JP2013536240A5 - - Google Patents
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- JP2013536240A5 JP2013536240A5 JP2013526099A JP2013526099A JP2013536240A5 JP 2013536240 A5 JP2013536240 A5 JP 2013536240A5 JP 2013526099 A JP2013526099 A JP 2013526099A JP 2013526099 A JP2013526099 A JP 2013526099A JP 2013536240 A5 JP2013536240 A5 JP 2013536240A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- pharmaceutical composition
- composition according
- epha2
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 108010055196 EphA2 Receptor Proteins 0.000 claims 10
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims 10
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims 10
- 108010002687 Survivin Proteins 0.000 claims 7
- 210000004443 dendritic cell Anatomy 0.000 claims 5
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 5
- 239000003607 modifier Substances 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 102100038196 Chitinase-3-like protein 1 Human genes 0.000 claims 4
- 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 claims 4
- 102100022748 Wilms tumor protein Human genes 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 239000012648 POLY-ICLC Substances 0.000 claims 1
- 229940000425 combination drug Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 108700002563 poly ICLC Proteins 0.000 claims 1
- 229940115270 poly iclc Drugs 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37658210P | 2010-08-24 | 2010-08-24 | |
| US61/376,582 | 2010-08-24 | ||
| PCT/US2011/048823 WO2012027379A2 (en) | 2010-08-24 | 2011-08-23 | Interleukin-13 receptor alpha 2 peptide-based brain cancer vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016139885A Division JP6511021B2 (ja) | 2010-08-24 | 2016-07-15 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013536240A JP2013536240A (ja) | 2013-09-19 |
| JP2013536240A5 true JP2013536240A5 (enExample) | 2014-10-02 |
Family
ID=45724024
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526099A Pending JP2013536240A (ja) | 2010-08-24 | 2011-08-23 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
| JP2016139885A Active JP6511021B2 (ja) | 2010-08-24 | 2016-07-15 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
| JP2019072379A Active JP6931240B2 (ja) | 2010-08-24 | 2019-04-05 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
| JP2021129288A Pending JP2021181464A (ja) | 2010-08-24 | 2021-08-05 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
| JP2023146554A Pending JP2023175764A (ja) | 2010-08-24 | 2023-09-08 | インターロイキン－１３受容体α２ペプチド脳がんワクチン |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016139885A Active JP6511021B2 (ja) | 2010-08-24 | 2016-07-15 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
| JP2019072379A Active JP6931240B2 (ja) | 2010-08-24 | 2019-04-05 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
| JP2021129288A Pending JP2021181464A (ja) | 2010-08-24 | 2021-08-05 | インターロイキン−１３受容体α２ペプチド脳がんワクチン |
| JP2023146554A Pending JP2023175764A (ja) | 2010-08-24 | 2023-09-08 | インターロイキン－１３受容体α２ペプチド脳がんワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20120052080A1 (enExample) |
| EP (3) | EP2608799B1 (enExample) |
| JP (5) | JP2013536240A (enExample) |
| AU (1) | AU2011293522B2 (enExample) |
| CA (2) | CA2809362C (enExample) |
| DK (1) | DK2608799T3 (enExample) |
| ES (2) | ES2930809T3 (enExample) |
| MX (1) | MX353165B (enExample) |
| WO (1) | WO2012027379A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612162B2 (en) | 2004-09-21 | 2009-11-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response |
| EP2565201B1 (en) | 2005-10-17 | 2014-11-26 | Sloan-Kettering Institute For Cancer Research | WT1 HLA class II-binding peptides and compositions and methods comprising same |
| EP2010209B1 (en) | 2006-04-10 | 2016-06-15 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and methods of use thereof |
| CA2700573C (en) | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| US8871211B2 (en) * | 2006-09-28 | 2014-10-28 | Cedars-Sinai Medical Center | Cancer vaccines and vaccination methods |
| PL2328923T3 (pl) * | 2008-09-02 | 2016-06-30 | Cedars Sinai Medical Center | Epitopy CD133 |
| DK2608799T3 (en) | 2010-08-24 | 2019-03-18 | Univ Pittsburgh Commonwealth Sys Higher Education | INTERLEUKIN 13-RECEPTOR-ALPHA 2-PEPTIDE-BASED BRAIN CANCER VACCINES |
| US9187534B2 (en) * | 2011-03-11 | 2015-11-17 | Universite De Geneve | Multi-epitopic vaccine |
| CN104684577B (zh) | 2012-01-13 | 2018-05-08 | 纪念斯隆凯特林癌症中心 | 免疫原性wt-1肽及其使用方法 |
| ES2887580T3 (es) * | 2012-03-19 | 2021-12-23 | Stemline Therapeutics Inc | Métodos para el tratamiento y seguimiento del estado del cáncer |
| WO2013148649A1 (en) | 2012-03-26 | 2013-10-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of survivin antagonists in polyomavirus-related disease |
| EP2849772A4 (en) * | 2012-05-16 | 2016-03-02 | Stemline Therapeutics Inc | TUMOR VACCINES TREATED AGAINST CANCER STEM CELLS |
| AU2013299724A1 (en) * | 2012-08-07 | 2015-02-26 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| CA2884677C (en) | 2012-09-13 | 2020-06-23 | Universite De Geneve | Cell penetrating peptides derived from the epstein barr virus, compositions and methods thereof |
| WO2014070663A1 (en) * | 2012-10-29 | 2014-05-08 | Anderson David E | Compositions and methods for diagnosis and treatment of malignant gliomas |
| CA2888803A1 (en) * | 2012-11-05 | 2014-05-08 | Jooeun Bae | Xbp1, cd138, and cs1 peptides, pharmaceutical compositions that include the peptides, and methods of using such peptides and compositions |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| KR102045029B1 (ko) * | 2013-02-05 | 2019-11-14 | 닛토덴코 가부시키가이샤 | 점막 투여용 ｗｔ1 펩티드 암 백신 조성물 |
| US20140234351A1 (en) | 2013-02-14 | 2014-08-21 | Immunocellular Therapeutics, Ltd. | Cancer vaccines and vaccination methods |
| US9868788B2 (en) | 2013-03-15 | 2018-01-16 | Wake Forest University Health Sciences | Antibodies against human and canine IL-13RA2 |
| CN105324128B (zh) * | 2013-03-27 | 2020-09-01 | 免疫疫苗技术有限公司 | 用于改善存活蛋白疫苗在癌症治疗中的功效的方法 |
| US20170035917A1 (en) * | 2013-06-10 | 2017-02-09 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| US10456470B2 (en) | 2013-08-30 | 2019-10-29 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP4052724A1 (en) * | 2013-12-06 | 2022-09-07 | The Broad Institute Inc. | Formulations for neoplasia vaccines |
| BR112016014410A2 (pt) | 2013-12-20 | 2018-02-20 | The Broad Institute Inc. | terapia de combinação com vacina de neoantígeno |
| CN103768595B (zh) * | 2014-01-27 | 2016-03-02 | 中国医学科学院医学生物学研究所 | 唑来膦酸佐剂及含唑来膦酸佐剂的疫苗 |
| WO2016011052A1 (en) | 2014-07-14 | 2016-01-21 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| EP3234130B1 (en) | 2014-12-19 | 2020-11-25 | The Broad Institute, Inc. | Methods for profiling the t-cell- receptor repertoire |
| EP3234193B1 (en) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molecular biomarkers for cancer immunotherapy |
| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
| BR112017024797A2 (pt) | 2015-05-20 | 2018-08-07 | The Broad Institute Inc. | neoantígenos partilhados |
| RU2748378C2 (ru) | 2016-03-16 | 2021-05-25 | Амаль Терапьютикс Са | Комбинация модулятора иммунных контрольных точек и комплекса, содержащего проникающий в клетку пептид, карго-молекулу и пептидный агонист tlr, для применения в медицине |
| DK3515476T3 (da) | 2016-09-21 | 2024-09-02 | Amal Therapeutics Sa | Fusion der omfatter et cellepenetrerende peptid, en multiepitop og en trl-peptidagnost til behandlingen af cancer |
| WO2018065628A2 (en) | 2016-10-07 | 2018-04-12 | Enterome | Microbiota sequence variants of tumor-related antigenic epitopes |
| IL302345B2 (en) | 2016-10-07 | 2024-12-01 | Enterome S A | Immunogenic compounds for cancer therapy |
| CN110022894B (zh) * | 2016-10-07 | 2024-01-19 | 恩特罗姆公司 | 用于癌症疗法的免疫原性化合物 |
| US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| CN111201032B (zh) * | 2017-10-09 | 2024-05-31 | 恩特罗姆公司 | 肿瘤相关抗原表位的小型生物群序列变体 |
| JP2018070629A (ja) * | 2017-11-28 | 2018-05-10 | イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | がんの処置におけるサバイビンワクチンの有効性を向上させるための方法 |
| CN107903305B (zh) * | 2017-12-25 | 2020-11-13 | 陕西慧康生物科技有限责任公司 | 一种固液联合合成地索莫泰的方法 |
| WO2019197563A2 (en) * | 2018-04-11 | 2019-10-17 | Enterome S.A. | Immunogenic compounds for treatment of fibrosis, autoimmune diseases and inflammation |
| ES2935702T3 (es) | 2018-04-11 | 2023-03-09 | Enterome S A | Péptidos antigénicos para la prevención y el tratamiento del cáncer |
| JP7591829B2 (ja) * | 2019-08-05 | 2024-11-29 | 国立大学法人佐賀大学 | 中空コラーゲンゲル |
| DE102019214359A1 (de) * | 2019-09-20 | 2021-03-25 | Siemens Healthcare Gmbh | Verfahren zu einer adaptiven Ansteuerung eines Magnetresonanzgerätes |
Family Cites Families (35)
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| CA117152A (en) | 1908-12-04 | 1909-03-09 | George A. Stebbins | Sulphur burner |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US6419931B1 (en) | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
| ATE161190T1 (de) | 1991-10-07 | 1998-01-15 | Biogen Inc | Vorbeugungsmethode oder behandlung von, durch antigen-präsentierende zellen hervorgerufene, hautkrankheiten mittels inhibitoren der cd2/lfa-3 wechselwirkung |
| US6162432A (en) | 1991-10-07 | 2000-12-19 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
| JPH10510988A (ja) | 1994-12-14 | 1998-10-27 | ザ スクリップス リサーチ インスティテュート | 腫瘍−特異的細胞毒性ｔ細胞のインビボ活性化 |
| WO2001058479A1 (en) | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| US20020012946A1 (en) | 2000-02-23 | 2002-01-31 | Luiz Belardinelli | Method of identifying partial agonists of the A2A receptor |
| AU2002322478A1 (en) | 2001-03-02 | 2002-12-16 | Medimmune, Inc. | Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders |
| WO2002070007A1 (en) | 2001-03-02 | 2002-09-12 | Medimmune, Inc. | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
| FR2838742B1 (fr) | 2002-04-23 | 2004-07-09 | Inst Nat Sante Rech Med | Epitopes t de l'antigene epha2 |
| WO2004087758A2 (en) * | 2003-03-26 | 2004-10-14 | Neopharm, Inc. | Il 13 receptor alpha 2 antibody and methods of use |
| KR20110094361A (ko) | 2003-04-11 | 2011-08-23 | 메디뮨 엘엘씨 | 재조합 ｉｌ９ 항체 및 그의 용도 |
| JP5156882B2 (ja) * | 2003-04-18 | 2013-03-06 | アイディーエム ファーマ，インコーポレイティド | Ｈｌａ−ａ２腫瘍関連抗原ペプチドおよび組成物 |
| JP2004353820A (ja) | 2003-05-30 | 2004-12-16 | Toyota Motor Corp | トリポート型等速ジョイント部品およびトリポート型等速ジョイント |
| CA2533789C (en) * | 2003-07-30 | 2013-09-17 | University Of Pittsburgh Of The Commnonwealth System Of Higher Education | Epha2 t-cell epitope agonists and uses therefor |
| IL158140A0 (en) * | 2003-09-25 | 2004-03-28 | Hadasit Med Res Service | Multiepitope polypeptides for cancer immunotherapy |
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| RU2367468C2 (ru) * | 2003-11-19 | 2009-09-20 | Мерк Патент Гмбх | БЕЛКИ, ОТНОСЯЩИЕСЯ К СЕМЕЙСТВУ Всl-2, И ИХ ФРАГМЕНТЫ И ИХ ПРИМЕНЕНИЕ У ПАЦИЕНТОВ СО ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛЬЮ |
| JP2007516966A (ja) | 2003-12-01 | 2007-06-28 | スローン−ケターリング インスティチュート フォー キャンサー リサーチ | 合成ｈｌａ結合ペプチド類似体及びその使用方法 |
| US20050153923A1 (en) | 2003-12-04 | 2005-07-14 | Kinch Michael S. | Targeted drug delivery using EphA2 or EphA4 binding moieties |
| EP1732580A4 (en) * | 2003-12-24 | 2008-01-23 | Medimmune Inc | EPHA2 VACCINES |
| US7612162B2 (en) | 2004-09-21 | 2009-11-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response |
| WO2006062094A1 (ja) | 2004-12-07 | 2006-06-15 | Toray Industries, Inc. | 新規癌抗原ペプチド及びその用途 |
| EP2565201B1 (en) * | 2005-10-17 | 2014-11-26 | Sloan-Kettering Institute For Cancer Research | WT1 HLA class II-binding peptides and compositions and methods comprising same |
| US8063063B2 (en) | 2006-03-23 | 2011-11-22 | Novartis Ag | Immunopotentiating compounds |
| EP2010537B1 (en) | 2006-03-23 | 2011-12-28 | Novartis AG | Imidazoquinoxaline compounds as immunomodulators |
| US8871211B2 (en) * | 2006-09-28 | 2014-10-28 | Cedars-Sinai Medical Center | Cancer vaccines and vaccination methods |
| ES2529193T3 (es) | 2007-07-19 | 2015-02-17 | Health Research, Inc. | Péptidos de survivina como vacunas contra el cáncer |
| JP5478260B2 (ja) * | 2007-12-05 | 2014-04-23 | 株式会社癌免疫研究所 | 癌ワクチン組成物 |
| RS53782B1 (sr) | 2008-10-01 | 2015-06-30 | Immatics Biotechnologies Gmbh | Preparati tumor-asociranih peptida i odgovarajuća antikancerska vakcina za tretman glioblastoma (gbm) i drugih kancera |
| US8728806B2 (en) * | 2008-12-06 | 2014-05-20 | The Board Of Regents, The University Of Texas System | Methods and compositions related to Th-1 dendritic cells |
| WO2011100754A1 (en) * | 2010-02-15 | 2011-08-18 | The Trustees Of The University Of Pennsylvania | Live listeria-based vaccines for central nervous system therapy |
| DK2608799T3 (en) | 2010-08-24 | 2019-03-18 | Univ Pittsburgh Commonwealth Sys Higher Education | INTERLEUKIN 13-RECEPTOR-ALPHA 2-PEPTIDE-BASED BRAIN CANCER VACCINES |
-
2011
- 2011-08-23 DK DK11820530.1T patent/DK2608799T3/en active
- 2011-08-23 CA CA2809362A patent/CA2809362C/en active Active
- 2011-08-23 US US13/215,938 patent/US20120052080A1/en not_active Abandoned
- 2011-08-23 ES ES18211075T patent/ES2930809T3/es active Active
- 2011-08-23 AU AU2011293522A patent/AU2011293522B2/en active Active
- 2011-08-23 EP EP11820530.1A patent/EP2608799B1/en active Active
- 2011-08-23 ES ES11820530T patent/ES2722799T3/es active Active
- 2011-08-23 JP JP2013526099A patent/JP2013536240A/ja active Pending
- 2011-08-23 CA CA3066981A patent/CA3066981A1/en active Pending
- 2011-08-23 MX MX2013002207A patent/MX353165B/es active IP Right Grant
- 2011-08-23 EP EP18211075.9A patent/EP3511013B1/en active Active
- 2011-08-23 WO PCT/US2011/048823 patent/WO2012027379A2/en not_active Ceased
- 2011-08-23 EP EP22193769.1A patent/EP4159226A1/en active Pending
-
2013
- 2013-06-24 US US13/925,093 patent/US20130295046A1/en not_active Abandoned
-
2014
- 2014-10-16 US US14/515,939 patent/US20150258185A1/en not_active Abandoned
-
2015
- 2015-05-28 US US14/724,127 patent/US10874730B2/en not_active Expired - Lifetime
-
2016
- 2016-07-15 JP JP2016139885A patent/JP6511021B2/ja active Active
-
2019
- 2019-04-05 JP JP2019072379A patent/JP6931240B2/ja active Active
-
2020
- 2020-12-02 US US17/109,463 patent/US20210338790A1/en not_active Abandoned
-
2021
- 2021-08-05 JP JP2021129288A patent/JP2021181464A/ja active Pending
-
2023
- 2023-09-08 JP JP2023146554A patent/JP2023175764A/ja active Pending
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