JP2019526537A5 - - Google Patents
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- Publication number
- JP2019526537A5 JP2019526537A5 JP2019503703A JP2019503703A JP2019526537A5 JP 2019526537 A5 JP2019526537 A5 JP 2019526537A5 JP 2019503703 A JP2019503703 A JP 2019503703A JP 2019503703 A JP2019503703 A JP 2019503703A JP 2019526537 A5 JP2019526537 A5 JP 2019526537A5
- Authority
- JP
- Japan
- Prior art keywords
- human insulin
- zinc complex
- acylated derivative
- group
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022066071A JP2022095872A (ja) | 2016-08-02 | 2022-04-13 | ヒトインスリンまたはそのアナログのアシル化誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610625257 | 2016-08-02 | ||
| CN201610625257.5 | 2016-08-02 | ||
| CN201610779132 | 2016-08-31 | ||
| CN201610779132.8 | 2016-08-31 | ||
| PCT/CN2017/095377 WO2018024186A1 (zh) | 2016-08-02 | 2017-08-01 | 一种人胰岛素或其类似物的酰化衍生物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066071A Division JP2022095872A (ja) | 2016-08-02 | 2022-04-13 | ヒトインスリンまたはそのアナログのアシル化誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526537A JP2019526537A (ja) | 2019-09-19 |
| JP2019526537A5 true JP2019526537A5 (enExample) | 2020-07-02 |
| JP7432361B2 JP7432361B2 (ja) | 2024-02-16 |
Family
ID=61074099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503703A Active JP7432361B2 (ja) | 2016-08-02 | 2017-08-01 | ヒトインスリンまたはそのアナログのアシル化誘導体 |
| JP2022066071A Pending JP2022095872A (ja) | 2016-08-02 | 2022-04-13 | ヒトインスリンまたはそのアナログのアシル化誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066071A Pending JP2022095872A (ja) | 2016-08-02 | 2022-04-13 | ヒトインスリンまたはそのアナログのアシル化誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10815287B2 (enExample) |
| EP (1) | EP3495384A4 (enExample) |
| JP (2) | JP7432361B2 (enExample) |
| CN (2) | CN114478747B (enExample) |
| TW (1) | TWI747929B (enExample) |
| WO (1) | WO2018024186A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019149245A1 (zh) * | 2018-02-01 | 2019-08-08 | 江苏恒瑞医药股份有限公司 | 含人胰岛素类似物的酰化衍生物的药物组合物及其制备方法 |
| US20210032307A1 (en) | 2018-02-09 | 2021-02-04 | Jiangsu Hengrui Medicine Co., Ltd. | Codon optimized precursor gene and signal peptide gene of human insulin analogue |
| KR20210016400A (ko) | 2018-05-24 | 2021-02-15 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 재조합 인간 인슐린 또는 그 유사체의 전구체를 제조하는 방법 |
| TW202039437A (zh) | 2018-12-11 | 2020-11-01 | 法商賽諾菲公司 | 肽黏合劑 |
| BR112022013009A2 (pt) | 2019-12-30 | 2022-09-06 | Gan & Lee Pharmaceuticals Co Ltd | Derivados de insulina, composição farmacêutica, uso do derivado da insulina e métodos para tratar ou prevenir diabetes, para aumentar a capacidade de um derivado de insulina e para aumentar a potência de um derivado de insulina |
| CN116583531A (zh) * | 2020-11-27 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 一种制备胰岛素或其类似物的酰化衍生物的方法 |
| CN112939771A (zh) * | 2021-01-28 | 2021-06-11 | 宁夏蓝博思化学技术有限公司 | 长链烷基二酸单叔丁酯的制备方法 |
| CA3217734A1 (en) * | 2021-05-24 | 2022-12-01 | Baoye ZHENG | A novel acylated insulin analog |
| WO2022268208A1 (zh) | 2021-06-25 | 2022-12-29 | 甘李药业股份有限公司 | 含酰化胰岛素的药物组合物 |
| WO2023143458A1 (zh) | 2022-01-28 | 2023-08-03 | 甘李药业股份有限公司 | 酰化胰岛素 |
| WO2025098457A1 (zh) | 2023-11-07 | 2025-05-15 | 甘李药业股份有限公司 | 用于降糖的酰化胰岛素 |
| CN117756914B (zh) * | 2023-12-15 | 2024-09-03 | 瀚晖制药有限公司 | 依柯胰岛素的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| NZ273285A (en) * | 1993-09-17 | 1997-10-24 | Novo Nordisk As | Insulin derivatives and compositions thereof |
| CN1163574A (zh) * | 1994-11-17 | 1997-10-29 | 伊莱利利公司 | 酰化的胰岛素类似物 |
| US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| US8003605B2 (en) * | 2002-03-13 | 2011-08-23 | Novo Nordisk A/S | Minimising body weight gain in insulin treatment |
| ES2472421T3 (es) | 2003-08-05 | 2014-07-01 | Novo Nordisk A/S | Nuevos derivados de insulina |
| AU2004261353B2 (en) * | 2003-08-05 | 2009-12-10 | Novo Nordisk A/S | Novel insulin derivatives |
| EP1969004B1 (en) * | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| WO2009022006A1 (en) * | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids |
| HUE032284T2 (en) * | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| US8935928B2 (en) * | 2011-10-10 | 2015-01-20 | Lockheed Martin Corporation | Integrated air-cycle refrigeration and power generation system |
| CN104788556A (zh) * | 2011-12-15 | 2015-07-22 | 上海恒瑞医药有限公司 | 人胰岛素类似物及其酰化衍生物 |
| CN106496322A (zh) * | 2015-09-07 | 2017-03-15 | 江苏恒瑞医药股份有限公司 | 人胰岛素或其类似物的酰化衍生物的制备方法 |
| JP7523885B2 (ja) * | 2016-02-05 | 2024-07-29 | メモリアル スローン ケタリング キャンサー センター | 幹細胞由来外胚葉系統前駆体を分化する方法 |
-
2017
- 2017-08-01 US US16/320,997 patent/US10815287B2/en active Active
- 2017-08-01 JP JP2019503703A patent/JP7432361B2/ja active Active
- 2017-08-01 WO PCT/CN2017/095377 patent/WO2018024186A1/zh not_active Ceased
- 2017-08-01 TW TW106125882A patent/TWI747929B/zh active
- 2017-08-01 EP EP17836368.5A patent/EP3495384A4/en not_active Withdrawn
- 2017-08-01 CN CN202210131921.6A patent/CN114478747B/zh active Active
- 2017-08-01 CN CN201780005001.7A patent/CN108463468B/zh active Active
-
2022
- 2022-04-13 JP JP2022066071A patent/JP2022095872A/ja active Pending
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