ZA201507526B - Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type - Google Patents
Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's typeInfo
- Publication number
- ZA201507526B ZA201507526B ZA2015/07526A ZA201507526A ZA201507526B ZA 201507526 B ZA201507526 B ZA 201507526B ZA 2015/07526 A ZA2015/07526 A ZA 2015/07526A ZA 201507526 A ZA201507526 A ZA 201507526A ZA 201507526 B ZA201507526 B ZA 201507526B
- Authority
- ZA
- South Africa
- Prior art keywords
- immunotherapy
- dementia
- alzheimer
- prevention
- type
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/843,883 US9102752B2 (en) | 2013-03-15 | 2013-03-15 | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| PCT/US2013/037865 WO2014143087A1 (en) | 2013-03-15 | 2013-04-23 | Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201507526B true ZA201507526B (en) | 2019-12-18 |
Family
ID=51527985
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2015/07526A ZA201507526B (en) | 2013-03-15 | 2015-10-09 | Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type |
| ZA2019/06683A ZA201906683B (en) | 2013-03-15 | 2019-10-10 | Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2019/06683A ZA201906683B (en) | 2013-03-15 | 2019-10-10 | Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9102752B2 (enExample) |
| EP (1) | EP2968485B1 (enExample) |
| JP (3) | JP6208319B2 (enExample) |
| KR (2) | KR20180132962A (enExample) |
| CN (2) | CN105228644B (enExample) |
| AU (3) | AU2013381835A1 (enExample) |
| BR (1) | BR112015023105A8 (enExample) |
| CA (1) | CA2906313A1 (enExample) |
| DK (1) | DK2968485T3 (enExample) |
| ES (1) | ES2800028T3 (enExample) |
| IL (2) | IL241597B (enExample) |
| MX (2) | MX364689B (enExample) |
| PT (1) | PT2968485T (enExample) |
| RU (1) | RU2696566C2 (enExample) |
| SG (1) | SG11201507669YA (enExample) |
| TW (1) | TWI561529B (enExample) |
| WO (1) | WO2014143087A1 (enExample) |
| ZA (2) | ZA201507526B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| KR20170002414A (ko) * | 2014-04-07 | 2017-01-06 | 멀겐져 바이오텍, 아이엔씨. | 헵시딘 모방 펩티드 및 그 용도 |
| EP3409130B1 (en) * | 2016-01-27 | 2020-11-25 | Industry-Academic Cooperation Foundation Gyeongsang National University | Composition for preventing, alleviating or treating neurological disorders, containing, as active ingredient, novel peptide activating adiponectin receptors |
| KR20180134373A (ko) * | 2016-04-14 | 2018-12-18 | 타오 헬스 라이프 파마 가부시키가이샤 | 아밀로스페로이드(aspd)형 구조체 및 의약 조성물 |
| CN106565847B (zh) * | 2016-10-26 | 2020-12-01 | 清华大学 | 化合物、多肽及其用途 |
| JP2021508672A (ja) * | 2017-06-16 | 2021-03-11 | ユナイテッド ニューロサイエンスＵｎｉｔｅｄ Ｎｅｕｒｏｓｃｉｅｎｃｅ | シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のｃ末端からのペプチド免疫原及びその製剤 |
| JP2021508673A (ja) * | 2017-10-27 | 2021-03-11 | ユナイテッド ニューロサイエンスＵｎｉｔｅｄ Ｎｅｕｒｏｓｃｉｅｎｃｅ | タウペプチド免疫原構築物 |
| US20210079054A1 (en) * | 2017-12-11 | 2021-03-18 | Ubi Us Holdings, Llc. | Peptide immunogens of il-31 and formulations thereof for the treatment and/or prevention of atopic dermatitis |
| KR20240110105A (ko) * | 2017-12-31 | 2024-07-12 | 유나이티드 바이오메디칼 인크. | Ige 매개 알레르기 질환의 치료를 위한 막 결합 ige를 표적하는 펩티드 면역원 및 이의 제제 |
| EP3752523A4 (en) * | 2018-02-13 | 2021-11-17 | Cedars-Sinai Medical Center | PROCEDURES AND SYSTEMS FOR IDENTIFICATION AND TREATMENT OF PATHOLOGICAL NEURODEGENERATION AND AGE-RELATED COGNITIVE DEGRADATION |
| MA52180A (fr) | 2018-04-10 | 2021-02-17 | Ac Immune Sa | Vaccins thérapeutiques anti-abêta |
| JP2021523127A (ja) * | 2018-05-04 | 2021-09-02 | ユービーアイ アイピー ホールディングスＵｂｉ Ｉｐ Ｈｏｌｄｉｎｇｓ | 限られたｔ細胞炎症反応で標的抗体産生を促進する人工的な無差別ｔヘルパー細胞エピトープ |
| TWI676635B (zh) * | 2018-06-15 | 2019-11-11 | 英屬開曼群島商聯腦科學公司 | α－突觸核蛋白Ｃ端胜肽免疫原及其用於治療突觸核蛋白疾病的配方 |
| CA3114657A1 (en) * | 2018-10-01 | 2020-04-09 | United Neuroscience | Peptide immunogen constructs directed against dipeptide repeat proteins from c9orf72 |
| MX2021007446A (es) * | 2018-12-19 | 2021-09-08 | United Biomedical Inc | Epítopos artificiales promiscuos de linfocitos t colaboradores como estimuladores inmunes para inmunógenos peptídicos sintéticos. |
| MX2021007906A (es) | 2018-12-28 | 2021-10-13 | United Biomedical Inc | Nmunógenos peptídicos dirigidos a la interleucina 6 (il-6) y sus formulaciones para la inmunoterapia de enfermedades afectadas por la desregulación de la il-6. |
| MX2021008035A (es) | 2018-12-31 | 2021-12-10 | United Neuroscience Ltd | Inmunógenos peptídicos dirigidos al péptido relacionado con el gen de la calcitonina (cgrp) y sus formulaciones para la prevención y el tratamiento de la migraña. |
| CN110759987B (zh) * | 2019-10-29 | 2021-06-08 | 中国人民解放军军事科学院军事医学研究院 | 构象特异性的重组Aβ1-42样寡聚体抗原、其制备方法和应用 |
| KR20260109964A (ko) * | 2020-01-23 | 2026-07-13 | 유나이티드 바이오메디칼 인크. | 편두통의 예방 및 치료를 위한 뇌하수체 아데닐레이트 사이클라제-활성화 펩티드(pacap)를 표적으로 하는 펩티드 면역원 및 이의 제형 |
| CN115698060A (zh) | 2020-03-10 | 2023-02-03 | 生命爱科 | 环肽 |
| CN116635517A (zh) | 2020-11-17 | 2023-08-22 | 伊利亚德生物技术有限公司 | 与神经退行性疾病相关的神经病理的治疗和预防 |
| JP2024514049A (ja) * | 2021-03-16 | 2024-03-28 | ニューロビジョン イメージング， インコーポレイテッド | アルツハイマー病関連状態を診断するための生物流体ベースの方法 |
| JP7884510B2 (ja) * | 2021-05-20 | 2026-07-03 | デンカ株式会社 | 抗ノロウイルス抗体 |
| WO2023034324A2 (en) * | 2021-08-30 | 2023-03-09 | The Brigham And Women’S Hospital, Inc. | Methods and materials to treat neurodegenerative disease |
| EP4445910A4 (en) | 2021-12-08 | 2026-04-01 | Univ Osaka | VACCINE COMPOSITION TO INDUCE AN ANTI-IL-23 ANTIBODY |
| CN119136838A (zh) | 2022-02-28 | 2024-12-13 | 特瑞德姆生物科技有限责任两合公司 | 由至少一种β-葡聚糖或甘露聚糖组成或包含至少一种β-葡聚糖或甘露聚糖的偶联物 |
| CN117586370A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 强毒性淀粉样蛋白寡聚体及其用途 |
| KR102530956B1 (ko) * | 2022-09-08 | 2023-05-11 | 주식회사 알츠코리아 | 아밀로이드 베타 유래 에피토프를 유효성분으로 포함하는 알츠하이머성 치매 백신 조성물 및 이의 용도 |
| CN115417915B (zh) * | 2022-11-03 | 2023-02-24 | 北京引正基因科技有限公司 | 多肽载体及其应用 |
| CN117122612B (zh) * | 2023-07-07 | 2024-08-27 | 河络新图生物科技(上海)有限公司 | 外周血单个核细胞在制备治疗/预防阿尔茨海默病的药物中的用途 |
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| WO2025109524A1 (en) | 2023-11-22 | 2025-05-30 | Ac Immune Sa | Assays and methods for assessing vaccine preparations |
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| AT506820B1 (de) | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
| WO2010035261A2 (en) * | 2008-09-29 | 2010-04-01 | Ben Gurion University Of The Negev Research And Development Authority | Amyloid beta-peptides and methods of use thereof |
| US9067981B1 (en) * | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| EP2633316A1 (en) * | 2010-10-28 | 2013-09-04 | Jonas Nilsson | Diagnosis and treatment of alzheimer's disease |
| US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
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2013
- 2013-03-15 US US13/843,883 patent/US9102752B2/en active Active
- 2013-04-23 SG SG11201507669YA patent/SG11201507669YA/en unknown
- 2013-04-23 CN CN201380076473.3A patent/CN105228644B/zh active Active
- 2013-04-23 ES ES13878092T patent/ES2800028T3/es active Active
- 2013-04-23 AU AU2013381835A patent/AU2013381835A1/en not_active Abandoned
- 2013-04-23 KR KR1020187034866A patent/KR20180132962A/ko not_active Ceased
- 2013-04-23 PT PT138780929T patent/PT2968485T/pt unknown
- 2013-04-23 BR BR112015023105A patent/BR112015023105A8/pt not_active Application Discontinuation
- 2013-04-23 EP EP13878092.9A patent/EP2968485B1/en active Active
- 2013-04-23 MX MX2015013235A patent/MX364689B/es active IP Right Grant
- 2013-04-23 DK DK13878092.9T patent/DK2968485T3/da active
- 2013-04-23 CA CA2906313A patent/CA2906313A1/en not_active Abandoned
- 2013-04-23 JP JP2016500078A patent/JP6208319B2/ja active Active
- 2013-04-23 WO PCT/US2013/037865 patent/WO2014143087A1/en not_active Ceased
- 2013-04-23 CN CN201810667175.6A patent/CN108794615A/zh active Pending
- 2013-04-23 KR KR1020157029184A patent/KR101926030B1/ko active Active
- 2013-04-23 RU RU2015142996A patent/RU2696566C2/ru active IP Right Revival
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2014
- 2014-03-14 TW TW103109373A patent/TWI561529B/zh active
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2015
- 2015-08-11 US US14/824,075 patent/US20160068581A1/en not_active Abandoned
- 2015-09-15 MX MX2019005268A patent/MX2019005268A/es unknown
- 2015-09-16 IL IL241597A patent/IL241597B/en active IP Right Grant
- 2015-10-09 ZA ZA2015/07526A patent/ZA201507526B/en unknown
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2017
- 2017-05-22 AU AU2017203425A patent/AU2017203425B2/en not_active Ceased
- 2017-06-07 JP JP2017112424A patent/JP6784646B2/ja not_active Expired - Fee Related
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2018
- 2018-04-19 US US15/957,798 patent/US20180244739A1/en not_active Abandoned
- 2018-12-31 US US16/237,531 patent/US20190194280A1/en not_active Abandoned
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2019
- 2019-04-08 IL IL265910A patent/IL265910A/en unknown
- 2019-07-26 JP JP2019137534A patent/JP2019196397A/ja active Pending
- 2019-10-10 ZA ZA2019/06683A patent/ZA201906683B/en unknown
- 2019-10-11 AU AU2019246916A patent/AU2019246916A1/en not_active Abandoned
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