CA2686827C - Bis-sulfhydryl macrocyclization systems - Google Patents
Bis-sulfhydryl macrocyclization systems Download PDFInfo
- Publication number
- CA2686827C CA2686827C CA2686827A CA2686827A CA2686827C CA 2686827 C CA2686827 C CA 2686827C CA 2686827 A CA2686827 A CA 2686827A CA 2686827 A CA2686827 A CA 2686827A CA 2686827 C CA2686827 C CA 2686827C
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- CA
- Canada
- Prior art keywords
- peptidomimetic macrocycle
- alkyl
- peptidomimetic
- substituted
- macrocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C07—ORGANIC CHEMISTRY
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Toxicology (AREA)
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- Epidemiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| US87481906P | 2006-12-14 | 2006-12-14 | |
| US60/874,819 | 2006-12-14 | ||
| PCT/US2007/087615 WO2008076904A1 (en) | 2006-12-14 | 2007-12-14 | Bis-sulfhydryl macrocyclization systems |
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| CA2686827A1 CA2686827A1 (en) | 2008-06-26 |
| CA2686827C true CA2686827C (en) | 2014-09-16 |
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| CA2686827A Expired - Fee Related CA2686827C (en) | 2006-12-14 | 2007-12-14 | Bis-sulfhydryl macrocyclization systems |
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| CA (1) | CA2686827C (enExample) |
| IL (1) | IL199301A (enExample) |
| WO (1) | WO2008076904A1 (enExample) |
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| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| PL2332968T3 (pl) | 2003-11-05 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Stabilizowane alfa-helikalne peptydy i ich zastosowania |
| US7202332B2 (en) | 2004-05-27 | 2007-04-10 | New York University | Methods for preparing internally constrained peptides and peptidomimetics |
| JP2010510236A (ja) | 2006-11-15 | 2010-04-02 | ダナ−ファーバー キャンサー インスティテュート インク． | 安定化させたｍａｍｌペプチドおよびその使用法 |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| CN105061577A (zh) * | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| ES2648687T3 (es) | 2007-02-23 | 2018-01-05 | Aileron Therapeutics, Inc. | Péptidos macrocíclicos unidos a triazol |
| KR20160061439A (ko) * | 2007-03-28 | 2016-05-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| ES2637687T3 (es) * | 2007-05-02 | 2017-10-16 | Dana-Farber Cancer Institute, Inc. | Péptido BAD de dominio BH3 para usar en el tratamiento o retardo de la aparición de la diabetes |
| JP5653219B2 (ja) * | 2007-12-31 | 2015-01-14 | ニューヨーク ユニバーシティ | 水素結合サロゲートをベースとする人工ヘリックスによるウイルス宿主膜融合の制御 |
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| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| US20170037086A1 (en) | 2014-04-09 | 2017-02-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with pth activity |
| SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| EP3197477A4 (en) | 2014-09-24 | 2018-07-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| AU2016235424A1 (en) | 2015-03-20 | 2017-10-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
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| CA2996685A1 (en) | 2015-09-03 | 2017-03-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN108368161A (zh) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
| WO2017165299A2 (en) | 2016-03-21 | 2017-09-28 | Aileron Therapeutics, Inc. | Companion diagnostic tool for peptidomimetic macrocycles |
| WO2017205786A1 (en) | 2016-05-27 | 2017-11-30 | Aileron Therapeutics, Inc. | Cell permeable peptidomimetic macrocycles |
| US20170360881A1 (en) | 2016-06-17 | 2017-12-21 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
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2007
- 2007-12-14 CN CN201510441012.2A patent/CN105061577A/zh active Pending
- 2007-12-14 EP EP16190185.5A patent/EP3170835A1/en not_active Withdrawn
- 2007-12-14 WO PCT/US2007/087615 patent/WO2008076904A1/en not_active Ceased
- 2007-12-14 CA CA2686827A patent/CA2686827C/en not_active Expired - Fee Related
- 2007-12-14 BR BRPI0720306-3A patent/BRPI0720306A2/pt not_active Application Discontinuation
- 2007-12-14 JP JP2009541617A patent/JP5656407B2/ja not_active Expired - Fee Related
- 2007-12-14 AU AU2007333846A patent/AU2007333846B2/en not_active Ceased
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2009
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2010
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2013
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2014
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2016
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2017
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| EP3170835A1 (en) | 2017-05-24 |
| US20140135473A1 (en) | 2014-05-15 |
| JP5931975B2 (ja) | 2016-06-08 |
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| JP5656407B2 (ja) | 2015-01-21 |
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| US20160095896A1 (en) | 2016-04-07 |
| JP2010513314A (ja) | 2010-04-30 |
| WO2008076904A9 (en) | 2017-04-27 |
| JP6259861B2 (ja) | 2018-01-10 |
| CN101636407B (zh) | 2015-08-26 |
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| AU2007333846B2 (en) | 2014-01-23 |
| US8609809B2 (en) | 2013-12-17 |
| US9175056B2 (en) | 2015-11-03 |
| CN101636407A (zh) | 2010-01-27 |
| CN105061577A (zh) | 2015-11-18 |
| HK1137184A1 (en) | 2010-07-23 |
| BRPI0720306A2 (pt) | 2014-02-04 |
| CA2686827A1 (en) | 2008-06-26 |
| EP2094721A1 (en) | 2009-09-02 |
| AU2007333846A1 (en) | 2008-06-26 |
| US20170296620A1 (en) | 2017-10-19 |
| EP2094721A4 (en) | 2011-01-19 |
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| JP2014231516A (ja) | 2014-12-11 |
| IL199301A (en) | 2014-09-30 |
| US10328117B2 (en) | 2019-06-25 |
| WO2008076904A1 (en) | 2008-06-26 |
| US20090047711A1 (en) | 2009-02-19 |
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