RU2684456C2 - Новые производные инсулина и их применение в медицине - Google Patents
Новые производные инсулина и их применение в медицине Download PDFInfo
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- RU2684456C2 RU2684456C2 RU2016135543A RU2016135543A RU2684456C2 RU 2684456 C2 RU2684456 C2 RU 2684456C2 RU 2016135543 A RU2016135543 A RU 2016135543A RU 2016135543 A RU2016135543 A RU 2016135543A RU 2684456 C2 RU2684456 C2 RU 2684456C2
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- insulin
- desb27
- human insulin
- gglu
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| CA3294636A1 (en) * | 2016-11-21 | 2026-02-10 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
| KR101909052B1 (ko) * | 2017-02-09 | 2018-10-17 | 강원대학교산학협력단 | 인슐린의 a 사슬로부터 유래된 펩타이드 단편 및 이를 포함하는 당뇨병 또는 당뇨병성 창상의 예방 또는 치료용 약학 조성물 |
| JP2020513019A (ja) * | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー／エス | オリゴマー伸長インスリン−Ｆｃコンジュゲート |
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| US10919949B2 (en) * | 2017-08-17 | 2021-02-16 | Novo Nordisk A/S | Acylated insulin analogues and uses thereof |
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| RU2020128624A (ru) | 2018-02-27 | 2022-03-28 | Зп Спв 3 К/С | Аналоги компстатина и их медицинское применение |
| TWI829687B (zh) * | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| KR20210102347A (ko) | 2018-12-11 | 2021-08-19 | 사노피 | 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체 |
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| CN115385843A (zh) * | 2021-05-24 | 2022-11-25 | 广东东阳光药业有限公司 | 一种新型的酰化胰岛素类似物 |
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|---|---|---|---|---|
| US5382574A (en) * | 1989-12-21 | 1995-01-17 | Novo Nordisk A/S | Insulin preparations containing nicotinic acid or nicotinamide |
| WO2009022005A1 (en) * | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulin analogues with an acyl and alkylene glycol moiety |
| WO2009112583A2 (en) * | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| RU2009114324A (ru) * | 2006-09-22 | 2010-10-27 | Ново Нордиск А/С (DK) | Аналоги инсулина, устойчивые к протеазам |
| WO2011161125A1 (en) * | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insulin derivatives containing additional disulfide bonds |
| RU2010141481A (ru) * | 2008-03-18 | 2012-04-27 | Ново Нордиск А/С (DK) | Стабилизированные по отношению к протеазам ацилированные аналоги инсулина |
| WO2012171994A1 (en) * | 2011-06-15 | 2012-12-20 | Novo Nordisk A/S | Multi substituted insulins |
| RU2012107487A (ru) * | 2009-07-31 | 2013-09-10 | Санофи-Авентис Дойчланд Гмбх | Композиция инсулина длительного действия |
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| US3528960A (en) | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
| US3869437A (en) | 1970-05-08 | 1975-03-04 | Nat Res Dev | Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin |
| GB1381274A (en) | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| US3864325A (en) | 1971-11-18 | 1975-02-04 | Nat Res Dev | (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives |
| JPH01254699A (ja) | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
| HUT56857A (en) * | 1988-12-23 | 1991-10-28 | Novo Nordisk As | Human insulin analogues |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
| EP1132404A3 (en) | 1993-09-17 | 2002-03-27 | Novo Nordisk A/S | Acylated insulin |
| US6703017B1 (en) * | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US5461031A (en) | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5646242A (en) | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
| CZ289343B6 (cs) | 1995-03-17 | 2002-01-16 | Novo Nordisk A/S | Inzulinový derivát a farmaceutický prostředek pro léčení diabetes |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| US5905140A (en) | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
| US5898067A (en) | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
| EP1005490B1 (en) | 1997-03-20 | 2006-03-29 | Novo Nordisk A/S | Zinc free insulin crystals for use in pulmonary compositions |
| RU2218349C2 (ru) | 1997-10-24 | 2003-12-10 | Ново Нордиск А/С | Агрегаты производных инсулина человека |
| US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
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2015
- 2015-02-25 AR ARP150100559A patent/AR099569A1/es unknown
- 2015-02-26 PT PT157071028T patent/PT3110840T/pt unknown
- 2015-02-26 PL PL15707102T patent/PL3110840T3/pl unknown
- 2015-02-26 MX MX2016010899A patent/MX368387B/es active IP Right Grant
- 2015-02-26 US US15/121,206 patent/US10040839B2/en active Active
- 2015-02-26 EP EP15707102.8A patent/EP3110840B1/en active Active
- 2015-02-26 JP JP2016554498A patent/JP6580583B2/ja active Active
- 2015-02-26 WO PCT/EP2015/053989 patent/WO2015128403A2/en not_active Ceased
- 2015-02-26 RU RU2016135543A patent/RU2684456C2/ru active
- 2015-02-26 ES ES15707102T patent/ES2831848T3/es active Active
- 2015-02-26 AU AU2015222135A patent/AU2015222135B2/en not_active Ceased
- 2015-02-26 HU HUE15707102A patent/HUE051355T2/hu unknown
- 2015-02-26 DK DK15707102.8T patent/DK3110840T3/da active
- 2015-02-26 RS RS20201399A patent/RS61137B1/sr unknown
- 2015-02-26 CA CA2941103A patent/CA2941103A1/en not_active Withdrawn
- 2015-02-26 TW TW104106145A patent/TWI686403B/zh not_active IP Right Cessation
- 2015-02-26 HR HRP20201732TT patent/HRP20201732T1/hr unknown
- 2015-02-26 BR BR112016017193A patent/BR112016017193A2/pt not_active Application Discontinuation
- 2015-02-26 SI SI201531416T patent/SI3110840T1/sl unknown
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- 2015-02-26 KR KR1020167024826A patent/KR20160125988A/ko not_active Withdrawn
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20160125988A (ko) | 2016-11-01 |
| PT3110840T (pt) | 2020-11-26 |
| JP2017508741A (ja) | 2017-03-30 |
| CN106459171B (zh) | 2020-12-15 |
| WO2015128403A3 (en) | 2015-12-10 |
| BR112016017193A2 (pt) | 2017-10-03 |
| TWI686403B (zh) | 2020-03-01 |
| HRP20201732T1 (hr) | 2020-12-25 |
| US10040839B2 (en) | 2018-08-07 |
| RU2016135543A (ru) | 2018-03-30 |
| AU2015222135B2 (en) | 2018-12-20 |
| IL246757B (en) | 2020-04-30 |
| HUE051355T2 (hu) | 2021-03-01 |
| US20170008945A1 (en) | 2017-01-12 |
| EP3110840A2 (en) | 2017-01-04 |
| EP3110840B1 (en) | 2020-10-21 |
| RS61137B1 (sr) | 2020-12-31 |
| CA2941103A1 (en) | 2015-09-03 |
| IL246757A0 (en) | 2016-08-31 |
| PL3110840T3 (pl) | 2021-04-06 |
| DK3110840T3 (da) | 2020-11-02 |
| MX368387B (es) | 2019-10-01 |
| ES2831848T3 (es) | 2021-06-09 |
| AR099569A1 (es) | 2016-08-03 |
| MX2016010899A (es) | 2016-11-18 |
| CN106459171A (zh) | 2017-02-22 |
| TW201620930A (zh) | 2016-06-16 |
| SA516371705B1 (ar) | 2019-10-08 |
| SI3110840T1 (sl) | 2020-12-31 |
| AU2015222135A1 (en) | 2016-07-28 |
| RU2016135543A3 (enExample) | 2018-08-30 |
| WO2015128403A2 (en) | 2015-09-03 |
| JP6580583B2 (ja) | 2019-09-25 |
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