JP2010513314A5 - - Google Patents
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- Publication number
- JP2010513314A5 JP2010513314A5 JP2009541617A JP2009541617A JP2010513314A5 JP 2010513314 A5 JP2010513314 A5 JP 2010513314A5 JP 2009541617 A JP2009541617 A JP 2009541617A JP 2009541617 A JP2009541617 A JP 2009541617A JP 2010513314 A5 JP2010513314 A5 JP 2010513314A5
- Authority
- JP
- Japan
- Prior art keywords
- peptidomimetic macrocycle
- alkyl
- unsubstituted
- independently
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000816 peptidomimetic Substances 0.000 claims 31
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000003710 aryl alkyl group Chemical group 0.000 claims 14
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 14
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 12
- 125000004404 heteroalkyl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 125000004450 alkenylene group Chemical group 0.000 claims 6
- 125000004419 alkynylene group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 125000004474 heteroalkylene group Chemical group 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000002993 cycloalkylene group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 239000002243 precursor Substances 0.000 claims 5
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 4
- 125000000732 arylene group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 238000010647 peptide synthesis reaction Methods 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- -1 heteroalkylalkyl Chemical group 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 230000017854 proteolysis Effects 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 238000001308 synthesis method Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87481906P | 2006-12-14 | 2006-12-14 | |
| US60/874,819 | 2006-12-14 | ||
| PCT/US2007/087615 WO2008076904A1 (en) | 2006-12-14 | 2007-12-14 | Bis-sulfhydryl macrocyclization systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014163070A Division JP5931975B2 (ja) | 2006-12-14 | 2014-08-08 | ビス−スルフヒドリル大環状化系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513314A JP2010513314A (ja) | 2010-04-30 |
| JP2010513314A5 true JP2010513314A5 (enExample) | 2011-02-10 |
| JP5656407B2 JP5656407B2 (ja) | 2015-01-21 |
Family
ID=39536693
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541617A Expired - Fee Related JP5656407B2 (ja) | 2006-12-14 | 2007-12-14 | ビス−スルフヒドリル大環状化系 |
| JP2014163070A Expired - Fee Related JP5931975B2 (ja) | 2006-12-14 | 2014-08-08 | ビス−スルフヒドリル大環状化系 |
| JP2016089950A Expired - Fee Related JP6259861B2 (ja) | 2006-12-14 | 2016-04-27 | ビス−スルフヒドリル大環状化系 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014163070A Expired - Fee Related JP5931975B2 (ja) | 2006-12-14 | 2014-08-08 | ビス−スルフヒドリル大環状化系 |
| JP2016089950A Expired - Fee Related JP6259861B2 (ja) | 2006-12-14 | 2016-04-27 | ビス−スルフヒドリル大環状化系 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7960506B2 (enExample) |
| EP (2) | EP2094721B1 (enExample) |
| JP (3) | JP5656407B2 (enExample) |
| CN (2) | CN105061577A (enExample) |
| AU (1) | AU2007333846B2 (enExample) |
| BR (1) | BRPI0720306A2 (enExample) |
| CA (1) | CA2686827C (enExample) |
| IL (1) | IL199301A (enExample) |
| WO (1) | WO2008076904A1 (enExample) |
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| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
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| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| EP2489360A1 (en) | 2006-11-15 | 2012-08-22 | Dana-Farber Cancer Institute, Inc. | Stabilized MAML peptides and uses thereof |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| EP2094721B1 (en) | 2006-12-14 | 2018-02-14 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
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| US9556229B2 (en) | 2012-05-18 | 2017-01-31 | The Regents Of The University Of California | Modification of peptides using a bis(thioether)arylbridge approach |
| HRP20210707T1 (hr) | 2012-09-26 | 2021-09-17 | President And Fellows Of Harvard College | Prolinom blokirani označeni peptidi i njihova uporaba |
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-
2007
- 2007-12-14 EP EP07869296.9A patent/EP2094721B1/en not_active Not-in-force
- 2007-12-14 CN CN201510441012.2A patent/CN105061577A/zh active Pending
- 2007-12-14 CN CN200780050407.3A patent/CN101636407B/zh not_active Expired - Fee Related
- 2007-12-14 US US11/957,325 patent/US7960506B2/en not_active Expired - Fee Related
- 2007-12-14 JP JP2009541617A patent/JP5656407B2/ja not_active Expired - Fee Related
- 2007-12-14 AU AU2007333846A patent/AU2007333846B2/en not_active Ceased
- 2007-12-14 EP EP16190185.5A patent/EP3170835A1/en not_active Withdrawn
- 2007-12-14 CA CA2686827A patent/CA2686827C/en not_active Expired - Fee Related
- 2007-12-14 BR BRPI0720306-3A patent/BRPI0720306A2/pt not_active Application Discontinuation
- 2007-12-14 WO PCT/US2007/087615 patent/WO2008076904A1/en not_active Ceased
-
2009
- 2009-06-11 IL IL199301A patent/IL199301A/en active IP Right Grant
-
2010
- 2010-01-19 US US12/690,076 patent/US8609809B2/en active Active
-
2013
- 2013-11-01 US US14/070,367 patent/US9175056B2/en not_active Expired - Fee Related
-
2014
- 2014-08-08 JP JP2014163070A patent/JP5931975B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-11 US US14/852,368 patent/US9675661B2/en not_active Expired - Fee Related
-
2016
- 2016-04-27 JP JP2016089950A patent/JP6259861B2/ja not_active Expired - Fee Related
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2017
- 2017-05-11 US US15/592,517 patent/US10328117B2/en not_active Expired - Fee Related
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