JP2015531789A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015531789A5 JP2015531789A5 JP2015532458A JP2015532458A JP2015531789A5 JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5 JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolysine
- mutein
- unnatural amino
- conjugated
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705116P | 2012-09-24 | 2012-09-24 | |
| US61/705,116 | 2012-09-24 | ||
| US201361862495P | 2013-08-05 | 2013-08-05 | |
| US61/862,495 | 2013-08-05 | ||
| PCT/EP2013/069888 WO2014044873A1 (en) | 2012-09-24 | 2013-09-24 | Amino acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531789A JP2015531789A (ja) | 2015-11-05 |
| JP2015531789A5 true JP2015531789A5 (enExample) | 2018-03-29 |
| JP6321658B2 JP6321658B2 (ja) | 2018-05-09 |
Family
ID=49237211
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532458A Expired - Fee Related JP6321658B2 (ja) | 2012-09-24 | 2013-09-24 | アミノ酸誘導体 |
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9732367B2 (enExample) |
| EP (2) | EP2897935B1 (enExample) |
| JP (2) | JP6321658B2 (enExample) |
| KR (1) | KR102155389B1 (enExample) |
| CN (2) | CN104812734B (enExample) |
| AU (1) | AU2013320184B2 (enExample) |
| BR (1) | BR112015006368B1 (enExample) |
| CA (1) | CA2885796C (enExample) |
| SG (2) | SG11201502216UA (enExample) |
| WO (2) | WO2014044873A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6088438B2 (ja) | 2010-12-22 | 2017-03-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 連続的定向進化 |
| JP6343604B2 (ja) | 2012-05-18 | 2018-06-13 | メディカル リサーチ カウンシル | ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法 |
| EP3505534A1 (en) | 2012-06-08 | 2019-07-03 | Sutro Biopharma, Inc. | Antibodies comprising sitespecific nonnatural amino acid residues, methods of their preparation and methods of their use |
| EP2863955B1 (en) | 2012-06-26 | 2016-11-23 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| CA2885796C (en) | 2012-09-24 | 2022-05-03 | Allozyne, Inc. | Cell lines |
| AU2014229999B2 (en) | 2013-03-15 | 2019-09-12 | Medimmune Limited | Novel nucleic acid molecules |
| US9764039B2 (en) * | 2013-07-10 | 2017-09-19 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| US9981908B2 (en) | 2013-08-05 | 2018-05-29 | Medimmune Limited | Amino acid derivatives |
| WO2015088990A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| US10179911B2 (en) | 2014-01-20 | 2019-01-15 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| GB2528227A (en) * | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| WO2016077052A2 (en) | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
| CA3220466A1 (en) | 2014-10-29 | 2016-05-06 | Bicyclerd Limited | Bicyclic peptide ligands specific for mt1-mmp |
| CN106146663B (zh) * | 2015-04-10 | 2019-11-08 | 北京大学 | 非天然氨基酸标记的新型抗体-药物偶联物及其制备 |
| US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| WO2017019895A1 (en) | 2015-07-30 | 2017-02-02 | President And Fellows Of Harvard College | Evolution of talens |
| EP3360960A4 (en) | 2015-08-19 | 2019-03-20 | Riken | ANTIBODIES WITH INGREDIENTS OF NON-NATURAL AMINO ACID |
| CA3002827A1 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| CN106929482A (zh) * | 2015-12-31 | 2017-07-07 | 北京大学 | 定点突变的流感病毒、其活疫苗及其制备方法和应用 |
| CA3011455A1 (en) | 2016-01-27 | 2017-08-03 | Sutro Biopharma, Inc. | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
| CN112725282A (zh) * | 2016-01-27 | 2021-04-30 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| CN105524167A (zh) * | 2016-01-30 | 2016-04-27 | 深圳市贝沃德克生物技术研究院有限公司 | 抗乙肝e抗原的绿色荧光抗体的制备方法 |
| CN105647918A (zh) * | 2016-02-20 | 2016-06-08 | 深圳市圣必智科技开发有限公司 | 抗乙肝e抗原的红色荧光抗体的制备方法 |
| KR20190038537A (ko) | 2016-06-17 | 2019-04-08 | 마젠타 테라퓨틱스 인코포레이티드 | Cd117+ 세포의 고갈을 위한 조성물 및 방법 |
| US11214820B2 (en) * | 2016-09-02 | 2022-01-04 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
| US10905107B2 (en) * | 2016-09-05 | 2021-02-02 | Korea Advanced Institute Of Science And Technology | Transgenic mouse capable of spatial and temporal control of expression and site-specific modification of target protein, production method and uses thereof |
| WO2018044143A1 (ko) * | 2016-09-05 | 2018-03-08 | 한국과학기술원 | 목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도 |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| KR102725761B1 (ko) | 2017-01-20 | 2024-11-04 | 하이델베르크 파마 리서치 게엠베하 | Cd137+ 세포의 고갈을 위한 조성물 및 방법 |
| WO2019010164A1 (en) * | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | Evolution of trna synthetases |
| US11261214B2 (en) | 2017-08-04 | 2022-03-01 | Bicycletx Limited | Bicyclic peptide ligand specific for CD137 |
| EP3673059A4 (en) | 2017-08-25 | 2021-09-01 | President And Fellows Of Harvard College | EVOLUTION OF BONT PEPTIDASES |
| US11624130B2 (en) | 2017-09-18 | 2023-04-11 | President And Fellows Of Harvard College | Continuous evolution for stabilized proteins |
| WO2019131964A1 (ja) | 2017-12-27 | 2019-07-04 | 協和発酵キリン株式会社 | Ｉｌ－２改変体 |
| MX2020008791A (es) | 2018-02-23 | 2021-01-08 | Bicycletx Ltd | Ligandos de peptidos biciclicos multimericos. |
| US11913044B2 (en) | 2018-06-14 | 2024-02-27 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| CN110835633B (zh) * | 2018-08-13 | 2021-10-01 | 北京大学 | 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用 |
| EP3847271A4 (en) * | 2018-09-07 | 2022-10-12 | MedImmune, LLC | Methods of cell selection |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| CN109553643B (zh) * | 2018-11-29 | 2020-09-22 | 深圳先进技术研究院 | 单糖类似物及包含其的分子探针和该分子探针的应用 |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| CN111850020B (zh) * | 2019-04-25 | 2021-05-07 | 苏州鲲鹏生物技术有限公司 | 利用质粒系统在蛋白中引入非天然氨基酸 |
| CN111909256A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 多肽衍生物及其制备方法 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| CN114846030A (zh) * | 2019-10-23 | 2022-08-02 | 佛罗里达大学研究基金会公司 | 催化抗体38c2的新型缀合化学 |
| US20240316209A1 (en) * | 2020-09-10 | 2024-09-26 | Brickbio, Inc. | Antibodies containing unnatural amino acids and methods of making and using the same |
| KR20240019759A (ko) * | 2021-04-21 | 2024-02-14 | 아시모브 인코포레이티드 | 아데노-연관 바이러스 생산을 위한 안정적인 생산 시스템 |
| EP4330214A4 (en) * | 2021-04-28 | 2025-11-26 | Univ California | BIOREACTIVE PROTEINS CONTAINING NON-NATURAL AMINO ACIDS |
| WO2023004686A1 (zh) * | 2021-07-29 | 2023-02-02 | 浙江新码生物医药有限公司 | 一种非天然氨基酸及其应用、包含其的重组蛋白以及重组蛋白偶联物 |
| EP4130254A1 (en) * | 2021-08-03 | 2023-02-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Eukaryotic cell lysates comprising exogenous enzymes and methods for preparing the same |
| CN113698468B (zh) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其应用 |
| CN113788890B (zh) * | 2021-09-01 | 2022-11-08 | 浙江新码生物医药有限公司 | 一种人白细胞介素2-聚乙二醇偶联物及其应用 |
| WO2023164676A1 (en) * | 2022-02-27 | 2023-08-31 | The Regents Of The University Of California | Methods to generate novel acyl-trna species |
| AU2024263582A1 (en) * | 2023-04-28 | 2025-10-09 | United Kingdom Research And Innovation | tRNA-BASED METHODS AND RELATED COMPOSITIONS |
| WO2025011557A1 (en) * | 2023-07-10 | 2025-01-16 | Surio Therapeutics Co. Ltd | Functionalized auristatins, pharmaceutical compositions, and therapeutic applications |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711458A (en) | 1969-08-21 | 1973-01-16 | Research Corp | Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides |
| US4512979A (en) | 1981-03-23 | 1985-04-23 | Merck & Co., Inc. | Dipeptides containing thialysine and related amino acids as antihypertensives |
| JPH0710451B2 (ja) | 1986-11-25 | 1995-02-08 | 三五重機株式会社 | 鋼板カツタ− |
| HU207287B (en) | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
| EP0481038B1 (en) | 1990-04-16 | 2002-10-02 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| MXPA03009566A (es) | 2001-04-19 | 2004-12-06 | Scripps Research Inst | Metodos y composicion para la produccion de pares trna-aminoaciltrna sintetasa ortogonales. |
| ES2556338T3 (es) | 2001-10-10 | 2016-01-15 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| KR20050073559A (ko) | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| US20040146941A1 (en) | 2002-11-04 | 2004-07-29 | Biliang Zhang | Chemical encoding technology for combinatorial synthesis |
| KR101171397B1 (ko) * | 2003-04-17 | 2012-08-07 | 더 스크립스 리서치 인스티튜트 | 진핵 유전자 코드의 확장 |
| WO2006050262A2 (en) | 2004-11-01 | 2006-05-11 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| JP2007037445A (ja) * | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| EP1992698B1 (en) | 2006-02-22 | 2018-09-05 | Riken | METHOD FOR SYNTHESIS OF SUPPRESSOR tRNA, DNA CONSTRUCT, AND PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE DNA CONSTRUCT |
| CA2653748A1 (en) | 2006-05-02 | 2007-11-15 | Allozyne, Inc. | Non-natural amino acid substituted polypeptides |
| RU2009112104A (ru) * | 2006-10-18 | 2010-11-27 | Зе Скрипс Ресеч Инститьют (Us) | Генетическое встраивание не встречающихся в природе аминокислот в белки клеток млекопитающих |
| JP5590649B2 (ja) | 2007-09-20 | 2014-09-17 | 独立行政法人理化学研究所 | 変異体ピロリジル−ｔＲＮＡ合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法 |
| EP2315922A1 (en) | 2008-07-18 | 2011-05-04 | Alantum Corporation | Filter device for filtering automobile exhaust gas |
| WO2010081110A1 (en) | 2009-01-12 | 2010-07-15 | Sutro Biopharma, Inc. | Dual charging system for selectively introducing non-native amino acids into proteins using an in vitro synthesis method |
| WO2010083148A1 (en) | 2009-01-13 | 2010-07-22 | Sutro Biopharma, Inc. | Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions |
| WO2010114615A2 (en) | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
| GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| WO2011044255A1 (en) | 2009-10-06 | 2011-04-14 | The Ohio State University | Pyrrolysine analogs |
| EA201290541A1 (ru) * | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
| EP2516455A4 (en) * | 2009-12-21 | 2013-05-22 | Ambrx Inc | MODIFIED SWINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES |
| EP2563753B9 (en) | 2010-04-27 | 2016-07-06 | SynAffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
| WO2012032181A2 (en) * | 2010-09-10 | 2012-03-15 | Allozyne, Inc | Novel antibody derivatives |
| DE102010041261A1 (de) * | 2010-09-23 | 2012-03-29 | Robert Bosch Gmbh | Flip-Chip Anordnung mit einem Kühlelement und Verfahren zur Herstellung einer Flip-Chip Anordnung |
| WO2012038706A1 (en) | 2010-09-24 | 2012-03-29 | Medical Research Council | Methods for incorporating unnatural amino acids in eukaryotic cells |
| EP2670767B1 (en) * | 2011-02-03 | 2017-12-20 | European Molecular Biology Laboratory | Unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and uses thereof |
| ES2728864T3 (es) | 2012-08-31 | 2019-10-29 | Sutro Biopharma Inc | Aminoácidos modificados que comprenden un grupo azido |
| CA2885796C (en) | 2012-09-24 | 2022-05-03 | Allozyne, Inc. | Cell lines |
| AU2014229999B2 (en) | 2013-03-15 | 2019-09-12 | Medimmune Limited | Novel nucleic acid molecules |
-
2013
- 2013-09-24 CA CA2885796A patent/CA2885796C/en active Active
- 2013-09-24 BR BR112015006368-3A patent/BR112015006368B1/pt active IP Right Grant
- 2013-09-24 WO PCT/EP2013/069888 patent/WO2014044873A1/en not_active Ceased
- 2013-09-24 US US14/430,542 patent/US9732367B2/en active Active
- 2013-09-24 SG SG11201502216UA patent/SG11201502216UA/en unknown
- 2013-09-24 SG SG10201702387YA patent/SG10201702387YA/en unknown
- 2013-09-24 US US14/430,412 patent/US9670521B2/en not_active Expired - Fee Related
- 2013-09-24 KR KR1020157010354A patent/KR102155389B1/ko active Active
- 2013-09-24 CN CN201380060971.9A patent/CN104812734B/zh not_active Expired - Fee Related
- 2013-09-24 CN CN201380060916.XA patent/CN105026574B/zh active Active
- 2013-09-24 JP JP2015532458A patent/JP6321658B2/ja not_active Expired - Fee Related
- 2013-09-24 EP EP13766526.1A patent/EP2897935B1/en not_active Not-in-force
- 2013-09-24 JP JP2015532457A patent/JP6532404B2/ja active Active
- 2013-09-24 AU AU2013320184A patent/AU2013320184B2/en active Active
- 2013-09-24 EP EP13766525.3A patent/EP2898085B1/en active Active
- 2013-09-24 WO PCT/EP2013/069887 patent/WO2014044872A1/en not_active Ceased
-
2017
- 2017-06-01 US US15/611,116 patent/US10253345B2/en active Active
- 2017-06-01 US US15/610,931 patent/US10214761B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015531789A5 (enExample) | ||
| EP4410317A3 (en) | Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids | |
| JP2015532295A5 (enExample) | ||
| JP2020097577A5 (enExample) | ||
| JP2016153410A5 (enExample) | ||
| JP2009523724A5 (enExample) | ||
| JP2016106149A5 (enExample) | ||
| JP2010521485A5 (enExample) | ||
| JP2016531842A5 (enExample) | ||
| JP2019524883A5 (enExample) | ||
| JP2020507589A5 (enExample) | ||
| JP2017515901A5 (enExample) | ||
| CY1115719T1 (el) | Νεοι φαρμακευτικοι συνδυασμοι για τη θεραπεια νοσων των αναπνευστικων οδων | |
| JP2016531871A5 (enExample) | ||
| JP2010077141A5 (enExample) | ||
| JP2013508279A5 (enExample) | ||
| JP2017531619A5 (enExample) | ||
| JP2011517683A5 (enExample) | ||
| JP2010500962A5 (enExample) | ||
| JP2020529994A5 (enExample) | ||
| JP2016510326A5 (enExample) | ||
| JP2019516739A5 (enExample) | ||
| JP2015051983A5 (enExample) | ||
| JP2003306481A5 (enExample) | ||
| JP2019510027A5 (enExample) |