JP2016513638A5 - - Google Patents
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- JP2016513638A5 JP2016513638A5 JP2016500078A JP2016500078A JP2016513638A5 JP 2016513638 A5 JP2016513638 A5 JP 2016513638A5 JP 2016500078 A JP2016500078 A JP 2016500078A JP 2016500078 A JP2016500078 A JP 2016500078A JP 2016513638 A5 JP2016513638 A5 JP 2016513638A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- peptide
- seq
- nos
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 6
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 5
- 239000002671 adjuvant Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 229910017119 AlPO Inorganic materials 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/843,883 US9102752B2 (en) | 2013-03-15 | 2013-03-15 | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| US13/843,883 | 2013-03-15 | ||
| PCT/US2013/037865 WO2014143087A1 (en) | 2013-03-15 | 2013-04-23 | Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017112424A Division JP6784646B2 (ja) | 2013-03-15 | 2017-06-07 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513638A JP2016513638A (ja) | 2016-05-16 |
| JP2016513638A5 true JP2016513638A5 (enExample) | 2016-06-23 |
| JP6208319B2 JP6208319B2 (ja) | 2017-10-04 |
Family
ID=51527985
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500078A Active JP6208319B2 (ja) | 2013-03-15 | 2013-04-23 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
| JP2017112424A Active JP6784646B2 (ja) | 2013-03-15 | 2017-06-07 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
| JP2019137534A Pending JP2019196397A (ja) | 2013-03-15 | 2019-07-26 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017112424A Active JP6784646B2 (ja) | 2013-03-15 | 2017-06-07 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
| JP2019137534A Pending JP2019196397A (ja) | 2013-03-15 | 2019-07-26 | アルツハイマー型認知症の予防用及び免疫療法用ペプチドワクチン |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9102752B2 (enExample) |
| EP (1) | EP2968485B1 (enExample) |
| JP (3) | JP6208319B2 (enExample) |
| KR (2) | KR101926030B1 (enExample) |
| CN (2) | CN108794615A (enExample) |
| AU (3) | AU2013381835A1 (enExample) |
| BR (1) | BR112015023105A8 (enExample) |
| CA (1) | CA2906313A1 (enExample) |
| DK (1) | DK2968485T3 (enExample) |
| ES (1) | ES2800028T3 (enExample) |
| IL (2) | IL241597B (enExample) |
| MX (2) | MX364689B (enExample) |
| PT (1) | PT2968485T (enExample) |
| RU (1) | RU2696566C2 (enExample) |
| SG (1) | SG11201507669YA (enExample) |
| TW (1) | TWI561529B (enExample) |
| WO (1) | WO2014143087A1 (enExample) |
| ZA (2) | ZA201507526B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| WO2015157283A1 (en) * | 2014-04-07 | 2015-10-15 | Merganser Biotech Llc | Hepdicin mimetic peptides and uses thereof |
| EP3409130B1 (en) | 2016-01-27 | 2020-11-25 | Industry-Academic Cooperation Foundation Gyeongsang National University | Composition for preventing, alleviating or treating neurological disorders, containing, as active ingredient, novel peptide activating adiponectin receptors |
| EP3444344A4 (en) * | 2016-04-14 | 2020-02-19 | TAO Health Life Pharma Co., Ltd. | AMYLOSPHEROID TYPE STRUCTURE (ASPD) AND PHARMACEUTICAL COMPOSITION |
| CN106565847B (zh) * | 2016-10-26 | 2020-12-01 | 清华大学 | 化合物、多肽及其用途 |
| BR112019026707A2 (pt) * | 2017-06-16 | 2020-06-30 | United Neuroscience | imunógenos de peptídeo da extremidade c-terminal da proteína alfa-sinucleína e formulações dos mesmos para o tratamento de sinucleinopatias |
| EP3700558A4 (en) * | 2017-10-27 | 2022-03-09 | United Neuroscience | TAU PEPTIDE IMMUNOGENIC CONSTRUCTIONS |
| CA3085318A1 (en) * | 2017-12-11 | 2019-06-20 | Ubi Ip Holdings | Peptide immunogens of il-31 and formulations thereof for the treatment and/or prevention of atopic dermatitis |
| CN111565801B (zh) * | 2017-12-31 | 2023-11-10 | 美国联合生物医学公司 | 用于IgE介导过敏性疾病治疗的靶向膜结合型IgE的肽免疫原及其剂型 |
| WO2019160978A1 (en) * | 2018-02-13 | 2019-08-22 | Cedars-Sinai Medical Center | Methods and systems for identification and treatment of pathological neurodegeneration and age-related cognitive decline |
| US10828351B2 (en) | 2018-04-10 | 2020-11-10 | Ac Immune Sa | Anti-abeta therapeutic vaccines |
| CA3099296A1 (en) * | 2018-05-04 | 2019-11-07 | Ubi Ip Holdings | Artificial promiscuous t helper cell epitopes that facilitate targeted antibody production with limited t cell inflammatory response |
| TWI676635B (zh) * | 2018-06-15 | 2019-11-11 | 英屬開曼群島商聯腦科學公司 | α－突觸核蛋白Ｃ端胜肽免疫原及其用於治療突觸核蛋白疾病的配方 |
| CN113227116A (zh) * | 2018-10-01 | 2021-08-06 | 联脑科学公司 | 针对源自c9orf72二肽重复蛋白的肽免疫原构建体 |
| PE20212156A1 (es) * | 2018-12-19 | 2021-11-09 | United Biomedical Inc | Epitopos artificiales promiscuos de linfocitos t colaboradores como estimuladores inmunes para inmunogenos peptidicos inteticos |
| KR20210110842A (ko) * | 2018-12-28 | 2021-09-09 | 유나이티드 바이오메디칼 인크. | 인터루킨 6(il-6)을 표적화하는 펩타이드 면역원 및 il-6 조절장애에 의해 영향을 받는 질환의 면역요법을 위한 이의 제형 |
| AU2019418627A1 (en) * | 2018-12-31 | 2021-07-29 | United Neuroscience Limited | Peptide immunogens targeting Calcitonin Gene-Related Peptide (CGRP) and formulations thereof for prevention and treatment of migraine |
| CN110759987B (zh) * | 2019-10-29 | 2021-06-08 | 中国人民解放军军事科学院军事医学研究院 | 构象特异性的重组Aβ1-42样寡聚体抗原、其制备方法和应用 |
| WO2021150910A1 (en) * | 2020-01-23 | 2021-07-29 | Ubi Ip Holdings | Peptide immunogens targeting pituitary adenylate cyclase-activating peptide (pacap) and formulations thereof for prevention and treatment of migraine |
| KR20230016164A (ko) | 2020-03-10 | 2023-02-01 | 라이프아크 | 시클릭 펩티드 |
| CN116635517A (zh) | 2020-11-17 | 2023-08-22 | 伊利亚德生物技术有限公司 | 与神经退行性疾病相关的神经病理的治疗和预防 |
| WO2022197651A1 (en) * | 2021-03-16 | 2022-09-22 | Neurovision Imaging, Inc. | Biofluid-based methods for diagnosing alzheimer's disease-associated conditions |
| WO2023034324A2 (en) * | 2021-08-30 | 2023-03-09 | The Brigham And Women’S Hospital, Inc. | Methods and materials to treat neurodegenerative disease |
| US20250057928A1 (en) | 2021-12-08 | 2025-02-20 | Osaka University | Vaccine composition for inducing anti-il-23 antibody |
| EP4486387A1 (en) | 2022-02-28 | 2025-01-08 | Tridem Bioscience GmbH & Co KG | A conjugate consisting of or comprising at least a ss-glucan or a mannan |
| KR102530956B1 (ko) * | 2022-09-08 | 2023-05-11 | 주식회사 알츠코리아 | 아밀로이드 베타 유래 에피토프를 유효성분으로 포함하는 알츠하이머성 치매 백신 조성물 및 이의 용도 |
| CN115417915B (zh) * | 2022-11-03 | 2023-02-24 | 北京引正基因科技有限公司 | 多肽载体及其应用 |
| CN117122612B (zh) * | 2023-07-07 | 2024-08-27 | 河络新图生物科技(上海)有限公司 | 外周血单个核细胞在制备治疗/预防阿尔茨海默病的药物中的用途 |
| WO2025109524A1 (en) | 2023-11-22 | 2025-05-30 | Ac Immune Sa | Assays and methods for assessing vaccine preparations |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2980677B2 (ja) | 1990-04-27 | 1999-11-22 | マクマイケル，ジョン | 不正常なアミロイドβタンパク質と関連する中枢神経系疾患状態の治療のための方法および組成物 |
| US5753624A (en) | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
| WO1994017197A1 (fr) | 1993-01-25 | 1994-08-04 | Takeda Chemical Industries, Ltd. | ANTICORPS DIRIGE CONTRE LE β-AMYLOIDE OU UN DERIVE DE CE DERNIER ET SON UTILISATION |
| US5955317A (en) | 1993-01-25 | 1999-09-21 | Takeda Chemical Industries, Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| WO1994028412A1 (en) | 1993-05-28 | 1994-12-08 | The Miriam Hospital | Composition and method for in vivo imaging of amyloid deposits |
| AU8091694A (en) | 1993-10-26 | 1995-05-22 | United Biomedical Inc. | Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6025468A (en) | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
| TWI229679B (en) | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| AU784568B2 (en) | 1999-09-03 | 2006-05-04 | Ramot At Tel-Aviv University Ltd | Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases |
| JP4804690B2 (ja) | 1999-12-08 | 2011-11-02 | インテレクト・ニューロサイエンシズ・インコーポレーテッド | 免疫原としてのキメラペプチド、それに対する抗体、およびキメラペプチドまたは抗体を用いた免疫法 |
| US20030083277A1 (en) * | 2000-02-24 | 2003-05-01 | Hersh Louis B. | Use of insulin degrading enzyme (IDE) for the treatment of alzheimer's disease in patients |
| US20030165481A1 (en) | 2000-02-24 | 2003-09-04 | Hersh Louis B. | Amyloid peptide inactivating enzyme to treat Alzheimer's disease |
| US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| CA2487528A1 (en) * | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Prevention, treatment and diagnosis of diseases associated with beta-amyloid formation and/or aggregation |
| JP2007522119A (ja) * | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
| CA2638775A1 (en) * | 2006-02-22 | 2007-08-30 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Peptide vaccine for inducing production of anti-amyloid-.beta.-peptide antibody |
| CN101384279B (zh) * | 2006-02-24 | 2012-02-22 | 奇斯药制品公司 | 抗淀粉样蛋白免疫原性组合物、方法和用途 |
| WO2008021296A2 (en) * | 2006-08-14 | 2008-02-21 | Thymon, L.L.C. | Compositions and methods for the treatment and prophylaxis of alzheimer's disease |
| AT506820B1 (de) * | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
| WO2010035261A2 (en) * | 2008-09-29 | 2010-04-01 | Ben Gurion University Of The Negev Research And Development Authority | Amyloid beta-peptides and methods of use thereof |
| US9067981B1 (en) * | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| WO2012056008A1 (en) * | 2010-10-28 | 2012-05-03 | Jonas Nilsson | Diagnosis and treatment of alzheimer's disease |
| US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
-
2013
- 2013-03-15 US US13/843,883 patent/US9102752B2/en active Active
- 2013-04-23 RU RU2015142996A patent/RU2696566C2/ru active IP Right Revival
- 2013-04-23 KR KR1020157029184A patent/KR101926030B1/ko active Active
- 2013-04-23 ES ES13878092T patent/ES2800028T3/es active Active
- 2013-04-23 KR KR1020187034866A patent/KR20180132962A/ko not_active Ceased
- 2013-04-23 DK DK13878092.9T patent/DK2968485T3/da active
- 2013-04-23 CN CN201810667175.6A patent/CN108794615A/zh active Pending
- 2013-04-23 SG SG11201507669YA patent/SG11201507669YA/en unknown
- 2013-04-23 CN CN201380076473.3A patent/CN105228644B/zh active Active
- 2013-04-23 CA CA2906313A patent/CA2906313A1/en not_active Abandoned
- 2013-04-23 JP JP2016500078A patent/JP6208319B2/ja active Active
- 2013-04-23 EP EP13878092.9A patent/EP2968485B1/en active Active
- 2013-04-23 WO PCT/US2013/037865 patent/WO2014143087A1/en not_active Ceased
- 2013-04-23 BR BR112015023105A patent/BR112015023105A8/pt not_active Application Discontinuation
- 2013-04-23 AU AU2013381835A patent/AU2013381835A1/en not_active Abandoned
- 2013-04-23 PT PT138780929T patent/PT2968485T/pt unknown
- 2013-04-23 MX MX2015013235A patent/MX364689B/es active IP Right Grant
-
2014
- 2014-03-14 TW TW103109373A patent/TWI561529B/zh active
-
2015
- 2015-08-11 US US14/824,075 patent/US20160068581A1/en not_active Abandoned
- 2015-09-15 MX MX2019005268A patent/MX2019005268A/es unknown
- 2015-09-16 IL IL241597A patent/IL241597B/en active IP Right Grant
- 2015-10-09 ZA ZA2015/07526A patent/ZA201507526B/en unknown
-
2017
- 2017-05-22 AU AU2017203425A patent/AU2017203425B2/en not_active Ceased
- 2017-06-07 JP JP2017112424A patent/JP6784646B2/ja active Active
-
2018
- 2018-04-19 US US15/957,798 patent/US20180244739A1/en not_active Abandoned
- 2018-12-31 US US16/237,531 patent/US20190194280A1/en not_active Abandoned
-
2019
- 2019-04-08 IL IL265910A patent/IL265910A/en unknown
- 2019-07-26 JP JP2019137534A patent/JP2019196397A/ja active Pending
- 2019-10-10 ZA ZA2019/06683A patent/ZA201906683B/en unknown
- 2019-10-11 AU AU2019246916A patent/AU2019246916A1/en not_active Abandoned
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