JP2017514471A - キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法 - Google Patents

キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法 Download PDF

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JP2017514471A
JP2017514471A JP2016563936A JP2016563936A JP2017514471A JP 2017514471 A JP2017514471 A JP 2017514471A JP 2016563936 A JP2016563936 A JP 2016563936A JP 2016563936 A JP2016563936 A JP 2016563936A JP 2017514471 A JP2017514471 A JP 2017514471A
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car
cells
cell
antigen
egfr
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JP2017514471A5 (enExample
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ローレンス ジェイ．エヌ． クーパー，
ローレンス ジェイ．エヌ． クーパー，
ヒラリー ギボンズ カルソー，
ヒラリー ギボンズ カルソー，
サイモン オリバレス，
サイモン オリバレス，
ソニー アン，
ソニー アン，
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University of Texas System
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University of Texas System
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/16—Physical preservation processes
    • A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/00—Fusion polypeptide
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    • C—CHEMISTRY; METALLURGY
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JP2016563936A 2014-04-23 2015-04-23 キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法 Withdrawn JP2017514471A (ja)

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US201461983298P 2014-04-23 2014-04-23
US201461983103P 2014-04-23 2014-04-23
US61/983,103 2014-04-23
US61/983,298 2014-04-23
PCT/US2015/027277 WO2015164594A1 (en) 2014-04-23 2015-04-23 Chimeric antigen receptors (car) for use in therapy and methods for making the same

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JP2017514471A5 JP2017514471A5 (enExample) 2018-05-24

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JP2020023077A Pending JP2020072755A (ja) 2014-04-23 2020-02-14 キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法
JP2022074648A Pending JP2022093564A (ja) 2014-04-23 2022-04-28 キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法
JP2023130951A Pending JP2023138812A (ja) 2014-04-23 2023-08-10 キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法

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JP2022074648A Pending JP2022093564A (ja) 2014-04-23 2022-04-28 キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法
JP2023130951A Pending JP2023138812A (ja) 2014-04-23 2023-08-10 キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法

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US (3) US20170158749A1 (enExample)
EP (1) EP3134437A1 (enExample)
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KR (1) KR20160145802A (enExample)
CN (1) CN106459924A (enExample)
AU (1) AU2015249655B2 (enExample)
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Cited By (7)

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JP2021504484A (ja) * 2017-11-28 2021-02-15 セントロ デ インミュノロヒア モレキュラル 上皮成長因子受容体に対する親和性が増加した抗体およびそれに由来するフラグメント
JP2021511826A (ja) * 2018-01-22 2021-05-13 シアトル チルドレンズ ホスピタル ディー／ビー／エー シアトル チルドレンズ リサーチ インスティテュート Ｃａｒ ｔ細胞の使用方法
JP2023500671A (ja) * 2019-11-06 2023-01-10 ベイラー カレッジ オブ メディスン がんのｔ細胞治療のための細胞傷害性エフェクターメモリーｔ細胞の産生方法
EP4130028A1 (en) 2021-08-03 2023-02-08 Rhazes Therapeutics Ltd Engineered tcr complex and methods of using same
WO2023012584A2 (en) 2021-08-03 2023-02-09 Genicity Limited Engineered tcr complex and methods of using same
JP2023522371A (ja) * 2020-04-24 2023-05-30 アストラゼネカ アクチボラグ 癌をキメラ抗原受容体により処置する組成物及び方法
JP2023134735A (ja) * 2017-07-25 2023-09-27 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 強化されたキメラ抗原受容体およびその使用

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US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
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