JP2012510430A - ペプチド模倣大環状分子 - Google Patents

ペプチド模倣大環状分子 Download PDF

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Publication number
JP2012510430A
JP2012510430A JP2011528082A JP2011528082A JP2012510430A JP 2012510430 A JP2012510430 A JP 2012510430A JP 2011528082 A JP2011528082 A JP 2011528082A JP 2011528082 A JP2011528082 A JP 2011528082A JP 2012510430 A JP2012510430 A JP 2012510430A
Authority
JP
Japan
Prior art keywords
amino acid
peptidomimetic macrocycle
peptidomimetic
macrocycle
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011528082A
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English (en)
Japanese (ja)
Other versions
JP2012510430A5 (enExample
Inventor
ヒュー エム． ナッシュ，
ロザナ カペラー−リバーマン，
ジア−ウェン ハン，
トミ ケー． ソーヤー，
ジャスティン ノーエレ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of JP2012510430A publication Critical patent/JP2012510430A/ja
Publication of JP2012510430A5 publication Critical patent/JP2012510430A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2011528082A 2008-09-22 2009-09-22 ペプチド模倣大環状分子 Withdrawn JP2012510430A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9916508P 2008-09-22 2008-09-22
US61/099,165 2008-09-22
PCT/US2009/057930 WO2010034031A1 (en) 2008-09-22 2009-09-22 Peptidomimetic macrocycles

Publications (2)

Publication Number Publication Date
JP2012510430A true JP2012510430A (ja) 2012-05-10
JP2012510430A5 JP2012510430A5 (enExample) 2012-06-21

Family

ID=41692050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011528082A Withdrawn JP2012510430A (ja) 2008-09-22 2009-09-22 ペプチド模倣大環状分子

Country Status (8)

Country Link
US (1) US20120178700A1 (enExample)
EP (1) EP2334697A1 (enExample)
JP (1) JP2012510430A (enExample)
CN (1) CN102884074A (enExample)
AU (1) AU2009294874A1 (enExample)
BR (1) BRPI0920889A2 (enExample)
CA (1) CA2737920A1 (enExample)
WO (1) WO2010034031A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019516779A (ja) * 2016-03-15 2019-06-20 アイディーピー ディスカバリー ファーマ， エセ．エレ． 抗癌活性を有するペプチド
JP2020529429A (ja) * 2017-08-01 2020-10-08 イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ 抗がんペプチド

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2686827C (en) 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
US8524653B2 (en) 2008-09-22 2013-09-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010060112A1 (en) 2008-11-24 2010-05-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
EP2376100B1 (en) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
WO2012051405A1 (en) 2010-10-13 2012-04-19 Bristol-Myers Squibb Company Methods for preparing macrocycles and macrocycle stabilized peptides
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
JP2015504048A (ja) 2011-12-21 2015-02-05 ニューヨーク・ユニバーシティ タンパク質分解抵抗性水素結合サロゲートヘリックス
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2015038938A1 (en) 2013-09-13 2015-03-19 The California Institute For Biomedical Research Modified therapeutic agents and compositions thereof
US10039809B2 (en) 2013-12-18 2018-08-07 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
JP2018503595A (ja) * 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) * 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
JP7361689B2 (ja) * 2017-07-25 2023-10-16 イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ 抗がんペプチド
CA3091948A1 (en) * 2017-09-08 2019-03-14 Idp Discovery Pharma, S.L. New treatments of multiple myeloma
EP4069726A4 (en) 2019-12-04 2024-03-20 The Scripps Research Institute GLP2 RECEPTOR AGONISTS AND METHOD OF USE
AU2022289610A1 (en) 2021-06-09 2024-01-25 The Scripps Research Institute Long-acting dual gip/glp-1 peptide conjugates and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633933A1 (en) * 1992-03-23 1995-01-18 Imperial Cancer Research Technology Limited Leucine zippers
US7192713B1 (en) * 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
CA2686827C (en) * 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CN109627287A (zh) * 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
EP2508531B1 (en) * 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019516779A (ja) * 2016-03-15 2019-06-20 アイディーピー ディスカバリー ファーマ， エセ．エレ． 抗癌活性を有するペプチド
JP7098163B2 (ja) 2016-03-15 2022-07-11 アイディーピー ディスカバリー ファーマ， エセ．エレ． 抗癌活性を有するペプチド
JP2020529429A (ja) * 2017-08-01 2020-10-08 イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ 抗がんペプチド

Also Published As

Publication number Publication date
BRPI0920889A2 (pt) 2017-10-10
US20120178700A1 (en) 2012-07-12
AU2009294874A1 (en) 2010-03-25
CN102884074A (zh) 2013-01-16
WO2010034031A1 (en) 2010-03-25
CA2737920A1 (en) 2010-03-25
EP2334697A1 (en) 2011-06-22

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