SG10201702387YA - Cell lines - Google Patents
Cell linesInfo
- Publication number
- SG10201702387YA SG10201702387YA SG10201702387YA SG10201702387YA SG10201702387YA SG 10201702387Y A SG10201702387Y A SG 10201702387YA SG 10201702387Y A SG10201702387Y A SG 10201702387YA SG 10201702387Y A SG10201702387Y A SG 10201702387YA SG 10201702387Y A SG10201702387Y A SG 10201702387YA
- Authority
- SG
- Singapore
- Prior art keywords
- cell lines
- lines
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01025—1,4-Lactonase (3.1.1.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261705116P | 2012-09-24 | 2012-09-24 | |
US201361862495P | 2013-08-05 | 2013-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201702387YA true SG10201702387YA (en) | 2017-04-27 |
Family
ID=49237211
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201502216UA SG11201502216UA (en) | 2012-09-24 | 2013-09-24 | Cell lines |
SG10201702387YA SG10201702387YA (en) | 2012-09-24 | 2013-09-24 | Cell lines |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201502216UA SG11201502216UA (en) | 2012-09-24 | 2013-09-24 | Cell lines |
Country Status (11)
Country | Link |
---|---|
US (4) | US9670521B2 (en) |
EP (2) | EP2897935B1 (en) |
JP (2) | JP6532404B2 (en) |
KR (1) | KR102155389B1 (en) |
CN (2) | CN104812734B (en) |
AU (1) | AU2013320184B2 (en) |
BR (1) | BR112015006368B1 (en) |
CA (1) | CA2885796C (en) |
HK (2) | HK1211569A1 (en) |
SG (2) | SG11201502216UA (en) |
WO (2) | WO2014044872A1 (en) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011348204B2 (en) | 2010-12-22 | 2017-03-02 | President And Fellows Of Harvard College | Continuous directed evolution |
CN104718285A (en) | 2012-05-18 | 2015-06-17 | 医药研究委员会 | Methods of incorporating an amino acid comprising a BCN group into a polypeptide using an orthogonal codon encoding it and an orthorgonal PylRS synthase. |
EP2859017B1 (en) | 2012-06-08 | 2019-02-20 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
BR112015006368B1 (en) | 2012-09-24 | 2022-02-08 | Medimmune Limited | PROCESS FOR PRODUCTION OF STABLE EUKARYOTIC CELL LINE |
WO2014140347A2 (en) | 2013-03-15 | 2014-09-18 | Allozyne, Inc | Novel nucleic acid molecules |
WO2015006555A2 (en) * | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
WO2015019192A2 (en) | 2013-08-05 | 2015-02-12 | Medimmune Limited | Amino acid derivatives |
CN105764491A (en) | 2013-12-09 | 2016-07-13 | 度瑞公司 | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
GB2528227A (en) * | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
WO2016077052A2 (en) | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
CN106146663B (en) * | 2015-04-10 | 2019-11-08 | 北京大学 | Novel antibodies-drug conjugates of unnatural amino acid label and its preparation |
US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
US10392674B2 (en) | 2015-07-22 | 2019-08-27 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
WO2017015559A2 (en) | 2015-07-23 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of bt toxins |
WO2017019895A1 (en) | 2015-07-30 | 2017-02-02 | President And Fellows Of Harvard College | Evolution of talens |
EP3360960A4 (en) | 2015-08-19 | 2019-03-20 | Riken | Antibody with non-natural amino acid introduced therein |
CN106929482A (en) * | 2015-12-31 | 2017-07-07 | 北京大学 | Influenza virus, its live vaccine of rite-directed mutagenesis and its preparation method and application |
CN107012121B (en) * | 2016-01-27 | 2021-01-26 | 北京大学 | Construction of Stable cell lines carrying orthogonal tRNA/aminoacyltRNA synthetases |
SG11201806419RA (en) | 2016-01-27 | 2018-08-30 | Sutro Biopharma Inc | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
CN105524167A (en) * | 2016-01-30 | 2016-04-27 | 深圳市贝沃德克生物技术研究院有限公司 | Preparation method of anti-HBeAg (hepatitis B virus e antigen) green fluorescent antibody |
CN105647918A (en) * | 2016-02-20 | 2016-06-08 | 深圳市圣必智科技开发有限公司 | Preparation method of red fluorescent antibody resisting HBeAg (hepatitis B virus e antigen) |
IL303455A (en) | 2016-06-17 | 2023-08-01 | Crispr Therapeutics Ag | Compositions and methods for the depletion of cd117+cells |
US11214820B2 (en) * | 2016-09-02 | 2022-01-04 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
US10905107B2 (en) * | 2016-09-05 | 2021-02-02 | Korea Advanced Institute Of Science And Technology | Transgenic mouse capable of spatial and temporal control of expression and site-specific modification of target protein, production method and uses thereof |
WO2018044143A1 (en) * | 2016-09-05 | 2018-03-08 | 한국과학기술원 | Mouse in which site-specific modification of target protein is temporospatially controlled, method for producing mouse, and use thereof |
WO2018115203A1 (en) * | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
WO2018134787A2 (en) | 2017-01-20 | 2018-07-26 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd137+ cells |
WO2019010164A1 (en) * | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | Evolution of trna synthetases |
US11624130B2 (en) | 2017-09-18 | 2023-04-11 | President And Fellows Of Harvard College | Continuous evolution for stabilized proteins |
US20210060169A1 (en) | 2017-12-27 | 2021-03-04 | Kyowa Kirin Co., Ltd. | Il-2 variant |
US11913044B2 (en) | 2018-06-14 | 2024-02-27 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
CN110835633B (en) * | 2018-08-13 | 2021-10-01 | 北京大学 | Preparation of PTC stable cell line by using optimized gene codon expansion system and application |
WO2020051331A1 (en) * | 2018-09-07 | 2020-03-12 | Medimmune, Llc | Methods of cell selection |
CN109553643B (en) * | 2018-11-29 | 2020-09-22 | 深圳先进技术研究院 | Monosaccharide analogue, molecular probe containing monosaccharide analogue and application of molecular probe |
CN111850020B (en) * | 2019-04-25 | 2021-05-07 | 苏州鲲鹏生物技术有限公司 | Introduction of unnatural amino acids in proteins using plasmid systems |
CN111909256A (en) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | Polypeptide derivatives and process for preparing the same |
CN117529558A (en) * | 2021-04-21 | 2024-02-06 | 阿西莫夫公司 | Stable production system for adeno-associated virus production |
WO2022232377A2 (en) * | 2021-04-28 | 2022-11-03 | The Regents Of The University Of California | Bioreactive proteins containing unnatural amino acids |
KR20240024235A (en) * | 2021-07-29 | 2024-02-23 | 노보코덱스 바이오파마슈티컬즈 컴퍼니 리미티드 | Non-natural amino acids and uses thereof, recombinant proteins containing them, and recombinant protein conjugates |
EP4130254A1 (en) * | 2021-08-03 | 2023-02-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Eukaryotic cell lysates comprising exogenous enzymes and methods for preparing the same |
CN113698468B (en) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | Human interleukin 2-polyethylene glycol conjugate and application thereof |
CN113788890B (en) * | 2021-09-01 | 2022-11-08 | 浙江新码生物医药有限公司 | Human interleukin 2-polyethylene glycol conjugate and application thereof |
WO2023164676A1 (en) * | 2022-02-27 | 2023-08-31 | The Regents Of The University Of California | Methods to generate novel acyl-trna species |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3711458A (en) | 1969-08-21 | 1973-01-16 | Research Corp | Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides |
US4512979A (en) | 1981-03-23 | 1985-04-23 | Merck & Co., Inc. | Dipeptides containing thialysine and related amino acids as antihypertensives |
JPH0710451B2 (en) | 1986-11-25 | 1995-02-08 | 三五重機株式会社 | Steel sheet cutter |
HU207287B (en) | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
US5180674A (en) | 1990-04-16 | 1993-01-19 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
DK1456360T3 (en) | 2001-04-19 | 2015-08-31 | Scripps Research Inst | Methods and Composition for Preparation of Orthogonal TRNA-Aminoacyl-TRNA Synthetase Pairs |
SG159381A1 (en) | 2001-10-10 | 2010-03-30 | Novo Nordisk As | Remodeling and glycoconjugation of peptides |
WO2004035605A2 (en) | 2002-10-16 | 2004-04-29 | The Scripps Research Institute | Glycoprotein synthesis |
US20040146941A1 (en) | 2002-11-04 | 2004-07-29 | Biliang Zhang | Chemical encoding technology for combinatorial synthesis |
AU2004233083B2 (en) * | 2003-04-17 | 2010-09-16 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
PT1812031E (en) | 2004-11-01 | 2015-10-01 | Univ California | Compositions and methods for modification of biomolecules |
JP2007037445A (en) | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | METHOD FOR SYNTHESIZING tRNA, NUCLEIC ACID, METHOD FOR SYNTHESIZING AMINOACYL tRNA, AND METHOD FOR PRODUCING NON-NATURAL-TYPE AMINO ACID-INCORPORATED PROTEIN |
EP1992698B1 (en) | 2006-02-22 | 2018-09-05 | Riken | METHOD FOR SYNTHESIS OF SUPPRESSOR tRNA, DNA CONSTRUCT, AND PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE DNA CONSTRUCT |
JP5313129B2 (en) | 2006-05-02 | 2013-10-09 | アロザイン, インコーポレイテッド | Unnatural amino acid substitution polypeptide |
RU2009112104A (en) * | 2006-10-18 | 2010-11-27 | Зе Скрипс Ресеч Инститьют (Us) | GENETIC INTEGRATION OF NON-MEETING AMINO ACIDS IN THE PROTEIN OF MAMMAL CELLS |
AU2008301614A1 (en) | 2007-09-20 | 2009-03-26 | Riken | Mutant pyrrolysyl-TRNA synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same |
EP2315922A1 (en) | 2008-07-18 | 2011-05-04 | Alantum Corporation | Filter device for filtering automobile exhaust gas |
WO2010081110A1 (en) | 2009-01-12 | 2010-07-15 | Sutro Biopharma, Inc. | Dual charging system for selectively introducing non-native amino acids into proteins using an in vitro synthesis method |
US20100203587A1 (en) | 2009-01-13 | 2010-08-12 | Sutro Biopharma, Inc. | Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions |
WO2010114615A2 (en) | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
WO2011044255A1 (en) * | 2009-10-06 | 2011-04-14 | The Ohio State University | Pyrrolysine analogs |
JP2013515080A (en) * | 2009-12-21 | 2013-05-02 | アンブルックス,インコーポレイテッド | Modified bovine somatotropin polypeptides and their use |
EP2805965A1 (en) * | 2009-12-21 | 2014-11-26 | Ambrx, Inc. | Modified porcine somatotropin polypeptides and their uses |
JP5920936B2 (en) | 2010-04-27 | 2016-05-18 | シンアフィックス ビー.ブイ. | Fused cyclooctyne compounds and their use in metal-free click reactions |
EP2640745B1 (en) | 2010-09-10 | 2018-11-07 | MedImmune Limited | Bivalent and bispecific anti-il6/anti-il23 antibodies |
DE102010041261A1 (en) | 2010-09-23 | 2012-03-29 | Robert Bosch Gmbh | Flip-chip arrangement with a cooling element and method for producing a flip-chip arrangement |
US20130183761A1 (en) * | 2010-09-24 | 2013-07-18 | North Carolina State University | Methods for Incorporating Unnatural Amino Acids in Eukaryotic Cells |
CA2826041C (en) * | 2011-02-03 | 2020-07-07 | Embl | Unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and uses thereof |
SG11201501464TA (en) | 2012-08-31 | 2015-03-30 | Sutro Biopharma Inc | Modified amino acids comprising an azido group |
BR112015006368B1 (en) | 2012-09-24 | 2022-02-08 | Medimmune Limited | PROCESS FOR PRODUCTION OF STABLE EUKARYOTIC CELL LINE |
WO2014140347A2 (en) | 2013-03-15 | 2014-09-18 | Allozyne, Inc | Novel nucleic acid molecules |
-
2013
- 2013-09-24 BR BR112015006368-3A patent/BR112015006368B1/en active IP Right Grant
- 2013-09-24 EP EP13766526.1A patent/EP2897935B1/en not_active Not-in-force
- 2013-09-24 US US14/430,412 patent/US9670521B2/en active Active
- 2013-09-24 US US14/430,542 patent/US9732367B2/en active Active
- 2013-09-24 KR KR1020157010354A patent/KR102155389B1/en active IP Right Grant
- 2013-09-24 CN CN201380060971.9A patent/CN104812734B/en not_active Expired - Fee Related
- 2013-09-24 AU AU2013320184A patent/AU2013320184B2/en active Active
- 2013-09-24 WO PCT/EP2013/069887 patent/WO2014044872A1/en active Application Filing
- 2013-09-24 SG SG11201502216UA patent/SG11201502216UA/en unknown
- 2013-09-24 CN CN201380060916.XA patent/CN105026574B/en active Active
- 2013-09-24 SG SG10201702387YA patent/SG10201702387YA/en unknown
- 2013-09-24 WO PCT/EP2013/069888 patent/WO2014044873A1/en active Application Filing
- 2013-09-24 JP JP2015532457A patent/JP6532404B2/en active Active
- 2013-09-24 CA CA2885796A patent/CA2885796C/en active Active
- 2013-09-24 JP JP2015532458A patent/JP6321658B2/en not_active Expired - Fee Related
- 2013-09-24 EP EP13766525.3A patent/EP2898085B1/en active Active
-
2015
- 2015-12-18 HK HK15112515.4A patent/HK1211569A1/en not_active IP Right Cessation
- 2015-12-18 HK HK15112514.5A patent/HK1211623A1/en unknown
-
2017
- 2017-06-01 US US15/610,931 patent/US10214761B2/en not_active Expired - Fee Related
- 2017-06-01 US US15/611,116 patent/US10253345B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1211623A1 (en) | Cell lines | |
DK3327112T3 (en) | Agse-deficient stamme | |
ZA201503358B (en) | Structure | |
HK1209295A1 (en) | Concentrator | |
EP2919313A4 (en) | Solid electrolyte | |
EP2754580A4 (en) | Dumptruck | |
DK2830816T3 (en) | Hidtil ukendt coatingkoncept | |
AU347859S (en) | Battery | |
AU346864S (en) | Battery | |
EP2911230A4 (en) | Cell | |
EP2824749A4 (en) | Laminated-structure battery | |
EP2939306A4 (en) | Battery | |
EP2831949A4 (en) | Sodium-oxygen cells | |
GB201319035D0 (en) | Spolier structure | |
IL239484A0 (en) | Agents for eliminating tumour-initiating cells | |
EP2863459A4 (en) | Flat cell | |
SG11201501314TA (en) | Azaindolines | |
EP2939294A4 (en) | Battery | |
HUP1300640A2 (en) | Belt-mounting structure | |
GB2518803B (en) | Headshaft | |
EP2871919A4 (en) | Structure | |
GB201218045D0 (en) | Battery | |
GB201218280D0 (en) | Photovoltaic cell | |
GB201218496D0 (en) | Cell | |
GB201214618D0 (en) | Double ended cell |