CN106459924A - 用于疗法中的嵌合抗原受体(car)及其制备方法 - Google Patents

用于疗法中的嵌合抗原受体(car)及其制备方法 Download PDF

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CN106459924A
CN106459924A CN201580026693.4A CN201580026693A CN106459924A CN 106459924 A CN106459924 A CN 106459924A CN 201580026693 A CN201580026693 A CN 201580026693A CN 106459924 A CN106459924 A CN 106459924A
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car
cell
cells
antigen
methods
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L·J·N·库珀
H·G·卡鲁索
S·奥利瓦雷斯
S·安
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University of Texas System
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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CN201580026693.4A 2014-04-23 2015-04-23 用于疗法中的嵌合抗原受体(car)及其制备方法 Pending CN106459924A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461983103P 2014-04-23 2014-04-23
US201461983298P 2014-04-23 2014-04-23
US61/983,298 2014-04-23
US61/983,103 2014-04-23
PCT/US2015/027277 WO2015164594A1 (en) 2014-04-23 2015-04-23 Chimeric antigen receptors (car) for use in therapy and methods for making the same

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US (3) US20170158749A1 (enExample)
EP (1) EP3134437A1 (enExample)
JP (4) JP2017514471A (enExample)
KR (1) KR20160145802A (enExample)
CN (1) CN106459924A (enExample)
AU (1) AU2015249655B2 (enExample)
CA (1) CA2945388A1 (enExample)
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Cited By (18)

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CN107099603A (zh) * 2017-05-31 2017-08-29 成都克里斯博生物科技有限公司 肿瘤免疫t细胞检测试剂盒和检测方法
CN107287165A (zh) * 2017-08-23 2017-10-24 湖南开启时代生物科技有限责任公司 一种car‑t细胞的制备方法
CN107488738A (zh) * 2017-10-12 2017-12-19 中国医学科学院肿瘤医院 一种预测乳腺癌对曲妥珠单抗联合化疗治疗敏感性的生物标志物
CN108070033A (zh) * 2017-12-12 2018-05-25 武汉波睿达生物科技有限公司 一种3bnc-car分子的构建及其在杀灭hiv-1感染细胞中的应用
CN109468278A (zh) * 2017-09-08 2019-03-15 科济生物医药（上海）有限公司 基因工程化的t细胞及应用
CN110741018A (zh) * 2017-06-09 2020-01-31 奥托路斯有限公司 抗原结合结构域
WO2020043076A1 (zh) * 2018-08-27 2020-03-05 天津天锐生物科技有限公司 一种不依赖细胞因子培养的自然杀伤细胞系silk-nk
CN111107855A (zh) * 2017-08-06 2020-05-05 强普生技股份有限公司 医药试剂盒及其用途
CN111253493A (zh) * 2020-03-05 2020-06-09 武汉科技大学 一种靶向hiv病毒囊膜双位点的嵌合抗原受体及其表达载体和应用
CN111373261A (zh) * 2017-11-20 2020-07-03 尤利乌斯·马克西米利安维尔茨堡大学 Cd19 cart细胞可清除表达极低水平cd19的骨髓瘤细胞
CN111727045A (zh) * 2017-12-15 2020-09-29 小利兰·斯坦福大学托管委员会 抑制t细胞衰竭的组合物和方法
CN112888786A (zh) * 2018-09-07 2021-06-01 Sotio有限责任公司 与调节细胞内乳酸浓度的反式代谢分子组合的嵌合受体多肽及其治疗用途
CN113795272A (zh) * 2019-02-08 2021-12-14 生物技术细胞和基因治疗公司 涉及car工程化的t细胞和细胞因子的治疗
CN115052887A (zh) * 2019-12-11 2022-09-13 A2生物治疗公司 基于lilrb1的嵌合抗原受体
CN115427440A (zh) * 2020-02-25 2022-12-02 圭尔医疗有限公司 用于工程化细胞的嵌合受体
TWI800522B (zh) * 2017-12-23 2023-05-01 宇越生醫科技股份有限公司 醫藥重組受體組成物及方法
CN116763943A (zh) * 2018-08-07 2023-09-19 普渡研究基金会 使car t细胞恢复活力
WO2024113649A1 (zh) * 2022-11-28 2024-06-06 上海恩凯细胞技术有限公司 提高nk细胞存活和抗肿瘤活性的方法及其应用

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US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
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Application publication date: 20170222