|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
CA1340323C
(en)
|
1988-09-20 |
1999-01-19 |
Arnold E. Hampel |
Rna catalyst for cleaving specific rna sequences
|
|
AU637800B2
(en)
|
1989-08-31 |
1993-06-10 |
City Of Hope |
Chimeric dna-rna catalytic sequences
|
|
US5591722A
(en)
|
1989-09-15 |
1997-01-07 |
Southern Research Institute |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
|
|
DK0942000T3
(da)
|
1989-10-24 |
2004-11-01 |
Isis Pharmaceuticals Inc |
2'-modificerede oligonukleotider
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
US5670633A
(en)
|
1990-01-11 |
1997-09-23 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
|
GB9009980D0
(en)
|
1990-05-03 |
1990-06-27 |
Amersham Int Plc |
Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
|
|
ATE167523T1
(de)
|
1990-05-11 |
1998-07-15 |
Microprobe Corp |
Teststreifen zum eintauchen für nukleinsäure- hybridisierungsassays und verfahren zur kovalenten immobilisierung von oligonucleotiden
|
|
US6365730B1
(en)
|
1990-06-19 |
2002-04-02 |
Gene Shears Pty. Limited |
DNA-Armed ribozymes and minizymes
|
|
WO1992007065A1
(en)
|
1990-10-12 |
1992-04-30 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Modified ribozymes
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
ES2103918T3
(es)
|
1991-10-17 |
1997-10-01 |
Ciba Geigy Ag |
Nucleosidos biciclicos, oligonucleotidos, procedimiento para su obtencion y productos intermedios.
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
FR2687679B1
(fr)
|
1992-02-05 |
1994-10-28 |
Centre Nat Rech Scient |
Oligothionucleotides.
|
|
WO1993023569A1
(en)
|
1992-05-11 |
1993-11-25 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for inhibiting viral replication
|
|
EP0577558A2
(de)
|
1992-07-01 |
1994-01-05 |
Ciba-Geigy Ag |
Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
|
|
EP1251170A3
(en)
|
1992-07-17 |
2002-10-30 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for treatment of NF-kappaB dependent animal diseases
|
|
RU95114435A
(ru)
|
1992-12-14 |
1997-05-20 |
Ханивелл Инк. (Us) |
Система с бесщеточным двигателем постоянного тока
|
|
WO1994022864A1
(en)
|
1993-03-30 |
1994-10-13 |
Sterling Winthrop Inc. |
Acyclic nucleoside analogs and oligonucleotide sequences containing them
|
|
DE4311944A1
(de)
|
1993-04-10 |
1994-10-13 |
Degussa |
Umhüllte Natriumpercarbonatpartikel, Verfahren zu deren Herstellung und sie enthaltende Wasch-, Reinigungs- und Bleichmittelzusammensetzungen
|
|
US5446137B1
(en)
|
1993-12-09 |
1998-10-06 |
Behringwerke Ag |
Oligonucleotides containing 4'-substituted nucleotides
|
|
US5519134A
(en)
|
1994-01-11 |
1996-05-21 |
Isis Pharmaceuticals, Inc. |
Pyrrolidine-containing monomers and oligomers
|
|
US5631359A
(en)
|
1994-10-11 |
1997-05-20 |
Ribozyme Pharmaceuticals, Inc. |
Hairpin ribozymes
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US5597909A
(en)
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
|
AU3889595A
(en)
|
1994-10-05 |
1996-05-02 |
Amgen, Inc. |
Method for inhibiting smooth muscle cell proliferation and oligonucleotides for use therein
|
|
US5792747A
(en)
|
1995-01-24 |
1998-08-11 |
The Administrators Of The Tulane Educational Fund |
Highly potent agonists of growth hormone releasing hormone
|
|
US20080119427A1
(en)
|
1996-06-06 |
2008-05-22 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
CA2303299C
(en)
|
1997-09-12 |
2016-02-23 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
JP2002535247A
(ja)
|
1998-11-26 |
2002-10-22 |
ペンタファルム アクチェンゲゼルシャフト |
輸送系複合体
|
|
PT1152009E
(pt)
|
1999-02-12 |
2005-03-31 |
Sankyo Co |
Novos analogos de nucleosidos e oligonucleotidos
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
NZ514348A
(en)
|
1999-05-04 |
2004-05-28 |
Exiqon As |
L-ribo-LNA analogues
|
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
|
JP4151751B2
(ja)
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
|
CA2392490A1
(en)
|
1999-11-24 |
2001-05-31 |
Mcs Micro Carrier Systems Gmbh |
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
JP4387669B2
(ja)
|
2000-10-13 |
2009-12-16 |
ザイジェン エス．アー． |
新規なトランスポーターペプチド配列による生物学的エフェクターの細胞内送達
|
|
US7033597B2
(en)
|
2000-10-13 |
2006-04-25 |
Université de Lausanne |
Intracellular delivery of biological effectors
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
|
WO2004041889A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
EP1661905B9
(en)
|
2003-08-28 |
2012-12-19 |
IMANISHI, Takeshi |
Novel artificial nucleic acids of n-o bond crosslinkage type
|
|
US7523096B2
(en)
|
2003-12-03 |
2009-04-21 |
Google Inc. |
Methods and systems for personalized network searching
|
|
US20090312532A1
(en)
|
2005-04-22 |
2009-12-17 |
Van Deutekom Judith Christina |
Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secodary rna structure
|
|
ES2351674T3
(es)
|
2006-01-27 |
2011-02-09 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en la posición 6.
|
|
US20100184209A1
(en)
|
2006-02-17 |
2010-07-22 |
Dharmacon, Inc. |
Compositions and methods for inhibiting gene silencing by rna interference
|
|
WO2007123391A1
(en)
|
2006-04-20 |
2007-11-01 |
Academisch Ziekenhuis Leiden |
Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
US8809514B2
(en)
|
2006-09-22 |
2014-08-19 |
Ge Healthcare Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by RNA interference
|
|
CA2667055C
(en)
|
2006-10-18 |
2017-05-09 |
Isis Pharmaceuticals, Inc. |
Antisense compounds
|
|
US20100016215A1
(en)
|
2007-06-29 |
2010-01-21 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
EP2203173B1
(en)
|
2007-10-26 |
2015-12-23 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
JP2012523225A
(ja)
|
2009-04-10 |
2012-10-04 |
アソシアシオン・アンスティテュ・ドゥ・ミオロジー |
疾患の処置のためのトリシクロ−ｄｎａアンチセンスオリゴヌクレオチド、組成物及び方法
|
|
US20110269665A1
(en)
*
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
KR102240217B1
(ko)
|
2012-09-25 |
2021-04-14 |
젠자임 코포레이션 |
근긴장성 이영양증의 치료용 펩티드-결합 모르폴리노 안티센스 올리고뉴클레오티드
|
|
JP2016504026A
(ja)
|
2012-12-12 |
2016-02-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための系、方法および最適化ガイド組成物のエンジニアリング
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
CN114634950A
(zh)
|
2012-12-12 |
2022-06-17 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
ES2905181T3
(es)
|
2015-05-01 |
2022-04-07 |
Prec Biosciences Inc |
Deleción precisa de secuencias cromosómicas in vivo
|
|
US10760076B2
(en)
|
2015-10-05 |
2020-09-01 |
Proqr Therapeutics Ii B.V. |
Use of single-stranded antisense oligonucleotide in prevention or treatment of genetic diseases involving a trinucleotide repeat expansion
|
|
JP6657520B2
(ja)
|
2016-02-03 |
2020-03-04 |
株式会社神戸製鋼所 |
タイヤ試験装置のタイヤ空気充填機構及びタイヤ空気充填方法
|
|
KR20170130253A
(ko)
|
2016-05-18 |
2017-11-28 |
에스케이텔레콤 주식회사 |
적응형 스트리밍 서비스 제공 방법 및 이를 위한 장치
|
|
US10265249B2
(en)
|
2016-09-29 |
2019-04-23 |
The Procter & Gamble Company |
Fibrous structures comprising glyceride copolymers
|
|
EP3541932A4
(en)
|
2016-11-16 |
2021-03-03 |
The Regents of the University of California |
INHIBITORS OF CRISPR-CAS9
|
|
KR20180102871A
(ko)
|
2017-03-08 |
2018-09-18 |
엘지전자 주식회사 |
이동단말기 및 이동단말기의 차량 제어 방법
|
|
EP3592365A4
(en)
|
2017-03-10 |
2021-01-13 |
The Board Of Regents Of The University Of Texas System |
TREATMENT FOR FOX ENDOTHAL CORNEAL DYSTROPHY
|
|
TW201945014A
(zh)
*
|
2018-02-22 |
2019-12-01 |
美商安卓達治療股份有限公司 |
用於治療粒線體性神經胃腸腦病變之組合物及方法
|
|
GB201812972D0
(en)
*
|
2018-08-09 |
2018-09-26 |
Univ Oxford Innovation Ltd |
Cell-penetrating peptides
|
|
EP4706689A2
(en)
*
|
2019-12-19 |
2026-03-11 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|