SG10201807532SA - Compositions and methods for detecting rare sequence variants - Google Patents
Compositions and methods for detecting rare sequence variantsInfo
- Publication number
- SG10201807532SA SG10201807532SA SG10201807532SA SG10201807532SA SG10201807532SA SG 10201807532S A SG10201807532S A SG 10201807532SA SG 10201807532S A SG10201807532S A SG 10201807532SA SG 10201807532S A SG10201807532S A SG 10201807532SA SG 10201807532S A SG10201807532S A SG 10201807532SA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- compositions
- sequence
- sequence variants
- detecting rare
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/501—Ligase
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- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
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- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/30—Oligonucleotides characterised by their secondary structure
- C12Q2525/307—Circular oligonucleotides
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- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/101—Temperature
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- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/113—PCR
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- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/125—Rolling circle
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- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
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- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
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- Spectroscopy & Molecular Physics (AREA)
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- Evolutionary Biology (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract
Compositions and methods for detecting rare sequence variants In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises identifying sequence differences between sequencing reads and a reference sequence, and calling a sequence difference that occurs in at least two different circular polynucleotides, such as two circular polynucleotides having different junctions, as the sequence variant. In some aspects, the present disclosure provides compositions and systems useful in the described methods. Fig. 7
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361914907P | 2013-12-11 | 2013-12-11 | |
US201461987414P | 2014-05-01 | 2014-05-01 | |
US201462010975P | 2014-06-11 | 2014-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201807532SA true SG10201807532SA (en) | 2018-09-27 |
Family
ID=53371852
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201807532SA SG10201807532SA (en) | 2013-12-11 | 2014-12-11 | Compositions and methods for detecting rare sequence variants |
SG11201604737VA SG11201604737VA (en) | 2013-12-11 | 2014-12-11 | Compositions and methods for detecting rare sequence variants |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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SG11201604737VA SG11201604737VA (en) | 2013-12-11 | 2014-12-11 | Compositions and methods for detecting rare sequence variants |
Country Status (13)
Country | Link |
---|---|
US (3) | US10767222B2 (en) |
EP (2) | EP3495506B1 (en) |
JP (1) | JP6435334B2 (en) |
KR (3) | KR20240025725A (en) |
CN (2) | CN104946737B (en) |
AU (3) | AU2014362227B2 (en) |
CA (1) | CA2933343A1 (en) |
ES (2) | ES2960338T3 (en) |
HK (1) | HK1214843A1 (en) |
IL (3) | IL300974A (en) |
MX (1) | MX2016007605A (en) |
SG (2) | SG10201807532SA (en) |
WO (1) | WO2015089333A1 (en) |
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