JP6290193B2 - ペグ化ｏｘｍ変異体 - Google Patents

ペグ化ｏｘｍ変異体 Download PDF

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Publication number
JP6290193B2
JP6290193B2 JP2015515646A JP2015515646A JP6290193B2 JP 6290193 B2 JP6290193 B2 JP 6290193B2 JP 2015515646 A JP2015515646 A JP 2015515646A JP 2015515646 A JP2015515646 A JP 2015515646A JP 6290193 B2 JP6290193 B2 JP 6290193B2
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Prior art keywords
oxm
fms
peg
fmoc
mal
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JP2015515646A
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Japanese (ja)
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JP2015520184A (ja
JP2015520184A5 (enExample
Inventor
エヤル フィマ、ウディ
エヤル フィマ、ウディ
ヘルシュコビッツ、オレン
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Prolor Biotech Inc
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Modigene Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015515646A 2012-06-04 2013-06-04 ペグ化ｏｘｍ変異体 Active JP6290193B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261655367P 2012-06-04 2012-06-04
US61/655,367 2012-06-04
PCT/IL2013/050481 WO2013183052A1 (en) 2012-06-04 2013-06-04 Pegylated oxm variants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018020172A Division JP6549741B2 (ja) 2012-06-04 2018-02-07 ペグ化ｏｘｍ変異体

Publications (3)

Publication Number Publication Date
JP2015520184A JP2015520184A (ja) 2015-07-16
JP2015520184A5 JP2015520184A5 (enExample) 2016-07-21
JP6290193B2 true JP6290193B2 (ja) 2018-03-07

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JP2018020172A Active JP6549741B2 (ja) 2012-06-04 2018-02-07 ペグ化ｏｘｍ変異体

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US (3) US10537646B2 (enExample)
EP (1) EP2854838B1 (enExample)
JP (2) JP6290193B2 (enExample)
KR (1) KR102092025B1 (enExample)
CN (2) CN109096387B (enExample)
AU (2) AU2013273135B2 (enExample)
CA (1) CA2875599C (enExample)
CL (1) CL2014003307A1 (enExample)
CO (1) CO7160097A2 (enExample)
EA (1) EA201492269A1 (enExample)
HK (1) HK1209045A1 (enExample)
IL (1) IL236034B (enExample)
IN (1) IN2015DN00003A (enExample)
MX (1) MX362432B (enExample)
PE (1) PE20150181A1 (enExample)
SG (2) SG10201702228QA (enExample)
WO (1) WO2013183052A1 (enExample)

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US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
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EP3988113A1 (en) 2015-06-19 2022-04-27 OPKO Biologics Ltd. Long-acting coagulation factors and methods of producing same
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CN113546159B (zh) * 2015-12-29 2023-09-08 派格生物医药(苏州)股份有限公司 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途
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CN109563145B (zh) 2016-07-11 2024-01-26 Opko生物科学有限公司 长效凝血因子及其制备方法
CN108299554B (zh) * 2017-01-13 2021-05-25 博瑞生物医药（苏州）股份有限公司 胃泌酸调节素类似物
AU2018318672B2 (en) * 2017-08-16 2021-04-15 Dong-A St Co., Ltd. Acylated oxyntomodulin peptide analog
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Publication number Publication date
US20180050113A1 (en) 2018-02-22
PE20150181A1 (es) 2015-02-28
CA2875599C (en) 2020-08-18
JP6549741B2 (ja) 2019-07-24
JP2015520184A (ja) 2015-07-16
CL2014003307A1 (es) 2015-04-10
EP2854838A4 (en) 2016-05-04
US9821070B2 (en) 2017-11-21
IL236034B (en) 2019-02-28
IL236034A0 (en) 2015-01-29
KR102092025B1 (ko) 2020-03-24
US10537646B2 (en) 2020-01-21
AU2013273135A1 (en) 2015-01-22
HK1209045A1 (en) 2016-03-24
MX362432B (es) 2019-01-17
SG10201702228QA (en) 2017-04-27
AU2018201623A1 (en) 2018-03-29
US20150119320A1 (en) 2015-04-30
WO2013183052A1 (en) 2013-12-12
JP2018100279A (ja) 2018-06-28
EP2854838A1 (en) 2015-04-08
AU2018201623B2 (en) 2019-08-29
KR20150021087A (ko) 2015-02-27
US20150148289A1 (en) 2015-05-28
CA2875599A1 (en) 2013-12-12
MX2014014890A (es) 2015-06-17
SG11201408054RA (en) 2015-01-29
CN109096387B (zh) 2021-11-30
CN104684576B (zh) 2019-08-06
EP2854838B1 (en) 2018-10-17
EA201492269A1 (ru) 2016-02-29
IN2015DN00003A (enExample) 2015-05-22
AU2013273135B2 (en) 2017-12-07
CN109096387A (zh) 2018-12-28
CN104684576A (zh) 2015-06-03
CO7160097A2 (es) 2015-01-15

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