JP2017510244A5 - - Google Patents
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- JP2017510244A5 JP2017510244A5 JP2016539051A JP2016539051A JP2017510244A5 JP 2017510244 A5 JP2017510244 A5 JP 2017510244A5 JP 2016539051 A JP2016539051 A JP 2016539051A JP 2016539051 A JP2016539051 A JP 2016539051A JP 2017510244 A5 JP2017510244 A5 JP 2017510244A5
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- 108091033319 polynucleotide Proteins 0.000 claims description 99
- 102000040430 polynucleotide Human genes 0.000 claims description 99
- 239000002157 polynucleotide Substances 0.000 claims description 99
- 238000000034 method Methods 0.000 claims description 78
- 230000003321 amplification Effects 0.000 claims description 34
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 34
- 239000000523 sample Substances 0.000 claims description 32
- 238000012163 sequencing technique Methods 0.000 claims description 24
- 239000011541 reaction mixture Substances 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 108020004414 DNA Proteins 0.000 claims description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 4
- 108091035707 Consensus sequence Proteins 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000001124 body fluid Anatomy 0.000 claims description 3
- 239000010839 body fluid Substances 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 238000006073 displacement reaction Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 210000004881 tumor cell Anatomy 0.000 claims description 3
- 210000002700 urine Anatomy 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 238000001514 detection method Methods 0.000 description 4
- 102000003960 Ligases Human genes 0.000 description 3
- 108090000364 Ligases Proteins 0.000 description 3
- 102000054767 gene variant Human genes 0.000 description 3
- 230000001364 causal effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012569 microbial contaminant Substances 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914907P | 2013-12-11 | 2013-12-11 | |
| US61/914,907 | 2013-12-11 | ||
| US201461987414P | 2014-05-01 | 2014-05-01 | |
| US61/987,414 | 2014-05-01 | ||
| US201462010975P | 2014-06-11 | 2014-06-11 | |
| US62/010,975 | 2014-06-11 | ||
| PCT/US2014/069848 WO2015089333A1 (en) | 2013-12-11 | 2014-12-11 | Compositions and methods for detecting rare sequence variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510244A JP2017510244A (ja) | 2017-04-13 |
| JP2017510244A5 true JP2017510244A5 (enExample) | 2018-01-25 |
| JP6435334B2 JP6435334B2 (ja) | 2018-12-05 |
Family
ID=53371852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539051A Active JP6435334B2 (ja) | 2013-12-11 | 2014-12-11 | 稀な配列変異体を検出するための組成物および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10767222B2 (enExample) |
| EP (2) | EP3495506B1 (enExample) |
| JP (1) | JP6435334B2 (enExample) |
| KR (3) | KR102379877B1 (enExample) |
| CN (2) | CN104946737B (enExample) |
| AU (3) | AU2014362227B2 (enExample) |
| CA (1) | CA2933343A1 (enExample) |
| ES (2) | ES2960338T3 (enExample) |
| IL (3) | IL300974A (enExample) |
| MX (1) | MX376900B (enExample) |
| SG (2) | SG11201604737VA (enExample) |
| WO (1) | WO2015089333A1 (enExample) |
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