JP2015523385A5 - - Google Patents

Download PDF

Info

Publication number
JP2015523385A5
JP2015523385A5 JP2015521820A JP2015521820A JP2015523385A5 JP 2015523385 A5 JP2015523385 A5 JP 2015523385A5 JP 2015521820 A JP2015521820 A JP 2015521820A JP 2015521820 A JP2015521820 A JP 2015521820A JP 2015523385 A5 JP2015523385 A5 JP 2015523385A5
Authority
JP
Japan
Prior art keywords
hydrocarbyl
ring
different
same
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015521820A
Other languages
English (en)
Japanese (ja)
Other versions
JP6417324B2 (ja
JP2015523385A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/050126 external-priority patent/WO2014011917A2/en
Publication of JP2015523385A publication Critical patent/JP2015523385A/ja
Publication of JP2015523385A5 publication Critical patent/JP2015523385A5/ja
Application granted granted Critical
Publication of JP6417324B2 publication Critical patent/JP6417324B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015521820A 2012-07-13 2013-07-11 τリン酸化を阻害する方法 Active JP6417324B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261671235P 2012-07-13 2012-07-13
US61/671,235 2012-07-13
US201361789180P 2013-03-15 2013-03-15
US61/789,180 2013-03-15
US13/940,016 2013-07-11
PCT/US2013/050126 WO2014011917A2 (en) 2012-07-13 2013-07-11 A method of inhibiting tau phosphorylation
US13/940,016 US10017736B2 (en) 2012-07-13 2013-07-11 Method of inhibiting tau phosphorylation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2018000198A Division JP6630374B2 (ja) 2012-07-13 2018-01-04 τリン酸化を阻害する方法
JP2018189789A Division JP2019031520A (ja) 2012-07-13 2018-10-05 τリン酸化を阻害する方法

Publications (3)

Publication Number Publication Date
JP2015523385A JP2015523385A (ja) 2015-08-13
JP2015523385A5 true JP2015523385A5 (enExample) 2016-09-01
JP6417324B2 JP6417324B2 (ja) 2018-11-07

Family

ID=49914489

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2015521820A Active JP6417324B2 (ja) 2012-07-13 2013-07-11 τリン酸化を阻害する方法
JP2018000198A Active JP6630374B2 (ja) 2012-07-13 2018-01-04 τリン酸化を阻害する方法
JP2018189789A Pending JP2019031520A (ja) 2012-07-13 2018-10-05 τリン酸化を阻害する方法
JP2021089538A Pending JP2022000421A (ja) 2012-07-13 2021-05-27 τリン酸化を阻害する方法
JP2022198455A Active JP7419486B2 (ja) 2012-07-13 2022-12-13 τリン酸化を阻害する方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2018000198A Active JP6630374B2 (ja) 2012-07-13 2018-01-04 τリン酸化を阻害する方法
JP2018189789A Pending JP2019031520A (ja) 2012-07-13 2018-10-05 τリン酸化を阻害する方法
JP2021089538A Pending JP2022000421A (ja) 2012-07-13 2021-05-27 τリン酸化を阻害する方法
JP2022198455A Active JP7419486B2 (ja) 2012-07-13 2022-12-13 τリン酸化を阻害する方法

Country Status (6)

Country Link
US (7) US10017736B2 (enExample)
EP (1) EP2882428B1 (enExample)
JP (5) JP6417324B2 (enExample)
DK (1) DK2882428T3 (enExample)
ES (1) ES2716049T3 (enExample)
WO (1) WO2014011917A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014012054A1 (en) * 2012-07-13 2014-01-16 Pain Therapeutics, Inc. Alzheimer's disease assay in a living patent
GB201312499D0 (en) * 2013-07-12 2013-08-28 Isis Innovation Therapeutic compounds
US9433604B2 (en) 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
CN104030933A (zh) * 2014-05-16 2014-09-10 烟台恒迪克能源科技有限公司 一种β-异烷醇基氨基戊酸环己胺的合成方法
MA44037B1 (fr) 2016-06-06 2020-03-31 Arena Pharm Inc Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci
AU2017340403B2 (en) 2016-10-05 2022-03-17 The United States as Represented by the Department of Veterans Affairs Small molecule AMPK activators
WO2020168096A1 (en) * 2019-02-13 2020-08-20 Yale University Methods of treating epilepsy
BR112021016622A2 (pt) 2019-02-21 2021-11-03 Pain Therapeutics Inc Polimorfos sólidos de um composto de ligação de flna e seus sais de cloridrato
EP4027987A4 (en) 2019-09-10 2023-11-29 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods and materials for increasing level of phosphorylated ampk protein
US20230045629A1 (en) * 2020-01-15 2023-02-09 National University Corporation Tokai National Higher Education And Research System Treatment of progressive supranuclear palsy
EP4240355A4 (en) * 2020-11-03 2024-10-09 Cassava Sciences, Inc. INHIBITION OF AN IMMUNE RESPONSE INDUCED BY ONE OR MORE COMPONENTS AMONG TLR2, RAGE, CCR5, CXCR4 AND CD4
CN114252324B (zh) * 2022-03-02 2022-05-13 中国人民解放军军事科学院军事医学研究院 一种方便使用的多孔脑片孵育装置
WO2024151661A2 (en) * 2023-01-10 2024-07-18 Washington University Methods of decreasing pathological neuroinflammation

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723442A (en) 1970-12-31 1973-03-27 Yoshitomi Pharmaceutical 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes
US4981858A (en) 1987-08-13 1991-01-01 State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research Optical isomers
ATE122353T1 (de) 1987-10-05 1995-05-15 Yamanouchi Pharma Co Ltd Heterozyklische spiroverbindungen und ihre herstellung.
US5852029A (en) 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5766846A (en) * 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
ATE169001T1 (de) 1993-01-28 1998-08-15 Merck & Co Inc Substituierte spiro-azaringen als tachykinine rezeptor antagonisten
WO1997019084A1 (en) 1995-11-23 1997-05-29 Merck Sharp & Dohme Limited Spiro-piperidine derivatives and their use as tachykinin antagonists
WO1999062505A2 (en) * 1998-06-01 1999-12-09 Ortho-Mcneil Pharmaceutical, Inc. Method for treating neurodegenerative disorders
DE10130020A1 (de) 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
EP1420020B1 (en) 2001-07-23 2008-05-28 Banyu Pharmaceutical Co., Ltd. 4-oxoimidazolidine-2-spiropiperidine derivative
US7439251B2 (en) 2002-05-03 2008-10-21 Israel Institute For Biological Research Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
DE102004014296A1 (de) 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen
DE102004014304A1 (de) 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
WO2005112931A2 (en) * 2004-05-12 2005-12-01 The Government Of The United States As Represented By The Secretary, Department Of Health And Human Services Methods related to the treatment of neurodegenerative and inflammatory conditions
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
AR057579A1 (es) 2005-11-23 2007-12-05 Merck & Co Inc Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
US8653068B2 (en) 2009-10-30 2014-02-18 Pain Therapeutics, Inc. Filamin A binding anti-inflammatory and analgesic
US20100280057A1 (en) * 2009-05-04 2010-11-04 Lindsay Burns Barbier Novel analgesic that binds filamin a
US8722851B2 (en) 2007-11-02 2014-05-13 Pain Therapeutics, Inc. Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A
US8614324B2 (en) 2008-10-31 2013-12-24 Pain Therapeutics, Inc. Filamin A binding anti-inflammatory and analgesic
US8580808B2 (en) 2009-10-30 2013-11-12 Pain Therapeutic, Inc. Filamin A-binding anti-inflammatory analgesic
US20100279996A1 (en) 2009-05-04 2010-11-04 Lindsay Burns Barbier Novel analgesic that binds filamin a
US20100279997A1 (en) 2009-05-04 2010-11-04 Lindsay Burns Barbier Analgesic that binds filamin a
WO2010051497A1 (en) * 2008-10-31 2010-05-06 Pain Therapeutics, Inc. Filamin a binding anti-inflammatory and analgesic
CA2750777C (en) 2009-01-26 2018-04-03 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
US20100280061A1 (en) 2009-05-04 2010-11-04 Lindsay Burns Barbier Novel analgesic that binds filamin a
TWI374662B (en) * 2009-05-18 2012-10-11 Novatek Microelectronics Corp Image processing circuit and method thereof
US8580809B2 (en) 2009-10-30 2013-11-12 Pain Therapeutics, Inc. Filamin A-binding anti-inflammatory analgesic
US20140094482A1 (en) * 2012-08-16 2014-04-03 George B. Thornton Benzazocine-ring compound inhibition of tau hyperphosphorylation

Similar Documents

Publication Publication Date Title
JP2022000421A5 (enExample)
RU2477723C2 (ru) Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
JP6629947B2 (ja) 高インスリン血症に関連した症状の処置
AU2019264253B2 (en) Factor XIIa inhibitors
JP2023036695A5 (enExample)
ES2552684T3 (es) Nuevos compuestos de imidazolidina como moduladores del receptor de andrógenos
JP2015529802A5 (enExample)
ES2794002T3 (es) Inhibidor de alquinil piridina prolil hidroxilasa, y método de preparación y uso médico del mismo
ZA200403685B (en) Cannabinoid receptor ligands.
JP2016518430A5 (enExample)
CA2800998A1 (en) Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
JP2021501756A5 (enExample)
CA2654315A1 (en) Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and their use
EP3191472A1 (en) Compounds and compositions as raf kinase inhibitors
HUT77735A (hu) Triazinszármazékok és ezeket tartalmazó gyógyászati készítmények
RS65966B1 (sr) Inhibitori p300/cbp hat
JP2017534591A (ja) 心肺障害の処置のためのスフィンゴシン−１−リン酸受容体モジュレーター
IL296653A (en) A process for producing profortin inhibitors
RU2016106125A (ru) Соли дасатиниба в кристаллической форме
BR112015028871B1 (pt) Novos compostos de 3,4-dihidro-2h-isoquinolina-1-ona e 2,3-dihidro-isoindol-1-ona
ES2782113T3 (es) Compuestos de quinolina fusionados como inhibidores de PI3K/mTor
TW201813965A (zh) 結晶型式
BR112021005445A2 (pt) piridazinas
CN111801325A (zh) 作为Wnt信号转导通路的抑制剂的吡唑衍生物
CN105085476B (zh) 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺二盐酸盐的晶型及其制备方法