JP2008518026A5 - - Google Patents

Info

Publication number

JP2008518026A5

JP2008518026A5 JP2007539117A JP2007539117A JP2008518026A5 JP 2008518026 A5 JP2008518026 A5 JP 2008518026A5 JP 2007539117 A JP2007539117 A JP 2007539117A JP 2007539117 A JP2007539117 A JP 2007539117A JP 2008518026 A5 JP2008518026 A5 JP 2008518026A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

acth

peptide

composition

Prior art date

2005-10-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 46
• 239000003997 corticotropin derivative Substances 0.000 claims 37
• 108090000765 processed proteins & peptides Proteins 0.000 claims 34
• 230000001919 adrenal effect Effects 0.000 claims 25
• 239000000203 mixture Substances 0.000 claims 24
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 22
• 239000012528 membrane Substances 0.000 claims 21
• 125000000539 amino acid group Chemical group 0.000 claims 20
• 239000003246 corticosteroid Substances 0.000 claims 16
• 125000003275 alpha amino acid group Chemical group 0.000 claims 15
• 238000006467 substitution reaction Methods 0.000 claims 14
• 239000003814 drug Substances 0.000 claims 11
• 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims 10
• 229960000258 corticotropin Drugs 0.000 claims 10
• 238000000034 method Methods 0.000 claims 9
• 238000003556 assay Methods 0.000 claims 6
• 238000000338 in vitro Methods 0.000 claims 6
• OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 5
• OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims 5
• 210000004369 blood Anatomy 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• 230000006698 induction Effects 0.000 claims 4
• 230000005764 inhibitory process Effects 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 230000028327 secretion Effects 0.000 claims 4
• 210000002966 serum Anatomy 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 3
• -1 ACTH analog compound Chemical class 0.000 claims 2
• 230000027455 binding Effects 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 238000012875 competitive assay Methods 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 claims 1
• 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
• 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 claims 1
• 208000006399 Premature Obstetric Labor Diseases 0.000 claims 1
• 238000010521 absorption reaction Methods 0.000 claims 1
• ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 claims 1
• 239000003405 delayed action preparation Substances 0.000 claims 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
• 229960003957 dexamethasone Drugs 0.000 claims 1
• 230000002267 hypothalamic effect Effects 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 230000001575 pathological effect Effects 0.000 claims 1
• 230000007170 pathology Effects 0.000 claims 1
• 230000001817 pituitary effect Effects 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 239000012679 serum free medium Substances 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1