JP2019043957A5 - - Google Patents
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- JP2019043957A5 JP2019043957A5 JP2018210606A JP2018210606A JP2019043957A5 JP 2019043957 A5 JP2019043957 A5 JP 2019043957A5 JP 2018210606 A JP2018210606 A JP 2018210606A JP 2018210606 A JP2018210606 A JP 2018210606A JP 2019043957 A5 JP2019043957 A5 JP 2019043957A5
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- JP
- Japan
- Prior art keywords
- formula
- group
- compound
- independently
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 24
- 239000011347 resin Substances 0.000 claims 17
- 229920005989 resin Polymers 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 102000007079 Peptide Fragments Human genes 0.000 claims 9
- 108010033276 Peptide Fragments Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- -1 4-methyl - trityl Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- JFLSOKIMYBSASW-UHFFFAOYSA-N 1-chloro-2-[chloro(diphenyl)methyl]benzene Chemical compound ClC1=CC=CC=C1C(Cl)(C=1C=CC=CC=1)C1=CC=CC=C1 JFLSOKIMYBSASW-UHFFFAOYSA-N 0.000 claims 1
- 108010032976 Enfuvirtide Proteins 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- PEASPLKKXBYDKL-FXEVSJAOSA-N enfuvirtide Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(C)=O)[C@@H](C)O)[C@@H](C)CC)C1=CN=CN1 PEASPLKKXBYDKL-FXEVSJAOSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229940099052 fuzeon Drugs 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 CC(C)(CC1)[C@](*)C1(C)SC1(CC2)CC2(CC(*)O)CC1 Chemical compound CC(C)(CC1)[C@](*)C1(C)SC1(CC2)CC2(CC(*)O)CC1 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1315335.8 | 2013-08-29 | ||
| GBGB1315335.8A GB201315335D0 (en) | 2013-08-29 | 2013-08-29 | Amino diacids containing peptide modifiers |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016537416A Division JP2016532705A (ja) | 2013-08-29 | 2014-08-28 | アミノ二酸含有ペプチド修飾剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019043957A JP2019043957A (ja) | 2019-03-22 |
| JP2019043957A5 true JP2019043957A5 (enExample) | 2019-05-09 |
| JP6767459B2 JP6767459B2 (ja) | 2020-10-14 |
Family
ID=49356024
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016537416A Pending JP2016532705A (ja) | 2013-08-29 | 2014-08-28 | アミノ二酸含有ペプチド修飾剤 |
| JP2018210606A Active JP6767459B2 (ja) | 2013-08-29 | 2018-11-08 | アミノ二酸含有ペプチド修飾剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016537416A Pending JP2016532705A (ja) | 2013-08-29 | 2014-08-28 | アミノ二酸含有ペプチド修飾剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20160207957A1 (enExample) |
| EP (2) | EP3725801A3 (enExample) |
| JP (2) | JP2016532705A (enExample) |
| KR (1) | KR102461744B1 (enExample) |
| CN (2) | CN110003055B (enExample) |
| AU (2) | AU2014313779B2 (enExample) |
| CA (1) | CA2922220C (enExample) |
| ES (1) | ES2831974T3 (enExample) |
| GB (1) | GB201315335D0 (enExample) |
| WO (1) | WO2015028966A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201315335D0 (en) * | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| JP6991196B2 (ja) * | 2016-03-23 | 2022-02-03 | バッヘン・ホールディング・アクチエンゲゼルシャフト | グルカゴン様ペプチドを製造するための方法 |
| US11338018B2 (en) | 2016-12-19 | 2022-05-24 | Harrow Ip, Llc | Adrenocorticotropic hormone-based pharmaceutical formulations and methods for fabricating and using thereof |
| CN110294800B (zh) * | 2018-03-22 | 2022-03-04 | 齐鲁制药有限公司 | 一种索玛鲁肽的制备方法 |
| AU2019319032B2 (en) | 2018-08-09 | 2022-06-02 | F. Hoffmann-La Roche Ag | Cleavable linker for peptide synthesis |
| EP3864032B1 (en) * | 2018-10-09 | 2022-11-30 | Fresenius Kabi iPSUM S.r.l. | Process for the manufacture of glp-1 analogues |
| GB201816639D0 (en) * | 2018-10-12 | 2018-11-28 | Heptares Therapeutics Ltd | GLP-1 Receptor Antagonist |
| EP3911350A4 (en) * | 2019-01-17 | 2022-12-14 | Harrow IP, LLC | ADRENOCORTICOTROPIC HORMONE BASED PHARMACEUTICAL FORMULATIONS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| CN109776323B (zh) * | 2019-01-28 | 2022-05-17 | 富乐马鸿凯（大连）医药有限公司 | 一种高效选择性制备脂肪二酸单叔丁酯的方法 |
| WO2020208409A1 (en) * | 2019-04-10 | 2020-10-15 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of peptide intermediates/modifiers |
| CN110372785B (zh) * | 2019-07-25 | 2020-10-23 | 成都诺和晟泰生物科技有限公司 | 一种索马鲁肽的合成方法 |
| CN111285780A (zh) * | 2020-01-16 | 2020-06-16 | 浙江工业大学 | 索马鲁肽侧链的汇聚式液相合成法 |
| CN111269137A (zh) * | 2020-01-16 | 2020-06-12 | 浙江工业大学 | 一种液相法制备索马鲁肽侧链的方法 |
| CN111253287A (zh) * | 2020-01-16 | 2020-06-09 | 浙江工业大学 | 液相汇聚式合成索马鲁肽侧链的方法 |
| WO2021175974A1 (en) | 2020-03-06 | 2021-09-10 | Sanofi | Peptides as selective gip receptor agonists |
| IS3063B (is) | 2020-08-19 | 2025-06-15 | Sanofi Sa | CRF2 viðtakaverkar og notkun þeirra í meðferð |
| EP4399224A1 (en) | 2021-09-06 | 2024-07-17 | Sanofi | New peptides as potent and selective gip receptor agonists |
| CN115504893B (zh) * | 2022-11-18 | 2023-03-10 | 成都普康生物科技有限公司 | 一种L-谷氨酸-α-叔丁酯的合成方法 |
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| CZ300837B6 (cs) | 1996-08-30 | 2009-08-26 | Novo Nordisk A/S | Deriváty GLP-1(7-37) nebo jeho analogy, farmaceutický prostredek je obsahující a jejich použití |
| ES2245505T3 (es) | 1998-03-23 | 2006-01-01 | Trimeris Inc. | Metodos y composiciones para la sintesis de peptidos (t-20). |
| US6716963B1 (en) * | 1998-05-22 | 2004-04-06 | Abbott Laboratories | Peptide antiangiogenic drugs |
| GB9812675D0 (en) | 1998-06-11 | 1998-08-12 | Univ Edinburgh | Peptides |
| DE19924606A1 (de) * | 1999-05-28 | 2000-11-30 | Graffinity Pharm Design Gmbh | Ligand-Anker-Konjugate |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| WO2001036003A2 (en) * | 1999-11-15 | 2001-05-25 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
| US6621548B2 (en) | 2001-06-15 | 2003-09-16 | Viztec, Inc. | Electrooptical displays constructed with polymer-coated elements positioned between substrates |
| US7671054B1 (en) * | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| CN1596120A (zh) | 2001-11-26 | 2005-03-16 | 第一三得利制药株式会社 | 经鼻吸收用药物组合物 |
| CA2484594C (en) | 2002-05-03 | 2012-06-26 | Avecia Limited | Process for the synthesis of peptides |
| SG2012000667A (en) | 2003-01-08 | 2015-03-30 | Univ Washington | Antibacterial agents |
| US20040142379A1 (en) * | 2003-01-16 | 2004-07-22 | Carlsberg Research Laboratory | Affinity fishing for ligands and proteins receptors |
| JP4463814B2 (ja) | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
| JP5697831B2 (ja) | 2003-12-03 | 2015-04-08 | ノヴォ ノルディスク アー／エス | 単鎖インシュリン |
| WO2005072061A2 (en) * | 2004-02-02 | 2005-08-11 | Biosight Ltd. | Conjugates for cancer therapy and diagnosis |
| WO2005082404A2 (en) * | 2004-02-27 | 2005-09-09 | Novo Nordisk A/S | Glp-2 derivatives modified by lipophilic substituents |
| JP2008515856A (ja) | 2004-10-07 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | 遅延性ｇｌｐ−１化合物 |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| CA2861601A1 (en) * | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Poly (ethylene glycol) containing chemically disparate endgroups |
| EP2074134A1 (en) | 2006-10-05 | 2009-07-01 | Lonza Ag | Method for peptide synthesis |
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| EP2178910B1 (en) | 2007-08-15 | 2014-10-08 | Novo Nordisk A/S | Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids |
| FR2921831B1 (fr) * | 2007-10-05 | 2014-05-09 | Oreal | Composition cosmetique ou dermatologique comprenant un polymere portant des groupes de jonction, et procede de traitement cosmetique |
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| MX2010009850A (es) * | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| CN106317164A (zh) | 2008-09-12 | 2017-01-11 | 诺沃—诺迪斯克有限公司 | 酰化肽或蛋白的方法 |
| KR20110097807A (ko) * | 2008-11-05 | 2011-08-31 | 에프. 호프만-라 로슈 아게 | 뉴로펩티드-2-수용체(ｙ-2ｒ) 작용제 및 이의 용도 |
| JP5635529B2 (ja) * | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| EP2413937A1 (en) | 2009-04-02 | 2012-02-08 | Shire LLC | Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof |
| KR101809024B1 (ko) | 2009-07-13 | 2017-12-14 | 질랜드 파마 에이/에스 | 아실화 글루카곤 유사체 |
| CN102596228A (zh) | 2009-10-13 | 2012-07-18 | 霍夫曼-拉罗奇有限公司 | 神经肽-2受体(y-2r)激动剂 |
| WO2011075393A2 (en) | 2009-12-18 | 2011-06-23 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
| CN118767115A (zh) | 2010-01-22 | 2024-10-15 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
| EP2552950A1 (en) | 2010-03-26 | 2013-02-06 | Novo Nordisk A/S | Novel glucagon analogues |
| BR112012033225A2 (pt) | 2010-06-24 | 2017-06-20 | Zealand Pharma As | análogos do glucagon |
| EP2596122B1 (en) * | 2010-07-07 | 2018-09-05 | Cornell University | Modulators for sirt5 and assays for screening same |
| JP2013209295A (ja) * | 2010-10-13 | 2013-10-10 | Takeda Chem Ind Ltd | ペプチド誘導体 |
| EP3192800A1 (en) * | 2010-12-17 | 2017-07-19 | Arrowhead Pharmaceuticals, Inc. | Galactose cluster-pharmacokinetic modulator targeting moiety for sirna |
| CN105713957B (zh) * | 2010-12-22 | 2021-03-02 | 康奈尔大学 | Sirt6的调节物及其筛选分析 |
| CN102286092B (zh) | 2011-09-14 | 2014-01-01 | 深圳翰宇药业股份有限公司 | 利拉鲁肽的固相合成方法 |
| WO2013086786A1 (zh) | 2011-12-15 | 2013-06-20 | Qin Shulin | 具有降血糖作用的化合物、组合物及其用途 |
| IN2014CN04401A (enExample) * | 2011-12-23 | 2015-09-04 | Zealand Pharma As | |
| CN102584944B (zh) | 2012-02-06 | 2014-12-17 | 成都圣诺生物科技股份有限公司 | 一种依非巴特的制备方法 |
| EP2664374A1 (en) * | 2012-05-15 | 2013-11-20 | F. Hoffmann-La Roche AG | Lysin-glutamic acid dipeptide derivatives |
| CN102875665B (zh) * | 2012-09-28 | 2014-11-26 | 深圳翰宇药业股份有限公司 | 一种合成利拉鲁肽的方法 |
| CN103214568B (zh) * | 2013-03-08 | 2014-09-24 | 深圳翰宇药业股份有限公司 | 一种固相制备促胰液素的方法 |
| CN103242200A (zh) * | 2013-04-10 | 2013-08-14 | 吉尔生化（上海）有限公司 | 一种Nα-芴甲氧羰基-Nε-乙酰基-赖氨酸的制备方法 |
| GB201315335D0 (en) * | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
-
2013
- 2013-08-29 GB GBGB1315335.8A patent/GB201315335D0/en not_active Ceased
-
2014
- 2014-08-28 JP JP2016537416A patent/JP2016532705A/ja active Pending
- 2014-08-28 KR KR1020167007531A patent/KR102461744B1/ko active Active
- 2014-08-28 CA CA2922220A patent/CA2922220C/en active Active
- 2014-08-28 CN CN201811562748.5A patent/CN110003055B/zh active Active
- 2014-08-28 CN CN201480059789.6A patent/CN105683156A/zh active Pending
- 2014-08-28 WO PCT/IB2014/064123 patent/WO2015028966A2/en not_active Ceased
- 2014-08-28 AU AU2014313779A patent/AU2014313779B2/en active Active
- 2014-08-28 EP EP20167381.1A patent/EP3725801A3/en active Pending
- 2014-08-28 US US14/914,374 patent/US20160207957A1/en not_active Abandoned
- 2014-08-28 ES ES14792591T patent/ES2831974T3/es active Active
- 2014-08-28 EP EP14792591.1A patent/EP3038658B1/en active Active
-
2018
- 2018-11-08 JP JP2018210606A patent/JP6767459B2/ja active Active
- 2018-11-19 US US16/195,145 patent/US11634455B2/en active Active
-
2020
- 2020-06-30 AU AU2020204382A patent/AU2020204382B2/en active Active
-
2023
- 2023-03-23 US US18/189,057 patent/US12441760B2/en active Active
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