JP2014513557A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014513557A5 JP2014513557A5 JP2014511555A JP2014511555A JP2014513557A5 JP 2014513557 A5 JP2014513557 A5 JP 2014513557A5 JP 2014511555 A JP2014511555 A JP 2014511555A JP 2014511555 A JP2014511555 A JP 2014511555A JP 2014513557 A5 JP2014513557 A5 JP 2014513557A5
- Authority
- JP
- Japan
- Prior art keywords
- target
- probe
- nucleic acid
- linking
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000523 sample Substances 0.000 claims 37
- 150000007523 nucleic acids Chemical class 0.000 claims 23
- 238000000034 method Methods 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 108091093088 Amplicon Proteins 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 102000003960 Ligases Human genes 0.000 claims 3
- 108090000364 Ligases Proteins 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000006850 spacer group Chemical group 0.000 claims 3
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 238000003390 bioluminescence detection Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000005251 capillar electrophoresis Methods 0.000 claims 1
- 238000002038 chemiluminescence detection Methods 0.000 claims 1
- 238000000835 electrochemical detection Methods 0.000 claims 1
- 238000001378 electrochemiluminescence detection Methods 0.000 claims 1
- 238000001917 fluorescence detection Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 238000010208 microarray analysis Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486817P | 2011-05-17 | 2011-05-17 | |
| US61/486,817 | 2011-05-17 | ||
| PCT/US2012/038436 WO2012158967A1 (en) | 2011-05-17 | 2012-05-17 | Methods and compositions for detecting target nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513557A JP2014513557A (ja) | 2014-06-05 |
| JP2014513557A5 true JP2014513557A5 (enExample) | 2015-05-21 |
Family
ID=46168641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511555A Pending JP2014513557A (ja) | 2011-05-17 | 2012-05-17 | 標的核酸を検出する方法及び組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9745616B2 (enExample) |
| EP (1) | EP2710145B1 (enExample) |
| JP (1) | JP2014513557A (enExample) |
| KR (1) | KR102085242B1 (enExample) |
| CN (2) | CN106434871B (enExample) |
| AU (1) | AU2012255121B2 (enExample) |
| CA (1) | CA2836577C (enExample) |
| DK (1) | DK2710145T3 (enExample) |
| WO (1) | WO2012158967A1 (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2677039B8 (en) * | 2006-05-10 | 2022-10-05 | DxTerity Diagnostics Incorporated | Detection of nucleic acid targets using chemically reactive oligonucleotide probes |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP2710145B1 (en) * | 2011-05-17 | 2015-12-09 | Dxterity Diagnostics Incorporated | Methods and compositions for detecting target nucleic acids |
| EP2729580B1 (en) | 2011-07-08 | 2015-09-16 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
| WO2014060483A1 (en) | 2012-10-17 | 2014-04-24 | Spatial Transcriptomics Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| US9080167B2 (en) * | 2012-11-16 | 2015-07-14 | Covaris, Inc. | System and method for processing paraffin embedded samples |
| BR112015013234B1 (pt) * | 2012-12-07 | 2021-12-21 | Invitae Corporation | Método para amplificação multiplex de sonda dependente de ligação |
| KR101829668B1 (ko) * | 2013-03-27 | 2018-02-14 | 김성천 | 생체분자와 단일가닥핵산의 결합정보를 생성하기 위한 기준물질 및 핵산칩, 이들의 제조방법 및 이들을 이용한 생체분자 분석방법 및 장치 |
| EP2992115B2 (en) | 2013-04-30 | 2025-03-12 | California Institute of Technology | Multiplex labeling of molecules by sequential hybridization barcoding |
| US10510435B2 (en) | 2013-04-30 | 2019-12-17 | California Institute Of Technology | Error correction of multiplex imaging analysis by sequential hybridization |
| US9868979B2 (en) | 2013-06-25 | 2018-01-16 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
| EP3154696B1 (en) | 2014-06-10 | 2020-04-08 | DxTerity Diagnostics Incorporated | Devices and methods for collecting and stabilizing biological samples |
| US10870845B2 (en) | 2014-07-01 | 2020-12-22 | Global Life Sciences Solutions Operations UK Ltd | Methods for capturing nucleic acids |
| US10683534B2 (en) | 2015-01-27 | 2020-06-16 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
| US11091810B2 (en) * | 2015-01-27 | 2021-08-17 | BioSpyder Technologies, Inc. | Focal gene expression profiling of stained FFPE tissues with spatial correlation to morphology |
| US9856521B2 (en) * | 2015-01-27 | 2018-01-02 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
| CN107002147B (zh) * | 2014-12-11 | 2022-01-28 | 环球生命科学解决方案运营英国有限公司 | 用于俘获核酸的方法 |
| CN105803055A (zh) * | 2014-12-31 | 2016-07-27 | 天昊生物医药科技（苏州）有限公司 | 一种基于多重循环延伸连接的靶基因区域富集新方法 |
| EP4282977B1 (en) | 2015-04-10 | 2024-06-05 | 10x Genomics Sweden AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| AU2016297513B2 (en) | 2015-07-17 | 2021-02-25 | Board Of Regents, The University Of Texas System | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
| DK3325669T3 (da) * | 2015-07-24 | 2023-10-09 | Univ Johns Hopkins | Sammensætninger og fremgangsmåder til RNA-analyse |
| DE212016000167U1 (de) * | 2015-08-10 | 2018-04-16 | Life Technologies Corporation | Vorrichtungen für eine Laser-Capture-Miktodissektion |
| US12421540B2 (en) | 2016-08-01 | 2025-09-23 | California Institute Of Technology | Sequential probing of molecular targets based on pseudo-color barcodes with embedded error correction mechanism |
| US10451599B2 (en) | 2016-09-02 | 2019-10-22 | Zepto Life Technology, LLC | Methods of isolating and detecting metal ions from proteins |
| WO2019046768A1 (en) * | 2017-08-31 | 2019-03-07 | William Marsh Rice University | SYMBOLIC SEQUENCING OF DNA AND RNA BY SEQUENCE CODING |
| EP4589017A3 (en) | 2017-10-06 | 2025-10-08 | 10x Genomics, Inc. | Rna templated ligation |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| US20220042090A1 (en) * | 2018-09-14 | 2022-02-10 | Cold Spring Harbor Laboratory | PROGRAMMABLE RNA-TEMPLATED SEQUENCING BY LIGATION (rSBL) |
| JP2022506752A (ja) * | 2018-11-05 | 2022-01-17 | サントル・アンリ・ベクレル | がんを診断するための方法及び関連するキット |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| WO2020123311A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Resolving spatial arrays using deconvolution |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| KR102403334B1 (ko) * | 2019-02-14 | 2022-06-02 | 고려대학교 산학협력단 | 생물학적 샘플로부터 미세 소포체를 추출하는 방법 |
| AU2020233286B2 (en) * | 2019-03-01 | 2022-10-20 | Mercy Bioanalytics, Inc. | Systems, compositions, and methods for target entity detection |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| CN214973877U (zh) * | 2019-08-09 | 2021-12-03 | 胡桃钳医疗公司 | 用于形成治疗性多核苷酸的微流体设备及微流体路径装置 |
| EP4028545A4 (en) * | 2019-09-09 | 2023-10-25 | Sherlock Biosciences, Inc. | SYSTEM |
| EP4047089B1 (en) * | 2019-09-18 | 2025-09-24 | Technosuruga Laboratory Co.,Ltd. | Sample preservation solution, and analysis device and analysis method using the same |
| JP2022553914A (ja) * | 2019-10-10 | 2022-12-27 | リキッド バイオプシー リサーチ リミティド ライアビリティ カンパニー | 生体試料およびｒｎａ安定化のための組成物、方法およびキット |
| EP4025711A2 (en) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| CA3158080A1 (en) * | 2019-11-26 | 2021-06-03 | Huy Quoc NGUYEN | Compositions, sets, and methods related to target analysis |
| DK3891300T3 (da) | 2019-12-23 | 2023-05-22 | 10X Genomics Inc | Fremgangsmåder til rumlig analyse ved anvendelse af rna-template-ligering |
| US12241890B2 (en) | 2019-12-23 | 2025-03-04 | 10X Genomics, Inc. | Methods for generating barcoded nucleic acid molecules using fixed cells |
| CN115135984B (zh) | 2019-12-23 | 2025-12-23 | 10X基因组学有限公司 | 可逆固定试剂及其使用方法 |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US12129516B2 (en) | 2020-02-07 | 2024-10-29 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| ES3014967T3 (en) | 2020-04-22 | 2025-04-28 | 10X Genomics Inc | Methods for spatial analysis using targeted rna depletion |
| EP4153776B1 (en) | 2020-05-22 | 2025-03-05 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| EP4414459B1 (en) | 2020-05-22 | 2025-09-03 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| EP4421186B1 (en) | 2020-06-08 | 2025-08-13 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| WO2021252591A1 (en) | 2020-06-10 | 2021-12-16 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| EP4450639B1 (en) | 2020-06-25 | 2025-10-15 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| CN111944875A (zh) * | 2020-06-28 | 2020-11-17 | 温州医科大学附属眼视光医院 | 一种防止rna降解的保护方法、保护序列、组合物和试剂盒及其应用 |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| JP2023545218A (ja) * | 2020-10-06 | 2023-10-26 | マテリアルズ アンド マシーンズ コーポレーション オブ アメリカ | 生物学的試料からのｒｎａ又はｄｎａの検出のための方法 |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| WO2022140028A1 (en) | 2020-12-21 | 2022-06-30 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4060049B1 (en) * | 2021-03-18 | 2023-08-23 | Genomill Health Oy | Methods for accurate parallel quantification of nucleic acids in dilute or non-purified samples |
| EP4305196B1 (en) | 2021-04-14 | 2025-04-02 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| WO2022236054A1 (en) | 2021-05-06 | 2022-11-10 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| EP4582555A3 (en) | 2021-06-03 | 2025-10-22 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| EP4196605B1 (en) | 2021-09-01 | 2024-12-04 | 10X Genomics, Inc. | Methods for blocking a capture probe on a spatial array |
| WO2023086880A1 (en) | 2021-11-10 | 2023-05-19 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| WO2023102118A2 (en) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| KR20230138683A (ko) * | 2022-03-24 | 2023-10-05 | 전북대학교산학협력단 | 역전사를 사용하지 않는 결찰 방법을 이용한 cDNA 합성 기반 표적 유전자 검출용 조성물 및 다중 결찰 보조 재조합효소 중합효소 증폭 방법 |
| CA3224264A1 (en) * | 2022-04-08 | 2023-10-12 | Illumina, Inc. | Aptamer dynamic range compression and detection techniques |
| WO2024080776A1 (ko) * | 2022-10-14 | 2024-04-18 | 고려대학교 산학협력단 | 비색 검출을 위한 황 함유 프로브 및 핵산 내 황 도입을 통한 효소 활성 가속화 방법 |
| EP4482979B1 (en) | 2022-11-09 | 2025-10-01 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of multiple analytes in a biological sample |
| WO2025168224A1 (en) * | 2024-02-08 | 2025-08-14 | Leica Microsystems Cms Gmbh | Marker and method for analysing a biological sample |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| JP2801051B2 (ja) | 1988-06-24 | 1998-09-21 | アムジエン・インコーポレーテツド | 核酸塩基配列を検出するための方法及び試薬 |
| DE68926504T2 (de) | 1988-07-20 | 1996-09-12 | David Segev | Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
| ATE137269T1 (de) | 1990-01-26 | 1996-05-15 | Abbott Lab | Verbessertes verfahren zur amplifikation von nuklein säurezielsequenz, einsetzbar für die polymerase und ligasekettenreaktion |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| IL99025A0 (en) | 1990-08-15 | 1992-07-15 | Astra Ab | Novel process for the detection of pathogens using dna probes |
| US5683874A (en) | 1991-03-27 | 1997-11-04 | Research Corporation Technologies, Inc. | Single-stranded circular oligonucleotides capable of forming a triplex with a target sequence |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| US5514545A (en) | 1992-06-11 | 1996-05-07 | Trustees Of The University Of Pennsylvania | Method for characterizing single cells based on RNA amplification for diagnostics and therapeutics |
| US5681943A (en) | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
| DE69433010T2 (de) | 1993-04-12 | 2004-06-09 | Northwestern University, Evanston | Verfahren zur darstellung von oligonukleotiden |
| US6077668A (en) | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
| US5714320A (en) | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
| US5846709A (en) | 1993-06-15 | 1998-12-08 | Imclone Systems Incorporated | Chemical process for amplifying and detecting nucleic acid sequences |
| CA2105364A1 (en) | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US5808036A (en) | 1993-09-01 | 1998-09-15 | Research Corporation Technologies Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US5824473A (en) | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5591578A (en) | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| WO1996015271A1 (en) | 1994-11-16 | 1996-05-23 | Abbott Laboratories | Multiplex ligations-dependent amplification |
| US5674683A (en) | 1995-03-21 | 1997-10-07 | Research Corporation Technologies, Inc. | Stem-loop and circular oligonucleotides and method of using |
| US5780613A (en) | 1995-08-01 | 1998-07-14 | Northwestern University | Covalent lock for self-assembled oligonucleotide constructs |
| CA2244891C (en) | 1996-02-09 | 2008-12-30 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| JP4468488B2 (ja) * | 1996-05-29 | 2010-05-26 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出 |
| EP0923595B1 (en) | 1996-06-07 | 2005-11-02 | Amersham Biosciences (SV) Corp. | Nucleic acid mediated electron transfer |
| US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| AU739375B2 (en) | 1996-11-05 | 2001-10-11 | Clinical Micro Sensors, Inc. | Electrodes linked via conductive oligomers to nucleic acids |
| US5922553A (en) | 1996-11-21 | 1999-07-13 | Trustees Of The University Of Pennsylvania | Method of detecting protein by immuno RNA |
| US7090804B2 (en) | 1998-01-27 | 2006-08-15 | Clinical Mirco Sensors, Inc. | Amplification of nucleic acids with electronic detection |
| US6225060B1 (en) | 1998-03-04 | 2001-05-01 | Onyx Pharmaceuticals, Inc. | Baculovirus expression system and method for high throughput expression of genetic material |
| EP1073766A1 (en) | 1998-04-29 | 2001-02-07 | Trustees Of Boston University | Methods and compositions pertaining to pd-loops |
| US7033753B1 (en) | 1999-01-15 | 2006-04-25 | University Of Rochester | Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| US6297016B1 (en) | 1999-10-08 | 2001-10-02 | Applera Corporation | Template-dependent ligation with PNA-DNA chimeric probes |
| US6479650B1 (en) | 1999-12-14 | 2002-11-12 | Research Corporation Technologies, Inc. | Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same |
| US20050214825A1 (en) * | 2000-02-07 | 2005-09-29 | John Stuelpnagel | Multiplex sample analysis on universal arrays |
| EP1130113A1 (en) | 2000-02-15 | 2001-09-05 | Johannes Petrus Schouten | Multiplex ligation dependent amplification assay |
| WO2001092579A2 (en) | 2000-05-30 | 2001-12-06 | Pe Corporation (Ny) | Methods for detecting target nucleic acids using coupled ligation and amplification |
| US6887664B2 (en) | 2000-06-06 | 2005-05-03 | Applera Corporation | Asynchronous primed PCR |
| JP2004507230A (ja) | 2000-07-03 | 2004-03-11 | アプレラ コーポレイション | ポリヌクレオチド配列アッセイ |
| AU2002257605B2 (en) * | 2001-02-27 | 2007-10-04 | Virco Bvba | Circular probe amplification (CPA) using energy-transfer primers |
| WO2002083837A1 (en) | 2001-04-11 | 2002-10-24 | Ptc Therapeutics, Inc. | Methods for identifying small molecules that bind specific rna structural motifs |
| FI20021325A0 (fi) | 2002-07-05 | 2002-07-05 | Valtion Teknillinen | Menetelmä ja reagenssipakkaus yksittäisten polynukleotidien määrän määrittämiseksi |
| EP1543156A4 (en) | 2002-07-18 | 2005-12-21 | Univ Leland Stanford Junior | DETECTION OF CHEMICAL LIGATION USING FLUORESCENCE QUENCHER SUB-GROUPS |
| EP1540003A4 (en) | 2002-09-19 | 2006-06-21 | Applera Corp | METHOD AND COMPOSITION FOR DETECTING TARGETS |
| AU2003275138A1 (en) | 2002-09-19 | 2004-04-08 | Applied Biosystems, Llc. | Methods and compositions for detecting targets |
| US20040259105A1 (en) | 2002-10-03 | 2004-12-23 | Jian-Bing Fan | Multiplex nucleic acid analysis using archived or fixed samples |
| EP2418287B1 (en) * | 2002-10-11 | 2013-09-18 | Erasmus Universiteit Rotterdam | Nucleic acid amplification primers for PCR-based clonality studies of the TCR-beta gene |
| US20040235005A1 (en) | 2002-10-23 | 2004-11-25 | Ernest Friedlander | Methods and composition for detecting targets |
| US20040110134A1 (en) | 2002-12-05 | 2004-06-10 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| KR100959101B1 (ko) | 2003-02-20 | 2010-05-25 | 삼성전자주식회사 | Ｐｃｒ 반응기 및 ｐｃｒ 반응기의 입구와 출구의 개폐를조절하는 방법 |
| GB0304371D0 (en) | 2003-02-26 | 2003-04-02 | Solexa Ltd | DNA Sequence analysis |
| JP4517114B2 (ja) * | 2003-03-28 | 2010-08-04 | 国立障害者リハビリテーションセンター総長 | ｃＤＮＡ合成方法 |
| US7198900B2 (en) | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
| WO2005047547A1 (en) * | 2003-11-04 | 2005-05-26 | Applera Corporation | Concatameric ligation products: compositions, methods and kits for same |
| US7323696B2 (en) | 2004-01-09 | 2008-01-29 | Applera Corporation | Phosphor particle coded beads |
| US20050208503A1 (en) | 2004-03-16 | 2005-09-22 | Handy Yowanto | Chemical ligation of nucleic acids |
| ATE431433T1 (de) | 2004-03-24 | 2009-05-15 | Applied Biosystems Llc | Ligation und amplifikationsreaktionen zur bestimmung von zielmolekülen |
| US7427479B2 (en) | 2004-04-30 | 2008-09-23 | Applera Corporation | Methods and kits for identifying target nucleotides in mixed populations |
| US7745614B2 (en) * | 2004-09-03 | 2010-06-29 | The Board Of Trustees Of The Leland Stanford Junior University | Universal linker compositions for the release or transfer of chemical agents from a polynucleotide |
| US20060223122A1 (en) * | 2005-03-08 | 2006-10-05 | Agnes Fogo | Classifying and predicting glomerulosclerosis using a proteomics approach |
| US20060223066A1 (en) * | 2005-03-29 | 2006-10-05 | Applera Corporation | Methods for normalizing and for identifying small nucleic acids |
| GB2424946A (en) * | 2005-04-05 | 2006-10-11 | Stratec Biomedical Systems Ag | A detection system for substance binding using up-converting fluorescent probes |
| US7799530B2 (en) | 2005-09-23 | 2010-09-21 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| EP2677039B8 (en) | 2006-05-10 | 2022-10-05 | DxTerity Diagnostics Incorporated | Detection of nucleic acid targets using chemically reactive oligonucleotide probes |
| GB0808413D0 (en) * | 2008-05-09 | 2008-06-18 | Univ Nottingham | Stabilisation of blood cell conjugates |
| AU2010232972B2 (en) * | 2009-04-01 | 2016-10-27 | Dxterity Diagnostics Incorporated | Chemical ligation dependent probe amplification (CLPA) |
| WO2011091393A1 (en) * | 2010-01-25 | 2011-07-28 | Rd Biosciences, Inc. | Self-folding amplification of target nucleic acid |
| US9506112B2 (en) * | 2010-02-05 | 2016-11-29 | Siemens Healthcare Diagnostics Inc. | Increasing multiplex level by externalization of passive reference in polymerase chain reactions |
| EP2363502B1 (en) * | 2010-03-04 | 2017-02-15 | miacom Diagnostics GmbH | Enhanced multiplex FISH |
| US9609769B2 (en) | 2010-07-29 | 2017-03-28 | Rockwell Automation Technologies, Inc. | System and method for ventilating and isolating electrical equipment |
| EP2710145B1 (en) * | 2011-05-17 | 2015-12-09 | Dxterity Diagnostics Incorporated | Methods and compositions for detecting target nucleic acids |
| WO2012162161A1 (en) * | 2011-05-20 | 2012-11-29 | Phthisis Diagnostics | Microsporidia detection system and method |
| EP2996863B1 (en) | 2013-03-15 | 2018-08-01 | Armour Technologies, Inc. | Medical device curving apparatus, system, and method of use |
| FR3054894A1 (fr) | 2016-08-03 | 2018-02-09 | Stmicroelectronics (Crolles 2) Sas | Dispositif integre photonique a compacite amelioree |
-
2012
- 2012-05-17 EP EP12723799.8A patent/EP2710145B1/en active Active
- 2012-05-17 WO PCT/US2012/038436 patent/WO2012158967A1/en not_active Ceased
- 2012-05-17 JP JP2014511555A patent/JP2014513557A/ja active Pending
- 2012-05-17 US US14/118,524 patent/US9745616B2/en active Active
- 2012-05-17 KR KR1020137033544A patent/KR102085242B1/ko active Active
- 2012-05-17 US US13/474,596 patent/US10066257B2/en active Active
- 2012-05-17 DK DK12723799.8T patent/DK2710145T3/en active
- 2012-05-17 CA CA2836577A patent/CA2836577C/en active Active
- 2012-05-17 AU AU2012255121A patent/AU2012255121B2/en active Active
- 2012-05-17 CN CN201610651714.8A patent/CN106434871B/zh active Active
- 2012-05-17 CN CN201280034508.2A patent/CN103827317B/zh active Active
-
2017
- 2017-08-07 US US15/670,963 patent/US20180030520A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014513557A5 (enExample) | ||
| Shi et al. | Isothermal and rapid detection of pathogenic microorganisms using a nano-rolling circle amplification-surface plasmon resonance biosensor | |
| JP2018524993A5 (enExample) | ||
| RU2008129127A (ru) | Анализ с использованием гибридизационных зондов и матрица | |
| JP2014204730A5 (enExample) | ||
| US10081825B2 (en) | Methods for amplification of nucleic acids utilizing a circularized template prepared from a target nucleic acid | |
| CA3075303A1 (en) | Multi-effector crispr based diagnostic systems | |
| JP2010207220A5 (enExample) | ||
| KR20210038541A (ko) | 핵산 검출 방법 | |
| JP2013507642A5 (enExample) | ||
| WO2007115242A3 (en) | Binary probes for fluorescent analysis of nucleic acids | |
| ATE469247T1 (de) | Verfahren zum nachweis von egfr-mutationen in blutproben | |
| Yao et al. | Sensitive and specific HBV genomic DNA detection using RCA-based QCM biosensor | |
| CN104838014A (zh) | 用于标靶核酸富集的组合物、方法、系统和试剂盒 | |
| RU2015139609A (ru) | Способы и композиции для секвенирования нуклеиновой кислоты, основанные на наноструктуре | |
| RU2015123459A (ru) | Одновременная детекция белка-мишени и нуклеиновых кислот-мишеней в одной клетке | |
| Sato et al. | Bead-based padlock rolling circle amplification for single DNA molecule counting | |
| JP2014530011A5 (enExample) | ||
| JP2013515458A5 (enExample) | ||
| US20120100526A1 (en) | Identification and differentiation of nucleic acid sequence using temperature-dependent hybridization | |
| JP2018504898A (ja) | 標的伸長を伴うシグナル増幅ｄｎａカスケード反応に基づく検出方法 | |
| Caneira et al. | A systematic implementation of padlock probing-based rolling circle amplification in an integrated microfluidic device for quantitative biomolecular analyses | |
| WO2023196973A1 (en) | Amplification assays using crispr-cas based detection | |
| DE602005017018D1 (de) | Verfahren zum nachweis von nukleinsäuren durch amplifikation auf einem array | |
| Thaitrong et al. | Integrated capillary electrophoresis microsystem for multiplex analysis of human respiratory viruses |