JP2015531789A5 - - Google Patents

Download PDF

Info

Publication number
JP2015531789A5
JP2015531789A5 JP2015532458A JP2015532458A JP2015531789A5 JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5 JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015532458 A JP2015532458 A JP 2015532458A JP 2015531789 A5 JP2015531789 A5 JP 2015531789A5
Authority
JP
Japan
Prior art keywords
pyrrolysine
mutein
unnatural amino
conjugated
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015532458A
Other languages
English (en)
Japanese (ja)
Other versions
JP6321658B2 (ja
JP2015531789A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2013/069888 external-priority patent/WO2014044873A1/en
Publication of JP2015531789A publication Critical patent/JP2015531789A/ja
Publication of JP2015531789A5 publication Critical patent/JP2015531789A5/ja
Application granted granted Critical
Publication of JP6321658B2 publication Critical patent/JP6321658B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015532458A 2012-09-24 2013-09-24 アミノ酸誘導体 Expired - Fee Related JP6321658B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261705116P 2012-09-24 2012-09-24
US61/705,116 2012-09-24
US201361862495P 2013-08-05 2013-08-05
US61/862,495 2013-08-05
PCT/EP2013/069888 WO2014044873A1 (en) 2012-09-24 2013-09-24 Amino acid derivatives

Publications (3)

Publication Number Publication Date
JP2015531789A JP2015531789A (ja) 2015-11-05
JP2015531789A5 true JP2015531789A5 (enExample) 2018-03-29
JP6321658B2 JP6321658B2 (ja) 2018-05-09

Family

ID=49237211

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015532457A Active JP6532404B2 (ja) 2012-09-24 2013-09-24 細胞株
JP2015532458A Expired - Fee Related JP6321658B2 (ja) 2012-09-24 2013-09-24 アミノ酸誘導体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2015532457A Active JP6532404B2 (ja) 2012-09-24 2013-09-24 細胞株

Country Status (10)

Country Link
US (4) US9732367B2 (enExample)
EP (2) EP2897935B1 (enExample)
JP (2) JP6532404B2 (enExample)
KR (1) KR102155389B1 (enExample)
CN (2) CN104812734B (enExample)
AU (1) AU2013320184B2 (enExample)
BR (1) BR112015006368B1 (enExample)
CA (1) CA2885796C (enExample)
SG (2) SG11201502216UA (enExample)
WO (2) WO2014044873A1 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2825370A1 (en) 2010-12-22 2012-06-28 President And Fellows Of Harvard College Continuous directed evolution
CA2873793C (en) 2012-05-18 2022-02-22 Medical Research Council Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase
ES2718478T3 (es) 2012-06-08 2019-07-02 Sutro Biopharma Inc Anticuerpos que comprenden restos de aminoácidos no naturales de localización específica, métodos para su preparación y métodos para su uso
DK2863955T3 (en) 2012-06-26 2017-01-23 Sutro Biopharma Inc MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF
WO2014044873A1 (en) 2012-09-24 2014-03-27 Allozyne, Inc Amino acid derivatives
BR112015022641B1 (pt) 2013-03-15 2023-02-28 Medimmune Limited Construção de dna e processo de preparação de uma proteína-alvo
US9764039B2 (en) * 2013-07-10 2017-09-19 Sutro Biopharma, Inc. Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
CA2918064C (en) 2013-08-05 2022-04-26 Medimmune Limited Amino acid derivatives
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
EP3097196B1 (en) 2014-01-20 2019-09-11 President and Fellows of Harvard College Negative selection and stringency modulation in continuous evolution systems
GB2528227A (en) * 2014-03-14 2016-01-20 Medical Res Council Cyclopropene amino acids and methods
WO2016077052A2 (en) 2014-10-22 2016-05-19 President And Fellows Of Harvard College Evolution of proteases
RS61853B1 (sr) 2014-10-29 2021-06-30 Bicyclerd Ltd Biciklični peptidni ligandi specifični za mt1-mmp
CN106146663B (zh) * 2015-04-10 2019-11-08 北京大学 非天然氨基酸标记的新型抗体-药物偶联物及其制备
WO2016168631A1 (en) 2015-04-17 2016-10-20 President And Fellows Of Harvard College Vector-based mutagenesis system
US10392674B2 (en) 2015-07-22 2019-08-27 President And Fellows Of Harvard College Evolution of site-specific recombinases
WO2017015559A2 (en) 2015-07-23 2017-01-26 President And Fellows Of Harvard College Evolution of bt toxins
WO2017019895A1 (en) 2015-07-30 2017-02-02 President And Fellows Of Harvard College Evolution of talens
US10906990B2 (en) 2015-08-19 2021-02-02 Riken Antibody with non-natural amino acid introduced therein
EP4434589A3 (en) 2015-10-23 2025-05-14 President and Fellows of Harvard College Evolved cas9 proteins for gene editing
CN106929482A (zh) * 2015-12-31 2017-07-07 北京大学 定点突变的流感病毒、其活疫苗及其制备方法和应用
CN112725282A (zh) * 2016-01-27 2021-04-30 北京大学 携带正交tRNA/氨酰tRNA合成酶的稳定细胞系的构建
SG11201806419RA (en) 2016-01-27 2018-08-30 Sutro Biopharma Inc Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates
CN105524167A (zh) * 2016-01-30 2016-04-27 深圳市贝沃德克生物技术研究院有限公司 抗乙肝e抗原的绿色荧光抗体的制备方法
CN105647918A (zh) * 2016-02-20 2016-06-08 深圳市圣必智科技开发有限公司 抗乙肝e抗原的红色荧光抗体的制备方法
KR20230066647A (ko) 2016-06-17 2023-05-16 마젠타 테라퓨틱스 인코포레이티드 Cd117+ 세포의 고갈을 위한 조성물 및 방법
US11214820B2 (en) * 2016-09-02 2022-01-04 Ikaria Inc. Functionally modified polypeptides and radiobiosynthesis
US10905107B2 (en) 2016-09-05 2021-02-02 Korea Advanced Institute Of Science And Technology Transgenic mouse capable of spatial and temporal control of expression and site-specific modification of target protein, production method and uses thereof
WO2018044143A1 (ko) * 2016-09-05 2018-03-08 한국과학기술원 목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도
US11730819B2 (en) 2016-12-23 2023-08-22 Bicycletx Limited Peptide derivatives having novel linkage structures
WO2018134787A2 (en) 2017-01-20 2018-07-26 Magenta Therapeutics, Inc. Compositions and methods for the depletion of cd137+ cells
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
WO2019010164A1 (en) * 2017-07-06 2019-01-10 President And Fellows Of Harvard College Evolution of trna synthetases
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Cd137に対して特異的な二環式ペプチドリガンド
US12060553B2 (en) 2017-08-25 2024-08-13 President And Fellows Of Harvard College Evolution of BoNT peptidases
US11624130B2 (en) 2017-09-18 2023-04-11 President And Fellows Of Harvard College Continuous evolution for stabilized proteins
KR102740971B1 (ko) 2017-12-27 2024-12-11 쿄와 기린 가부시키가이샤 Il-2 개변체
KR20200128518A (ko) 2018-02-23 2020-11-13 바이사이클티엑스 리미티드 다량체성 비사이클릭 펩타이드 리간드
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
CN110835633B (zh) * 2018-08-13 2021-10-01 北京大学 利用优化的基因密码子扩展系统制备ptc稳定细胞系及应用
US20210356377A1 (en) * 2018-09-07 2021-11-18 Medimmune, Llc Methods Of Cell Selection
GB201817444D0 (en) 2018-10-26 2018-12-12 Res & Innovation Uk Methods and compositions
WO2020084034A1 (en) 2018-10-26 2020-04-30 F. Hoffmann-La Roche Ag Multispecific antibody screening method using recombinase mediated cassette exchange
CN109553643B (zh) * 2018-11-29 2020-09-22 深圳先进技术研究院 单糖类似物及包含其的分子探针和该分子探针的应用
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
CN113474045A (zh) 2018-12-21 2021-10-01 拜斯科技术开发有限公司 Pd-l1特异性的双环肽配体
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
CN111850020B (zh) * 2019-04-25 2021-05-07 苏州鲲鹏生物技术有限公司 利用质粒系统在蛋白中引入非天然氨基酸
CN111909256A (zh) * 2019-05-10 2020-11-10 宁波鲲鹏生物科技有限公司 多肽衍生物及其制备方法
TWI862640B (zh) 2019-07-30 2024-11-21 英商拜西可泰克斯有限公司 異質雙環肽複合物
AU2020369479A1 (en) * 2019-10-23 2022-05-26 University Of Florida Research Foundation, Incorporated Novel conjugation chemistry for catalytic antibody 38C2
KR20230074119A (ko) 2020-08-03 2023-05-26 바이사이클티엑스 리미티드 펩타이드 기반 링커
US20240316209A1 (en) * 2020-09-10 2024-09-26 Brickbio, Inc. Antibodies containing unnatural amino acids and methods of making and using the same
US20240360422A1 (en) * 2021-04-21 2024-10-31 Michael T. Leonard Stable production systems for adeno-associated virus production
US20240262791A1 (en) * 2021-04-28 2024-08-08 The Regents Of The University Of California Bioreactive proteins containing unnatural amino acids
US20240317832A1 (en) * 2021-07-29 2024-09-26 Novocodex Biopharmaceuticals Co., Ltd. Unnatural amino acid, and use thereof, recombinant protein containing same, and recombinant protein conjugate
EP4130254A1 (en) * 2021-08-03 2023-02-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Eukaryotic cell lysates comprising exogenous enzymes and methods for preparing the same
CN113788890B (zh) * 2021-09-01 2022-11-08 浙江新码生物医药有限公司 一种人白细胞介素2-聚乙二醇偶联物及其应用
CN113698468B (zh) * 2021-09-01 2022-10-11 浙江新码生物医药有限公司 人白细胞介素2-聚乙二醇偶联物及其应用
WO2023164676A1 (en) * 2022-02-27 2023-08-31 The Regents Of The University Of California Methods to generate novel acyl-trna species
CN121399272A (zh) * 2023-04-28 2026-01-23 英国研究与创新署 基于tRNA的方法和相关组合物
AU2024288440A1 (en) * 2023-07-10 2026-01-22 Surio Therapeutics Co. Ltd Functionalized auristatins, pharmaceutical compositions, and therapeutic applications

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3711458A (en) 1969-08-21 1973-01-16 Research Corp Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides
US4512979A (en) 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
JPH0710451B2 (ja) 1986-11-25 1995-02-08 三五重機株式会社 鋼板カツタ−
HU207287B (en) 1989-01-17 1993-03-29 Biosignal Kutato Fejlesztoe Kf Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component
EP0481038B1 (en) 1990-04-16 2002-10-02 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
DK2322631T3 (en) 2001-04-19 2015-01-12 Scripps Research Inst Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar
EP2305312B1 (en) 2001-10-10 2015-03-04 ratiopharm GmbH Remodelling and glycoconjugation of follicle-stimulating hormone (FSH)
CA2500653A1 (en) 2002-10-16 2004-04-29 The Scripps Research Institute Glycoprotein synthesis
US20040146941A1 (en) * 2002-11-04 2004-07-29 Biliang Zhang Chemical encoding technology for combinatorial synthesis
KR101171397B1 (ko) * 2003-04-17 2012-08-07 더 스크립스 리서치 인스티튜트 진핵 유전자 코드의 확장
US7807619B2 (en) 2004-11-01 2010-10-05 The Regents Of The University Of California Compositions and methods for modification of biomolecules
JP2007037445A (ja) * 2005-08-02 2007-02-15 Institute Of Physical & Chemical Research tRNA合成方法、核酸、アミノアシルtRNA合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法
WO2007099854A1 (ja) 2006-02-22 2007-09-07 Riken サプレッサーtRNAの合成方法、DNA構築物及びそれを用いた非天然型アミノ酸組み込みタンパク質の製造
WO2007130453A2 (en) 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides
EP2069481A4 (en) * 2006-10-18 2010-01-06 Scripps Research Inst GENETIC ASSEMBLY OF UNNATURAL AMINO ACIDS IN PROTEINS IN MAMMALIAN CELLS
CN101952428B (zh) 2007-09-20 2013-10-23 独立行政法人理化学研究所 突变体吡咯赖氨酰-tRNA合成酶以及使用该酶的非天然氨基酸整合蛋白质的制造方法
EP2315922A1 (en) 2008-07-18 2011-05-04 Alantum Corporation Filter device for filtering automobile exhaust gas
JP5798489B2 (ja) 2009-01-12 2015-10-21 ストロ バイオファーマ, インコーポレイテッド インビトロタンパク質合成システムを用いて非天然アミノ酸をタンパク質に選択的に導入するためのモノチャージシステム
US20100203587A1 (en) 2009-01-13 2010-08-12 Sutro Biopharma, Inc. Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions
WO2010114615A2 (en) 2009-04-03 2010-10-07 The Scripps Research Institute A facile system for encoding unnatural amino acids in mammalian cells
GB2470770A (en) 2009-06-04 2010-12-08 Medical Res Council Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs
WO2011044255A1 (en) 2009-10-06 2011-04-14 The Ohio State University Pyrrolysine analogs
US20120283172A1 (en) * 2009-12-21 2012-11-08 Ambrx, Inc. Modified porcine somatotropin polypeptides and their uses
BR112012015461A2 (pt) * 2009-12-21 2017-01-10 Ambrx Inc polipeptídeos de somatotropina boviina modificados e seus usos
EP3604264A1 (en) 2010-04-27 2020-02-05 SynAffix B.V. Fused cyclooctyne compounds
WO2012032181A2 (en) * 2010-09-10 2012-03-15 Allozyne, Inc Novel antibody derivatives
DE102010041261A1 (de) * 2010-09-23 2012-03-29 Robert Bosch Gmbh Flip-Chip Anordnung mit einem Kühlelement und Verfahren zur Herstellung einer Flip-Chip Anordnung
US20130183761A1 (en) 2010-09-24 2013-07-18 North Carolina State University Methods for Incorporating Unnatural Amino Acids in Eukaryotic Cells
ES2661095T3 (es) * 2011-02-03 2018-03-27 European Molecular Biology Laboratory Aminoácidos no naturales que comprenden un grupo análogo de ciclooctinilo o trans-ciclooctenilo y usos de los mismos
SG11201501464TA (en) 2012-08-31 2015-03-30 Sutro Biopharma Inc Modified amino acids comprising an azido group
WO2014044873A1 (en) 2012-09-24 2014-03-27 Allozyne, Inc Amino acid derivatives
BR112015022641B1 (pt) 2013-03-15 2023-02-28 Medimmune Limited Construção de dna e processo de preparação de uma proteína-alvo

Similar Documents

Publication Publication Date Title
JP2015531789A5 (enExample)
EP4410317A3 (en) Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
JP2015532295A5 (enExample)
JP2020097577A5 (enExample)
JP2016153410A5 (enExample)
JP2009523724A5 (enExample)
JP2019524883A5 (enExample)
JP2016106149A5 (enExample)
JP2012518029A5 (enExample)
JP2016531842A5 (enExample)
JP2017511360A5 (enExample)
JP2020507589A5 (enExample)
JP2017515901A5 (enExample)
JP2016531871A5 (enExample)
JP2013518107A5 (enExample)
JP2010077141A5 (enExample)
JP2013508279A5 (enExample)
JP2017531619A5 (enExample)
JP2020529994A5 (enExample)
JP2016510326A5 (enExample)
JP2003306481A5 (enExample)
JP2019510027A5 (enExample)
JP2015508092A5 (enExample)
JP2017517565A5 (enExample)
JP2014515407A5 (enExample)