CN102884074A - 拟肽大环化合物 - Google Patents

拟肽大环化合物 Download PDF

Info

Publication number
CN102884074A
CN102884074A CN2009801429897A CN200980142989A CN102884074A CN 102884074 A CN102884074 A CN 102884074A CN 2009801429897 A CN2009801429897 A CN 2009801429897A CN 200980142989 A CN200980142989 A CN 200980142989A CN 102884074 A CN102884074 A CN 102884074A
Authority
CN
China
Prior art keywords
amino acid
peptidomimetic macrocycle
alkyl
peptide
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801429897A
Other languages
English (en)
Chinese (zh)
Inventor
H·M·纳什
R·卡佩勒-利伯曼
J-w·韩
T·K·索耶
J·诺伊赫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of CN102884074A publication Critical patent/CN102884074A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2009801429897A 2008-09-22 2009-09-22 拟肽大环化合物 Pending CN102884074A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9916508P 2008-09-22 2008-09-22
US61/099,165 2008-09-22
PCT/US2009/057930 WO2010034031A1 (en) 2008-09-22 2009-09-22 Peptidomimetic macrocycles

Publications (1)

Publication Number Publication Date
CN102884074A true CN102884074A (zh) 2013-01-16

Family

ID=41692050

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801429897A Pending CN102884074A (zh) 2008-09-22 2009-09-22 拟肽大环化合物

Country Status (8)

Country Link
US (1) US20120178700A1 (enExample)
EP (1) EP2334697A1 (enExample)
JP (1) JP2012510430A (enExample)
CN (1) CN102884074A (enExample)
AU (1) AU2009294874A1 (enExample)
BR (1) BRPI0920889A2 (enExample)
CA (1) CA2737920A1 (enExample)
WO (1) WO2010034031A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106642A (zh) * 2014-09-24 2017-08-29 艾瑞朗医疗公司 拟肽大环化合物及其制剂
CN107614003A (zh) * 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
CN109071622A (zh) * 2016-03-15 2018-12-21 Idp研发制药有限公司 具有抗癌活性的肽
CN111263768A (zh) * 2017-07-25 2020-06-09 Idp研发制药有限公司 抗癌肽
CN111405903A (zh) * 2017-09-08 2020-07-10 Idp研发制药有限公司 多发性骨髓瘤的新疗法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008076904A1 (en) 2006-12-14 2008-06-26 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US7981999B2 (en) 2007-02-23 2011-07-19 Aileron Therapeutics, Inc. Triazole macrocycle systems
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
CA2737922A1 (en) 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
BRPI0920899A2 (pt) 2008-11-24 2016-04-26 Aileron Therapeutics Inc macrociclos peptidomiméticos com propriedades melhoradas
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
AU2010298338A1 (en) 2009-09-22 2012-04-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
WO2012051405A1 (en) 2010-10-13 2012-04-19 Bristol-Myers Squibb Company Methods for preparing macrocycles and macrocycle stabilized peptides
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
EP2793920A4 (en) * 2011-12-21 2015-07-01 Univ New York PROTEOLYTIC RESISTANT HYDROGEN BOND SURROGATE HELICES
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER
KR20150082307A (ko) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 이치환 아미노산 및 이의 제조 및 사용 방법
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
US10039809B2 (en) 2013-12-18 2018-08-07 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
CN106999541A (zh) 2014-09-24 2017-08-01 艾瑞朗医疗公司 拟肽大环化合物及其用途
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
KR20200032730A (ko) * 2017-08-01 2020-03-26 아이디피 디스커버리 파마, 에스.엘. 항암 펩타이드
KR20240032010A (ko) 2021-06-09 2024-03-08 더 스크립스 리서치 인스티튜트 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019176A1 (en) * 1992-03-23 1993-09-30 Imperial Cancer Research Technology Limited Leucine zippers
US7192713B1 (en) * 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
WO2008076904A1 (en) * 2006-12-14 2008-06-26 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US7981999B2 (en) * 2007-02-23 2011-07-19 Aileron Therapeutics, Inc. Triazole macrocycle systems
KR101623985B1 (ko) * 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106642A (zh) * 2014-09-24 2017-08-29 艾瑞朗医疗公司 拟肽大环化合物及其制剂
CN107106642B (zh) * 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
CN107614003A (zh) * 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
CN109071622A (zh) * 2016-03-15 2018-12-21 Idp研发制药有限公司 具有抗癌活性的肽
CN109071622B (zh) * 2016-03-15 2023-01-13 Idp研发制药有限公司 具有抗癌活性的肽
CN111263768A (zh) * 2017-07-25 2020-06-09 Idp研发制药有限公司 抗癌肽
CN111263768B (zh) * 2017-07-25 2023-10-13 Idp研发制药有限公司 抗癌肽
CN111405903A (zh) * 2017-09-08 2020-07-10 Idp研发制药有限公司 多发性骨髓瘤的新疗法

Also Published As

Publication number Publication date
AU2009294874A1 (en) 2010-03-25
JP2012510430A (ja) 2012-05-10
WO2010034031A1 (en) 2010-03-25
BRPI0920889A2 (pt) 2017-10-10
EP2334697A1 (en) 2011-06-22
US20120178700A1 (en) 2012-07-12
CA2737920A1 (en) 2010-03-25

Similar Documents

Publication Publication Date Title
CN102884074A (zh) 拟肽大环化合物
US10300109B2 (en) Peptidomimetic macrocycles
US11008366B2 (en) Peptidomimetic macrocycles
CN112119085B (zh) 稳定肽-介导的靶向蛋白降解
CN102482336B (zh) 拟肽大环化合物
CN101636407A (zh) 双巯基大环化系统
US20120115793A1 (en) Peptidomimetic macrocycles
US20120115783A1 (en) Peptidomimetic macrocycles
US20170349638A1 (en) Companion diagnostic tool for peptidomimetic macrocycles
US20120101047A1 (en) Peptidomimetic macrocycles
CN102223891A (zh) 具有改善性质的拟肽大环化合物
WO2014138429A2 (en) Peptidomimetic macrocycles and use thereof in regulating hif1alpha
WO2012173846A2 (en) Peptidomimetic macrocycles
HK1162181A (en) Peptidomimetic macrocycles
HK1161742A (en) Peptidomimetic marcrocycles

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130116