JP2014231516A5 - - Google Patents
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- Publication number
- JP2014231516A5 JP2014231516A5 JP2014163070A JP2014163070A JP2014231516A5 JP 2014231516 A5 JP2014231516 A5 JP 2014231516A5 JP 2014163070 A JP2014163070 A JP 2014163070A JP 2014163070 A JP2014163070 A JP 2014163070A JP 2014231516 A5 JP2014231516 A5 JP 2014231516A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- substituted
- peptidomimetic macrocycle
- unsubstituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000816 peptidomimetic Substances 0.000 claims 25
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 23
- 238000000034 method Methods 0.000 claims 18
- 235000001014 amino acid Nutrition 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 12
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000004404 heteroalkyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 150000003573 thiols Chemical group 0.000 claims 8
- 125000005647 linker group Chemical group 0.000 claims 7
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 235000018417 cysteine Nutrition 0.000 claims 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 5
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- 125000000732 arylene group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000007850 fluorescent dye Substances 0.000 claims 4
- 125000004474 heteroalkylene group Chemical group 0.000 claims 4
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- -1 macrocycle compound Chemical class 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000001923 cyclic compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000001308 synthesis method Methods 0.000 claims 1
- 238000010189 synthetic method Methods 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87481906P | 2006-12-14 | 2006-12-14 | |
| US60/874,819 | 2006-12-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541617A Division JP5656407B2 (ja) | 2006-12-14 | 2007-12-14 | ビス−スルフヒドリル大環状化系 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016089950A Division JP6259861B2 (ja) | 2006-12-14 | 2016-04-27 | ビス−スルフヒドリル大環状化系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014231516A JP2014231516A (ja) | 2014-12-11 |
| JP2014231516A5 true JP2014231516A5 (enExample) | 2015-05-07 |
| JP5931975B2 JP5931975B2 (ja) | 2016-06-08 |
Family
ID=39536693
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541617A Expired - Fee Related JP5656407B2 (ja) | 2006-12-14 | 2007-12-14 | ビス−スルフヒドリル大環状化系 |
| JP2014163070A Expired - Fee Related JP5931975B2 (ja) | 2006-12-14 | 2014-08-08 | ビス−スルフヒドリル大環状化系 |
| JP2016089950A Expired - Fee Related JP6259861B2 (ja) | 2006-12-14 | 2016-04-27 | ビス−スルフヒドリル大環状化系 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541617A Expired - Fee Related JP5656407B2 (ja) | 2006-12-14 | 2007-12-14 | ビス−スルフヒドリル大環状化系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016089950A Expired - Fee Related JP6259861B2 (ja) | 2006-12-14 | 2016-04-27 | ビス−スルフヒドリル大環状化系 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7960506B2 (enExample) |
| EP (2) | EP2094721B1 (enExample) |
| JP (3) | JP5656407B2 (enExample) |
| CN (2) | CN105061577A (enExample) |
| AU (1) | AU2007333846B2 (enExample) |
| BR (1) | BRPI0720306A2 (enExample) |
| CA (1) | CA2686827C (enExample) |
| IL (1) | IL199301A (enExample) |
| WO (1) | WO2008076904A1 (enExample) |
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2007
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- 2007-12-14 CN CN201510441012.2A patent/CN105061577A/zh active Pending
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2009
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