JP5461009B2 - 非ペプチド及びペプチドｂｄｎｆニューロトロフィン類似体を用いた神経細胞生存促進法 - Google Patents

非ペプチド及びペプチドｂｄｎｆニューロトロフィン類似体を用いた神経細胞生存促進法 Download PDF

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JP5461009B2
JP5461009B2 JP2008515915A JP2008515915A JP5461009B2 JP 5461009 B2 JP5461009 B2 JP 5461009B2 JP 2008515915 A JP2008515915 A JP 2008515915A JP 2008515915 A JP2008515915 A JP 2008515915A JP 5461009 B2 JP5461009 B2 JP 5461009B2
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compound
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bdnf
hydrogen atom
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JP2008545793A (ja
JP2008545793A5 (enExample
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エム ロンゴ フランク
エム マッサ ステフェン
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University of North Carolina at Chapel Hill
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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JP2008515915A 2005-06-08 2006-06-08 非ペプチド及びペプチドｂｄｎｆニューロトロフィン類似体を用いた神経細胞生存促進法 Expired - Lifetime JP5461009B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68876705P 2005-06-08 2005-06-08
US60/688,767 2005-06-08
PCT/US2006/022268 WO2006133353A2 (en) 2005-06-08 2006-06-08 Methods of facilitating neural cell survival using non-peptide and peptide bdnf neurotrophin mimetics

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JP2008545793A JP2008545793A (ja) 2008-12-18
JP2008545793A5 JP2008545793A5 (enExample) 2009-07-30
JP5461009B2 true JP5461009B2 (ja) 2014-04-02

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US (2) US8686045B2 (enExample)
EP (3) EP2581440B1 (enExample)
JP (1) JP5461009B2 (enExample)
ES (1) ES2569881T3 (enExample)
WO (1) WO2006133353A2 (enExample)

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EP1893192A2 (en) 2008-03-05
EP2526942B1 (en) 2017-08-09
EP1893192A4 (en) 2010-03-31
WO2006133353A3 (en) 2009-04-30
US20070060526A1 (en) 2007-03-15
US8686045B2 (en) 2014-04-01
US9604907B2 (en) 2017-03-28
US20140200277A1 (en) 2014-07-17
JP2008545793A (ja) 2008-12-18
EP2581440A2 (en) 2013-04-17
EP2581440B1 (en) 2016-03-16
ES2569881T3 (es) 2016-05-12
EP2581440A3 (en) 2013-06-26
EP2526942A3 (en) 2013-07-17
EP2526942A2 (en) 2012-11-28
WO2006133353A2 (en) 2006-12-14

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