JP2016513638A5 - - Google Patents
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- Publication number
- JP2016513638A5 JP2016513638A5 JP2016500078A JP2016500078A JP2016513638A5 JP 2016513638 A5 JP2016513638 A5 JP 2016513638A5 JP 2016500078 A JP2016500078 A JP 2016500078A JP 2016500078 A JP2016500078 A JP 2016500078A JP 2016513638 A5 JP2016513638 A5 JP 2016513638A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- peptide
- seq
- nos
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 6
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 5
- 239000002671 adjuvant Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 229910017119 AlPO Inorganic materials 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/843,883 US9102752B2 (en) | 2013-03-15 | 2013-03-15 | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| US13/843,883 | 2013-03-15 | ||
| PCT/US2013/037865 WO2014143087A1 (en) | 2013-03-15 | 2013-04-23 | Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017112424A Division JP6784646B2 (ja) | 2013-03-15 | 2017-06-07 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513638A JP2016513638A (ja) | 2016-05-16 |
| JP2016513638A5 true JP2016513638A5 (enExample) | 2016-06-23 |
| JP6208319B2 JP6208319B2 (ja) | 2017-10-04 |
Family
ID=51527985
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500078A Active JP6208319B2 (ja) | 2013-03-15 | 2013-04-23 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
| JP2017112424A Active JP6784646B2 (ja) | 2013-03-15 | 2017-06-07 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
| JP2019137534A Pending JP2019196397A (ja) | 2013-03-15 | 2019-07-26 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017112424A Active JP6784646B2 (ja) | 2013-03-15 | 2017-06-07 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
| JP2019137534A Pending JP2019196397A (ja) | 2013-03-15 | 2019-07-26 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9102752B2 (enExample) |
| EP (1) | EP2968485B1 (enExample) |
| JP (3) | JP6208319B2 (enExample) |
| KR (2) | KR101926030B1 (enExample) |
| CN (2) | CN108794615A (enExample) |
| AU (3) | AU2013381835A1 (enExample) |
| BR (1) | BR112015023105A8 (enExample) |
| CA (1) | CA2906313A1 (enExample) |
| DK (1) | DK2968485T3 (enExample) |
| ES (1) | ES2800028T3 (enExample) |
| IL (2) | IL241597B (enExample) |
| MX (2) | MX364689B (enExample) |
| PT (1) | PT2968485T (enExample) |
| RU (1) | RU2696566C2 (enExample) |
| SG (1) | SG11201507669YA (enExample) |
| TW (1) | TWI561529B (enExample) |
| WO (1) | WO2014143087A1 (enExample) |
| ZA (2) | ZA201507526B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| AU2015243990A1 (en) * | 2014-04-07 | 2016-11-10 | La Jolla Pharmaceutical Company | Hepcidin mimetic peptides and uses thereof |
| EP3409130B1 (en) | 2016-01-27 | 2020-11-25 | Industry-Academic Cooperation Foundation Gyeongsang National University | Composition for preventing, alleviating or treating neurological disorders, containing, as active ingredient, novel peptide activating adiponectin receptors |
| WO2017179646A1 (ja) * | 2016-04-14 | 2017-10-19 | Ｔａｏヘルスライフファーマ株式会社 | アミロスフェロイド（ａｓｐｄ）様構造体及び医薬組成物 |
| CN106565847B (zh) * | 2016-10-26 | 2020-12-01 | 清华大学 | 化合物、多肽及其用途 |
| US20210138049A1 (en) * | 2017-06-16 | 2021-05-13 | United Neuroscience | Peptide immunogens from the c-terminal end of alpha-synuclein protein and formulations thereof for treatment of synucleinopathies |
| AU2018355574B2 (en) * | 2017-10-27 | 2025-09-04 | United Neuroscience | Tau peptide immunogen constructs |
| KR102745247B1 (ko) * | 2017-12-11 | 2024-12-23 | 유비아이 아이피 홀딩스 | 아토피성 피부염의 치료 및/또는 예방을 위한 il-31의 펩타이드 면역원 및 이의 제형물 |
| WO2019133024A1 (en) * | 2017-12-31 | 2019-07-04 | United Biomedical, Inc. | Peptide immunogens and formulations thereof targeting membrane-bound ige for treatment of ige mediated allergic diseases |
| CA3091020A1 (en) * | 2018-02-13 | 2019-08-22 | Cedars-Sinai Medical Center | Methods and systems for identification and treatment of pathological neurodegeneration and age-related cognitive decline |
| PE20201344A1 (es) | 2018-04-10 | 2020-11-25 | Ac Immune Sa | Vacunas terapeuticas anti-abeta |
| WO2019213555A1 (en) * | 2018-05-04 | 2019-11-07 | Ubi Us Holdings, Llc | Artificial promiscuous t helper cell epitopes that facilitate targeted antibody production with limited t cell inflammatory response |
| TWI676635B (zh) * | 2018-06-15 | 2019-11-11 | 英屬開曼群島商聯腦科學公司 | α－突觸核蛋白Ｃ端胜肽免疫原及其用於治療突觸核蛋白疾病的配方 |
| US20210347866A1 (en) * | 2018-10-01 | 2021-11-11 | United Neuroscience | Peptide immunogen constructs directed against dipeptide repeat proteins from c9orf72 |
| WO2020132275A1 (en) * | 2018-12-19 | 2020-06-25 | Ubi Ip Holdings | Artificial promiscuous t helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| BR112021012668A2 (pt) * | 2018-12-28 | 2021-12-28 | United Biomedical Inc | Imunógenos de peptídeos que possuem como alvo interleucina 6 (il-6) e formulações dos mesmos para imunoterapia de doenças impactadas pela desregulação de il-6 |
| BR112021012906A2 (pt) * | 2018-12-31 | 2021-12-28 | United Neuroscience Ltd | Imunógenos de peptídeo que têm como alvo peptídeo relacionado ao gene da calcitonina (cgrp) e formulações dos mesmos para prevenção e tratamento de enxaqueca |
| CN110759987B (zh) * | 2019-10-29 | 2021-06-08 | 中国人民解放军军事科学院军事医学研究院 | 构象特异性的重组Aβ1-42样寡聚体抗原、其制备方法和应用 |
| BR112022014616A2 (pt) * | 2020-01-23 | 2022-12-13 | United Biomedical Inc | Imunógenos peptídicos de alvejamento de peptídeo ativador de adenilato ciclase pituitária (pacap) e formulações do mesmo para prevenção e tratamento de enxaqueca |
| US20230151069A1 (en) | 2020-03-10 | 2023-05-18 | Lifearc | Cyclic Peptides |
| AU2021385036A1 (en) | 2020-11-17 | 2023-06-08 | ILiAD Biotechnologies, Inc. | Treatment and prevention of neuropathology associated with neurodegenerative diseases |
| US20240159777A1 (en) * | 2021-03-16 | 2024-05-16 | Neurovision Imaging, Inc. | Biofluid-Based Methods for Diagnosing Alzheimer’s Disease-Associated Conditions |
| US20240241122A1 (en) * | 2021-05-20 | 2024-07-18 | Denka Company Limited | Anti-norovirus antibody |
| JP2024534269A (ja) * | 2021-08-30 | 2024-09-18 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 神経変性疾患を治療するための方法および物質 |
| US20250057928A1 (en) | 2021-12-08 | 2025-02-20 | Osaka University | Vaccine composition for inducing anti-il-23 antibody |
| US20250186580A1 (en) | 2022-02-28 | 2025-06-12 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE COMPRISING AT LEAST A ß-GLUCAN |
| CN117586370A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 强毒性淀粉样蛋白寡聚体及其用途 |
| KR102530956B1 (ko) * | 2022-09-08 | 2023-05-11 | 주식회사 알츠코리아 | 아밀로이드 베타 유래 에피토프를 유효성분으로 포함하는 알츠하이머성 치매 백신 조성물 및 이의 용도 |
| CN115417915B (zh) * | 2022-11-03 | 2023-02-24 | 北京引正基因科技有限公司 | 多肽载体及其应用 |
| CN117122612B (zh) * | 2023-07-07 | 2024-08-27 | 河络新图生物科技(上海)有限公司 | 外周血单个核细胞在制备治疗/预防阿尔茨海默病的药物中的用途 |
| WO2025109524A1 (en) | 2023-11-22 | 2025-05-30 | Ac Immune Sa | Assays and methods for assessing vaccine preparations |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753624A (en) | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
| JP2980677B2 (ja) | 1990-04-27 | 1999-11-22 | マクマイケル，ジョン | 不正常なアミロイドβタンパク質と関連する中枢神経系疾患状態の治療のための方法および組成物 |
| US5955317A (en) | 1993-01-25 | 1999-09-21 | Takeda Chemical Industries, Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
| EP0683234B2 (en) | 1993-01-25 | 2007-06-06 | Takeda Chemical Industries, Ltd. | Antibody against beta-amyloid or their derivative and use thereof |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| AU7043894A (en) | 1993-05-28 | 1994-12-20 | Miriam Hospital, The | Composition and method for (in vivo) imaging of amyloid deposits |
| WO1995011998A1 (en) | 1993-10-26 | 1995-05-04 | United Biomedical, Inc. | Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI229679B (en) | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| US6025468A (en) | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
| ES2344189T3 (es) | 1999-09-03 | 2010-08-20 | RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. | Agentes, composiciones y metodos que los utilizan utiles en el tratamiento o la prevencion de la enfermedad de alzheimer. |
| CN101935352A (zh) | 1999-12-08 | 2011-01-05 | 智力神经系统学公司 | 作为免疫原的嵌合肽及其抗体,以及利用嵌合肽或抗体进行免疫的方法 |
| US20030165481A1 (en) | 2000-02-24 | 2003-09-04 | Hersh Louis B. | Amyloid peptide inactivating enzyme to treat Alzheimer's disease |
| US20030083277A1 (en) * | 2000-02-24 | 2003-05-01 | Hersh Louis B. | Use of insulin degrading enzyme (IDE) for the treatment of alzheimer's disease in patients |
| US6906169B2 (en) | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| EP1523499A2 (en) * | 2002-07-24 | 2005-04-20 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
| JP2007522119A (ja) * | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
| US8034353B2 (en) * | 2006-02-22 | 2011-10-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Peptide vaccine for inducing the production of anti-amyloid β-peptide antibody |
| EP1996227A2 (en) * | 2006-02-24 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Anti-amyloid immunogenic compositions, methods and uses |
| WO2008021296A2 (en) * | 2006-08-14 | 2008-02-21 | Thymon, L.L.C. | Compositions and methods for the treatment and prophylaxis of alzheimer's disease |
| AT509611B1 (de) | 2008-06-12 | 2012-04-15 | Affiris Forschungs-Und Entwicklungs Gmbh | Vakzin |
| EP2342356A4 (en) * | 2008-09-29 | 2012-11-21 | Univ Ben Gurion | AMYLOID BETA PEPTIDASES AND METHOD OF USE THEREOF |
| US9067981B1 (en) * | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| US8916387B2 (en) * | 2010-10-28 | 2014-12-23 | Jonas Nilsson | Diagnosis and treatment of Alzheimer's disease |
| US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
-
2013
- 2013-03-15 US US13/843,883 patent/US9102752B2/en active Active
- 2013-04-23 SG SG11201507669YA patent/SG11201507669YA/en unknown
- 2013-04-23 DK DK13878092.9T patent/DK2968485T3/da active
- 2013-04-23 KR KR1020157029184A patent/KR101926030B1/ko active Active
- 2013-04-23 CA CA2906313A patent/CA2906313A1/en not_active Abandoned
- 2013-04-23 ES ES13878092T patent/ES2800028T3/es active Active
- 2013-04-23 JP JP2016500078A patent/JP6208319B2/ja active Active
- 2013-04-23 KR KR1020187034866A patent/KR20180132962A/ko not_active Ceased
- 2013-04-23 AU AU2013381835A patent/AU2013381835A1/en not_active Abandoned
- 2013-04-23 EP EP13878092.9A patent/EP2968485B1/en active Active
- 2013-04-23 RU RU2015142996A patent/RU2696566C2/ru active IP Right Revival
- 2013-04-23 CN CN201810667175.6A patent/CN108794615A/zh active Pending
- 2013-04-23 CN CN201380076473.3A patent/CN105228644B/zh active Active
- 2013-04-23 WO PCT/US2013/037865 patent/WO2014143087A1/en not_active Ceased
- 2013-04-23 PT PT138780929T patent/PT2968485T/pt unknown
- 2013-04-23 MX MX2015013235A patent/MX364689B/es active IP Right Grant
- 2013-04-23 BR BR112015023105A patent/BR112015023105A8/pt not_active Application Discontinuation
-
2014
- 2014-03-14 TW TW103109373A patent/TWI561529B/zh active
-
2015
- 2015-08-11 US US14/824,075 patent/US20160068581A1/en not_active Abandoned
- 2015-09-15 MX MX2019005268A patent/MX2019005268A/es unknown
- 2015-09-16 IL IL241597A patent/IL241597B/en active IP Right Grant
- 2015-10-09 ZA ZA2015/07526A patent/ZA201507526B/en unknown
-
2017
- 2017-05-22 AU AU2017203425A patent/AU2017203425B2/en not_active Ceased
- 2017-06-07 JP JP2017112424A patent/JP6784646B2/ja active Active
-
2018
- 2018-04-19 US US15/957,798 patent/US20180244739A1/en not_active Abandoned
- 2018-12-31 US US16/237,531 patent/US20190194280A1/en not_active Abandoned
-
2019
- 2019-04-08 IL IL265910A patent/IL265910A/en unknown
- 2019-07-26 JP JP2019137534A patent/JP2019196397A/ja active Pending
- 2019-10-10 ZA ZA2019/06683A patent/ZA201906683B/en unknown
- 2019-10-11 AU AU2019246916A patent/AU2019246916A1/en not_active Abandoned
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