JP2015529802A5 - - Google Patents
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- Publication number
- JP2015529802A5 JP2015529802A5 JP2015521863A JP2015521863A JP2015529802A5 JP 2015529802 A5 JP2015529802 A5 JP 2015529802A5 JP 2015521863 A JP2015521863 A JP 2015521863A JP 2015521863 A JP2015521863 A JP 2015521863A JP 2015529802 A5 JP2015529802 A5 JP 2015529802A5
- Authority
- JP
- Japan
- Prior art keywords
- nachr
- flna
- amount
- hydrocarbyl
- tlr4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261671445P | 2012-07-13 | 2012-07-13 | |
| US61/671,445 | 2012-07-13 | ||
| US201361789180P | 2013-03-15 | 2013-03-15 | |
| US61/789,180 | 2013-03-15 | ||
| PCT/US2013/050368 WO2014012054A1 (en) | 2012-07-13 | 2013-07-12 | Alzheimer's disease assay in a living patent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019139317A Division JP6796168B2 (ja) | 2012-07-13 | 2019-07-30 | 生きている患者でのアルツハイマー病アッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529802A JP2015529802A (ja) | 2015-10-08 |
| JP2015529802A5 true JP2015529802A5 (enExample) | 2016-09-01 |
| JP6566867B2 JP6566867B2 (ja) | 2019-08-28 |
Family
ID=49914282
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521863A Active JP6566867B2 (ja) | 2012-07-13 | 2013-07-12 | 生きている患者でのアルツハイマー病アッセイ |
| JP2019139317A Active JP6796168B2 (ja) | 2012-07-13 | 2019-07-30 | 生きている患者でのアルツハイマー病アッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019139317A Active JP6796168B2 (ja) | 2012-07-13 | 2019-07-30 | 生きている患者でのアルツハイマー病アッセイ |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US9354223B2 (enExample) |
| EP (1) | EP2872899B1 (enExample) |
| JP (2) | JP6566867B2 (enExample) |
| WO (1) | WO2014012054A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014012054A1 (en) | 2012-07-13 | 2014-01-16 | Pain Therapeutics, Inc. | Alzheimer's disease assay in a living patent |
| US8993555B2 (en) | 2012-12-21 | 2015-03-31 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9745291B2 (en) | 2012-12-21 | 2017-08-29 | Epizyme, Inc. | PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP2016505597A (ja) | 2012-12-21 | 2016-02-25 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US10653693B2 (en) | 2014-08-04 | 2020-05-19 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP6463162B2 (ja) * | 2015-02-10 | 2019-01-30 | キヤノン株式会社 | 記録制御装置、記録制御方法、及びプログラム |
| MX2018000298A (es) * | 2015-06-26 | 2018-03-08 | Bisio Progetti Spa | Capsula de una sola dosis para la preparacion de bebidas. |
| HK1249101A1 (zh) | 2015-07-31 | 2018-10-26 | 辉瑞公司 | 作为magl抑制剂的1，1，1-三氟-3-羟基丙-2-基氨基甲酸酯衍生物及1，1，1-三氟-4-羟基丁-2-基氨基甲酸酯衍生物 |
| MA44037B1 (fr) | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| AU2017340403B2 (en) | 2016-10-05 | 2022-03-17 | The United States as Represented by the Department of Veterans Affairs | Small molecule AMPK activators |
| BR112019014688A2 (pt) | 2017-01-20 | 2020-02-18 | Pfizer Inc. | Derivados de carbamato de 1,1,1-trifluoro-3-hidroxipropan-2-il como inibidores de magl |
| EP3571202B1 (en) | 2017-01-23 | 2021-06-30 | Pfizer Inc. | Heterocyclic spiro compounds as magl inhibitors |
| CA3185336A1 (en) * | 2017-11-06 | 2019-05-09 | Acelot, Inc. | Small molecule drugs and related methods for treatment of diseases related to a.beta.42 oligomer formation |
| WO2020168096A1 (en) | 2019-02-13 | 2020-08-20 | Yale University | Methods of treating epilepsy |
| BR112021016622A2 (pt) | 2019-02-21 | 2021-11-03 | Pain Therapeutics Inc | Polimorfos sólidos de um composto de ligação de flna e seus sais de cloridrato |
| JP7502320B2 (ja) * | 2019-03-06 | 2024-06-18 | エルディーエヌ ファーマ リミテッド | 効力を判定するための方法 |
| EP4027987A4 (en) | 2019-09-10 | 2023-11-29 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Methods and materials for increasing level of phosphorylated ampk protein |
| EP4240355A4 (en) * | 2020-11-03 | 2024-10-09 | Cassava Sciences, Inc. | INHIBITION OF AN IMMUNE RESPONSE INDUCED BY ONE OR MORE COMPONENTS AMONG TLR2, RAGE, CCR5, CXCR4 AND CD4 |
| CN118043671A (zh) * | 2021-07-23 | 2024-05-14 | 卡萨瓦科学公司 | 用于活体受试者中阿尔茨海默病的组分测定 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1220440B (de) | 1962-02-14 | 1966-07-07 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von Derivaten des 1-(o-Bromphenoxy)-2-hydroxy-3-amino-propans und deren Saeureadditionssalzen |
| US5852029A (en) | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| NZ502872A (en) * | 1997-08-28 | 2002-10-25 | Novartis Ag | Mevinolin and compaction as LFA-1 antagonists for treating autoimmune diseases |
| WO1999062505A2 (en) * | 1998-06-01 | 1999-12-09 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating neurodegenerative disorders |
| WO2001040261A1 (en) * | 1999-12-01 | 2001-06-07 | Ortho-Mcneil Pharmaceutical, Inc. | Method of diagnosing neurodegenerative disease |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| AU2003223098A1 (en) | 2002-01-14 | 2003-09-02 | Sun Pharmaceutical Industries Limited | Novel process for the preparation of substantially pure 5-(3,5-dimethylphenoxy)methyl-2-oxazolidinone |
| US7439251B2 (en) | 2002-05-03 | 2008-10-21 | Israel Institute For Biological Research | Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor |
| US20070149543A1 (en) | 2003-01-29 | 2007-06-28 | Stockwell Brent R | Agents For Treating Neurodegenerative Diseases |
| DE102004014304A1 (de) * | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen |
| DE102004014296A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen |
| DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| WO2007119108A2 (en) | 2005-10-13 | 2007-10-25 | Waratah Pharmaceuticals Inc. | Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| FR2905009A1 (fr) * | 2006-08-18 | 2008-02-22 | Servier Lab | Methode de criblage de composes aux proprietes anti-amyloide |
| US8614324B2 (en) | 2008-10-31 | 2013-12-24 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| US8722851B2 (en) | 2007-11-02 | 2014-05-13 | Pain Therapeutics, Inc. | Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A |
| US8653068B2 (en) | 2009-10-30 | 2014-02-18 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| CL2008003507A1 (es) * | 2007-11-26 | 2009-11-27 | Neuroderm Ltd | Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico. |
| US8580808B2 (en) | 2009-10-30 | 2013-11-12 | Pain Therapeutic, Inc. | Filamin A-binding anti-inflammatory analgesic |
| US20100279996A1 (en) | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Novel analgesic that binds filamin a |
| US20100279997A1 (en) | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Analgesic that binds filamin a |
| WO2010088400A1 (en) | 2009-01-28 | 2010-08-05 | Catholic Healthcare West | Methods of diagnosing and treating neurodegenerative diseases |
| US20100280061A1 (en) | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Novel analgesic that binds filamin a |
| US8580809B2 (en) | 2009-10-30 | 2013-11-12 | Pain Therapeutics, Inc. | Filamin A-binding anti-inflammatory analgesic |
| WO2014012054A1 (en) | 2012-07-13 | 2014-01-16 | Pain Therapeutics, Inc. | Alzheimer's disease assay in a living patent |
| JP6417324B2 (ja) * | 2012-07-13 | 2018-11-07 | ペイン セラピューティクス インコーポレイテッド | τリン酸化を阻害する方法 |
-
2013
- 2013-07-12 WO PCT/US2013/050368 patent/WO2014012054A1/en not_active Ceased
- 2013-07-12 JP JP2015521863A patent/JP6566867B2/ja active Active
- 2013-07-12 EP EP13816628.5A patent/EP2872899B1/en active Active
- 2013-07-15 US US13/942,326 patent/US9354223B2/en active Active
- 2013-07-18 US US13/945,612 patent/US9500640B2/en active Active
-
2016
- 2016-05-27 US US15/167,370 patent/US10222368B2/en active Active
-
2019
- 2019-02-28 US US16/289,215 patent/US11385221B2/en active Active
- 2019-07-30 JP JP2019139317A patent/JP6796168B2/ja active Active
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