JP2019196400A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019196400A5 JP2019196400A5 JP2019137587A JP2019137587A JP2019196400A5 JP 2019196400 A5 JP2019196400 A5 JP 2019196400A5 JP 2019137587 A JP2019137587 A JP 2019137587A JP 2019137587 A JP2019137587 A JP 2019137587A JP 2019196400 A5 JP2019196400 A5 JP 2019196400A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- ros
- gene
- ros fusion
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 230000004927 fusion Effects 0.000 claims 16
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 101150042287 ros gene Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 7
- 238000003556 assay Methods 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 101150016193 fig gene Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000002853 nucleic acid probe Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 238000002944 PCR assay Methods 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20748409P | 2009-02-12 | 2009-02-12 | |
| US61/207,484 | 2009-02-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113248A Division JP6564500B2 (ja) | 2009-02-12 | 2018-06-14 | ヒト癌における変異ｒｏｓ発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019196400A JP2019196400A (ja) | 2019-11-14 |
| JP2019196400A5 true JP2019196400A5 (enExample) | 2020-01-23 |
| JP6797977B2 JP6797977B2 (ja) | 2020-12-09 |
Family
ID=42562298
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550275A Active JP5979877B2 (ja) | 2009-02-12 | 2010-02-12 | ヒト癌における変異ｒｏｓ発現 |
| JP2015226709A Active JP6356654B2 (ja) | 2009-02-12 | 2015-11-19 | ヒト癌における変異ｒｏｓ発現 |
| JP2018113248A Active JP6564500B2 (ja) | 2009-02-12 | 2018-06-14 | ヒト癌における変異ｒｏｓ発現 |
| JP2019137587A Active JP6797977B2 (ja) | 2009-02-12 | 2019-07-26 | ヒト癌における変異ｒｏｓ発現 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550275A Active JP5979877B2 (ja) | 2009-02-12 | 2010-02-12 | ヒト癌における変異ｒｏｓ発現 |
| JP2015226709A Active JP6356654B2 (ja) | 2009-02-12 | 2015-11-19 | ヒト癌における変異ｒｏｓ発現 |
| JP2018113248A Active JP6564500B2 (ja) | 2009-02-12 | 2018-06-14 | ヒト癌における変異ｒｏｓ発現 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9364477B2 (enExample) |
| EP (3) | EP3266795A1 (enExample) |
| JP (4) | JP5979877B2 (enExample) |
| AU (1) | AU2010213578B2 (enExample) |
| CA (1) | CA2744236C (enExample) |
| DK (1) | DK2881402T3 (enExample) |
| ES (1) | ES2637174T3 (enExample) |
| HK (1) | HK1248259A1 (enExample) |
| HU (1) | HUE035769T2 (enExample) |
| PL (1) | PL2881402T3 (enExample) |
| PT (1) | PT2881402T (enExample) |
| SI (1) | SI2881402T1 (enExample) |
| WO (1) | WO2010093928A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| MX353308B (es) | 2008-05-21 | 2018-01-08 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| CN102224153B (zh) | 2008-09-22 | 2014-04-30 | 阵列生物制药公司 | 作为trk激酶抑制剂的取代的咪唑并[1，2-b]哒嗪化合物 |
| PL3372605T3 (pl) | 2008-10-22 | 2022-03-07 | Array Biopharma Inc. | Podstawione związki pirazolo[1,5-a]pirymidynowe jako inhibitory kinaz trk |
| US9364477B2 (en) * | 2009-02-12 | 2016-06-14 | Cell Signaling Technology, Inc. | Mutant ROS expression in human cancer |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| GEP20196956B (en) | 2009-10-23 | 2019-03-25 | British Columbia Amgen | Anti-gcc antibody molecules and related compositions and methods |
| HUE044025T2 (hu) | 2010-05-20 | 2019-09-30 | Array Biopharma Inc | Makrociklusos vegyületek mint TRK-kináz inhibitorok |
| US20130288240A1 (en) * | 2010-05-21 | 2013-10-31 | Cell Signaling Technology, Inc. | Alk and ros kinase in cancer |
| EP2586862B9 (en) | 2010-06-22 | 2016-07-13 | LSI Medience Corporation | Detection method for novel ros1 fusion product |
| WO2012151561A1 (en) | 2011-05-04 | 2012-11-08 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| RU2014102935A (ru) * | 2011-08-02 | 2015-09-10 | Пфайзер Инк. | Кризотиниб для применения в лечении рака |
| AU2013216904A1 (en) * | 2012-02-08 | 2014-08-28 | Insight Genetics, Inc. | Methods and compositions relating to fusions of ROS1 for diagnosing and treating cancer |
| EP2838998B1 (en) | 2012-04-18 | 2017-10-11 | Cell Signaling Technology, Inc. | Egfr and ros1 in cancer |
| GEP201706737B (en) * | 2012-04-27 | 2017-09-25 | Millennium Pharm Inc | Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| WO2013180183A1 (ja) | 2012-05-30 | 2013-12-05 | 日本新薬株式会社 | 芳香族複素環誘導体及び医薬 |
| WO2014033136A1 (en) * | 2012-08-27 | 2014-03-06 | Cemm - Research Center For Molecular Medicine Of The Austrian Academy Of Sciences | Aminoheteroaryl compounds as mth1 inhibitors |
| CA2906965C (en) * | 2013-03-15 | 2018-07-31 | Expression Pathology, Inc. | Srm assay to indicate cancer therapy |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| EP3906921A1 (en) | 2014-04-25 | 2021-11-10 | Exelixis, Inc. | Method of treating lung adenocarcinoma |
| PT3699181T (pt) | 2014-11-16 | 2023-04-05 | Array Biopharma Inc | Forma cristalina de hidrogenossulfato de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| JP2018534296A (ja) | 2015-10-26 | 2018-11-22 | ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． | Ｔｒｋ阻害薬耐性がんにおける点変異およびそれに関連する方法 |
| RU2743169C2 (ru) * | 2015-11-06 | 2021-02-15 | Вентана Медикал Системз, Инк. | Репрезентативная диагностика |
| CU20180125A7 (es) | 2016-04-04 | 2019-05-03 | Loxo Oncology Inc | Formulaciones líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil) -pirrolidin-1-il)-pirazolo[1,5-alpirimidin-3-il)-3 hidroxipirrolidina-1-carboxamida |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| MX392604B (es) | 2016-05-18 | 2025-03-24 | Array Biopharma Inc | Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo. |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| CN115997008A (zh) | 2020-04-22 | 2023-04-21 | 艾欧凡斯生物治疗公司 | 协调用于患者特异性免疫疗法的细胞的制造的系统和方法 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3023787A1 (de) | 1980-06-25 | 1982-01-21 | Studiengesellschaft Kohle mbH, 4330 Mülheim | Verfahren zur erhoehung der inkorporation und der expression von genetischem material in die kerne von intakten zellen mit hilfe von liposomen |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4727022A (en) | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
| CA1255586A (en) | 1984-07-24 | 1989-06-13 | Hendrik M. Geysen | Method of determining mimotopes |
| WO1987001130A1 (en) | 1985-08-15 | 1987-02-26 | Stauffer Chemical Company | Tryptophan producing microorganism |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5756696A (en) | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
| US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
| AU625013B2 (en) | 1989-11-03 | 1992-06-25 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| EP1566442B1 (de) | 1990-02-01 | 2009-11-25 | Siemens Healthcare Diagnostics Products GmbH | Herstellung und Verwendung von Genbanken menschlicher Antikörper("Human-Antikörper-Bibliotheken") |
| DE4002897A1 (de) | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken") |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| ATE309376T1 (de) | 1990-06-28 | 2005-11-15 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5491224A (en) | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US6025165A (en) | 1991-11-25 | 2000-02-15 | Enzon, Inc. | Methods for producing multivalent antigen-binding proteins |
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| EP1251170A3 (en) | 1992-07-17 | 2002-10-30 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of NF-kappaB dependent animal diseases |
| US6710174B2 (en) | 2001-09-13 | 2004-03-23 | Isis Pharmaceuticals, Inc. | Antisense inhibition of vascular endothelial growth factor receptor-1 expression |
| IL108367A0 (en) | 1993-01-27 | 1994-04-12 | Hektoen Inst For Medical Resea | Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells |
| US6340674B1 (en) | 1993-03-26 | 2002-01-22 | Thomas Jefferson University | Method of inhibiting the proliferation and causing the differentiation of cells with IGF-1 receptor antisense oligonucleotides |
| US5480971A (en) | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
| ES2247204T3 (es) | 1994-01-31 | 2006-03-01 | Trustees Of Boston University | Bancos de anticuerpos policlonales. |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5783683A (en) | 1995-01-10 | 1998-07-21 | Genta Inc. | Antisense oligonucleotides which reduce expression of the FGFRI gene |
| US5675063A (en) | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
| DK1143006T3 (da) | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| US6617162B2 (en) | 2001-12-18 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Antisense modulation of estrogen receptor alpha expression |
| WO1999031262A2 (en) | 1997-12-16 | 1999-06-24 | Valentis, Inc. | Needle-free injection of formulated nucleic acid molecules |
| US7198896B2 (en) | 1998-09-04 | 2007-04-03 | Cell Signaling Technology, Inc. | Immunoaffinity isolation of modified peptides from complex mixtures |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| EP1159441B8 (en) | 1999-03-10 | 2008-10-29 | Marie Curie Cancer Care | Delivery of nucleic acids and proteins to cells |
| US7662793B2 (en) | 1999-06-18 | 2010-02-16 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from a Pol III promoter |
| US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| PT1309726E (pt) | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| CA2422162C (en) | 2000-09-09 | 2012-10-23 | The Research Foundation Of State University Of New York | Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof |
| DK1407044T4 (en) | 2000-12-01 | 2017-12-04 | Max-Planck-Gesellschaft Zur Förderung Der Wss E V | RNA interference mediating small RNA molecules |
| SG138469A1 (en) | 2001-01-05 | 2008-01-28 | Pfizer | Antibodies to insulin-like growth factor i receptor |
| JP2005514002A (ja) | 2001-05-17 | 2005-05-19 | ザ パブリック ヘルス リサーチ インスティテュート オブ ザ シティ オブ ニューヨーク，インコーポレーテッド | Ｒｎａをアンチセンス攻撃するための標的部位の選択 |
| US20030170891A1 (en) | 2001-06-06 | 2003-09-11 | Mcswiggen James A. | RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20040209832A1 (en) | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| IL159177A0 (en) | 2001-06-20 | 2004-06-01 | Prochon Biotech Ltd | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| DE60239962D1 (de) | 2001-08-14 | 2011-06-16 | Harvard College | Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie |
| US20030219839A1 (en) | 2001-09-20 | 2003-11-27 | Katherine Bowdish | Anti-PDGF antibodies and methods for producing engineered antibodies |
| US6734017B2 (en) | 2001-09-28 | 2004-05-11 | Isis Pharmaceuticals, Inc. | Antisense modulation of vascular endothelial growth factor receptor-2 expression |
| DE10230997A1 (de) | 2001-10-26 | 2003-07-17 | Ribopharma Ag | Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels |
| US20040033543A1 (en) | 2002-05-20 | 2004-02-19 | Gisela Schwab | Treatment of renal carcinoma using antibodies against the EGFr |
| CN101537180B (zh) | 2002-07-18 | 2016-02-10 | 莫鲁斯有限公司 | 抗体混合物的重组生产 |
| US20040023390A1 (en) | 2002-08-05 | 2004-02-05 | Davidson Beverly L. | SiRNA-mediated gene silencing with viral vectors |
| US20050181375A1 (en) | 2003-01-10 | 2005-08-18 | Natasha Aziz | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer |
| BRPI0408317A (pt) | 2003-03-14 | 2006-03-07 | Pharmacia Corp | anticorpos do receptor de igf-i para o tratamento de cáncer |
| US20050214301A1 (en) | 2004-03-24 | 2005-09-29 | Cell Signaling Technology, Inc. | Antibodies specific for BCR-ABL fusion protein and uses thereof |
| US20120208824A1 (en) * | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| ES2539830T3 (es) | 2006-01-20 | 2015-07-06 | Cell Signaling Technology, Inc. | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
| WO2008066498A1 (en) * | 2006-12-01 | 2008-06-05 | Agency For Science, Technology And Research | Cancer-related protein kinases |
| CA2702686C (en) | 2007-10-18 | 2023-04-04 | Cell Signaling Technology, Inc. | Translocation and mutant ros kinase in human non-small cell lung carcinoma |
| US9364477B2 (en) * | 2009-02-12 | 2016-06-14 | Cell Signaling Technology, Inc. | Mutant ROS expression in human cancer |
| RU2014102935A (ru) * | 2011-08-02 | 2015-09-10 | Пфайзер Инк. | Кризотиниб для применения в лечении рака |
-
2010
- 2010-02-12 US US13/146,705 patent/US9364477B2/en active Active
- 2010-02-12 PT PT141846915T patent/PT2881402T/pt unknown
- 2010-02-12 CA CA2744236A patent/CA2744236C/en active Active
- 2010-02-12 ES ES14184691.5T patent/ES2637174T3/es active Active
- 2010-02-12 SI SI201031519T patent/SI2881402T1/sl unknown
- 2010-02-12 EP EP17169877.2A patent/EP3266795A1/en not_active Withdrawn
- 2010-02-12 PL PL14184691T patent/PL2881402T3/pl unknown
- 2010-02-12 HU HUE14184691A patent/HUE035769T2/en unknown
- 2010-02-12 JP JP2011550275A patent/JP5979877B2/ja active Active
- 2010-02-12 DK DK14184691.5T patent/DK2881402T3/en active
- 2010-02-12 WO PCT/US2010/024109 patent/WO2010093928A2/en not_active Ceased
- 2010-02-12 EP EP14184691.5A patent/EP2881402B1/en active Active
- 2010-02-12 AU AU2010213578A patent/AU2010213578B2/en active Active
- 2010-02-12 EP EP10741807.1A patent/EP2396342B1/en active Active
-
2014
- 2014-09-11 US US14/483,681 patent/US9539254B2/en active Active
-
2015
- 2015-11-19 JP JP2015226709A patent/JP6356654B2/ja active Active
-
2016
- 2016-11-30 US US15/364,870 patent/US20170071941A1/en not_active Abandoned
-
2018
- 2018-06-14 JP JP2018113248A patent/JP6564500B2/ja active Active
- 2018-06-15 HK HK18107825.6A patent/HK1248259A1/en unknown
-
2019
- 2019-07-26 JP JP2019137587A patent/JP6797977B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019196400A5 (enExample) | ||
| US20240229105A1 (en) | Attenuators | |
| US11293048B2 (en) | Attenuators | |
| JP2017510244A5 (enExample) | ||
| JP2017536813A5 (enExample) | ||
| CN110719957B (zh) | 用于核酸靶向富集的方法和试剂盒 | |
| TW200930818A (en) | Method and kits for multiplex amplification of short tandem repeat loci | |
| US20250257350A1 (en) | Integrative DNA and RNA Library Preparations and Uses Thereof | |
| JP2016509833A5 (enExample) | ||
| JP2015091235A5 (enExample) | ||
| JP2016533708A5 (enExample) | ||
| JP4490988B2 (ja) | 血清アミロイドａ１（ｓａａ１）の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法 | |
| JP2018516594A5 (enExample) | ||
| KR101875199B1 (ko) | Ｐｎａ 기반의 실시간 ｐｃｒ 클램핑을 이용한 ｂｃｒ-ａｂｌ 융합 유전자의 돌연변이 검출 방법 및 키트 | |
| JP2011500063A (ja) | Ｄｎａ増幅方法 | |
| JP2007520236A (ja) | 抗凍結タンパク質により高められた核酸増幅 | |
| WO2009098789A1 (ja) | Lamp法による甲殻類病原性ウイルスの検出方法及び検出試薬キット | |
| KR101815105B1 (ko) | 멀티플렉스 pcr-기반된 차세대 시퀀싱을 이용한 한타바이러스 전장 유전체 서열 획득 방법 및 이의 용도 | |
| JP2016510982A5 (enExample) | ||
| WO2014023318A1 (en) | New dna polymerases with increased substrate scope | |
| CN114381496A (zh) | 一种原位杂交探针及其制备方法与应用 | |
| JP2006520587A5 (enExample) | ||
| JP2016049107A (ja) | 核酸増幅の特異的抑制方法 | |
| ES3030914T3 (en) | Bivalent reverse primer | |
| TWI531654B (zh) | 用於鑑別ｈ５禽流感病毒病原性之寡核酸探針、含其之套組及方法 |