|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
CA1340323C
(en)
|
1988-09-20 |
1999-01-19 |
Arnold E. Hampel |
Rna catalyst for cleaving specific rna sequences
|
|
CA2039718C
(en)
|
1989-08-31 |
2003-02-25 |
John J. Rossi |
Chimeric dna-rna catalytic sequences
|
|
US5591722A
(en)
|
1989-09-15 |
1997-01-07 |
Southern Research Institute |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
|
|
WO1991006556A1
(en)
|
1989-10-24 |
1991-05-16 |
Gilead Sciences, Inc. |
2' modified oligonucleotides
|
|
US5670633A
(en)
|
1990-01-11 |
1997-09-23 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
GB9009980D0
(en)
|
1990-05-03 |
1990-06-27 |
Amersham Int Plc |
Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
|
|
EP0455905B1
(en)
|
1990-05-11 |
1998-06-17 |
Microprobe Corporation |
Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides
|
|
US6365730B1
(en)
|
1990-06-19 |
2002-04-02 |
Gene Shears Pty. Limited |
DNA-Armed ribozymes and minizymes
|
|
AU649074B2
(en)
|
1990-10-12 |
1994-05-12 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Modified ribozymes
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
DE59208572D1
(de)
|
1991-10-17 |
1997-07-10 |
Ciba Geigy Ag |
Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
FR2687679B1
(fr)
|
1992-02-05 |
1994-10-28 |
Centre Nat Rech Scient |
Oligothionucleotides.
|
|
CA2135646A1
(en)
|
1992-05-11 |
1993-11-25 |
Kenneth G. Draper |
Method and reagent for inhibiting viral replication
|
|
EP0577558A2
(de)
|
1992-07-01 |
1994-01-05 |
Ciba-Geigy Ag |
Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
|
|
JPH07509133A
(ja)
|
1992-07-17 |
1995-10-12 |
リボザイム・ファーマシューティカルズ・インコーポレイテッド |
動物疾患の処置のための方法および剤
|
|
WO1994014226A1
(en)
|
1992-12-14 |
1994-06-23 |
Honeywell Inc. |
Motor system with individually controlled redundant windings
|
|
EP0691968B1
(en)
|
1993-03-30 |
1997-07-16 |
Sanofi |
Acyclic nucleoside analogs and oligonucleotide sequences containing them
|
|
DE4311944A1
(de)
|
1993-04-10 |
1994-10-13 |
Degussa |
Umhüllte Natriumpercarbonatpartikel, Verfahren zu deren Herstellung und sie enthaltende Wasch-, Reinigungs- und Bleichmittelzusammensetzungen
|
|
US5446137B1
(en)
|
1993-12-09 |
1998-10-06 |
Behringwerke Ag |
Oligonucleotides containing 4'-substituted nucleotides
|
|
US5519134A
(en)
|
1994-01-11 |
1996-05-21 |
Isis Pharmaceuticals, Inc. |
Pyrrolidine-containing monomers and oligomers
|
|
US5631359A
(en)
|
1994-10-11 |
1997-05-20 |
Ribozyme Pharmaceuticals, Inc. |
Hairpin ribozymes
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US5597909A
(en)
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
|
AU3889595A
(en)
|
1994-10-05 |
1996-05-02 |
Amgen, Inc. |
Method for inhibiting smooth muscle cell proliferation and oligonucleotides for use therein
|
|
US5792747A
(en)
|
1995-01-24 |
1998-08-11 |
The Administrators Of The Tulane Educational Fund |
Highly potent agonists of growth hormone releasing hormone
|
|
US20080119427A1
(en)
|
1996-06-06 |
2008-05-22 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
EP1015469B2
(en)
|
1997-09-12 |
2015-11-18 |
Exiqon A/S |
Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
JP2002535247A
(ja)
|
1998-11-26 |
2002-10-22 |
ペンタファルム アクチェンゲゼルシャフト |
輸送系複合体
|
|
BRPI0008131B8
(pt)
|
1999-02-12 |
2021-05-25 |
Daiichi Sankyo Co Ltd |
composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
ATE356824T1
(de)
|
1999-05-04 |
2007-04-15 |
Santaris Pharma As |
L-ribo-lna analoge
|
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
|
JP4151751B2
(ja)
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
|
JP2003514564A
(ja)
|
1999-11-24 |
2003-04-22 |
エムシーエス マイクロ キャリア システムズ ゲーエムベーハー |
核局在化シグナルまたはタンパク質導入領域の多量体を含むポリペプチド、および分子を細胞内へ移入するためのその使用法
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
US7033597B2
(en)
|
2000-10-13 |
2006-04-25 |
Université de Lausanne |
Intracellular delivery of biological effectors
|
|
CA2425610A1
(en)
|
2000-10-13 |
2002-04-18 |
University Of Lausanne |
Intracellular delivery of biological effectors by novel transporter peptide sequences
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
DK1661905T3
(da)
|
2003-08-28 |
2012-07-23 |
Takeshi Imanishi |
Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype
|
|
US7523096B2
(en)
|
2003-12-03 |
2009-04-21 |
Google Inc. |
Methods and systems for personalized network searching
|
|
US20090312532A1
(en)
|
2005-04-22 |
2009-12-17 |
Van Deutekom Judith Christina |
Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secodary rna structure
|
|
DE602007009487D1
(de)
|
2006-01-27 |
2010-11-11 |
Isis Pharmaceutical Inc |
6-modifizierte bicyclische nukleinsäureanaloga
|
|
EP1986697B1
(en)
|
2006-02-17 |
2016-06-29 |
GE Healthcare Dharmacon, Inc. |
Compositions and methods for inhibiting gene silencing by rna interference
|
|
WO2007123391A1
(en)
|
2006-04-20 |
2007-11-01 |
Academisch Ziekenhuis Leiden |
Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
EP2081949B1
(en)
|
2006-09-22 |
2014-12-10 |
GE Healthcare Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
|
|
EP2410053B2
(en)
|
2006-10-18 |
2020-07-15 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
|
US20100016215A1
(en)
|
2007-06-29 |
2010-01-21 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
NZ584793A
(en)
|
2007-10-26 |
2012-05-25 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
CA2758189C
(en)
|
2009-04-10 |
2020-12-29 |
Association Institut De Myologie |
Tricyclo-dna antisense oligonucleotides, compositions, and methods for the treatment of disease
|
|
US20110269665A1
(en)
*
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
US10111962B2
(en)
|
2012-09-25 |
2018-10-30 |
Genzyme Corporation |
Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy
|
|
PT2931898E
(pt)
|
2012-12-12 |
2016-06-16 |
Harvard College |
Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
CN105209621B
(zh)
|
2012-12-12 |
2021-05-25 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
|
KR102955556B1
(ko)
|
2012-12-12 |
2026-04-22 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
|
|
MX380562B
(es)
|
2012-12-12 |
2025-03-12 |
Broad Inst Inc |
Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias.
|
|
KR20160097338A
(ko)
|
2013-12-12 |
2016-08-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
뉴클레오티드 반복 장애에서의 ｃｒｉｓｐｒ-ｃａｓ 시스템의 조성물 및 방법 및 용도
|
|
US20180344817A1
(en)
|
2015-05-01 |
2018-12-06 |
Precision Biosciences, Inc. |
Precise deletion of chromosomal sequences in vivo and treatment of nucleotide repeat expansion disorders using engineered nucleases
|
|
AU2016335032B2
(en)
|
2015-10-05 |
2022-04-14 |
Proqr Therapeutics Ii B.V. |
Use of single-stranded antisense oligonucleotide in prevention or treatment of genetic diseases involving a trinucleotide repeat expansion
|
|
JP6657520B2
(ja)
|
2016-02-03 |
2020-03-04 |
株式会社神戸製鋼所 |
タイヤ試験装置のタイヤ空気充填機構及びタイヤ空気充填方法
|
|
KR20170130253A
(ko)
|
2016-05-18 |
2017-11-28 |
에스케이텔레콤 주식회사 |
적응형 스트리밍 서비스 제공 방법 및 이를 위한 장치
|
|
US10265249B2
(en)
|
2016-09-29 |
2019-04-23 |
The Procter & Gamble Company |
Fibrous structures comprising glyceride copolymers
|
|
CA3042880A1
(en)
|
2016-11-16 |
2018-05-24 |
The Regents Of The University Of California |
Inhibitors of crispr-cas9
|
|
KR20180102871A
(ko)
|
2017-03-08 |
2018-09-18 |
엘지전자 주식회사 |
이동단말기 및 이동단말기의 차량 제어 방법
|
|
WO2018165541A1
(en)
|
2017-03-10 |
2018-09-13 |
The Board Of Regents Of The University Of Texas System |
Treatment of fuchs' endothelial corneal dystrophy
|
|
WO2019165183A1
(en)
*
|
2018-02-22 |
2019-08-29 |
Entrada Therapeutics, Inc. |
Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
|
|
GB201812972D0
(en)
*
|
2018-08-09 |
2018-09-26 |
Univ Oxford Innovation Ltd |
Cell-penetrating peptides
|
|
EP4058032A4
(en)
*
|
2019-12-19 |
2024-01-10 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|