JP2018524993A5 - - Google Patents

Info

Publication number

JP2018524993A5

JP2018524993A5 JP2018503647A JP2018503647A JP2018524993A5 JP 2018524993 A5 JP2018524993 A5 JP 2018524993A5 JP 2018503647 A JP2018503647 A JP 2018503647A JP 2018503647 A JP2018503647 A JP 2018503647A JP 2018524993 A5 JP2018524993 A5 JP 2018524993A5

Authority

JP

Japan

Prior art keywords

mip

sequence

target

population

sample

Prior art date

2016-07-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000523 sample Substances 0.000 claims 30
• 239000002157 polynucleotide Substances 0.000 claims 29
• 108091033319 polynucleotide Proteins 0.000 claims 27
• 102000040430 polynucleotide Human genes 0.000 claims 27
• 238000000034 method Methods 0.000 claims 20
• 108091093088 Amplicon Proteins 0.000 claims 19
• 238000012163 sequencing technique Methods 0.000 claims 15
• 239000000203 mixture Substances 0.000 claims 8
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 150000007523 nucleic acids Chemical class 0.000 claims 8
• 108020004414 DNA Proteins 0.000 claims 6
• 239000002773 nucleotide Substances 0.000 claims 6
• 125000003729 nucleotide group Chemical group 0.000 claims 6
• 230000003321 amplification Effects 0.000 claims 5
• 208000036878 aneuploidy Diseases 0.000 claims 5
• 231100001075 aneuploidy Toxicity 0.000 claims 5
• 238000003199 nucleic acid amplification method Methods 0.000 claims 5
• 239000008280 blood Substances 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 210000003754 fetus Anatomy 0.000 claims 4
• FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 3
• 238000002844 melting Methods 0.000 claims 3
• 230000008018 melting Effects 0.000 claims 3
• GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 2
• 230000002759 chromosomal effect Effects 0.000 claims 2
• 210000000349 chromosome Anatomy 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 230000008774 maternal effect Effects 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108060002716 Exonuclease Proteins 0.000 claims 1
• 102000003960 Ligases Human genes 0.000 claims 1
• 108090000364 Ligases Proteins 0.000 claims 1
• 102000013165 exonuclease Human genes 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 238000007689 inspection Methods 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1