JP2015110654A5 - - Google Patents
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- Publication number
- JP2015110654A5 JP2015110654A5 JP2015037711A JP2015037711A JP2015110654A5 JP 2015110654 A5 JP2015110654 A5 JP 2015110654A5 JP 2015037711 A JP2015037711 A JP 2015037711A JP 2015037711 A JP2015037711 A JP 2015037711A JP 2015110654 A5 JP2015110654 A5 JP 2015110654A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- amino acid
- peptidomimetic macrocycle
- independently
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 20
- 150000001413 amino acids Chemical class 0.000 claims 19
- 239000000816 peptidomimetic Substances 0.000 claims 18
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000000304 alkynyl group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000003431 cross linking reagent Substances 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000004404 heteroalkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 6
- 239000003054 catalyst Substances 0.000 claims 6
- 238000005649 metathesis reaction Methods 0.000 claims 6
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 5
- 229910052751 metal Inorganic materials 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- 229910052762 osmium Inorganic materials 0.000 claims 5
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 claims 5
- 238000000746 purification Methods 0.000 claims 5
- 229910052707 ruthenium Inorganic materials 0.000 claims 5
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 125000002993 cycloalkylene group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000004474 heteroalkylene group Chemical group 0.000 claims 4
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 238000009616 inductively coupled plasma Methods 0.000 claims 3
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000011097 chromatography purification Methods 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9909908P | 2008-09-22 | 2008-09-22 | |
| US61/099,099 | 2008-09-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528083A Division JP2012503025A (ja) | 2008-09-22 | 2009-09-22 | 精製されたポリペプチド組成物を調製するための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017118507A Division JP2017155063A (ja) | 2008-09-22 | 2017-06-16 | 精製されたポリペプチド組成物を調製するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015110654A JP2015110654A (ja) | 2015-06-18 |
| JP2015110654A5 true JP2015110654A5 (enExample) | 2015-10-15 |
| JP6196640B2 JP6196640B2 (ja) | 2017-09-13 |
Family
ID=41693036
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528083A Withdrawn JP2012503025A (ja) | 2008-09-22 | 2009-09-22 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2015037711A Active JP6196640B2 (ja) | 2008-09-22 | 2015-02-27 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2017118507A Pending JP2017155063A (ja) | 2008-09-22 | 2017-06-16 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019153604A Pending JP2019214614A (ja) | 2008-09-22 | 2019-08-26 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019172908A Pending JP2020015748A (ja) | 2008-09-22 | 2019-09-24 | 精製されたポリペプチド組成物を調製するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528083A Withdrawn JP2012503025A (ja) | 2008-09-22 | 2009-09-22 | 精製されたポリペプチド組成物を調製するための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017118507A Pending JP2017155063A (ja) | 2008-09-22 | 2017-06-16 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019153604A Pending JP2019214614A (ja) | 2008-09-22 | 2019-08-26 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019172908A Pending JP2020015748A (ja) | 2008-09-22 | 2019-09-24 | 精製されたポリペプチド組成物を調製するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9206223B2 (enExample) |
| EP (2) | EP3492492A1 (enExample) |
| JP (5) | JP2012503025A (enExample) |
| CN (2) | CN104961795A (enExample) |
| AU (1) | AU2009294875C1 (enExample) |
| BR (1) | BRPI0918838A2 (enExample) |
| CA (1) | CA2737921C (enExample) |
| IL (2) | IL211837A (enExample) |
| WO (1) | WO2010034032A2 (enExample) |
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| EP3126375B1 (en) * | 2014-04-02 | 2023-12-13 | University of Rochester | Macrocyclic peptidomimetics for alpha-helix mimicry |
| US10905739B2 (en) | 2014-09-24 | 2021-02-02 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| SG11201702223UA (en) * | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
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-
2009
- 2009-09-22 EP EP18195669.9A patent/EP3492492A1/en not_active Withdrawn
- 2009-09-22 US US12/564,909 patent/US9206223B2/en active Active
- 2009-09-22 EP EP09736334.5A patent/EP2342221B1/en active Active
- 2009-09-22 WO PCT/US2009/057931 patent/WO2010034032A2/en not_active Ceased
- 2009-09-22 AU AU2009294875A patent/AU2009294875C1/en active Active
- 2009-09-22 JP JP2011528083A patent/JP2012503025A/ja not_active Withdrawn
- 2009-09-22 CN CN201510159021.2A patent/CN104961795A/zh active Pending
- 2009-09-22 CA CA2737921A patent/CA2737921C/en active Active
- 2009-09-22 BR BRPI0918838A patent/BRPI0918838A2/pt not_active Application Discontinuation
- 2009-09-22 CN CN2009801425171A patent/CN102203126A/zh active Pending
-
2011
- 2011-03-21 IL IL211837A patent/IL211837A/en active IP Right Grant
-
2012
- 2012-01-13 US US13/350,644 patent/US9394336B2/en not_active Expired - Fee Related
-
2015
- 2015-02-27 JP JP2015037711A patent/JP6196640B2/ja active Active
- 2015-10-23 US US14/921,573 patent/US20160115204A1/en not_active Abandoned
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2017
- 2017-06-16 JP JP2017118507A patent/JP2017155063A/ja active Pending
- 2017-09-14 IL IL254498A patent/IL254498B/en active IP Right Grant
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2019
- 2019-08-26 JP JP2019153604A patent/JP2019214614A/ja active Pending
- 2019-09-24 JP JP2019172908A patent/JP2020015748A/ja active Pending
-
2021
- 2021-07-23 US US17/383,675 patent/US20220017569A1/en not_active Abandoned
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2023
- 2023-06-02 US US18/328,029 patent/US20240124518A1/en not_active Abandoned
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