B1
(fr)
|
2014-10-06 |
2024-04-19 |
Hopitaux Paris Assist Publique |
Methode de generation de progeniteurs de cellules t
|
|
CA2964783C
(en)
|
2014-11-05 |
2024-01-23 |
Board Of Regents, The University Of Texas System |
Chimeric antigen receptors (car) to selectively target protein complexes
|
|
WO2016100232A1
(en)
|
2014-12-15 |
2016-06-23 |
The Regents Of The University Of California |
Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
|
|
US10808230B2
(en)
|
2015-02-24 |
2020-10-20 |
Board Of Regents, The University Of Texas System |
Selection methods for genetically-modified T cells
|
|
JP6775515B2
(ja)
|
2015-03-11 |
2020-10-28 |
ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム |
トランスポザーゼポリペプチド及びその使用
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
US11021699B2
(en)
|
2015-04-29 |
2021-06-01 |
FioDesign Sonics, Inc. |
Separation using angled acoustic waves
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
GB201507368D0
(en)
*
|
2015-04-30 |
2015-06-17 |
Ucl Business Plc |
Cell
|
|
US11474085B2
(en)
|
2015-07-28 |
2022-10-18 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
US11459540B2
(en)
|
2015-07-28 |
2022-10-04 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
WO2017023859A1
(en)
|
2015-07-31 |
2017-02-09 |
Memorial Sloan-Kettering Cancer Center |
Antigen-binding proteins targeting cd56 and uses thereof
|
|
EP4339287A3
(en)
|
2015-07-31 |
2024-05-22 |
Regents Of The University Of Minnesota |
Modified cells and methods of therapy
|
|
EP3349791A1
(en)
|
2015-09-15 |
2018-07-25 |
Board of Regents, The University of Texas System |
T-cell receptor (tcr)-binding antibodies and uses thereof
|
|
WO2017075147A1
(en)
|
2015-10-27 |
2017-05-04 |
Board Of Regents, The University Of Texas System |
Chimeric antigen receptor molecules and uses thereof
|
|
ES2909973T3
(es)
*
|
2015-11-04 |
2022-05-10 |
Hope City |
Receptores quiméricos para el antígeno que se dirigen a HER2
|
|
WO2017083441A1
(en)
*
|
2015-11-09 |
2017-05-18 |
Aperisys, Inc. |
Modified immune cells and uses thereof
|
|
US11034933B2
(en)
|
2016-01-28 |
2021-06-15 |
The Regents Of The University Of California |
Methods for selectively expanding and enriching cells transduced with chimeric antigen receptors and treating HIV infection
|
|
JP7189019B2
(ja)
|
2016-02-05 |
2022-12-13 |
シティ・オブ・ホープ |
中枢神経系の癌の治療のための操作されたｔ細胞の投与
|
|
CA3019835A1
(en)
|
2016-04-08 |
2017-10-12 |
Purdue Research Foundation |
Methods and compositions for car t cell therapy
|
|
US20190119758A1
(en)
*
|
2016-04-22 |
2019-04-25 |
Kura Oncology, Inc. |
Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
|
|
US11085035B2
(en)
|
2016-05-03 |
2021-08-10 |
Flodesign Sonics, Inc. |
Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
EP3464371B1
(en)
|
2016-06-06 |
2026-07-29 |
City of Hope |
Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof
|
|
WO2017214569A1
(en)
*
|
2016-06-09 |
2017-12-14 |
Regents Of The University Of Minnesota |
Genome-edited nk cell and methods of making and using
|
|
CN107523547A
(zh)
*
|
2016-06-20 |
2017-12-29 |
上海细胞治疗研究院 |
一种高效稳定表达抑制性抗体的car‑t细胞及其用途
|
|
WO2017223557A1
(en)
*
|
2016-06-24 |
2017-12-28 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Genetic re-engineering of immune cells to improve metabolic fitness for immunotherapy
|
|
CN107663240B
(zh)
|
2016-07-29 |
2021-01-12 |
中国人民解放军第四军医大学 |
高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用
|
|
CA3034691A1
(en)
|
2016-08-30 |
2018-03-08 |
Memorial Sloan Kettering Cancer Center |
Immune cell compositions and methods of use for treating viral and other infections
|
|
EP3529347A1
(en)
|
2016-10-19 |
2019-08-28 |
Flodesign Sonics, Inc. |
Affinity cell extraction by acoustics
|
|
WO2018124766A2
(ko)
|
2016-12-28 |
2018-07-05 |
주식회사 녹십자랩셀 |
키메라 항원 수용체 및 이를 발현하는 자연 살해 세포
|
|
ES2931530T3
(es)
|
2017-02-13 |
2022-12-30 |
Hopitaux Paris Assist Publique |
Método para generar progenitores de células T
|
|
CN110582288B
(zh)
|
2017-02-28 |
2024-09-20 |
恩多塞特公司 |
用于car t细胞疗法的组合物和方法
|
|
US11629340B2
(en)
|
2017-03-03 |
2023-04-18 |
Obsidian Therapeutics, Inc. |
DHFR tunable protein regulation
|
|
BR112019023608A2
(pt)
|
2017-05-12 |
2020-05-26 |
Crispr Therapeutics Ag |
Materiais e métodos para células manipuladas e seus usos em imuno-oncologia
|
|
US11166985B2
(en)
|
2017-05-12 |
2021-11-09 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
|
CN107099603A
(zh)
*
|
2017-05-31 |
2017-08-29 |
成都克里斯博生物科技有限公司 |
肿瘤免疫t细胞检测试剂盒和检测方法
|
|
GB201709203D0
(en)
|
2017-06-09 |
2017-07-26 |
Autolus Ltd |
Antigen-binding domain
|
|
CA3069527A1
(en)
*
|
2017-07-12 |
2019-01-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for treatment of cancers harboring an h3k27m mutation
|
|
TW201908335A
(zh)
*
|
2017-07-25 |
2019-03-01 |
美國德州系統大學評議委員會 |
增強之嵌合抗原受體及其用途
|
|
TWI676483B
(zh)
*
|
2017-08-06 |
2019-11-11 |
強普生技股份有限公司 |
醫藥套組及其用途
|
|
CN107287165A
(zh)
*
|
2017-08-23 |
2017-10-24 |
湖南开启时代生物科技有限责任公司 |
一种car‑t细胞的制备方法
|
|
WO2019047932A1
(zh)
*
|
2017-09-08 |
2019-03-14 |
科济生物医药（上海）有限公司 |
基因工程化的t细胞及应用
|
|
IL273515B2
(en)
|
2017-09-29 |
2026-03-01 |
Us Health |
T cell receptors that recognize mutated P53
|
|
CN107488738B
(zh)
*
|
2017-10-12 |
2020-04-28 |
中国医学科学院肿瘤医院 |
一种预测乳腺癌对曲妥珠单抗联合化疗治疗敏感性的生物标志物
|
|
WO2019094360A1
(en)
|
2017-11-07 |
2019-05-16 |
The Board Of Regents Of The University Of Texas System |
Targeting lilrb4 with car-t or car-nk cells in the treatment of cancer
|
|
US11649294B2
(en)
|
2017-11-14 |
2023-05-16 |
GC Cell Corporation |
Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
|
|
KR102774451B1
(ko)
|
2017-11-14 |
2025-02-28 |
앱클론(주) |
항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체
|
|
CA3082334A1
(en)
*
|
2017-11-20 |
2019-05-23 |
Julius-Maximilians-Universitat Wurzburg |
Cd19cart cells eliminate myeloma cells that express very low levels of cd19
|
|
CU24558B1
(es)
*
|
2017-11-28 |
2021-12-08 |
Ct Inmunologia Molecular |
Anticuerpos monoclonales que reconocen al receptor del factor de crecimiento epidérmico y sus fragmentos derivados
|
|
CN108070033A
(zh)
*
|
2017-12-12 |
2018-05-25 |
武汉波睿达生物科技有限公司 |
一种3bnc-car分子的构建及其在杀灭hiv-1感染细胞中的应用
|
|
CN114900773A
(zh)
|
2017-12-14 |
2022-08-12 |
弗洛设计声能学公司 |
声泳系统及其操作方法、控制声换能器及声学系统的方法
|
|
EP3723774A4
(en)
|
2017-12-15 |
2021-09-08 |
The Board of Trustees of the Leland Stanford Junior University |
COMPOSITIONS AND METHODS OF INHIBITION OF T-CELL EXHAUSTATION
|
|
WO2019119822A1
(en)
|
2017-12-23 |
2019-06-27 |
Uwell Biopharma Inc. |
Pharmaceutical chimeric receptor composition and method thereof
|
|
CN111867619A
(zh)
|
2018-01-03 |
2020-10-30 |
曲生物制品公司 |
过继性细胞治疗的先天寻靶
|
|
US11965191B2
(en)
|
2018-01-18 |
2024-04-23 |
California Institute Of Technology |
Programmable protein circuits in living cells
|
|
WO2019144095A1
(en)
*
|
2018-01-22 |
2019-07-25 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Methods of use for car t cells
|
|
WO2019147604A2
(en)
*
|
2018-01-23 |
2019-08-01 |
Vanderbilt University |
Self-antigen specific t-cells as vacines for augmenting engraftment and stability of autologous transfer
|
|
AU2019218729B2
(en)
|
2018-02-06 |
2025-12-04 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors
|
|
JP7568224B2
(ja)
|
2018-02-23 |
2024-10-16 |
エンドサイト・インコーポレイテッド |
Ｃａｒ ｔ細胞療法のための配列決定法
|
|
SG11202008261WA
(en)
*
|
2018-03-08 |
2020-09-29 |
Rubius Therapeutics Inc |
Therapeutic cell systems and methods for treating cancer and infectious diseases
|
|
WO2019204664A2
(en)
*
|
2018-04-19 |
2019-10-24 |
Apdn (B.V.I), Inc. |
Engineered lymphocyte compositions, methods and systems
|
|
US20200063100A1
(en)
|
2018-05-11 |
2020-02-27 |
Crispr Therapeutics Ag |
Methods and compositions for treating cancer
|
|
CN112672753B
(zh)
*
|
2018-07-09 |
2025-07-08 |
普瑞赛格恩公司 |
融合构建体及其使用方法
|
|
AU2019317278B2
(en)
*
|
2018-08-07 |
2025-05-22 |
Purdue Research Foundation |
Rejuvenation of CAR T cell
|
|
CN110862967A
(zh)
*
|
2018-08-27 |
2020-03-06 |
天津天锐生物科技有限公司 |
一种不依赖细胞因子培养的自然杀伤细胞系silk-nk
|
|
US11542305B2
(en)
|
2018-08-31 |
2023-01-03 |
California Institute Of Technology |
Synthetic protein circuits detecting signal transducer activity
|
|
CN112888786A
(zh)
*
|
2018-09-07 |
2021-06-01 |
Sotio有限责任公司 |
与调节细胞内乳酸浓度的反式代谢分子组合的嵌合受体多肽及其治疗用途
|
|
JP2022512594A
(ja)
*
|
2018-10-05 |
2022-02-07 |
ザンクト アンナ キンダークレプスフォルシュング |
キメラ抗原受容体（ｃａｒ）の群
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
CN113226340A
(zh)
|
2018-11-26 |
2021-08-06 |
恩卡尔塔公司 |
同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途
|
|
WO2020146627A1
(en)
*
|
2019-01-10 |
2020-07-16 |
California Institute Of Technology |
A synthetic system for tunable thresholding of protein signals
|
|
CA3127673A1
(en)
*
|
2019-01-25 |
2020-07-30 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeting mutant ras
|
|
CA3130671A1
(en)
|
2019-02-07 |
2020-08-13 |
Board Of Regents, The University Of Texas Systems |
Glucuronoxylomannan (gxm) receptor chimeric antigen receptors and use thereof
|
|
CA3129100A1
(en)
*
|
2019-02-08 |
2020-08-13 |
Biontech Cell & Gene Therapies Gmbh |
Treatment involving car-engineered t cells and cytokines
|
|
BR112021016046A2
(pt)
|
2019-02-15 |
2021-11-09 |
Editas Medicine Inc |
Células assassinas naturais modificadas (nk) para imunoterapia
|
|
KR20210129125A
(ko)
|
2019-02-20 |
2021-10-27 |
시티 오브 호프 |
Baff-r/cd19 표적화된 키메라 항원 수용체-변형된 t 세포 및 그의 용도
|
|
KR20210137085A
(ko)
|
2019-03-05 |
2021-11-17 |
엔카르타, 인크. |
Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
|
|
CA3138633A1
(en)
|
2019-04-30 |
2020-11-05 |
Crispr Therapeutics Ag |
Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
|
|
US20220228101A1
(en)
*
|
2019-06-07 |
2022-07-21 |
Juno Therapeutics, Inc. |
Automated t cell culture
|
|
AU2020286471B2
(en)
*
|
2019-06-07 |
2025-07-31 |
The Trustees Of The University Of Pennsylvania |
Dual CAR expressing T cells individually linked to CD28 and 4-1BB
|
|
CN114651003A
(zh)
|
2019-09-10 |
2022-06-21 |
黑曜石疗法公司 |
用于可调调节的ca2-il15融合蛋白
|
|
CN120605327A
(zh)
*
|
2019-11-06 |
2025-09-09 |
贝勒医学院 |
用于产生细胞毒性效应子记忆t细胞以用于癌症的t细胞治疗的方法
|
|
AU2020382219A1
(en)
|
2019-11-13 |
2022-05-12 |
Crispr Therapeutics Ag |
Manufacturing process for making T cells expressing chimeric antigen receptors
|
|
WO2021108543A1
(en)
*
|
2019-11-27 |
2021-06-03 |
The Trustees Of The University Of Pennsylvania |
Anti-cd3 scfv and cytokine producing artificial antigen presenting cells
|
|
WO2021119489A1
(en)
*
|
2019-12-11 |
2021-06-17 |
A2 Biotherapeutics, Inc. |
Lilrb1-based chimeric antigen receptor
|
|
IL295063A
(en)
|
2020-02-04 |
2022-09-01 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Chimeric antigen receptors (car) against dinitrophenol
|
|
US20230138428A1
(en)
*
|
2020-02-25 |
2023-05-04 |
Quell Therapeutics Limited |
Chimeric receptors for use in engineered cells
|
|
CN111253493B
(zh)
*
|
2020-03-05 |
2021-03-23 |
武汉科技大学 |
一种靶向hiv病毒囊膜双位点的嵌合抗原受体及其表达载体和应用
|
|
US12264190B2
(en)
*
|
2020-04-24 |
2025-04-01 |
Astrazeneca Ab |
Compositions and methods of treating cancer with chimeric antigen receptors
|
|
CN113913459A
(zh)
*
|
2020-07-09 |
2022-01-11 |
杭州优凯瑞医药科技有限公司 |
一种应用非病毒方法制备高纯度嵌合抗原受体修饰的t细胞的方法及其应用
|
|
US12194094B2
(en)
|
2020-07-10 |
2025-01-14 |
Precigen, Inc. |
Fusion constructs and methods of using thereof
|
|
KR102605723B1
(ko)
*
|
2020-11-11 |
2023-11-24 |
한국과학기술원 |
키메라 항원 수용체를 위한 타깃 항원 발굴 방법 및 분석 장치
|
|
CN114716548B
(zh)
*
|
2021-01-05 |
2024-11-05 |
(株)爱恩德生物 |
抗-fgfr3抗体及其用途
|
|
US20240327889A1
(en)
*
|
2021-04-05 |
2024-10-03 |
Victor TETS |
Regulation of cells and organisms
|
|
IL307417A
(en)
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