CN102223891A - 具有改善性质的拟肽大环化合物 - Google Patents

具有改善性质的拟肽大环化合物 Download PDF

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Publication number
CN102223891A
CN102223891A CN2009801468497A CN200980146849A CN102223891A CN 102223891 A CN102223891 A CN 102223891A CN 2009801468497 A CN2009801468497 A CN 2009801468497A CN 200980146849 A CN200980146849 A CN 200980146849A CN 102223891 A CN102223891 A CN 102223891A
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polypeptide
cross
linked
peptide
alkyl
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H·M·纳什
D·A·安尼斯
R·卡佩勒-利伯曼
T·K·索耶
河畑纪之
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Rein Therapeutics Inc
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Aileron Therapeutics Inc
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CN2009801468497A 2008-11-24 2009-11-24 具有改善性质的拟肽大环化合物 Pending CN102223891A (zh)

Applications Claiming Priority (3)

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US11750808P 2008-11-24 2008-11-24
US61/117,508 2008-11-24
PCT/US2009/065824 WO2010060112A1 (en) 2008-11-24 2009-11-24 Peptidomimetic macrocycles with improved properties

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EP (1) EP2352507A4 (enExample)
JP (3) JP2012509902A (enExample)
CN (1) CN102223891A (enExample)
AU (2) AU2009316288B2 (enExample)
BR (1) BRPI0920899A2 (enExample)
CA (1) CA2743177A1 (enExample)
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Cited By (13)

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CN104144695A (zh) * 2012-02-15 2014-11-12 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
CN104159595A (zh) * 2012-02-15 2014-11-19 爱勒让治疗公司 拟肽大环化合物
US9845287B2 (en) 2012-11-01 2017-12-19 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
US9957299B2 (en) 2010-08-13 2018-05-01 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
CN108348571A (zh) * 2015-09-03 2018-07-31 艾瑞朗医疗公司 拟肽大环化合物及其用途
US10202431B2 (en) 2007-01-31 2019-02-12 Aileron Therapeutics, Inc. Stabilized P53 peptides and uses thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10301351B2 (en) 2007-03-28 2019-05-28 President And Fellows Of Harvard College Stitched polypeptides
US10308699B2 (en) 2011-10-18 2019-06-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10471120B2 (en) 2014-09-24 2019-11-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

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US7960506B2 (en) * 2006-12-14 2011-06-14 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US7981998B2 (en) * 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
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US8871899B2 (en) * 2007-12-31 2014-10-28 New York University Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices
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JP2012503025A (ja) 2008-09-22 2012-02-02 エルロン・セラピューティクス・インコーポレイテッド 精製されたポリペプチド組成物を調製するための方法
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JP2012509902A (ja) 2008-11-24 2012-04-26 エルロン・セラピューティクス・インコーポレイテッド 改善された特性を有するペプチド模倣大環状分子
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
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US10774114B2 (en) 2014-03-10 2020-09-15 Fondation The Ark Respiratory syncytial virus (RSV) replication inhibitors
CN114805527A (zh) 2014-05-21 2022-07-29 哈佛大学的校长及成员们 Ras抑制肽和其用途
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WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
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WO2018039545A2 (en) 2016-08-26 2018-03-01 Dana-Farber Cancer Institute, Inc. Bcl-w polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss
US12344643B2 (en) 2016-12-07 2025-07-01 The University Of Chicago Compositions and methods for inhibition of FOXP3
US20200031895A1 (en) 2016-12-16 2020-01-30 Biogen Ma Inc. Stabilized proteolytically activated growth differentiation factor 11
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JP2021506814A (ja) 2017-12-15 2021-02-22 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 安定化ペプチドによって介在される標的タンパク質の分解
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