JP2015531789A5 - - Google Patents
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- Publication number
- JP2015531789A5 JP2015531789A5 JP2015532458A JP2015532458A JP2015531789A5 JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5 JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolysine
- mutein
- unnatural amino
- conjugated
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705116P | 2012-09-24 | 2012-09-24 | |
| US61/705,116 | 2012-09-24 | ||
| US201361862495P | 2013-08-05 | 2013-08-05 | |
| US61/862,495 | 2013-08-05 | ||
| PCT/EP2013/069888 WO2014044873A1 (en) | 2012-09-24 | 2013-09-24 | Amino acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531789A JP2015531789A (ja) | 2015-11-05 |
| JP2015531789A5 true JP2015531789A5 (enExample) | 2018-03-29 |
| JP6321658B2 JP6321658B2 (ja) | 2018-05-09 |
Family
ID=49237211
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
| JP2015532458A Expired - Fee Related JP6321658B2 (ja) | 2012-09-24 | 2013-09-24 | アミノ酸誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532457A Active JP6532404B2 (ja) | 2012-09-24 | 2013-09-24 | 細胞株 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9670521B2 (enExample) |
| EP (2) | EP2897935B1 (enExample) |
| JP (2) | JP6532404B2 (enExample) |
| KR (1) | KR102155389B1 (enExample) |
| CN (2) | CN105026574B (enExample) |
| AU (1) | AU2013320184B2 (enExample) |
| BR (1) | BR112015006368B1 (enExample) |
| CA (1) | CA2885796C (enExample) |
| SG (2) | SG11201502216UA (enExample) |
| WO (2) | WO2014044873A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088381A2 (en) | 2010-12-22 | 2012-06-28 | President And Fellows Of Harvard College | Continuous directed evolution |
| US20150148525A1 (en) | 2012-05-18 | 2015-05-28 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
| CN104583235B (zh) | 2012-06-08 | 2019-03-01 | 苏特罗生物制药公司 | 含位点特异非天然氨基酸残基的抗体、其制备和使用方法 |
| US9732161B2 (en) | 2012-06-26 | 2017-08-15 | Sutro Biopharma, Inc. | Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| WO2014044873A1 (en) | 2012-09-24 | 2014-03-27 | Allozyne, Inc | Amino acid derivatives |
| SG11201507104WA (en) | 2013-03-15 | 2015-10-29 | Medimmune Ltd | Novel nucleic acid molecules |
| ES2865473T3 (es) * | 2013-07-10 | 2021-10-15 | Sutro Biopharma Inc | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
| US9981908B2 (en) | 2013-08-05 | 2018-05-29 | Medimmune Limited | Amino acid derivatives |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| WO2015134121A2 (en) | 2014-01-20 | 2015-09-11 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| GB2528227A (en) * | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| US10920208B2 (en) | 2014-10-22 | 2021-02-16 | President And Fellows Of Harvard College | Evolution of proteases |
| RU2708459C2 (ru) | 2014-10-29 | 2019-12-09 | БайсиклРД Лимитед | Бициклические пептидные лиганды, специфичные для мт1-ммр |
| CN106146663B (zh) * | 2015-04-10 | 2019-11-08 | 北京大学 | 非天然氨基酸标记的新型抗体-药物偶联物及其制备 |
| WO2016168631A1 (en) | 2015-04-17 | 2016-10-20 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| US10392674B2 (en) | 2015-07-22 | 2019-08-27 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| WO2017015559A2 (en) | 2015-07-23 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of bt toxins |
| US10612011B2 (en) | 2015-07-30 | 2020-04-07 | President And Fellows Of Harvard College | Evolution of TALENs |
| JP6967221B2 (ja) * | 2015-08-19 | 2021-11-17 | 国立研究開発法人理化学研究所 | 非天然アミノ酸導入抗体 |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| CN106929482A (zh) * | 2015-12-31 | 2017-07-07 | 北京大学 | 定点突变的流感病毒、其活疫苗及其制备方法和应用 |
| CN112725282A (zh) * | 2016-01-27 | 2021-04-30 | 北京大学 | 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建 |
| KR20180104106A (ko) | 2016-01-27 | 2018-09-19 | 서트로 바이오파마, 인크. | anti-CD74 항체 접합체, anti-CD74 항체 접합체를 포함하는 조성물 및 anti-CD74 항체 접합체의 이용 방법 |
| CN105524167A (zh) * | 2016-01-30 | 2016-04-27 | 深圳市贝沃德克生物技术研究院有限公司 | 抗乙肝e抗原的绿色荧光抗体的制备方法 |
| CN105647918A (zh) * | 2016-02-20 | 2016-06-08 | 深圳市圣必智科技开发有限公司 | 抗乙肝e抗原的红色荧光抗体的制备方法 |
| CA3028134A1 (en) | 2016-06-17 | 2017-12-21 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+ cells |
| US11214820B2 (en) * | 2016-09-02 | 2022-01-04 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
| KR102013742B1 (ko) * | 2016-09-05 | 2019-11-04 | 한국과학기술원 | 목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도 |
| WO2018044143A1 (ko) * | 2016-09-05 | 2018-03-08 | 한국과학기술원 | 목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도 |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| SG10202102897PA (en) | 2017-01-20 | 2021-04-29 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd137+ cells |
| US11447809B2 (en) | 2017-07-06 | 2022-09-20 | President And Fellows Of Harvard College | Evolution of tRNA synthetases |
| EP3661948B1 (en) | 2017-08-04 | 2022-06-01 | BicycleTx Limited | Bicyclic peptide ligands specific for cd137 |
| US12060553B2 (en) | 2017-08-25 | 2024-08-13 | President And Fellows Of Harvard College | Evolution of BoNT peptidases |
| WO2019056002A1 (en) | 2017-09-18 | 2019-03-21 | President And Fellows Of Harvard College | CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS |
| EP3733693A4 (en) | 2017-12-27 | 2021-12-22 | Kyowa Kirin Co., Ltd. | IL-2 VARIANT |
| EP3755725A1 (en) | 2018-02-23 | 2020-12-30 | BicycleTX Limited | Multimeric bicyclic peptide ligands |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| CN110835633B (zh) * | 2018-08-13 | 2021-10-01 | 北京大学 | 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用 |
| JP2021536263A (ja) * | 2018-09-07 | 2021-12-27 | メディミューン，エルエルシー | 細胞選択の方法 |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| CN109553643B (zh) * | 2018-11-29 | 2020-09-22 | 深圳先进技术研究院 | 单糖类似物及包含其的分子探针和该分子探针的应用 |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| JP2022514618A (ja) | 2018-12-21 | 2022-02-14 | バイスクルテクス・リミテッド | Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| CN111850020B (zh) * | 2019-04-25 | 2021-05-07 | 苏州鲲鹏生物技术有限公司 | 利用质粒系统在蛋白中引入非天然氨基酸 |
| CN111909256A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 多肽衍生物及其制备方法 |
| TWI862640B (zh) | 2019-07-30 | 2024-11-21 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| IL292440A (en) * | 2019-10-23 | 2022-06-01 | Univ Florida | Novel conjugation chemistry for catalytic antibody 38c2 |
| EP4210725A4 (en) * | 2020-09-10 | 2025-01-01 | Brickbio, Inc. | ANTIBODIES WITH UNNATURAL AMINO ACIDS AND METHODS FOR THE PRODUCTION AND USE THEREOF |
| KR20240019759A (ko) * | 2021-04-21 | 2024-02-14 | 아시모브 인코포레이티드 | 아데노-연관 바이러스 생산을 위한 안정적인 생산 시스템 |
| WO2022232377A2 (en) * | 2021-04-28 | 2022-11-03 | The Regents Of The University Of California | Bioreactive proteins containing unnatural amino acids |
| WO2023004686A1 (zh) * | 2021-07-29 | 2023-02-02 | 浙江新码生物医药有限公司 | 一种非天然氨基酸及其应用、包含其的重组蛋白以及重组蛋白偶联物 |
| EP4130254A1 (en) * | 2021-08-03 | 2023-02-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Eukaryotic cell lysates comprising exogenous enzymes and methods for preparing the same |
| CN113698468B (zh) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其应用 |
| CN113788890B (zh) * | 2021-09-01 | 2022-11-08 | 浙江新码生物医药有限公司 | 一种人白细胞介素2-聚乙二醇偶联物及其应用 |
| WO2023164676A1 (en) * | 2022-02-27 | 2023-08-31 | The Regents Of The University Of California | Methods to generate novel acyl-trna species |
| WO2024223923A1 (en) * | 2023-04-28 | 2024-10-31 | United Kingdom Research And Innovation | tRNA-BASED METHODS AND RELATED COMPOSITIONS |
| WO2025011557A1 (en) * | 2023-07-10 | 2025-01-16 | Surio Therapeutics Co. Ltd | Functionalized auristatins, pharmaceutical compositions, and therapeutic applications |
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|---|---|---|---|---|
| US3711458A (en) | 1969-08-21 | 1973-01-16 | Research Corp | Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides |
| US4512979A (en) | 1981-03-23 | 1985-04-23 | Merck & Co., Inc. | Dipeptides containing thialysine and related amino acids as antihypertensives |
| JPH0710451B2 (ja) | 1986-11-25 | 1995-02-08 | 三五重機株式会社 | 鋼板カツタ− |
| HU207287B (en) | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
| US5180674A (en) | 1990-04-16 | 1993-01-19 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| IL158418A0 (en) | 2001-04-19 | 2004-05-12 | Scripps Research Inst | In vivo incorporation of unnatural amino acids |
| EP2305313B1 (en) | 2001-10-10 | 2014-03-26 | ratiopharm GmbH | Remodelling and glycoconjugation of interferon-alpha (IFNa) |
| JP4752001B2 (ja) | 2002-10-16 | 2011-08-17 | ザ スクリプス リサーチ インスティチュート | 糖蛋白質合成 |
| US20040146941A1 (en) * | 2002-11-04 | 2004-07-29 | Biliang Zhang | Chemical encoding technology for combinatorial synthesis |
| US7618775B2 (en) * | 2003-04-17 | 2009-11-17 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| PT1812031E (pt) | 2004-11-01 | 2015-10-01 | Univ California | Composições e métodos para modificação de biomoléculas |
| JP2007037445A (ja) * | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| EP1992698B1 (en) | 2006-02-22 | 2018-09-05 | Riken | METHOD FOR SYNTHESIS OF SUPPRESSOR tRNA, DNA CONSTRUCT, AND PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE DNA CONSTRUCT |
| US7632492B2 (en) | 2006-05-02 | 2009-12-15 | Allozyne, Inc. | Modified human interferon-β polypeptides |
| CA2665678A1 (en) * | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| CA2706889C (en) | 2007-09-20 | 2018-08-28 | Riken | Mutant pyrrolysyl-trna synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same |
| WO2010008110A1 (en) | 2008-07-18 | 2010-01-21 | Alantum Corporation | Filter device for filtering automobile exhaust gas |
| JP5798489B2 (ja) | 2009-01-12 | 2015-10-21 | ストロ バイオファーマ， インコーポレイテッド | インビトロタンパク質合成システムを用いて非天然アミノ酸をタンパク質に選択的に導入するためのモノチャージシステム |
| US20100203587A1 (en) | 2009-01-13 | 2010-08-12 | Sutro Biopharma, Inc. | Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions |
| WO2010114615A2 (en) | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
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| US8921571B2 (en) | 2009-10-06 | 2014-12-30 | The Ohio State University | Pyrrolysine analogs |
| AU2010341516B2 (en) * | 2009-12-21 | 2014-01-16 | Ambrx, Inc. | Modified bovine somatotropin polypeptides and their uses |
| NZ600363A (en) | 2009-12-21 | 2014-07-25 | Ambrx Inc | Modified porcine somatotropin polypeptides and their uses |
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| EP2640745B1 (en) * | 2010-09-10 | 2018-11-07 | MedImmune Limited | Bivalent and bispecific anti-il6/anti-il23 antibodies |
| DE102010041261A1 (de) * | 2010-09-23 | 2012-03-29 | Robert Bosch Gmbh | Flip-Chip Anordnung mit einem Kühlelement und Verfahren zur Herstellung einer Flip-Chip Anordnung |
| EP2619305A1 (en) * | 2010-09-24 | 2013-07-31 | Medical Research Council | Methods for incorporating unnatural amino acids in eukaryotic cells |
| CA2826041C (en) * | 2011-02-03 | 2020-07-07 | Embl | Unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and uses thereof |
| SG11201501464TA (en) | 2012-08-31 | 2015-03-30 | Sutro Biopharma Inc | Modified amino acids comprising an azido group |
| WO2014044873A1 (en) | 2012-09-24 | 2014-03-27 | Allozyne, Inc | Amino acid derivatives |
| SG11201507104WA (en) | 2013-03-15 | 2015-10-29 | Medimmune Ltd | Novel nucleic acid molecules |
-
2013
- 2013-09-24 WO PCT/EP2013/069888 patent/WO2014044873A1/en not_active Ceased
- 2013-09-24 CN CN201380060916.XA patent/CN105026574B/zh active Active
- 2013-09-24 EP EP13766526.1A patent/EP2897935B1/en not_active Not-in-force
- 2013-09-24 SG SG11201502216UA patent/SG11201502216UA/en unknown
- 2013-09-24 US US14/430,412 patent/US9670521B2/en not_active Expired - Fee Related
- 2013-09-24 EP EP13766525.3A patent/EP2898085B1/en active Active
- 2013-09-24 CN CN201380060971.9A patent/CN104812734B/zh not_active Expired - Fee Related
- 2013-09-24 WO PCT/EP2013/069887 patent/WO2014044872A1/en not_active Ceased
- 2013-09-24 JP JP2015532457A patent/JP6532404B2/ja active Active
- 2013-09-24 US US14/430,542 patent/US9732367B2/en active Active
- 2013-09-24 AU AU2013320184A patent/AU2013320184B2/en active Active
- 2013-09-24 KR KR1020157010354A patent/KR102155389B1/ko active Active
- 2013-09-24 SG SG10201702387YA patent/SG10201702387YA/en unknown
- 2013-09-24 CA CA2885796A patent/CA2885796C/en active Active
- 2013-09-24 JP JP2015532458A patent/JP6321658B2/ja not_active Expired - Fee Related
- 2013-09-24 BR BR112015006368-3A patent/BR112015006368B1/pt active IP Right Grant
-
2017
- 2017-06-01 US US15/611,116 patent/US10253345B2/en active Active
- 2017-06-01 US US15/610,931 patent/US10214761B2/en not_active Expired - Fee Related