JP2015520184A5 - - Google Patents

Info

Publication number

JP2015520184A5

JP2015520184A5 JP2015515646A JP2015515646A JP2015520184A5 JP 2015520184 A5 JP2015520184 A5 JP 2015520184A5 JP 2015515646 A JP2015515646 A JP 2015515646A JP 2015515646 A JP2015515646 A JP 2015515646A JP 2015520184 A5 JP2015520184 A5 JP 2015520184A5

Authority

JP

Japan

Prior art keywords

oxm

mal

lys

fms

fmoc

Prior art date

2013-06-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102400000319 Oxyntomodulin Human genes 0.000 claims 44
• 101800001388 Oxyntomodulin Proteins 0.000 claims 44
• 238000000034 method Methods 0.000 claims 31
• 239000011347 resin Substances 0.000 claims 25
• 229920005989 resin Polymers 0.000 claims 25
• PXZWGQLGAKCNKD-DPNMSELWSA-N molport-023-276-326 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 PXZWGQLGAKCNKD-DPNMSELWSA-N 0.000 claims 19
• 125000006239 protecting group Chemical group 0.000 claims 13
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
• 238000004519 manufacturing process Methods 0.000 claims 7
• 229920000642 polymer Polymers 0.000 claims 6
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
• JLPNPVIABCLANH-UHFFFAOYSA-N 9-[(2,5-dioxopyrrolidin-1-yl)oxycarbonyloxymethyl]-7-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-9h-fluorene-2-sulfonic acid Chemical compound C=1C(S(=O)(=O)O)=CC=C(C2=CC=C(NC(=O)CCN3C(C=CC3=O)=O)C=C22)C=1C2COC(=O)ON1C(=O)CCC1=O JLPNPVIABCLANH-UHFFFAOYSA-N 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 208000008589 Obesity Diseases 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 0 *C(*)NC(OCC1c2cc(NC(CCN(C(CC3S*)=O)C3=O)=*)ccc2-c2ccccc12)=O Chemical compound *C(*)NC(OCC1c2cc(NC(CCN(C(CC3S*)=O)C3=O)=*)ccc2-c2ccccc12)=O 0.000 description 1
• FTIFNUDLFYHCBW-UHFFFAOYSA-N O=C(CCN(C(C=C1)=O)C1=O)Nc1ccc2-c3ccccc3C(COC(ON(C(CC3)=O)C3=O)=O)c2c1 Chemical compound O=C(CCN(C(C=C1)=O)C1=O)Nc1ccc2-c3ccccc3C(COC(ON(C(CC3)=O)C3=O)=O)c2c1 FTIFNUDLFYHCBW-UHFFFAOYSA-N 0.000 description 1