SA516371705B1 - نظير إنسولين بشري من a22k، desb27، b29r، des b30 مُعالج بالأسيل، عند موضع الإيبسيلون لليسيين 22 - Google Patents

نظير إنسولين بشري من a22k، desb27، b29r، des b30 مُعالج بالأسيل، عند موضع الإيبسيلون لليسيين 22 Download PDF

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Publication number
SA516371705B1
SA516371705B1 SA516371705A SA516371705A SA516371705B1 SA 516371705 B1 SA516371705 B1 SA 516371705B1 SA 516371705 A SA516371705 A SA 516371705A SA 516371705 A SA516371705 A SA 516371705A SA 516371705 B1 SA516371705 B1 SA 516371705B1
Authority
SA
Saudi Arabia
Prior art keywords
insulin
desb27
desb30
human insulin
human
Prior art date
Application number
SA516371705A
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Arabic (ar)
English (en)
Inventor
كريستيان فليديلوس
توماس بورجلوم كجيلدسين
بيتير ماديسن
مارتين مونزيل
كلوديا اولريش هجورينجارد
سوسان هوستروب
Original Assignee
نوفو نورديسك ايه / اس
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by نوفو نورديسك ايه / اس filed Critical نوفو نورديسك ايه / اس
Publication of SA516371705B1 publication Critical patent/SA516371705B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
SA516371705A 2014-02-28 2016-08-21 نظير إنسولين بشري من a22k، desb27، b29r، des b30 مُعالج بالأسيل، عند موضع الإيبسيلون لليسيين 22 SA516371705B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14157215 2014-02-28
PCT/EP2015/053989 WO2015128403A2 (en) 2014-02-28 2015-02-26 Novel insulin derivatives and the medical uses hereof

Publications (1)

Publication Number Publication Date
SA516371705B1 true SA516371705B1 (ar) 2019-10-08

Family

ID=50184804

Family Applications (1)

Application Number Title Priority Date Filing Date
SA516371705A SA516371705B1 (ar) 2014-02-28 2016-08-21 نظير إنسولين بشري من a22k، desb27، b29r، des b30 مُعالج بالأسيل، عند موضع الإيبسيلون لليسيين 22

Country Status (23)

Country Link
US (1) US10040839B2 (enExample)
EP (1) EP3110840B1 (enExample)
JP (1) JP6580583B2 (enExample)
KR (1) KR20160125988A (enExample)
CN (1) CN106459171B (enExample)
AR (1) AR099569A1 (enExample)
AU (1) AU2015222135B2 (enExample)
BR (1) BR112016017193A2 (enExample)
CA (1) CA2941103A1 (enExample)
DK (1) DK3110840T3 (enExample)
ES (1) ES2831848T3 (enExample)
HR (1) HRP20201732T1 (enExample)
HU (1) HUE051355T2 (enExample)
IL (1) IL246757B (enExample)
MX (1) MX368387B (enExample)
PL (1) PL3110840T3 (enExample)
PT (1) PT3110840T (enExample)
RS (1) RS61137B1 (enExample)
RU (1) RU2684456C2 (enExample)
SA (1) SA516371705B1 (enExample)
SI (1) SI3110840T1 (enExample)
TW (1) TWI686403B (enExample)
WO (1) WO2015128403A2 (enExample)

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JP2020513019A (ja) * 2017-04-05 2020-04-30 ノヴォ ノルディスク アー／エス オリゴマー伸長インスリン−Ｆｃコンジュゲート
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BR112020017385A2 (pt) 2018-02-27 2020-12-15 Zp Spv 3 K/S Análogos de compstatina, métodos e seus usos médicos
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BR112022013009A2 (pt) * 2019-12-30 2022-09-06 Gan & Lee Pharmaceuticals Co Ltd Derivados de insulina, composição farmacêutica, uso do derivado da insulina e métodos para tratar ou prevenir diabetes, para aumentar a capacidade de um derivado de insulina e para aumentar a potência de um derivado de insulina
CA3217734A1 (en) * 2021-05-24 2022-12-01 Baoye ZHENG A novel acylated insulin analog

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IL246757B (en) 2020-04-30
PT3110840T (pt) 2020-11-26
TWI686403B (zh) 2020-03-01
CN106459171A (zh) 2017-02-22
CA2941103A1 (en) 2015-09-03
HUE051355T2 (hu) 2021-03-01
RU2016135543A (ru) 2018-03-30
SI3110840T1 (sl) 2020-12-31
JP2017508741A (ja) 2017-03-30
AR099569A1 (es) 2016-08-03
HRP20201732T1 (hr) 2020-12-25
RU2684456C2 (ru) 2019-04-09
WO2015128403A2 (en) 2015-09-03
US20170008945A1 (en) 2017-01-12
CN106459171B (zh) 2020-12-15
PL3110840T3 (pl) 2021-04-06
EP3110840A2 (en) 2017-01-04
AU2015222135A1 (en) 2016-07-28
BR112016017193A2 (pt) 2017-10-03
RU2016135543A3 (enExample) 2018-08-30
US10040839B2 (en) 2018-08-07
TW201620930A (zh) 2016-06-16
WO2015128403A3 (en) 2015-12-10
DK3110840T3 (da) 2020-11-02
ES2831848T3 (es) 2021-06-09
AU2015222135B2 (en) 2018-12-20
MX2016010899A (es) 2016-11-18
EP3110840B1 (en) 2020-10-21
RS61137B1 (sr) 2020-12-31
IL246757A0 (en) 2016-08-31
MX368387B (es) 2019-10-01
JP6580583B2 (ja) 2019-09-25
KR20160125988A (ko) 2016-11-01

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