|
US3528960A
(en)
|
1968-10-07 |
1970-09-15 |
Lilly Co Eli |
N-carboxyaroyl insulins
|
|
US3869437A
(en)
|
1970-05-08 |
1975-03-04 |
Nat Res Dev |
Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
|
|
GB1381274A
(en)
|
1971-01-28 |
1975-01-22 |
Nat Res Dev |
Insulin derivatives
|
|
US3864325A
(en)
|
1971-11-18 |
1975-02-04 |
Nat Res Dev |
(N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
|
|
JPH01254699A
(ja)
|
1988-04-05 |
1989-10-11 |
Kodama Kk |
インスリン誘導体及びその用途
|
|
HUT56857A
(en)
*
|
1988-12-23 |
1991-10-28 |
Novo Nordisk As |
Human insulin analogues
|
|
JP3122128B2
(ja)
*
|
1989-12-21 |
2001-01-09 |
ノボ ノルディスク アクティーゼルスカブ |
ペプチド製剤
|
|
SI0792290T1
(en)
|
1993-09-17 |
2001-12-31 |
Novo Nordisk As |
Acylated insulin
|
|
US6011007A
(en)
|
1993-09-17 |
2000-01-04 |
Novo Nordisk A/S |
Acylated insulin
|
|
US6869930B1
(en)
|
1993-09-17 |
2005-03-22 |
Novo Nordisk A/S |
Acylated insulin
|
|
US6703017B1
(en)
*
|
1994-04-28 |
2004-03-09 |
Ixion Biotechnology, Inc. |
Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
|
|
US5461031A
(en)
|
1994-06-16 |
1995-10-24 |
Eli Lilly And Company |
Monomeric insulin analog formulations
|
|
US5646242A
(en)
|
1994-11-17 |
1997-07-08 |
Eli Lilly And Company |
Selective acylation of epsilon-amino groups
|
|
US5693609A
(en)
|
1994-11-17 |
1997-12-02 |
Eli Lilly And Company |
Acylated insulin analogs
|
|
US6251856B1
(en)
|
1995-03-17 |
2001-06-26 |
Novo Nordisk A/S |
Insulin derivatives
|
|
CA2215694A1
(en)
|
1995-03-17 |
1996-09-26 |
Novo Nordisk A/S |
Insulin derivatives
|
|
US6451970B1
(en)
|
1996-02-21 |
2002-09-17 |
Novo Nordisk A/S |
Peptide derivatives
|
|
US5905140A
(en)
|
1996-07-11 |
1999-05-18 |
Novo Nordisk A/S, Novo Alle |
Selective acylation method
|
|
US5898067A
(en)
|
1997-02-07 |
1999-04-27 |
Novo Nordisk A/S |
Crystallization of proteins
|
|
IL131796A0
(en)
|
1997-03-20 |
2001-03-19 |
Novo Nordisk As |
Zinc free insulin crystals for use in pulmonary compositions
|
|
ES2202899T3
(es)
|
1997-10-24 |
2004-04-01 |
Novo Nordisk A/S |
Agregados de derivados de la insulina humana.
|
|
US6444641B1
(en)
|
1997-10-24 |
2002-09-03 |
Eli Lilly Company |
Fatty acid-acylated insulin analogs
|
|
SV1998000125A
(es)
|
1997-10-24 |
1999-05-24 |
Lilly Co Eli |
Composiciones de insulina insoluble ref. x-11232
|
|
US6451762B1
(en)
|
1997-10-24 |
2002-09-17 |
Novo Nordisk A/S |
Aggregates of human insulin derivatives
|
|
ZA989744B
(en)
|
1997-10-31 |
2000-04-26 |
Lilly Co Eli |
Method for administering acylated insulin.
|
|
US6531448B1
(en)
|
1997-12-23 |
2003-03-11 |
Eli Lilly And Company |
Insoluble compositions for controlling blood glucose
|
|
EP1044016B1
(en)
|
1998-01-09 |
2005-03-16 |
Novo Nordisk A/S |
Stabilised insulin compositions
|
|
EP1086130A1
(en)
|
1998-06-12 |
2001-03-28 |
Kings College London |
Insulin analogue
|
|
AU5454200A
(en)
|
1999-06-29 |
2001-01-31 |
Eli Lilly And Company |
Protamine-free insoluble acylated insulin compositions
|
|
WO2001093837A2
(en)
|
2000-06-08 |
2001-12-13 |
Eli Lilly And Company |
Protein powder for pulmonary delivery
|
|
DE10114178A1
(de)
|
2001-03-23 |
2002-10-10 |
Aventis Pharma Gmbh |
Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
|
|
WO2003048195A2
(en)
|
2001-12-02 |
2003-06-12 |
Novo Nordisk A/S |
Glucose dependant release of insulin from glucose sensing insulin derivatives
|
|
BR0215029A
(pt)
|
2001-12-20 |
2005-12-20 |
Lilly Co Eli |
Molécula de insulina, uso da mesma, composição, uso desta, microcristal, processo para prepará-lo, uso deste, e, métodos para preparar uma molécula de insulina, para tratar hiperglicemia, e para tratar diabetes mellitus
|
|
AU2003208316A1
(en)
|
2002-03-13 |
2003-09-22 |
Novo Nordisk A/S |
Minimising body weight gain in insulin treatment
|
|
US20040138099A1
(en)
|
2002-11-29 |
2004-07-15 |
Draeger Eberhard Kurt |
Insulin administration regimens for the treatment of subjects with diabetes
|
|
US20060217290A1
(en)
|
2003-04-29 |
2006-09-28 |
Kohn Wayne D |
Insulin analogs having protracted time action
|
|
EP1644411A2
(en)
|
2003-07-11 |
2006-04-12 |
Novo Nordisk A/S |
Stabilised insulin compositions
|
|
US20060183667A1
(en)
|
2003-07-11 |
2006-08-17 |
Novo Nordisk A/S |
Stabilised insulin compositions
|
|
KR101159559B1
(ko)
|
2003-08-05 |
2012-06-26 |
노보 노르디스크 에이/에스 |
신규의 인슐린 유도체
|
|
CN102552917A
(zh)
|
2003-08-13 |
2012-07-11 |
比奥孔有限公司 |
用于治疗剂的微-粒子脂肪酸盐固体剂量制剂
|
|
EP1687428A1
(en)
|
2003-11-14 |
2006-08-09 |
Novo Nordisk A/S |
Processes for making acylated insulin
|
|
JP5697831B2
(ja)
|
2003-12-03 |
2015-04-08 |
ノヴォ ノルディスク アー／エス |
単鎖インシュリン
|
|
WO2006008238A1
(en)
|
2004-07-16 |
2006-01-26 |
Novo Nordisk A/S |
Method for selective acylation
|
|
MX2007000883A
(es)
|
2004-07-19 |
2007-04-02 |
Biocon Ltd |
Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
|
|
JP5410020B2
(ja)
|
2005-02-02 |
2014-02-05 |
ノヴォ ノルディスク アー／エス |
インスリン誘導体
|
|
EP2256130B1
(en)
|
2005-02-02 |
2013-09-25 |
Novo Nordisk A/S |
Novel insulin derivatives
|
|
WO2006097521A1
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Pegylated single-chain insulin
|
|
US20090074882A1
(en)
|
2005-12-28 |
2009-03-19 |
Novo Nordisk A/S |
Insulin compositions and method of making a composition
|
|
DE602007009496D1
(de)
|
2006-02-27 |
2010-11-11 |
Novo Nordisk As |
Insulinderivate
|
|
EP2015770B1
(en)
|
2006-05-09 |
2012-09-26 |
Novo Nordisk A/S |
Insulin derivative
|
|
US8796205B2
(en)
|
2006-05-09 |
2014-08-05 |
Novo Nordisk A/S |
Insulin derivative
|
|
WO2008013938A2
(en)
|
2006-07-27 |
2008-01-31 |
Nektar Therapeutics |
Aerosolizable formulation comprising insulin for pulmonary delivery
|
|
EP2049149B1
(en)
|
2006-07-31 |
2015-04-15 |
Novo Nordisk A/S |
Pegylated extended insulins
|
|
EP2404934A1
(en)
*
|
2006-09-22 |
2012-01-11 |
Novo Nordisk A/S |
Protease resistant insulin analogues
|
|
WO2008145721A2
(en)
|
2007-06-01 |
2008-12-04 |
Novo Nordisk A/S |
N-terminal modification of polypeptides for protection against degradation by aminopeptidases
|
|
WO2008152106A1
(en)
|
2007-06-13 |
2008-12-18 |
Novo Nordisk A/S |
Pharmaceutical formulation comprising an insulin derivative
|
|
WO2009015456A1
(en)
|
2007-07-30 |
2009-02-05 |
Generex Pharmaceuticals Inc. |
Pharmaceutical formulation in mixed micellar form and dispenser for oral delivery of agents as a spray
|
|
KR20100053561A
(ko)
|
2007-08-15 |
2010-05-20 |
노보 노르디스크 에이/에스 |
아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체
|
|
WO2009060071A1
(en)
|
2007-11-08 |
2009-05-14 |
Novo Nordisk A/S |
Insulin derivative
|
|
ES2612736T3
(es)
|
2007-11-16 |
2017-05-18 |
Novo Nordisk A/S |
Composiciones farmacéuticas estables que comprenden liraglutida y degludec
|
|
US8946148B2
(en)
|
2007-11-20 |
2015-02-03 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
ES2618073T3
(es)
|
2008-03-14 |
2017-06-20 |
Novo Nordisk A/S |
Análogos de insulina estabilizados frente a proteasas
|
|
MX2010009850A
(es)
*
|
2008-03-18 |
2010-09-30 |
Novo Nordisk As |
Analogos de insulina acilados y etabilizados contra proteasas.
|
|
CN106317164A
(zh)
|
2008-09-12 |
2017-01-11 |
诺沃—诺迪斯克有限公司 |
酰化肽或蛋白的方法
|
|
CA2738615A1
(en)
|
2008-10-30 |
2010-05-06 |
Novo Nordisk A/S |
Treating diabetes melitus using insulin injections with less than daily injection frequency
|
|
CN102245624B
(zh)
|
2008-12-19 |
2016-08-10 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰岛素前药
|
|
EP2448962B1
(en)
|
2009-06-30 |
2016-10-19 |
Novo Nordisk A/S |
Insulin derivatives
|
|
PT2459171T
(pt)
*
|
2009-07-31 |
2017-08-16 |
Sanofi Aventis Deutschland |
Composição de insulina de atuação longa
|
|
EP2569002B1
(en)
|
2010-05-10 |
2016-10-26 |
Novo Nordisk A/S |
Process for the preparation of insulin-zinc complexes
|
|
EP2585484A1
(en)
|
2010-06-23 |
2013-05-01 |
Novo Nordisk A/S |
Insulin analogues containing additional disulfide bonds
|
|
WO2011161125A1
(en)
*
|
2010-06-23 |
2011-12-29 |
Novo Nordisk A/S |
Insulin derivatives containing additional disulfide bonds
|
|
CN103415300B
(zh)
|
2010-07-20 |
2018-02-23 |
诺沃—诺迪斯克有限公司 |
N‑末端修饰的fgf21化合物
|
|
CN103596584B
(zh)
*
|
2011-06-15 |
2016-12-14 |
诺沃—诺迪斯克有限公司 |
多取代的胰岛素
|
|
AU2012328407A1
(en)
|
2011-10-27 |
2014-05-22 |
Case Western Reserve University |
Ultra-concentrated rapid-acting insulin analogue formulations
|