JP2012503025A5 - - Google Patents
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- JP2012503025A5 JP2012503025A5 JP2011528083A JP2011528083A JP2012503025A5 JP 2012503025 A5 JP2012503025 A5 JP 2012503025A5 JP 2011528083 A JP2011528083 A JP 2011528083A JP 2011528083 A JP2011528083 A JP 2011528083A JP 2012503025 A5 JP2012503025 A5 JP 2012503025A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- amino acid
- peptidomimetic macrocycle
- ppm
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000816 peptidomimetic Substances 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 45
- 150000002678 macrocyclic compounds Chemical class 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 42
- 150000001413 amino acids Chemical class 0.000 claims description 34
- 239000003054 catalyst Substances 0.000 claims description 15
- 239000003431 cross linking reagent Substances 0.000 claims description 13
- 238000005649 metathesis reaction Methods 0.000 claims description 13
- 229910052751 metal Inorganic materials 0.000 claims description 10
- 239000002184 metal Substances 0.000 claims description 10
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 7
- 239000004971 Cross linker Substances 0.000 claims description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 6
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 6
- 229910052762 osmium Inorganic materials 0.000 claims description 6
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 claims description 6
- 229910052707 ruthenium Inorganic materials 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 3
- 239000002243 precursor Substances 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 claims description 3
- 238000011097 chromatography purification Methods 0.000 claims description 2
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 238000009616 inductively coupled plasma Methods 0.000 claims 2
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 239000007801 affinity label Substances 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 102000051485 Bcl-2 family Human genes 0.000 description 1
- 108700038897 Bcl-2 family Proteins 0.000 description 1
- 159000000021 acetate salts Chemical class 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9909908P | 2008-09-22 | 2008-09-22 | |
| US61/099,099 | 2008-09-22 | ||
| PCT/US2009/057931 WO2010034032A2 (en) | 2008-09-22 | 2009-09-22 | Methods for preparing purified polypeptide compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015037711A Division JP6196640B2 (ja) | 2008-09-22 | 2015-02-27 | 精製されたポリペプチド組成物を調製するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503025A JP2012503025A (ja) | 2012-02-02 |
| JP2012503025A5 true JP2012503025A5 (enExample) | 2013-04-25 |
Family
ID=41693036
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528083A Withdrawn JP2012503025A (ja) | 2008-09-22 | 2009-09-22 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2015037711A Active JP6196640B2 (ja) | 2008-09-22 | 2015-02-27 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2017118507A Pending JP2017155063A (ja) | 2008-09-22 | 2017-06-16 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019153604A Pending JP2019214614A (ja) | 2008-09-22 | 2019-08-26 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019172908A Pending JP2020015748A (ja) | 2008-09-22 | 2019-09-24 | 精製されたポリペプチド組成物を調製するための方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015037711A Active JP6196640B2 (ja) | 2008-09-22 | 2015-02-27 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2017118507A Pending JP2017155063A (ja) | 2008-09-22 | 2017-06-16 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019153604A Pending JP2019214614A (ja) | 2008-09-22 | 2019-08-26 | 精製されたポリペプチド組成物を調製するための方法 |
| JP2019172908A Pending JP2020015748A (ja) | 2008-09-22 | 2019-09-24 | 精製されたポリペプチド組成物を調製するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9206223B2 (enExample) |
| EP (2) | EP2342221B1 (enExample) |
| JP (5) | JP2012503025A (enExample) |
| CN (2) | CN102203126A (enExample) |
| AU (1) | AU2009294875C1 (enExample) |
| BR (1) | BRPI0918838A2 (enExample) |
| CA (1) | CA2737921C (enExample) |
| IL (2) | IL211837A (enExample) |
| WO (1) | WO2010034032A2 (enExample) |
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| CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
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| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| EP3126375B1 (en) * | 2014-04-02 | 2023-12-13 | University of Rochester | Macrocyclic peptidomimetics for alpha-helix mimicry |
| KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| MX389354B (es) | 2014-09-24 | 2025-03-20 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y formulaciones de los mismos. |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
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-
2009
- 2009-09-22 CN CN2009801425171A patent/CN102203126A/zh active Pending
- 2009-09-22 AU AU2009294875A patent/AU2009294875C1/en active Active
- 2009-09-22 US US12/564,909 patent/US9206223B2/en active Active
- 2009-09-22 CA CA2737921A patent/CA2737921C/en active Active
- 2009-09-22 CN CN201510159021.2A patent/CN104961795A/zh active Pending
- 2009-09-22 EP EP09736334.5A patent/EP2342221B1/en active Active
- 2009-09-22 EP EP18195669.9A patent/EP3492492A1/en not_active Withdrawn
- 2009-09-22 BR BRPI0918838A patent/BRPI0918838A2/pt not_active Application Discontinuation
- 2009-09-22 JP JP2011528083A patent/JP2012503025A/ja not_active Withdrawn
- 2009-09-22 WO PCT/US2009/057931 patent/WO2010034032A2/en not_active Ceased
-
2011
- 2011-03-21 IL IL211837A patent/IL211837A/en active IP Right Grant
-
2012
- 2012-01-13 US US13/350,644 patent/US9394336B2/en not_active Expired - Fee Related
-
2015
- 2015-02-27 JP JP2015037711A patent/JP6196640B2/ja active Active
- 2015-10-23 US US14/921,573 patent/US20160115204A1/en not_active Abandoned
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2017
- 2017-06-16 JP JP2017118507A patent/JP2017155063A/ja active Pending
- 2017-09-14 IL IL254498A patent/IL254498B/en active IP Right Grant
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2019
- 2019-08-26 JP JP2019153604A patent/JP2019214614A/ja active Pending
- 2019-09-24 JP JP2019172908A patent/JP2020015748A/ja active Pending
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2021
- 2021-07-23 US US17/383,675 patent/US20220017569A1/en not_active Abandoned
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2023
- 2023-06-02 US US18/328,029 patent/US20240124518A1/en not_active Abandoned
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