JP2015529802A5 - - Google Patents
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- Publication number
- JP2015529802A5 JP2015529802A5 JP2015521863A JP2015521863A JP2015529802A5 JP 2015529802 A5 JP2015529802 A5 JP 2015529802A5 JP 2015521863 A JP2015521863 A JP 2015521863A JP 2015521863 A JP2015521863 A JP 2015521863A JP 2015529802 A5 JP2015529802 A5 JP 2015529802A5
- Authority
- JP
- Japan
- Prior art keywords
- nachr
- flna
- amount
- hydrocarbyl
- tlr4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261671445P | 2012-07-13 | 2012-07-13 | |
| US61/671,445 | 2012-07-13 | ||
| US201361789180P | 2013-03-15 | 2013-03-15 | |
| US61/789,180 | 2013-03-15 | ||
| PCT/US2013/050368 WO2014012054A1 (en) | 2012-07-13 | 2013-07-12 | Alzheimer's disease assay in a living patent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019139317A Division JP6796168B2 (ja) | 2012-07-13 | 2019-07-30 | 生きている患者でのアルツハイマー病アッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529802A JP2015529802A (ja) | 2015-10-08 |
| JP2015529802A5 true JP2015529802A5 (enExample) | 2016-09-01 |
| JP6566867B2 JP6566867B2 (ja) | 2019-08-28 |
Family
ID=49914282
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521863A Active JP6566867B2 (ja) | 2012-07-13 | 2013-07-12 | 生きている患者でのアルツハイマー病アッセイ |
| JP2019139317A Active JP6796168B2 (ja) | 2012-07-13 | 2019-07-30 | 生きている患者でのアルツハイマー病アッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019139317A Active JP6796168B2 (ja) | 2012-07-13 | 2019-07-30 | 生きている患者でのアルツハイマー病アッセイ |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US9354223B2 (enExample) |
| EP (1) | EP2872899B1 (enExample) |
| JP (2) | JP6566867B2 (enExample) |
| WO (1) | WO2014012054A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2872899B1 (en) | 2012-07-13 | 2018-07-11 | Pain Therapeutics, Inc. | Alzheimer's disease assay in a living patient |
| EP2882428B1 (en) | 2012-07-13 | 2019-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
| US9365555B2 (en) | 2012-12-21 | 2016-06-14 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP2016505002A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用 |
| US9604930B2 (en) | 2012-12-21 | 2017-03-28 | Epizyme, Inc. | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof |
| US10118918B2 (en) | 2012-12-21 | 2018-11-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| AU2015301196A1 (en) | 2014-08-04 | 2017-01-12 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP6463162B2 (ja) * | 2015-02-10 | 2019-01-30 | キヤノン株式会社 | 記録制御装置、記録制御方法、及びプログラム |
| US10836566B2 (en) * | 2015-06-26 | 2020-11-17 | Bisio Progetti S.P.A. | Single-dose capsule for the preparation of beverages |
| MX375424B (es) | 2015-07-31 | 2025-03-06 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl |
| MA44037B1 (fr) | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| AU2017340403B2 (en) | 2016-10-05 | 2022-03-17 | The United States as Represented by the Department of Veterans Affairs | Small molecule AMPK activators |
| MX2019008626A (es) | 2017-01-20 | 2019-09-19 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). |
| JP2020506903A (ja) | 2017-01-23 | 2020-03-05 | ファイザー・インク | Ｍａｇｌ阻害薬としての複素環式スピロ化合物 |
| CA3079819C (en) * | 2017-11-06 | 2023-03-14 | Acelot, Inc. | Small molecule drugs and related methods for treatment of diseases related to a.beta.42 oligomer formation |
| US12186307B2 (en) | 2019-02-13 | 2025-01-07 | Yale University | Methods of treating epilepsy |
| JP7895041B2 (ja) * | 2019-02-21 | 2026-07-27 | フィラナ セラピューティクス インコーポレイテッド | Ｆｌｎａ結合化合物及びその塩酸塩の固体多形 |
| JP7502320B2 (ja) * | 2019-03-06 | 2024-06-18 | エルディーエヌ ファーマ リミテッド | 効力を判定するための方法 |
| AU2020345766A1 (en) | 2019-09-10 | 2022-03-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for increasing level of phosphorylated AMPK protein |
| WO2022098700A1 (en) * | 2020-11-03 | 2022-05-12 | Cassava Sciences, Inc. | Inhibiting an immune response mediated by one or more of tlr2, rage, ccr5, cxcr4 and cd4 |
| EP4374175A4 (en) * | 2021-07-23 | 2025-08-20 | Cassava Sciences Inc | DOSAGE OF COMPONENT FOR ALZHEIMER'S DISEASE IN A LIVING SUBJECT |
| JP2024064487A (ja) * | 2022-10-28 | 2024-05-14 | 国立大学法人 東京医科歯科大学 | 認知症の診断マーカー |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1220440B (de) | 1962-02-14 | 1966-07-07 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von Derivaten des 1-(o-Bromphenoxy)-2-hydroxy-3-amino-propans und deren Saeureadditionssalzen |
| US5852029A (en) | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| ES2306482T3 (es) * | 1997-08-28 | 2008-11-01 | Novartis Ag | Antagonistas de antigeno-1 funcion con funcion de linfocito. |
| AU765142B2 (en) * | 1998-06-01 | 2003-09-11 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating neurodegenerative disorders |
| WO2001040261A1 (en) | 1999-12-01 | 2001-06-07 | Ortho-Mcneil Pharmaceutical, Inc. | Method of diagnosing neurodegenerative disease |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| AU2003223098A1 (en) | 2002-01-14 | 2003-09-02 | Sun Pharmaceutical Industries Limited | Novel process for the preparation of substantially pure 5-(3,5-dimethylphenoxy)methyl-2-oxazolidinone |
| JP4584706B2 (ja) | 2002-05-03 | 2010-11-24 | イスラエル インスティチュート フォー バイオロジカル リサーチ | 中枢及び末梢神経系障害を治療するための方法及び組成物、並びにそれらに有用な新規の化合物 |
| US20070149543A1 (en) | 2003-01-29 | 2007-06-28 | Stockwell Brent R | Agents For Treating Neurodegenerative Diseases |
| DE102004014296A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen |
| DE102004014304A1 (de) * | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen |
| DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| WO2007041855A1 (en) | 2005-10-13 | 2007-04-19 | Waratah Pharmaceuticals, Inc. | Scyllo-inositol derivatives and their use in the treatment of diseases characterised by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| FR2905009A1 (fr) | 2006-08-18 | 2008-02-22 | Servier Lab | Methode de criblage de composes aux proprietes anti-amyloide |
| US8722851B2 (en) | 2007-11-02 | 2014-05-13 | Pain Therapeutics, Inc. | Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A |
| US8614324B2 (en) | 2008-10-31 | 2013-12-24 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| US8653068B2 (en) | 2009-10-30 | 2014-02-18 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| CL2008003507A1 (es) * | 2007-11-26 | 2009-11-27 | Neuroderm Ltd | Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico. |
| US20100279996A1 (en) | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Novel analgesic that binds filamin a |
| US8580808B2 (en) | 2009-10-30 | 2013-11-12 | Pain Therapeutic, Inc. | Filamin A-binding anti-inflammatory analgesic |
| US20100279997A1 (en) | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Analgesic that binds filamin a |
| WO2010088400A1 (en) | 2009-01-28 | 2010-08-05 | Catholic Healthcare West | Methods of diagnosing and treating neurodegenerative diseases |
| US20100280061A1 (en) | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Novel analgesic that binds filamin a |
| US8580809B2 (en) | 2009-10-30 | 2013-11-12 | Pain Therapeutics, Inc. | Filamin A-binding anti-inflammatory analgesic |
| EP2872899B1 (en) | 2012-07-13 | 2018-07-11 | Pain Therapeutics, Inc. | Alzheimer's disease assay in a living patient |
| EP2882428B1 (en) * | 2012-07-13 | 2019-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
-
2013
- 2013-07-12 EP EP13816628.5A patent/EP2872899B1/en active Active
- 2013-07-12 JP JP2015521863A patent/JP6566867B2/ja active Active
- 2013-07-12 WO PCT/US2013/050368 patent/WO2014012054A1/en not_active Ceased
- 2013-07-15 US US13/942,326 patent/US9354223B2/en active Active
- 2013-07-18 US US13/945,612 patent/US9500640B2/en active Active
-
2016
- 2016-05-27 US US15/167,370 patent/US10222368B2/en active Active
-
2019
- 2019-02-28 US US16/289,215 patent/US11385221B2/en active Active
- 2019-07-30 JP JP2019139317A patent/JP6796168B2/ja active Active
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