CL2014003307A1 - Variantes de oxm pegilada. - Google Patents
Variantes de oxm pegilada.Info
- Publication number
- CL2014003307A1 CL2014003307A1 CL2014003307A CL2014003307A CL2014003307A1 CL 2014003307 A1 CL2014003307 A1 CL 2014003307A1 CL 2014003307 A CL2014003307 A CL 2014003307A CL 2014003307 A CL2014003307 A CL 2014003307A CL 2014003307 A1 CL2014003307 A1 CL 2014003307A1
- Authority
- CL
- Chile
- Prior art keywords
- variants
- pegylated oxm
- oxm
- pegylated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Marine Sciences & Fisheries (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261655367P | 2012-06-04 | 2012-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014003307A1 true CL2014003307A1 (es) | 2015-04-10 |
Family
ID=49711501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014003307A CL2014003307A1 (es) | 2012-06-04 | 2014-12-03 | Variantes de oxm pegilada. |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10537646B2 (enExample) |
| EP (1) | EP2854838B1 (enExample) |
| JP (2) | JP6290193B2 (enExample) |
| KR (1) | KR102092025B1 (enExample) |
| CN (2) | CN109096387B (enExample) |
| AU (2) | AU2013273135B2 (enExample) |
| CA (1) | CA2875599C (enExample) |
| CL (1) | CL2014003307A1 (enExample) |
| CO (1) | CO7160097A2 (enExample) |
| EA (1) | EA201492269A1 (enExample) |
| HK (1) | HK1209045A1 (enExample) |
| IL (1) | IL236034B (enExample) |
| IN (1) | IN2015DN00003A (enExample) |
| MX (1) | MX362432B (enExample) |
| PE (1) | PE20150181A1 (enExample) |
| SG (2) | SG11201408054RA (enExample) |
| WO (1) | WO2013183052A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US10166295B2 (en) | 2011-06-02 | 2019-01-01 | Opko Biologics Ltd. | Pegylated OXM variants |
| WO2013157002A1 (en) | 2012-04-19 | 2013-10-24 | Prolor Biotech Inc. | Long-acting oxyntomodulin variants and methods of producing same |
| MX362432B (es) | 2012-06-04 | 2019-01-17 | Opko Biologics Ltd | Variantes de oxm pegilada. |
| SG11201503879QA (en) | 2012-11-20 | 2015-06-29 | Opko Biolog Ltd | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| CN106519015B (zh) * | 2014-09-23 | 2020-04-17 | 深圳市图微安创科技开发有限公司 | 胃泌酸调节素类似物 |
| KR102527180B1 (ko) | 2014-12-10 | 2023-04-27 | 옵코 바이오로직스 리미티드 | 장기간 작용성 ctp-변형된 성장 호르몬 폴리펩타이드의 제조 방법 |
| WO2016193969A2 (en) | 2015-05-29 | 2016-12-08 | Opko Biologics Ltd. | Pegylated oxyntomodulin variants |
| KR102662956B1 (ko) | 2015-06-19 | 2024-05-03 | 옵코 바이오로직스 리미티드 | 장기-작용성 응고 인자 및 그의 제조 방법 |
| EP3368693A4 (en) * | 2015-10-30 | 2019-03-27 | The Research Foundation For The State University Of New York University at Buffalo | OXYNTOMODULINANALOGA AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| CN106938050B (zh) * | 2015-12-29 | 2021-08-24 | 派格生物医药(苏州)股份有限公司 | 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途 |
| EP3468610A1 (en) * | 2016-06-09 | 2019-04-17 | OPKO Biologics Ltd. | Long-acting oxyntomodulin formulation and methods of producing and administering same |
| EP4303228B1 (en) | 2016-07-11 | 2026-05-27 | OPKO Biologics Ltd. | Long-acting coagulation factor vii and methods of producing same |
| CN108299554B (zh) * | 2017-01-13 | 2021-05-25 | 博瑞生物医药（苏州）股份有限公司 | 胃泌酸调节素类似物 |
| ES2973986T3 (es) * | 2017-08-16 | 2024-06-25 | Dong A St Co Ltd | Análogo peptídico acilado de oxintomodulina |
| US12441776B2 (en) | 2018-11-30 | 2025-10-14 | Eirgen Pharma Ltd. | Oxyntomodulin peptide analog formulations |
| US20200254065A1 (en) * | 2019-02-11 | 2020-08-13 | Opko Biologics Ltd. | Long-acting glp-2 analogs |
| WO2025184364A1 (en) * | 2024-03-01 | 2025-09-04 | University Of Notre Dame Du Lac | Self-assembling depots of adjuvant peptide therapies |
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| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
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| WO1996014336A1 (en) | 1994-11-07 | 1996-05-17 | Kyowa Hakko Kogyo Co., Ltd. | Novel oxyntomodulin |
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| TWM345876U (en) | 2008-06-17 | 2008-12-01 | Yong-Xuan Ji | Auxiliary device for mobile engine |
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| JP5759976B2 (ja) | 2009-03-20 | 2015-08-05 | ハンミ・サイエンス・カンパニー・リミテッド | 位置特異的な生理活性ポリペプチド結合体の調製方法 |
| AR079344A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
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| EP2714070B1 (en) * | 2011-06-02 | 2024-03-20 | OPKO Biologics Ltd. | Long-acting glp-1/glucagon receptor agonists |
| US10166295B2 (en) | 2011-06-02 | 2019-01-01 | Opko Biologics Ltd. | Pegylated OXM variants |
| TWI601744B (zh) | 2011-06-17 | 2017-10-11 | 韓美科學股份有限公司 | 包含調酸素與免疫球蛋白片段之複合物及其用途 |
| WO2013157002A1 (en) | 2012-04-19 | 2013-10-24 | Prolor Biotech Inc. | Long-acting oxyntomodulin variants and methods of producing same |
| MX362432B (es) | 2012-06-04 | 2019-01-17 | Opko Biologics Ltd | Variantes de oxm pegilada. |
-
2013
- 2013-06-04 MX MX2014014890A patent/MX362432B/es active IP Right Grant
- 2013-06-04 CN CN201811001898.9A patent/CN109096387B/zh active Active
- 2013-06-04 WO PCT/IL2013/050481 patent/WO2013183052A1/en not_active Ceased
- 2013-06-04 JP JP2015515646A patent/JP6290193B2/ja active Active
- 2013-06-04 SG SG11201408054RA patent/SG11201408054RA/en unknown
- 2013-06-04 KR KR1020147037080A patent/KR102092025B1/ko active Active
- 2013-06-04 IN IN3DEN2015 patent/IN2015DN00003A/en unknown
- 2013-06-04 AU AU2013273135A patent/AU2013273135B2/en active Active
- 2013-06-04 SG SG10201702228QA patent/SG10201702228QA/en unknown
- 2013-06-04 CN CN201380040700.7A patent/CN104684576B/zh active Active
- 2013-06-04 EP EP13800444.5A patent/EP2854838B1/en active Active
- 2013-06-04 EA EA201492269A patent/EA201492269A1/ru unknown
- 2013-06-04 PE PE2014002372A patent/PE20150181A1/es not_active Application Discontinuation
- 2013-06-04 CA CA2875599A patent/CA2875599C/en active Active
- 2013-06-04 US US14/405,597 patent/US10537646B2/en active Active
- 2013-06-04 HK HK15109770.0A patent/HK1209045A1/xx unknown
-
2014
- 2014-12-02 IL IL236034A patent/IL236034B/en active IP Right Grant
- 2014-12-03 CL CL2014003307A patent/CL2014003307A1/es unknown
- 2014-12-26 CO CO14284184A patent/CO7160097A2/es unknown
-
2015
- 2015-01-08 US US14/592,641 patent/US9821070B2/en active Active
-
2017
- 2017-11-02 US US15/801,554 patent/US20180050113A1/en not_active Abandoned
-
2018
- 2018-02-07 JP JP2018020172A patent/JP6549741B2/ja active Active
- 2018-03-06 AU AU2018201623A patent/AU2018201623B2/en active Active
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|---|---|---|
| FIC20230015I1 (fi) | Sutimlimabi | |
| EP2854838A4 (en) | PEGYLATED OXM VARIANTS | |
| BR112015004233A2 (pt) | inalador. | |
| DK3354728T3 (da) | Alpha-amylase-varianter | |
| DK4389885T3 (da) | Alfa-amylasevarianter | |
| EP2807309A4 (en) | ABFLUSSSIEB | |
| DK3293183T3 (da) | Hæmmerforbindelser | |
| DK2825087T3 (da) | Otoscanner | |
| EP2902071A4 (en) | CONNECTION | |
| EP2886050A4 (en) | BODY OF WATER METER | |
| DE112012006109A5 (de) | Okklusionsschienenanordnung | |
| EP2836110C0 (en) | MINIATURIZED SCANNING SYSTEM | |
| BR112015004230A2 (pt) | inalador. | |
| BR302012004030S1 (pt) | Configuração aplicada em jaqueta. | |
| FR2998638B1 (fr) | Raccord | |
| HRP20181662T1 (hr) | Poboljšani čvrsti herbicidni pripravci s integralnim adjuvansom | |
| EP2765913A4 (en) | LANCET | |
| BR112014028921A2 (pt) | injetor. | |
| BR112014022506A2 (pt) | variantes de cbh1a | |
| EP2871398A4 (en) | INTERCONNECTS | |
| DE112012006214T8 (de) | Wulstringwickler | |
| EP2883547A4 (en) | MEDICINE | |
| FR2986872B1 (fr) | . | |
| EP2814560A4 (en) | INTERCONNECTS | |
| DE112012005566T8 (de) | Seltenerdnanoverbundmagnet |