JP2015513544A5 - - Google Patents

Info

Publication number

JP2015513544A5

JP2015513544A5 JP2014559183A JP2014559183A JP2015513544A5 JP 2015513544 A5 JP2015513544 A5 JP 2015513544A5 JP 2014559183 A JP2014559183 A JP 2014559183A JP 2014559183 A JP2014559183 A JP 2014559183A JP 2015513544 A5 JP2015513544 A5 JP 2015513544A5

Authority

JP

Japan

Prior art keywords

chem

glp

compound according

peptide

amide

Prior art date

2013-02-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 13
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 12
• 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 10
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 10
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 150000001408 amides Chemical class 0.000 claims 5
• 150000002148 esters Chemical class 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• 206010012601 diabetes mellitus Diseases 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 102000009027 Albumins Human genes 0.000 claims 3
• 108010088751 Albumins Proteins 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• 208000002249 Diabetes Complications Diseases 0.000 claims 2
• 206010012655 Diabetic complications Diseases 0.000 claims 2
• 208000030814 Eating disease Diseases 0.000 claims 2
• 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
• 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
• 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 2
• 235000014632 disordered eating Nutrition 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 150000002632 lipids Chemical class 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 238000011282 treatment Methods 0.000 claims 2
• -1 GLP-1 compound Chemical class 0.000 claims 1
• ACZFBYCNAVEFLC-UHFFFAOYSA-N Imidazole lactic acid Natural products OC(=O)C(O)CC1=CN=CN1 ACZFBYCNAVEFLC-UHFFFAOYSA-N 0.000 claims 1
• 206010036049 Polycystic ovaries Diseases 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 0 CC[C@](C)[C@@](C(N[C@@](C(C)C)C(O[C@@](Cc1c[n]cn1)C(NC(C)(C)C(*)=O)=O)=O)=O)NC Chemical compound CC[C@](C)[C@@](C(N[C@@](C(C)C)C(O[C@@](Cc1c[n]cn1)C(NC(C)(C)C(*)=O)=O)=O)=O)NC 0.000 description 4