JP2012509902A - 改善された特性を有するペプチド模倣大環状分子 - Google Patents

改善された特性を有するペプチド模倣大環状分子 Download PDF

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JP2012509902A
JP2012509902A JP2011537728A JP2011537728A JP2012509902A JP 2012509902 A JP2012509902 A JP 2012509902A JP 2011537728 A JP2011537728 A JP 2011537728A JP 2011537728 A JP2011537728 A JP 2011537728A JP 2012509902 A JP2012509902 A JP 2012509902A
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polypeptide
cross
linked
helical
amino acid
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JP2012509902A5 (enExample
Inventor
ハウ エム． ナッシュ，
デイビッド アレン アニス，
ロサナ カペラー−リバーマン，
トミ ケー． ソーヤー，
ノリユキ カワハタ，
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Rein Therapeutics Inc
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Aileron Therapeutics Inc
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof

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  • Proteomics, Peptides & Aminoacids (AREA)
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JP2011537728A 2008-11-24 2009-11-24 改善された特性を有するペプチド模倣大環状分子 Pending JP2012509902A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11750808P 2008-11-24 2008-11-24
US61/117,508 2008-11-24
PCT/US2009/065824 WO2010060112A1 (en) 2008-11-24 2009-11-24 Peptidomimetic macrocycles with improved properties

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JP2015012176A Division JP6194325B2 (ja) 2008-11-24 2015-01-26 改善された特性を有するペプチド模倣大環状分子

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JP2012509902A5 JP2012509902A5 (enExample) 2012-06-07

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JP2011537728A Pending JP2012509902A (ja) 2008-11-24 2009-11-24 改善された特性を有するペプチド模倣大環状分子
JP2015012176A Expired - Fee Related JP6194325B2 (ja) 2008-11-24 2015-01-26 改善された特性を有するペプチド模倣大環状分子
JP2017118484A Withdrawn JP2017186363A (ja) 2008-11-24 2017-06-16 改善された特性を有するペプチド模倣大環状分子

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JP2017118484A Withdrawn JP2017186363A (ja) 2008-11-24 2017-06-16 改善された特性を有するペプチド模倣大環状分子

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US (2) US9458202B2 (enExample)
EP (1) EP2352507A4 (enExample)
JP (3) JP2012509902A (enExample)
CN (1) CN102223891A (enExample)
AU (2) AU2009316288B2 (enExample)
BR (1) BRPI0920899A2 (enExample)
CA (1) CA2743177A1 (enExample)
IL (1) IL212748A (enExample)
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