JP2012509902A5 - - Google Patents
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- JP2012509902A5 JP2012509902A5 JP2011537728A JP2011537728A JP2012509902A5 JP 2012509902 A5 JP2012509902 A5 JP 2012509902A5 JP 2011537728 A JP2011537728 A JP 2011537728A JP 2011537728 A JP2011537728 A JP 2011537728A JP 2012509902 A5 JP2012509902 A5 JP 2012509902A5
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- JP
- Japan
- Prior art keywords
- polypeptide
- item
- cross
- linked
- life
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920001184 polypeptide Polymers 0.000 claims description 112
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 112
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 112
- 238000000034 method Methods 0.000 claims description 51
- 238000001727 in vivo Methods 0.000 claims description 21
- 238000004132 cross linking Methods 0.000 claims description 7
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 210000000170 cell membrane Anatomy 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 4
- 230000003834 intracellular effect Effects 0.000 claims description 4
- 239000012466 permeate Substances 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 102000051485 Bcl-2 family Human genes 0.000 description 2
- 108700038897 Bcl-2 family Proteins 0.000 description 2
- 239000007801 affinity label Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11750808P | 2008-11-24 | 2008-11-24 | |
| US61/117,508 | 2008-11-24 | ||
| PCT/US2009/065824 WO2010060112A1 (en) | 2008-11-24 | 2009-11-24 | Peptidomimetic macrocycles with improved properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012176A Division JP6194325B2 (ja) | 2008-11-24 | 2015-01-26 | 改善された特性を有するペプチド模倣大環状分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012509902A JP2012509902A (ja) | 2012-04-26 |
| JP2012509902A5 true JP2012509902A5 (enExample) | 2012-06-07 |
Family
ID=42198556
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537728A Pending JP2012509902A (ja) | 2008-11-24 | 2009-11-24 | 改善された特性を有するペプチド模倣大環状分子 |
| JP2015012176A Expired - Fee Related JP6194325B2 (ja) | 2008-11-24 | 2015-01-26 | 改善された特性を有するペプチド模倣大環状分子 |
| JP2017118484A Withdrawn JP2017186363A (ja) | 2008-11-24 | 2017-06-16 | 改善された特性を有するペプチド模倣大環状分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012176A Expired - Fee Related JP6194325B2 (ja) | 2008-11-24 | 2015-01-26 | 改善された特性を有するペプチド模倣大環状分子 |
| JP2017118484A Withdrawn JP2017186363A (ja) | 2008-11-24 | 2017-06-16 | 改善された特性を有するペプチド模倣大環状分子 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9458202B2 (enExample) |
| EP (1) | EP2352507A4 (enExample) |
| JP (3) | JP2012509902A (enExample) |
| CN (1) | CN102223891A (enExample) |
| AU (2) | AU2009316288B2 (enExample) |
| BR (1) | BRPI0920899A2 (enExample) |
| CA (1) | CA2743177A1 (enExample) |
| IL (1) | IL212748A (enExample) |
| WO (1) | WO2010060112A1 (enExample) |
Families Citing this family (78)
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|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
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| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| CA2686827C (en) * | 2006-12-14 | 2014-09-16 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CN109627287A (zh) | 2007-02-23 | 2019-04-16 | 爱勒让治疗公司 | 三唑大环系统 |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| WO2009110952A2 (en) * | 2007-12-31 | 2009-09-11 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| BRPI0907754A2 (pt) | 2008-02-08 | 2015-07-21 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos terapêuticos |
| US20110144303A1 (en) * | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| EP2356139A4 (en) * | 2008-07-23 | 2013-01-09 | Harvard College | LIGURE COMBINED POLYPEPTIDES |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| US8524653B2 (en) | 2008-09-22 | 2013-09-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2010060112A1 (en) | 2008-11-24 | 2010-05-27 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with improved properties |
| EP2376100B1 (en) | 2009-01-14 | 2017-10-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
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| BR112012008831A2 (pt) * | 2009-10-14 | 2019-09-24 | Aileron Therapeutics Inc | macrociclos de peptideomiméticos aprimorados. |
| SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| US9029332B2 (en) | 2010-12-15 | 2015-05-12 | The Research Foundation For The State University Of New York | Cross-linked peptides and proteins, methods of making same, and uses thereof |
| WO2012174423A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of rab gtpase function |
| IN2014CN02398A (enExample) * | 2011-08-31 | 2015-06-19 | Univ New York | |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| WO2013102211A2 (en) | 2011-12-29 | 2013-07-04 | Walensky Loren D | Stabilized antiviral fusion helices |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| KR102112373B1 (ko) * | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
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| WO2014201370A1 (en) | 2013-06-14 | 2014-12-18 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
| WO2015038938A1 (en) | 2013-09-13 | 2015-03-19 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| US10039809B2 (en) | 2013-12-18 | 2018-08-07 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| US10774114B2 (en) | 2014-03-10 | 2020-09-15 | Fondation The Ark | Respiratory syncytial virus (RSV) replication inhibitors |
| CN114805527A (zh) | 2014-05-21 | 2022-07-29 | 哈佛大学的校长及成员们 | Ras抑制肽和其用途 |
| JP2018503595A (ja) | 2014-09-24 | 2018-02-08 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその製剤 |
| BR112017005598A2 (pt) * | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
| EP3270945A4 (en) | 2015-03-18 | 2018-09-05 | Massachusetts Institute of Technology | Selective mcl-1 binding peptides |
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| CN109069578A (zh) | 2016-02-29 | 2018-12-21 | 达纳-法伯癌症研究所股份有限公司 | 用于治疗感染的钉合的细胞内靶向抗微生物肽 |
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| US11198715B2 (en) | 2016-07-22 | 2021-12-14 | Massachusetts Institute Of Technology | Selective Bfl-1 peptides |
| ES2935622T3 (es) | 2016-08-26 | 2023-03-08 | Dana Farber Cancer Inst Inc | Polipéptidos y miméticos de bcl-w para el tratamiento o la prevención de la neuropatía periférica y la pérdida auditiva inducidas por la quimioterapia |
| US12344643B2 (en) | 2016-12-07 | 2025-07-01 | The University Of Chicago | Compositions and methods for inhibition of FOXP3 |
| US20200031895A1 (en) | 2016-12-16 | 2020-01-30 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
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| WO2021247882A2 (en) * | 2020-06-04 | 2021-12-09 | The Trustees Of The University Of Pennsylvania | Compounds and methods for treating, ameliorating, or preventing herpes ocular keratitis |
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| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| US9068805B2 (en) | 2013-06-26 | 2015-06-30 | Matthew James Owen | Arrow modification and fletching system |
| US20170037086A1 (en) | 2014-04-09 | 2017-02-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with pth activity |
-
2009
- 2009-11-24 WO PCT/US2009/065824 patent/WO2010060112A1/en not_active Ceased
- 2009-11-24 JP JP2011537728A patent/JP2012509902A/ja active Pending
- 2009-11-24 BR BRPI0920899A patent/BRPI0920899A2/pt not_active Application Discontinuation
- 2009-11-24 US US12/625,533 patent/US9458202B2/en not_active Expired - Fee Related
- 2009-11-24 CA CA2743177A patent/CA2743177A1/en not_active Abandoned
- 2009-11-24 CN CN2009801468497A patent/CN102223891A/zh active Pending
- 2009-11-24 EP EP09828398A patent/EP2352507A4/en not_active Withdrawn
- 2009-11-24 AU AU2009316288A patent/AU2009316288B2/en not_active Ceased
-
2011
- 2011-05-05 IL IL212748A patent/IL212748A/en active IP Right Grant
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2015
- 2015-01-26 JP JP2015012176A patent/JP6194325B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-10 US US15/233,796 patent/US20170212125A1/en not_active Abandoned
- 2016-08-19 AU AU2016216698A patent/AU2016216698B2/en not_active Ceased
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2017
- 2017-06-16 JP JP2017118484A patent/JP2017186363A/ja not_active Withdrawn
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