JP2012510430A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012510430A5 JP2012510430A5 JP2011528082A JP2011528082A JP2012510430A5 JP 2012510430 A5 JP2012510430 A5 JP 2012510430A5 JP 2011528082 A JP2011528082 A JP 2011528082A JP 2011528082 A JP2011528082 A JP 2011528082A JP 2012510430 A5 JP2012510430 A5 JP 2012510430A5
- Authority
- JP
- Japan
- Prior art keywords
- peptidomimetic macrocycle
- amino acid
- independently
- alkyl
- cycloalkylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000002678 macrocyclic compounds Chemical class 0.000 claims description 59
- 239000000816 peptidomimetic Substances 0.000 claims description 58
- 150000001413 amino acids Chemical class 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 22
- 125000003342 alkenyl group Chemical group 0.000 claims description 18
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 18
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 18
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 125000004450 alkenylene group Chemical group 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 125000004419 alkynylene group Chemical group 0.000 claims description 8
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 8
- 125000004474 heteroalkylene group Chemical group 0.000 claims description 8
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 230000003993 interaction Effects 0.000 claims description 5
- 108010000591 Myc associated factor X Proteins 0.000 claims description 4
- 101710150912 Myc protein Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 230000003042 antagnostic effect Effects 0.000 claims description 4
- 125000000732 arylene group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 125000001475 halogen functional group Chemical group 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005549 heteroarylene group Chemical group 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 2
- 125000005647 linker group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000004971 Cross linker Substances 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9916508P | 2008-09-22 | 2008-09-22 | |
| US61/099,165 | 2008-09-22 | ||
| PCT/US2009/057930 WO2010034031A1 (en) | 2008-09-22 | 2009-09-22 | Peptidomimetic macrocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510430A JP2012510430A (ja) | 2012-05-10 |
| JP2012510430A5 true JP2012510430A5 (enExample) | 2012-06-21 |
Family
ID=41692050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528082A Withdrawn JP2012510430A (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120178700A1 (enExample) |
| EP (1) | EP2334697A1 (enExample) |
| JP (1) | JP2012510430A (enExample) |
| CN (1) | CN102884074A (enExample) |
| AU (1) | AU2009294874A1 (enExample) |
| BR (1) | BRPI0920889A2 (enExample) |
| CA (1) | CA2737920A1 (enExample) |
| WO (1) | WO2010034031A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2686827C (en) | 2006-12-14 | 2014-09-16 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| CN109627287A (zh) | 2007-02-23 | 2019-04-16 | 爱勒让治疗公司 | 三唑大环系统 |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| US8524653B2 (en) | 2008-09-22 | 2013-09-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2010060112A1 (en) | 2008-11-24 | 2010-05-27 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with improved properties |
| EP2376100B1 (en) | 2009-01-14 | 2017-10-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| WO2012051405A1 (en) | 2010-10-13 | 2012-04-19 | Bristol-Myers Squibb Company | Methods for preparing macrocycles and macrocycle stabilized peptides |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| JP2015504048A (ja) | 2011-12-21 | 2015-02-05 | ニューヨーク・ユニバーシティ | タンパク質分解抵抗性水素結合サロゲートヘリックス |
| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| WO2015038938A1 (en) | 2013-09-13 | 2015-03-19 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| US10039809B2 (en) | 2013-12-18 | 2018-08-07 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| JP2018503595A (ja) * | 2014-09-24 | 2018-02-08 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその製剤 |
| BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
| WO2016154058A1 (en) * | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
| PL3430031T3 (pl) * | 2016-03-15 | 2022-04-19 | Idp Discovery Pharma, S.L. | Peptydy o aktywności przeciwnowotworowej |
| JP7361689B2 (ja) * | 2017-07-25 | 2023-10-16 | イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ | 抗がんペプチド |
| AU2018311129B2 (en) * | 2017-08-01 | 2022-09-29 | Idp Discovery Pharma, S.L. | Anticancer peptides |
| CA3091948A1 (en) * | 2017-09-08 | 2019-03-14 | Idp Discovery Pharma, S.L. | New treatments of multiple myeloma |
| EP4069726A4 (en) | 2019-12-04 | 2024-03-20 | The Scripps Research Institute | GLP2 RECEPTOR AGONISTS AND METHOD OF USE |
| AU2022289610A1 (en) | 2021-06-09 | 2024-01-25 | The Scripps Research Institute | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0633933A1 (en) * | 1992-03-23 | 1995-01-18 | Imperial Cancer Research Technology Limited | Leucine zippers |
| US7192713B1 (en) * | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| CA2686827C (en) * | 2006-12-14 | 2014-09-16 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| CN109627287A (zh) * | 2007-02-23 | 2019-04-16 | 爱勒让治疗公司 | 三唑大环系统 |
| EP2508531B1 (en) * | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
-
2009
- 2009-09-22 CN CN2009801429897A patent/CN102884074A/zh active Pending
- 2009-09-22 AU AU2009294874A patent/AU2009294874A1/en not_active Abandoned
- 2009-09-22 WO PCT/US2009/057930 patent/WO2010034031A1/en not_active Ceased
- 2009-09-22 BR BRPI0920889A patent/BRPI0920889A2/pt not_active IP Right Cessation
- 2009-09-22 CA CA2737920A patent/CA2737920A1/en not_active Abandoned
- 2009-09-22 EP EP09740563A patent/EP2334697A1/en not_active Withdrawn
- 2009-09-22 US US13/120,360 patent/US20120178700A1/en not_active Abandoned
- 2009-09-22 JP JP2011528082A patent/JP2012510430A/ja not_active Withdrawn