JP2008545793A5 - - Google Patents
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- JP2008545793A5 JP2008545793A5 JP2008515915A JP2008515915A JP2008545793A5 JP 2008545793 A5 JP2008545793 A5 JP 2008545793A5 JP 2008515915 A JP2008515915 A JP 2008515915A JP 2008515915 A JP2008515915 A JP 2008515915A JP 2008545793 A5 JP2008545793 A5 JP 2008545793A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- aralkyl
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C1*)C(*C(*=C(C*I*)C=*)=O)*C1I* Chemical compound *C(C1*)C(*C(*=C(C*I*)C=*)=O)*C1I* 0.000 description 12
- CXIGIXHNCUFRDV-UHFFFAOYSA-N CCCN(CCO)c1ccc(C(c(cc2)ccc2N(CCO)CCO)c(cc2)ccc2Cl)cc1 Chemical compound CCCN(CCO)c1ccc(C(c(cc2)ccc2N(CCO)CCO)c(cc2)ccc2Cl)cc1 CXIGIXHNCUFRDV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68876705P | 2005-06-08 | 2005-06-08 | |
| US60/688,767 | 2005-06-08 | ||
| PCT/US2006/022268 WO2006133353A2 (en) | 2005-06-08 | 2006-06-08 | Methods of facilitating neural cell survival using non-peptide and peptide bdnf neurotrophin mimetics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008545793A JP2008545793A (ja) | 2008-12-18 |
| JP2008545793A5 true JP2008545793A5 (enExample) | 2009-07-30 |
| JP5461009B2 JP5461009B2 (ja) | 2014-04-02 |
Family
ID=37499118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515915A Expired - Lifetime JP5461009B2 (ja) | 2005-06-08 | 2006-06-08 | 非ペプチド及びペプチドｂｄｎｆニューロトロフィン類似体を用いた神経細胞生存促進法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8686045B2 (enExample) |
| EP (3) | EP2581440B1 (enExample) |
| JP (1) | JP5461009B2 (enExample) |
| ES (1) | ES2569881T3 (enExample) |
| WO (1) | WO2006133353A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1606409T3 (pl) | 2003-03-19 | 2011-02-28 | Biogen Ma Inc | Białko wiążące receptor Nogo |
| PT1776136E (pt) | 2004-06-24 | 2012-12-05 | Biogen Idec Inc | Tratamento de estados que envolvem desmielinização |
| WO2006113097A2 (en) * | 2005-04-15 | 2006-10-26 | The University Of North Carolina At Chapel Hill | Methods of facilitating cell survival using neurotrophin mimetics |
| US20110230479A1 (en) * | 2005-04-15 | 2011-09-22 | Longo Frank M | Neurotrophin mimetics and uses thereof |
| EP2581440B1 (en) | 2005-06-08 | 2016-03-16 | The University of North Carolina At Chapel Hill | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics |
| SI1904104T1 (sl) | 2005-07-08 | 2013-12-31 | Biogen Idec Ma Inc. | Protitelesa SP35 in njihova uporaba |
| CA2672750A1 (en) * | 2006-12-20 | 2008-07-03 | Rinat Neuroscience Corporation | Trkb agonists for treating autoimmune disorders |
| CA2701189C (en) * | 2007-10-11 | 2017-05-16 | Biogen Idec Ma Inc. | Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell survival via administration of lingo-1 antagonists and trkb agonists |
| WO2009061500A1 (en) * | 2007-11-08 | 2009-05-14 | Biogen Idec Ma Inc. | Use of lingo-4 antagonists in the treatment of conditions involving demyelination |
| WO2009086202A2 (en) * | 2007-12-19 | 2009-07-09 | Afraxis, Inc. | Methods for treating neuropsychiatric conditions |
| US20100317715A1 (en) * | 2007-12-21 | 2010-12-16 | Vollrath Benedikt | Methods for treating neuropsychiatric conditions |
| EP2315779A2 (en) | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprising antibodies to lingo or fragments thereof |
| CA2762680C (en) | 2009-05-21 | 2018-04-17 | Chlorion Pharma, Inc. | Methyl sulfanyl pyrmidmes useful as antiinflammatories, analgesics, and antiepileptics |
| KR101138048B1 (ko) | 2009-11-06 | 2012-04-23 | 성균관대학교산학협력단 | Ｂｄｎｆ의 발현을 증가시키는 신규 펩타이드 및 이를 포함하는 알츠하이머병 또는 파킨슨병의 예방 및 치료용 약학 조성물 |
| WO2011060262A1 (en) | 2009-11-12 | 2011-05-19 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| WO2011070177A2 (en) | 2009-12-11 | 2011-06-16 | Baltic Technology Development, Ltd. | Methods of facilitating neural cell survival using gdnf family ligand (gfl) mimetics or ret signaling pathway activators |
| US20120004310A1 (en) * | 2010-05-28 | 2012-01-05 | Longo Frank M | Non-peptide bdnf neurotrophin mimetics |
| US9796780B2 (en) | 2012-05-14 | 2017-10-24 | Biogen Ma Inc. | LINGO-2 antagonists for treatment of conditions involving motor neurons |
| JP6120311B2 (ja) * | 2013-02-12 | 2017-04-26 | 学校法人銀杏学園 | ポリフェノール化合物 |
| US9828330B2 (en) | 2013-03-15 | 2017-11-28 | Pharmatrophix, Inc. | Non-peptide BDNF neurotrophin mimetics |
| CA2901839A1 (en) * | 2013-03-15 | 2014-09-18 | Pharmatrophix, Inc. | Non-peptide bdnf neurotrophin mimetics |
| AU2014250762A1 (en) | 2013-04-12 | 2015-10-29 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of HCV |
| WO2016106050A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| WO2016112270A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
| EA201792261A1 (ru) * | 2015-05-29 | 2018-04-30 | Зе Боард Оф Трастис Оф Зе Лилэнд Стэнфорд Джуниор Юниверсити | Нуклеозидные вещества для уменьшения вредной активности генов, содержащих удлиненные нуклеотидные повторы |
| WO2017019905A1 (en) | 2015-07-28 | 2017-02-02 | Otonomy, Inc. | Treatment using truncated trk b and trk c antagonists |
| WO2017123826A1 (en) | 2016-01-14 | 2017-07-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| RU2020116571A (ru) | 2017-12-07 | 2021-11-22 | Эмори Юниверсити | N4-гидроксицитидин и производные и связанные с этим противовирусные применения |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| BR112022024071A2 (pt) | 2020-05-27 | 2022-12-20 | Axial Therapeutics Inc | Compostos moduladores de tlr2, composições farmacêuticas e usos dos mesmos |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| SMT202500447T1 (it) | 2021-11-02 | 2026-01-12 | Flare Therapeutics Inc | Agonisti inversi di pparg e loro usi |
| CN118401539A (zh) | 2021-12-15 | 2024-07-26 | 兆维生物科技公司 | 官能化的n-乙酰半乳糖胺类似物 |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
| CN116554123A (zh) * | 2023-04-27 | 2023-08-08 | 山东大学 | 六种噻唑酰腙类化合物在抗肿瘤药物中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2109262A5 (enExample) | 1970-10-08 | 1972-05-26 | Inst Francais Du Petrole | |
| US3953416A (en) * | 1971-12-20 | 1976-04-27 | Karl Folkers | Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same |
| JPS5025442B2 (enExample) * | 1972-03-14 | 1975-08-23 | ||
| DE2343037A1 (de) * | 1973-08-25 | 1975-03-06 | Hoechst Ag | Arzneimittel mit antidepressiver wirkung |
| HU185535B (en) * | 1982-05-25 | 1985-02-28 | Mta Koezponti Hivatala | Process for preparing new gonadoliberin derivatives |
| US5321029A (en) | 1988-11-14 | 1994-06-14 | Beecham-Wuelfing Gmbh & Co.K.G. | Xanthines |
| GB9402331D0 (en) | 1994-02-07 | 1994-03-30 | Univ Mcgill | Nerve growth factor structural analogs and their uses |
| AU4117396A (en) | 1994-11-29 | 1996-06-19 | Novartis Ag | Morpholinoethylamide derivatives |
| US5958875A (en) | 1996-03-29 | 1999-09-28 | The Regents Of The University Of California | Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
| EP1008656A4 (en) * | 1996-06-13 | 2000-09-20 | Itoham Foods Inc | METHOD FOR PRODUCING LH-RH DERIVATIVES |
| JP4676061B2 (ja) | 1998-07-30 | 2011-04-27 | アボット・ラボラトリーズ | グルココルチコイド選択性薬剤 |
| EP2112511B1 (en) | 1999-03-17 | 2012-01-18 | University Of North Carolina At Chapel Hill | Method of screening candidate compounds for susceptibility to biliary excretion |
| US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
| WO2001052843A1 (en) | 2000-01-18 | 2001-07-26 | Mcgill University | β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS |
| AU2002228316A1 (en) | 2001-01-29 | 2002-08-12 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
| EP1553964A4 (en) | 2002-09-25 | 2009-08-12 | Georgia Tech Res Inst | KETOAMID INHIBITORS IN CHRONIC NERVE DISEASES |
| WO2006113097A2 (en) | 2005-04-15 | 2006-10-26 | The University Of North Carolina At Chapel Hill | Methods of facilitating cell survival using neurotrophin mimetics |
| EP2581440B1 (en) | 2005-06-08 | 2016-03-16 | The University of North Carolina At Chapel Hill | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics |
-
2006
- 2006-06-08 EP EP12169982.1A patent/EP2581440B1/en not_active Expired - Lifetime
- 2006-06-08 JP JP2008515915A patent/JP5461009B2/ja not_active Expired - Lifetime
- 2006-06-08 US US11/449,381 patent/US8686045B2/en active Active
- 2006-06-08 ES ES12169982.1T patent/ES2569881T3/es not_active Expired - Lifetime
- 2006-06-08 EP EP12169984.7A patent/EP2526942B1/en not_active Expired - Lifetime
- 2006-06-08 WO PCT/US2006/022268 patent/WO2006133353A2/en not_active Ceased
- 2006-06-08 EP EP06784665A patent/EP1893192A4/en not_active Withdrawn
-
2014
- 2014-01-27 US US14/165,090 patent/US9604907B2/en active Active
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