JP2017514471A5 - - Google Patents
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- JP2017514471A5 JP2017514471A5 JP2016563936A JP2016563936A JP2017514471A5 JP 2017514471 A5 JP2017514471 A5 JP 2017514471A5 JP 2016563936 A JP2016563936 A JP 2016563936A JP 2016563936 A JP2016563936 A JP 2016563936A JP 2017514471 A5 JP2017514471 A5 JP 2017514471A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983298P | 2014-04-23 | 2014-04-23 | |
| US201461983103P | 2014-04-23 | 2014-04-23 | |
| US61/983,103 | 2014-04-23 | ||
| US61/983,298 | 2014-04-23 | ||
| PCT/US2015/027277 WO2015164594A1 (en) | 2014-04-23 | 2015-04-23 | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023077A Division JP2020072755A (ja) | 2014-04-23 | 2020-02-14 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017514471A JP2017514471A (ja) | 2017-06-08 |
| JP2017514471A5 true JP2017514471A5 (enExample) | 2018-05-24 |
Family
ID=53055122
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563936A Withdrawn JP2017514471A (ja) | 2014-04-23 | 2015-04-23 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
| JP2020023077A Pending JP2020072755A (ja) | 2014-04-23 | 2020-02-14 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
| JP2022074648A Pending JP2022093564A (ja) | 2014-04-23 | 2022-04-28 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
| JP2023130951A Pending JP2023138812A (ja) | 2014-04-23 | 2023-08-10 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023077A Pending JP2020072755A (ja) | 2014-04-23 | 2020-02-14 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
| JP2022074648A Pending JP2022093564A (ja) | 2014-04-23 | 2022-04-28 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
| JP2023130951A Pending JP2023138812A (ja) | 2014-04-23 | 2023-08-10 | キメラ抗原受容体(car)並びにその製造及び使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20170158749A1 (enExample) |
| EP (1) | EP3134437A1 (enExample) |
| JP (4) | JP2017514471A (enExample) |
| KR (1) | KR20160145802A (enExample) |
| CN (1) | CN106459924A (enExample) |
| AU (1) | AU2015249655B2 (enExample) |
| CA (1) | CA2945388A1 (enExample) |
| WO (1) | WO2015164594A1 (enExample) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
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| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
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| US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CN105408473B9 (zh) | 2013-05-14 | 2021-09-17 | 得克萨斯州大学系统董事会 | 工程化嵌合抗原受体(car)t细胞的人应用 |
| HK1223943A1 (zh) | 2013-05-24 | 2017-08-11 | Board Of Regents, The University Of Texas System | 嵌合的靶向抗原受体的单克隆抗体 |
| US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| WO2015123642A1 (en) | 2014-02-14 | 2015-08-20 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors and methods of making |
| MX382541B (es) | 2014-04-23 | 2025-03-13 | Juno Therapeutics Inc | Métodos para aislar, cultivar y diseñar genéticamente poblaciones de células inmunes para terapia adoptiva. |
| US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
| GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| FR3026744B1 (fr) | 2014-10-06 | 2024-04-19 | Hopitaux Paris Assist Publique | Methode de generation de progeniteurs de cellules t |
| CA2964783C (en) | 2014-11-05 | 2024-01-23 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
| EP3240805B1 (en) | 2014-12-15 | 2024-11-27 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| CN107667169B (zh) | 2015-02-24 | 2021-10-29 | 得克萨斯州大学系统董事会 | 遗传修饰的t细胞的选择方法 |
| WO2016145146A1 (en) | 2015-03-11 | 2016-09-15 | Board Of Regents, The University Of Texas System | Transposase polypeptides and uses thereof |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| WO2017023859A1 (en) | 2015-07-31 | 2017-02-09 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting cd56 and uses thereof |
| WO2017023801A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Intracellular genomic transplant and methods of therapy |
| US10633445B2 (en) | 2015-09-15 | 2020-04-28 | Board Of Regents The University Of Texas System | T-cell receptor (TCR)-binding antibodies and uses thereof |
| US11059879B2 (en) | 2015-10-27 | 2021-07-13 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
| WO2017079694A2 (en) * | 2015-11-04 | 2017-05-11 | Priceman Saul J | Chimeric antigen receptors targeting her2 |
| US20180325953A1 (en) * | 2015-11-09 | 2018-11-15 | Aperisys, Inc. | Modified immune cells and uses thereof |
| EP3407919A4 (en) * | 2016-01-28 | 2019-09-04 | The Regents of the University of California | METHOD FOR THE SELECTIVE EXPANSION AND ENRICHMENT OF CELLS TRANSDUCED WITH CHIMERIC ANTIGEN RECEPTORS AND TREATMENT OF HIV INFECTION |
| EP3411393B1 (en) | 2016-02-05 | 2021-04-07 | City of Hope | Administration of engineered t cells for treatment of cancers in the central nervous system |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| WO2017184968A1 (en) * | 2016-04-22 | 2017-10-26 | Kura Oncology, Inc. | Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| KR102584944B1 (ko) * | 2016-06-06 | 2023-10-05 | 시티 오브 호프 | Baff-r 표적 키메라 항원 수용체-변형된 t 세포 및 그 용도 |
| US20200208111A1 (en) * | 2016-06-09 | 2020-07-02 | Branden S. Moriarity | Genome-edited nk cell and methods of making and using |
| CN107523547A (zh) * | 2016-06-20 | 2017-12-29 | 上海细胞治疗研究院 | 一种高效稳定表达抑制性抗体的car‑t细胞及其用途 |
| US11583555B2 (en) | 2016-06-24 | 2023-02-21 | University of Pittsburgh—of the Commonwealth System of Higher Education | Genetic re-engineering of immune cells to improve metabolic fitness for immunotherapy |
| CN107663240B (zh) * | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | 高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用 |
| AU2017319151B2 (en) | 2016-08-30 | 2024-01-11 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use for treating viral and other infections |
| JP2020513248A (ja) | 2016-10-19 | 2020-05-14 | フロデザイン ソニックス, インク.Flodesign Sonics, Inc. | 音響による親和性細胞抽出 |
| EP3567049A4 (en) | 2016-12-28 | 2020-08-26 | Green Cross Lab Cell Corporation | CHEMERICAL ANTIGENIC RECEPTOR AND NATURAL KILLER CELLS EXPRESSING THE SAME |
| KR102666158B1 (ko) | 2017-02-13 | 2024-05-16 | 아시스땅스 퍼블리끄-오삐또 드 빠리 | T 세포 전구체(progenitor)의 생성 방법 |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| US11622977B2 (en) | 2017-05-12 | 2023-04-11 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| CN107099603A (zh) * | 2017-05-31 | 2017-08-29 | 成都克里斯博生物科技有限公司 | 肿瘤免疫t细胞检测试剂盒和检测方法 |
| GB201709203D0 (en) * | 2017-06-09 | 2017-07-26 | Autolus Ltd | Antigen-binding domain |
| US11433098B2 (en) * | 2017-07-12 | 2022-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for treatment of cancers harboring an H3K27M mutation |
| EP3658163A4 (en) * | 2017-07-25 | 2021-08-04 | Board Of Regents, The University Of Texas System | IMPROVED ANTIGENIC CHEMICAL RECEPTORS AND THEIR USES |
| TWI676483B (zh) * | 2017-08-06 | 2019-11-11 | 強普生技股份有限公司 | 醫藥套組及其用途 |
| CN107287165A (zh) * | 2017-08-23 | 2017-10-24 | 湖南开启时代生物科技有限责任公司 | 一种car‑t细胞的制备方法 |
| CN109468278A (zh) * | 2017-09-08 | 2019-03-15 | 科济生物医药(上海)有限公司 | 基因工程化的t细胞及应用 |
| US11939365B2 (en) * | 2017-09-29 | 2024-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing mutated P53 |
| CN107488738B (zh) * | 2017-10-12 | 2020-04-28 | 中国医学科学院肿瘤医院 | 一种预测乳腺癌对曲妥珠单抗联合化疗治疗敏感性的生物标志物 |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| CN111655732B (zh) | 2017-11-14 | 2023-09-12 | Gc细胞治疗 | 抗her2抗体或其抗原结合片段及包含其的嵌合抗原受体 |
| CA3082334A1 (en) * | 2017-11-20 | 2019-05-23 | Julius-Maximilians-Universitat Wurzburg | Cd19cart cells eliminate myeloma cells that express very low levels of cd19 |
| CU24558B1 (es) * | 2017-11-28 | 2021-12-08 | Ct Inmunologia Molecular | Anticuerpos monoclonales que reconocen al receptor del factor de crecimiento epidérmico y sus fragmentos derivados |
| CN108070033A (zh) * | 2017-12-12 | 2018-05-25 | 武汉波睿达生物科技有限公司 | 一种3bnc-car分子的构建及其在杀灭hiv-1感染细胞中的应用 |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| SG11202005609PA (en) | 2017-12-15 | 2020-07-29 | Univ Leland Stanford Junior | Compositions and methods for inhibiting t cell exhaustion |
| TWI800522B (zh) * | 2017-12-23 | 2023-05-01 | 宇越生醫科技股份有限公司 | 醫藥重組受體組成物及方法 |
| WO2019134036A1 (en) | 2018-01-03 | 2019-07-11 | Qu Biologics Inc. | Innate targeting of adoptive cellular therapies |
| US11965191B2 (en) | 2018-01-18 | 2024-04-23 | California Institute Of Technology | Programmable protein circuits in living cells |
| CA3089319A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| WO2019147604A2 (en) * | 2018-01-23 | 2019-08-01 | Vanderbilt University | Self-antigen specific t-cells as vacines for augmenting engraftment and stability of autologous transfer |
| BR112020015884A2 (pt) | 2018-02-06 | 2020-12-08 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Receptores de antígeno quimérico (cars) específicos de fluoresceína exibindo a função de célula t ótima contra os tumores marcados por fl-ple |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| SG11202008261WA (en) * | 2018-03-08 | 2020-09-29 | Rubius Therapeutics Inc | Therapeutic cell systems and methods for treating cancer and infectious diseases |
| WO2019204664A2 (en) * | 2018-04-19 | 2019-10-24 | Apdn (B.V.I), Inc. | Engineered lymphocyte compositions, methods and systems |
| IL278348B2 (en) | 2018-05-11 | 2025-03-01 | Crispr Therapeutics Ag | Methods and preparations for treating cancer |
| US11535669B2 (en) | 2018-07-09 | 2022-12-27 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| SG11202100616VA (en) * | 2018-08-07 | 2021-03-30 | Purdue Research Foundation | Rejuvenation of car t cell |
| CN110862967A (zh) * | 2018-08-27 | 2020-03-06 | 天津天锐生物科技有限公司 | 一种不依赖细胞因子培养的自然杀伤细胞系silk-nk |
| EP3844180A4 (en) | 2018-08-31 | 2022-07-20 | California Institute of Technology | Synthetic protein circuits detecting signal transducer activity |
| EP3847260A4 (en) * | 2018-09-07 | 2022-09-07 | SOTIO Biotech Inc. | CHIMERIC RECEPTOR POLYPEPTIDES IN COMBINATION WITH TRANSMETABOLIC MOLECULES THAT MODULATE INTRACELLULAR LACTATE CONCENTRATIONS AND THERAPEUTIC USES THEREOF |
| WO2020070290A1 (en) * | 2018-10-05 | 2020-04-09 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US11667676B2 (en) | 2019-01-10 | 2023-06-06 | California Institute Of Technology | Synthetic system for tunable thresholding of protein signals |
| EP3914270A4 (en) * | 2019-01-25 | 2023-01-11 | The Trustees of the University of Pennsylvania | COMPOSITIONS AND METHODS FOR TARGETING MUTANT RAS |
| US12404347B2 (en) | 2019-02-07 | 2025-09-02 | Board Of Regents, The University Of Texas System | Glucuronoxylomannan (GXM) receptor chimeric antigen receptors and use thereof |
| EP4414033A3 (en) * | 2019-02-08 | 2024-10-30 | Biontech Cell & Gene Therapies Gmbh | Treatment involving car-engineered t cells and cytokines |
| US20220143084A1 (en) | 2019-02-15 | 2022-05-12 | Editas Medicine, Inc. | Modified natural killer (nk) cells for immunotherapy |
| SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| EA202192975A1 (ru) | 2019-04-30 | 2022-02-01 | Криспр Терапьютикс Аг | Аллогенная клеточная терапия b-клеточных злокачественных новообразований с применением генетически сконструированных т-клеток, нацеливающихся на cd19 |
| EP3980530A1 (en) * | 2019-06-07 | 2022-04-13 | Juno Therapeutics, Inc. | Automated t cell culture |
| US20200384029A1 (en) * | 2019-06-07 | 2020-12-10 | The Trustees Of The University Of Pennsylvania | Dual car expressing t cells individually linked to cd28 and 4-1bb |
| AU2020345943A1 (en) | 2019-09-10 | 2022-03-31 | Obsidian Therapeutics, Inc. | CA2-IL15 fusion proteins for tunable regulation |
| KR20220095228A (ko) * | 2019-11-06 | 2022-07-06 | 베이롤 칼리지 오브 메드신 | 암의 t 세포 치료를 위한 세포독성 효과기 기억 t 세포를 생산하는 방법 |
| WO2021108543A1 (en) * | 2019-11-27 | 2021-06-03 | The Trustees Of The University Of Pennsylvania | Anti-cd3 scfv and cytokine producing artificial antigen presenting cells |
| BR112022011399A2 (pt) * | 2019-12-11 | 2022-08-30 | A2 Biotherapeutics Inc | Receptor de antígeno quimérico baseado em lilrb1 |
| EP4110801A1 (en) * | 2020-02-25 | 2023-01-04 | Quell Therapeutics Limited | Chimeric receptors for use in engineered cells |
| CN111253493B (zh) * | 2020-03-05 | 2021-03-23 | 武汉科技大学 | 一种靶向hiv病毒囊膜双位点的嵌合抗原受体及其表达载体和应用 |
| US12264190B2 (en) * | 2020-04-24 | 2025-04-01 | Astrazeneca Ab | Compositions and methods of treating cancer with chimeric antigen receptors |
| IL299764A (en) | 2020-07-10 | 2023-03-01 | Precigen Inc | Fusion constructs and methods for using them |
| CN114716548B (zh) * | 2021-01-05 | 2024-11-05 | (株)爱恩德生物 | 抗-fgfr3抗体及其用途 |
| US20240327889A1 (en) * | 2021-04-05 | 2024-10-03 | Victor TETS | Regulation of cells and organisms |
| IL307417A (en) * | 2021-04-08 | 2023-12-01 | Artiva Biotherapeutics Inc | Chimeric antigen receptor comprising an anti-her2 antibody or antigen-binding fragment thereof and natural killer cells comprising the same |
| JP2024536647A (ja) | 2021-08-03 | 2024-10-07 | ジェニシティー リミテッド | 操作されたtcr複合体及びそれを使用する方法 |
| EP4130028A1 (en) | 2021-08-03 | 2023-02-08 | Rhazes Therapeutics Ltd | Engineered tcr complex and methods of using same |
| WO2023021494A1 (en) * | 2021-08-20 | 2023-02-23 | Rudd Christopher E | Compositions and methods for anti-virus chimeric antigen receptor |
| CA3247010A1 (en) * | 2022-04-08 | 2023-10-12 | Ono Pharmaceutical Co | CHIMERIC ANTIGEN RECEPTOR FOR TUMOR TARGETING |
| CN119256075A (zh) | 2022-04-08 | 2025-01-03 | 菲特治疗公司 | 具有实体瘤靶向骨架的细胞及其用途 |
| CN115873803B (zh) * | 2022-11-28 | 2025-06-17 | 上海恩凯细胞技术有限公司 | 提高nk细胞存活和抗肿瘤活性的方法及应用 |
| US20250152743A1 (en) * | 2023-11-13 | 2025-05-15 | California Institute Of Technology | Synpoptosis circuits for programmable cell death control |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US6461867B1 (en) | 1995-03-08 | 2002-10-08 | The Scripps Research Institute | Synthetic antigen presenting matrix |
| AU723355B2 (en) | 1996-05-23 | 2000-08-24 | Scripps Research Institute, The | MHC class II antigen presenting systems and methods for activating CD4+ T cells |
| KR20000076157A (ko) * | 1997-03-11 | 2000-12-26 | 리전츠 오브 더 유니버스티 오브 미네소타 | 세포의 디엔에이로 핵산을 도입하는 디엔에이-기초 전이인자 시스템 |
| AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| US6790662B1 (en) | 1999-03-12 | 2004-09-14 | Ortho-Mcneil Pharmaceutical, Inc. | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides |
| US20040071671A1 (en) | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
| JP4733635B2 (ja) | 2003-07-31 | 2011-07-27 | イミューノメディクス、インコーポレイテッド | 抗cd19抗体 |
| CA2643337C (en) | 2006-03-01 | 2016-01-12 | Janssen Pharmaceutica N.V. | Cancer treatment combining lymphodepleting agent with ctls and cytokines |
| US8124408B2 (en) | 2006-10-04 | 2012-02-28 | Janssen Pharmaceutica N.V. | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies |
| WO2009091826A2 (en) * | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| PL3006459T3 (pl) * | 2008-08-26 | 2022-01-17 | City Of Hope | Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu |
| CN103442768A (zh) * | 2011-01-18 | 2013-12-11 | 宾夕法尼亚大学董事会 | 治疗癌的组合物和方法 |
| CA2825255C (en) | 2011-01-24 | 2021-05-18 | Ym Biosciences Inc. | Antibodies selective for cells presenting egfr at high density |
| CA2832569A1 (en) * | 2011-04-08 | 2012-10-11 | Baylor College Of Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
| US9447194B2 (en) * | 2012-02-13 | 2016-09-20 | Seattle Children's Hospital | Bispecific chimeric antigen receptors and encoding polynucleotides thereof |
| HK1223943A1 (zh) | 2013-05-24 | 2017-08-11 | Board Of Regents, The University Of Texas System | 嵌合的靶向抗原受体的单克隆抗体 |
| CN105873952A (zh) * | 2013-10-31 | 2016-08-17 | 弗莱德哈钦森癌症研究中心 | 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途 |
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2015
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- 2015-04-23 JP JP2016563936A patent/JP2017514471A/ja not_active Withdrawn
- 2015-04-23 CA CA2945388A patent/CA2945388A1/en active Pending
- 2015-04-23 WO PCT/US2015/027277 patent/WO2015164594A1/en not_active Ceased
- 2015-04-23 AU AU2015249655A patent/AU2015249655B2/en not_active Ceased
- 2015-04-23 EP EP15721090.7A patent/EP3134437A1/en active Pending
- 2015-04-23 KR KR1020167032607A patent/KR20160145802A/ko not_active Ceased
- 2015-04-23 US US15/305,996 patent/US20170158749A1/en not_active Abandoned
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2019
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