JP2015531789A5 - - Google Patents
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- Publication number
- JP2015531789A5 JP2015531789A5 JP2015532458A JP2015532458A JP2015531789A5 JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5 JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolysine
- mutein
- unnatural amino
- conjugated
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705116P | 2012-09-24 | 2012-09-24 | |
| US61/705,116 | 2012-09-24 | ||
| US201361862495P | 2013-08-05 | 2013-08-05 | |
| US61/862,495 | 2013-08-05 | ||
| PCT/EP2013/069888 WO2014044873A1 (en) | 2012-09-24 | 2013-09-24 | Amino acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531789A JP2015531789A (ja) | 2015-11-05 |
| JP2015531789A5 true JP2015531789A5 (enExample) | 2018-03-29 |
| JP6321658B2 JP6321658B2 (ja) | 2018-05-09 |
Family
ID=49237211
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
| JP2015532458A Expired - Fee Related JP6321658B2 (ja) | 2012-09-24 | 2013-09-24 | アミノ酸誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9670521B2 (enExample) |
| EP (2) | EP2897935B1 (enExample) |
| JP (2) | JP6532404B2 (enExample) |
| KR (1) | KR102155389B1 (enExample) |
| CN (2) | CN104812734B (enExample) |
| AU (1) | AU2013320184B2 (enExample) |
| BR (1) | BR112015006368B1 (enExample) |
| CA (1) | CA2885796C (enExample) |
| SG (2) | SG11201502216UA (enExample) |
| WO (2) | WO2014044873A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2825370A1 (en) | 2010-12-22 | 2012-06-28 | President And Fellows Of Harvard College | Continuous directed evolution |
| JP6343604B2 (ja) | 2012-05-18 | 2018-06-13 | メディカル リサーチ カウンシル | ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法 |
| JP6498600B2 (ja) | 2012-06-08 | 2019-04-10 | ストロ バイオファーマ インコーポレーテッド | 部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法 |
| EP2863955B1 (en) | 2012-06-26 | 2016-11-23 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| BR112015006368B1 (pt) | 2012-09-24 | 2022-02-08 | Medimmune Limited | Processo para produção de linha celular eucariótica estável |
| CA2906292C (en) | 2013-03-15 | 2022-08-02 | Medimmune Limited | Novel dna constructs for the expression of trnapyl genes in eukaryotic cells |
| WO2015006555A2 (en) * | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3030545B1 (en) | 2013-08-05 | 2020-10-07 | MedImmune Limited | Amino acid derivatives |
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| EP3097196B1 (en) | 2014-01-20 | 2019-09-11 | President and Fellows of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| GB2528227A (en) * | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| WO2016077052A2 (en) | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
| KR102754019B1 (ko) | 2014-10-29 | 2025-01-14 | 바이시클러드 리미티드 | Mt1-mmp에 특이적인 바이사이클릭 펩타이드 리간드 |
| CN106146663B (zh) * | 2015-04-10 | 2019-11-08 | 北京大学 | 非天然氨基酸标记的新型抗体-药物偶联物及其制备 |
| US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| WO2017015559A2 (en) | 2015-07-23 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of bt toxins |
| WO2017019895A1 (en) | 2015-07-30 | 2017-02-02 | President And Fellows Of Harvard College | Evolution of talens |
| JP6967221B2 (ja) * | 2015-08-19 | 2021-11-17 | 国立研究開発法人理化学研究所 | 非天然アミノ酸導入抗体 |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| CN106929482A (zh) * | 2015-12-31 | 2017-07-07 | 北京大学 | 定点突变的流感病毒、其活疫苗及其制备方法和应用 |
| MX2018009085A (es) | 2016-01-27 | 2019-05-09 | Sutro Biopharma Inc | Conjugados de anticuerpos anti-cd74, composiciones que comprenden conjugados de anticuerpos anti-cd74 y metodos de uso de congujados de anticuerpos anti-cd74. |
| CN107012121B (zh) * | 2016-01-27 | 2021-01-26 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN105524167A (zh) * | 2016-01-30 | 2016-04-27 | 深圳市贝沃德克生物技术研究院有限公司 | 抗乙肝e抗原的绿色荧光抗体的制备方法 |
| CN105647918A (zh) * | 2016-02-20 | 2016-06-08 | 深圳市圣必智科技开发有限公司 | 抗乙肝e抗原的红色荧光抗体的制备方法 |
| MX2018015684A (es) | 2016-06-17 | 2019-08-29 | Magenta Therapeutics Inc | Composiciones y metodos para el agotamiento de celulas cd117. |
| US11214820B2 (en) * | 2016-09-02 | 2022-01-04 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
| US10905107B2 (en) * | 2016-09-05 | 2021-02-02 | Korea Advanced Institute Of Science And Technology | Transgenic mouse capable of spatial and temporal control of expression and site-specific modification of target protein, production method and uses thereof |
| WO2018044143A1 (ko) * | 2016-09-05 | 2018-03-08 | 한국과학기술원 | 목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도 |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| IL268058B2 (en) | 2017-01-20 | 2023-09-01 | Magenta Therapeutics Inc | Compositions and methods for depleting cd137 plus cells |
| CN111032678A (zh) | 2017-06-26 | 2020-04-17 | 拜西克尔德有限公司 | 具有可检测部分的双环肽配体和其用途 |
| WO2019010164A1 (en) * | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | Evolution of trna synthetases |
| ES2926195T3 (es) | 2017-08-04 | 2022-10-24 | Bicycletx Ltd | Ligandos peptídicos bicíclicos específicos de CD137 |
| WO2019040935A1 (en) | 2017-08-25 | 2019-02-28 | President And Fellows Of Harvard College | EVOLUTION OF PEPTIDASES BONT |
| WO2019056002A1 (en) | 2017-09-18 | 2019-03-21 | President And Fellows Of Harvard College | CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS |
| JP7275049B2 (ja) | 2017-12-27 | 2023-05-17 | 協和キリン株式会社 | Ｉｌ－２改変体 |
| AU2019224659A1 (en) | 2018-02-23 | 2020-10-15 | Bicycletx Limited | Multimeric bicyclic peptide ligands |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| CN110835633B (zh) * | 2018-08-13 | 2021-10-01 | 北京大学 | 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用 |
| CN112673109A (zh) * | 2018-09-07 | 2021-04-16 | 免疫医疗有限责任公司 | 细胞选择方法 |
| KR102559149B1 (ko) | 2018-10-26 | 2023-07-24 | 에프. 호프만-라 로슈 아게 | 재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법 |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| CN109553643B (zh) * | 2018-11-29 | 2020-09-22 | 深圳先进技术研究院 | 单糖类似物及包含其的分子探针和该分子探针的应用 |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| US12551567B2 (en) | 2018-12-21 | 2026-02-17 | Bicyclerd Limited | Bicyclic peptide ligands specific for PD-L1 |
| CN113474045A (zh) | 2018-12-21 | 2021-10-01 | 拜斯科技术开发有限公司 | Pd-l1特异性的双环肽配体 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| CN111850020B (zh) * | 2019-04-25 | 2021-05-07 | 苏州鲲鹏生物技术有限公司 | 利用质粒系统在蛋白中引入非天然氨基酸 |
| CN111909256A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 多肽衍生物及其制备方法 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| CA3155908A1 (en) * | 2019-10-23 | 2021-04-29 | University Of Florida Research Foundation, Incorporated | Novel conjugation chemistry for catalytic antibody 38c2 |
| CA3189761A1 (en) | 2020-08-03 | 2022-02-10 | Gemma Mudd | Peptide-based linkers |
| WO2022056318A1 (en) * | 2020-09-10 | 2022-03-17 | Brickbio, Inc. | Antibodies containing unnatural amino acids and methods of making and using the same |
| MX2023012518A (es) * | 2021-04-21 | 2024-02-08 | Asimov Inc | Sistemas de producción estables para la producción de virus adenoasociado. |
| WO2022232377A2 (en) * | 2021-04-28 | 2022-11-03 | The Regents Of The University Of California | Bioreactive proteins containing unnatural amino acids |
| AU2021458069B2 (en) * | 2021-07-29 | 2025-04-24 | Novocodex Biopharmaceuticals Co., Ltd. | Unnatural amino acid, and use thereof, recombinant protein containing same, and recombinant protein conjugate |
| EP4130254A1 (en) * | 2021-08-03 | 2023-02-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Eukaryotic cell lysates comprising exogenous enzymes and methods for preparing the same |
| CN113698468B (zh) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其应用 |
| CN113788890B (zh) * | 2021-09-01 | 2022-11-08 | 浙江新码生物医药有限公司 | 一种人白细胞介素2-聚乙二醇偶联物及其应用 |
| WO2023164676A1 (en) * | 2022-02-27 | 2023-08-31 | The Regents Of The University Of California | Methods to generate novel acyl-trna species |
| US20260070874A1 (en) * | 2023-04-05 | 2026-03-12 | Kj Chemicals Corporation | Benzoylformic acid amide derivative |
| WO2024223923A1 (en) * | 2023-04-28 | 2024-10-31 | United Kingdom Research And Innovation | tRNA-BASED METHODS AND RELATED COMPOSITIONS |
| WO2025011557A1 (en) * | 2023-07-10 | 2025-01-16 | Surio Therapeutics Co. Ltd | Functionalized auristatins, pharmaceutical compositions, and therapeutic applications |
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| US3711458A (en) | 1969-08-21 | 1973-01-16 | Research Corp | Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides |
| US4512979A (en) | 1981-03-23 | 1985-04-23 | Merck & Co., Inc. | Dipeptides containing thialysine and related amino acids as antihypertensives |
| JPH0710451B2 (ja) | 1986-11-25 | 1995-02-08 | 三五重機株式会社 | 鋼板カツタ− |
| HU207287B (en) | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
| WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| IL158418A0 (en) | 2001-04-19 | 2004-05-12 | Scripps Research Inst | In vivo incorporation of unnatural amino acids |
| EP2042196B1 (en) | 2001-10-10 | 2016-07-13 | ratiopharm GmbH | Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF) |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| US20040146941A1 (en) * | 2002-11-04 | 2004-07-29 | Biliang Zhang | Chemical encoding technology for combinatorial synthesis |
| CN103289960B (zh) * | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| EP1812031B1 (en) | 2004-11-01 | 2015-06-24 | The Regents of the University of California | Compositions and methods for modification of biomolecules |
| JP2007037445A (ja) | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| EP1992698B1 (en) | 2006-02-22 | 2018-09-05 | Riken | METHOD FOR SYNTHESIS OF SUPPRESSOR tRNA, DNA CONSTRUCT, AND PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE DNA CONSTRUCT |
| EP2581450B1 (en) | 2006-05-02 | 2018-08-15 | MedImmune Limited | Non-natural amino acid substituted polypeptides |
| KR20090094812A (ko) * | 2006-10-18 | 2009-09-08 | 더 스크립스 리서치 인스티튜트 | 포유동물 세포에서 비천연 아미노산의 단백질 내로의 유전적 도입 |
| JP5590649B2 (ja) | 2007-09-20 | 2014-09-17 | 独立行政法人理化学研究所 | 変異体ピロリジル−ｔＲＮＡ合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法 |
| JP2011528416A (ja) | 2008-07-18 | 2011-11-17 | アラントゥーム | 自動車の排気ガス浄化用フィルタ装置 |
| EP2376647B1 (en) | 2009-01-12 | 2014-03-05 | Sutro Biopharma, Inc. | Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system |
| US20100203587A1 (en) | 2009-01-13 | 2010-08-12 | Sutro Biopharma, Inc. | Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions |
| WO2010114615A2 (en) | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
| GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| US8921571B2 (en) * | 2009-10-06 | 2014-12-30 | The Ohio State University | Pyrrolysine analogs |
| NZ600361A (en) * | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
| EP2516455A4 (en) * | 2009-12-21 | 2013-05-22 | Ambrx Inc | MODIFIED SWINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES |
| EP2894142B1 (en) | 2010-04-27 | 2019-06-12 | SynAffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
| WO2012032181A2 (en) | 2010-09-10 | 2012-03-15 | Allozyne, Inc | Novel antibody derivatives |
| DE102010041261A1 (de) * | 2010-09-23 | 2012-03-29 | Robert Bosch Gmbh | Flip-Chip Anordnung mit einem Kühlelement und Verfahren zur Herstellung einer Flip-Chip Anordnung |
| EP2619305A1 (en) * | 2010-09-24 | 2013-07-31 | Medical Research Council | Methods for incorporating unnatural amino acids in eukaryotic cells |
| EP3279211B1 (en) * | 2011-02-03 | 2020-04-29 | Embl | Unnatural amino acids comprising a norbornenyl group and uses thereof |
| DK2890402T3 (da) | 2012-08-31 | 2019-07-15 | Sutro Biopharma Inc | Modificerede aminosyrer omfattende en azidogruppe |
| BR112015006368B1 (pt) | 2012-09-24 | 2022-02-08 | Medimmune Limited | Processo para produção de linha celular eucariótica estável |
| CA2906292C (en) | 2013-03-15 | 2022-08-02 | Medimmune Limited | Novel dna constructs for the expression of trnapyl genes in eukaryotic cells |
-
2013
- 2013-09-24 BR BR112015006368-3A patent/BR112015006368B1/pt active IP Right Grant
- 2013-09-24 EP EP13766526.1A patent/EP2897935B1/en not_active Not-in-force
- 2013-09-24 US US14/430,412 patent/US9670521B2/en not_active Expired - Fee Related
- 2013-09-24 AU AU2013320184A patent/AU2013320184B2/en active Active
- 2013-09-24 CN CN201380060971.9A patent/CN104812734B/zh not_active Expired - Fee Related
- 2013-09-24 US US14/430,542 patent/US9732367B2/en active Active
- 2013-09-24 SG SG11201502216UA patent/SG11201502216UA/en unknown
- 2013-09-24 EP EP13766525.3A patent/EP2898085B1/en active Active
- 2013-09-24 CA CA2885796A patent/CA2885796C/en active Active
- 2013-09-24 CN CN201380060916.XA patent/CN105026574B/zh active Active
- 2013-09-24 JP JP2015532457A patent/JP6532404B2/ja active Active
- 2013-09-24 JP JP2015532458A patent/JP6321658B2/ja not_active Expired - Fee Related
- 2013-09-24 KR KR1020157010354A patent/KR102155389B1/ko active Active
- 2013-09-24 WO PCT/EP2013/069888 patent/WO2014044873A1/en not_active Ceased
- 2013-09-24 SG SG10201702387YA patent/SG10201702387YA/en unknown
- 2013-09-24 WO PCT/EP2013/069887 patent/WO2014044872A1/en not_active Ceased
-
2017
- 2017-06-01 US US15/610,931 patent/US10214761B2/en not_active Expired - Fee Related
- 2017-06-01 US US15/611,116 patent/US10253345B2/en active Active
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