JP2015091868A5 - - Google Patents
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- Publication number
- JP2015091868A5 JP2015091868A5 JP2015012176A JP2015012176A JP2015091868A5 JP 2015091868 A5 JP2015091868 A5 JP 2015091868A5 JP 2015012176 A JP2015012176 A JP 2015012176A JP 2015012176 A JP2015012176 A JP 2015012176A JP 2015091868 A5 JP2015091868 A5 JP 2015091868A5
- Authority
- JP
- Japan
- Prior art keywords
- cross
- linked polypeptide
- polypeptide
- alkyl
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001184 polypeptide Polymers 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 238000000034 method Methods 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004474 heteroalkylene group Chemical group 0.000 claims 2
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 102000051485 Bcl-2 family Human genes 0.000 claims 1
- 108700038897 Bcl-2 family Proteins 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000012466 permeate Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11750808P | 2008-11-24 | 2008-11-24 | |
| US61/117,508 | 2008-11-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537728A Division JP2012509902A (ja) | 2008-11-24 | 2009-11-24 | 改善された特性を有するペプチド模倣大環状分子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017118484A Division JP2017186363A (ja) | 2008-11-24 | 2017-06-16 | 改善された特性を有するペプチド模倣大環状分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015091868A JP2015091868A (ja) | 2015-05-14 |
| JP2015091868A5 true JP2015091868A5 (enExample) | 2015-10-01 |
| JP6194325B2 JP6194325B2 (ja) | 2017-09-06 |
Family
ID=42198556
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537728A Pending JP2012509902A (ja) | 2008-11-24 | 2009-11-24 | 改善された特性を有するペプチド模倣大環状分子 |
| JP2015012176A Expired - Fee Related JP6194325B2 (ja) | 2008-11-24 | 2015-01-26 | 改善された特性を有するペプチド模倣大環状分子 |
| JP2017118484A Withdrawn JP2017186363A (ja) | 2008-11-24 | 2017-06-16 | 改善された特性を有するペプチド模倣大環状分子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537728A Pending JP2012509902A (ja) | 2008-11-24 | 2009-11-24 | 改善された特性を有するペプチド模倣大環状分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017118484A Withdrawn JP2017186363A (ja) | 2008-11-24 | 2017-06-16 | 改善された特性を有するペプチド模倣大環状分子 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9458202B2 (enExample) |
| EP (1) | EP2352507A4 (enExample) |
| JP (3) | JP2012509902A (enExample) |
| CN (1) | CN102223891A (enExample) |
| AU (2) | AU2009316288B2 (enExample) |
| BR (1) | BRPI0920899A2 (enExample) |
| CA (1) | CA2743177A1 (enExample) |
| IL (1) | IL212748A (enExample) |
| WO (1) | WO2010060112A1 (enExample) |
Families Citing this family (75)
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|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| WO2005044839A2 (en) | 2003-11-05 | 2005-05-19 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides and uses thereof |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| WO2008076904A1 (en) | 2006-12-14 | 2008-06-26 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| US7981999B2 (en) | 2007-02-23 | 2011-07-19 | Aileron Therapeutics, Inc. | Triazole macrocycle systems |
| KR101623985B1 (ko) * | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| JP5653219B2 (ja) * | 2007-12-31 | 2015-01-14 | ニューヨーク ユニバーシティ | 水素結合サロゲートをベースとする人工ヘリックスによるウイルス宿主膜融合の制御 |
| CN101980718A (zh) | 2008-02-08 | 2011-02-23 | 爱勒让治疗公司 | 治疗性的拟肽大环化合物 |
| US20110144303A1 (en) * | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| WO2010011313A2 (en) | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| CA2737922A1 (en) * | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| AU2009294875C1 (en) | 2008-09-22 | 2015-05-14 | Aileron Therapeutics, Inc. | Methods for preparing purified polypeptide compositions |
| BRPI0920899A2 (pt) | 2008-11-24 | 2016-04-26 | Aileron Therapeutics Inc | macrociclos peptidomiméticos com propriedades melhoradas |
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| CA2768299C (en) | 2009-07-13 | 2018-03-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
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| US20110223149A1 (en) * | 2009-10-14 | 2011-09-15 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
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| EP2970418A4 (en) | 2013-03-15 | 2016-08-17 | Dana Farber Cancer Inst Inc | STABILIZED EZH2 PEPTIDES |
| EP2970392B1 (en) | 2013-03-15 | 2019-07-10 | Dana-Farber Cancer Institute, Inc. | Stabilized sos1 peptides |
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| JP6822839B2 (ja) | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
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| JP6759109B2 (ja) | 2014-05-21 | 2020-09-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Ｒａｓ抑制性ペプチドおよびその使用 |
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| US11078246B2 (en) | 2015-08-28 | 2021-08-03 | Dana-Farber Cancer Institute, Inc. | Peptides binding to Bfl-1 |
| US20170114098A1 (en) * | 2015-09-03 | 2017-04-27 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子 |
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| US11466064B2 (en) | 2016-08-26 | 2022-10-11 | Dana-Farber Cancer Institute, Inc. | Bcl-w polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss |
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| AU2010298338A1 (en) | 2009-09-22 | 2012-04-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US20110223149A1 (en) | 2009-10-14 | 2011-09-15 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| ES2586411T3 (es) | 2011-03-04 | 2016-10-14 | New York University | Macrociclos sustitutos de enlace de hidrógeno como moduladores de Ras |
| WO2012173846A2 (en) | 2011-06-06 | 2012-12-20 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2013033645A1 (en) | 2011-08-31 | 2013-03-07 | New York University | Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| WO2013059530A2 (en) | 2011-10-18 | 2013-04-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER |
| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
| KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| US9068805B2 (en) | 2013-06-26 | 2015-06-30 | Matthew James Owen | Arrow modification and fletching system |
| WO2015157508A1 (en) | 2014-04-09 | 2015-10-15 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with pth activity |
-
2009
- 2009-11-24 BR BRPI0920899A patent/BRPI0920899A2/pt not_active Application Discontinuation
- 2009-11-24 WO PCT/US2009/065824 patent/WO2010060112A1/en not_active Ceased
- 2009-11-24 CA CA2743177A patent/CA2743177A1/en not_active Abandoned
- 2009-11-24 EP EP09828398A patent/EP2352507A4/en not_active Withdrawn
- 2009-11-24 CN CN2009801468497A patent/CN102223891A/zh active Pending
- 2009-11-24 US US12/625,533 patent/US9458202B2/en not_active Expired - Fee Related
- 2009-11-24 JP JP2011537728A patent/JP2012509902A/ja active Pending
- 2009-11-24 AU AU2009316288A patent/AU2009316288B2/en not_active Ceased
-
2011
- 2011-05-05 IL IL212748A patent/IL212748A/en active IP Right Grant
-
2015
- 2015-01-26 JP JP2015012176A patent/JP6194325B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-10 US US15/233,796 patent/US20170212125A1/en not_active Abandoned
- 2016-08-19 AU AU2016216698A patent/AU2016216698B2/en not_active Ceased
-
2017
- 2017-06-16 JP JP2017118484A patent/JP2017186363A/ja not_active Withdrawn
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