JP2013530974A5 - - Google Patents
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- Publication number
- JP2013530974A5 JP2013530974A5 JP2013515874A JP2013515874A JP2013530974A5 JP 2013530974 A5 JP2013530974 A5 JP 2013530974A5 JP 2013515874 A JP2013515874 A JP 2013515874A JP 2013515874 A JP2013515874 A JP 2013515874A JP 2013530974 A5 JP2013530974 A5 JP 2013530974A5
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- human insulin
- desb30 human
- amino acid
- cysteine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10167046 | 2010-06-23 | ||
| EP10167033.9 | 2010-06-23 | ||
| EP10167033 | 2010-06-23 | ||
| EP10167046.1 | 2010-06-23 | ||
| US35915010P | 2010-06-28 | 2010-06-28 | |
| US61/359,150 | 2010-06-28 | ||
| US35950010P | 2010-06-29 | 2010-06-29 | |
| US61/359,500 | 2010-06-29 | ||
| PCT/EP2011/060383 WO2011161125A1 (en) | 2010-06-23 | 2011-06-21 | Insulin derivatives containing additional disulfide bonds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013530974A JP2013530974A (ja) | 2013-08-01 |
| JP2013530974A5 true JP2013530974A5 (enExample) | 2014-07-10 |
| JP5931857B2 JP5931857B2 (ja) | 2016-06-08 |
Family
ID=44508482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515874A Expired - Fee Related JP5931857B2 (ja) | 2010-06-23 | 2011-06-21 | 追加のジスルフィド結合を含有するインスリン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8853155B2 (enExample) |
| EP (1) | EP2585485A1 (enExample) |
| JP (1) | JP5931857B2 (enExample) |
| KR (1) | KR20130036290A (enExample) |
| CN (2) | CN102985440B (enExample) |
| AU (1) | AU2011269000C1 (enExample) |
| BR (1) | BR112012033107A2 (enExample) |
| CA (1) | CA2802510A1 (enExample) |
| IL (1) | IL223288A0 (enExample) |
| MX (1) | MX337549B (enExample) |
| RU (1) | RU2598273C2 (enExample) |
| WO (1) | WO2011161125A1 (enExample) |
| ZA (1) | ZA201209345B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| CN103533952B (zh) * | 2011-03-15 | 2017-02-15 | 诺沃—诺迪斯克有限公司 | 包含半胱氨酸置换的人胰岛素类似物和衍生物 |
| WO2013093009A1 (en) * | 2011-12-21 | 2013-06-27 | Novo Nordisk A/S | N -terminally modified insulin derivatives |
| EP2836508B1 (en) | 2012-04-11 | 2016-06-29 | Novo Nordisk A/S | Insulin formulations |
| WO2014009316A1 (en) | 2012-07-09 | 2014-01-16 | Novo Nordisk A/S | Novel use of insulin derivatives |
| CA2926701A1 (en) * | 2013-10-07 | 2015-04-16 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| JP6737793B2 (ja) * | 2015-01-29 | 2020-08-12 | ノヴォ ノルディスク アー／エス | 錠剤コアとポリビニルアルコールコーティングとを含む経口インスリン投与のための医薬組成物 |
| HK1255634A1 (zh) | 2015-12-23 | 2019-08-23 | Case Western Reserve University | 超稳胰岛素类似物在聚合物熔体中的包囊 |
| CN107436311B (zh) * | 2016-05-25 | 2021-11-19 | 正大天晴药业集团股份有限公司 | 一种鉴别胰岛素单体或胰岛素多聚体的方法 |
| ES2886837T3 (es) | 2016-12-16 | 2021-12-21 | Novo Nordisk As | Composiciones farmacéuticas que contienen insulina |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| CN113121649B (zh) * | 2019-12-26 | 2022-10-04 | 李瑛� | 一种新型两亲性蛋白、其制备方法及用途 |
| CN116789801B (zh) * | 2023-08-21 | 2023-11-14 | 南京赛诺生物技术有限公司 | 新型胰岛素衍生物及其用途 |
| WO2025104600A1 (en) * | 2023-11-15 | 2025-05-22 | Ambio, Inc. | Insulin analogs for the treatment of human metabolic disorder and disease |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50892B1 (en) | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK155690D0 (da) * | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| HUP0004169A3 (en) * | 1997-10-24 | 2001-06-28 | Lilly Co Eli | Insoluble insulin compositions and process for production thereof |
| CA2361830A1 (en) | 1999-03-17 | 2000-09-21 | Novo Nordisk A/S | Method for acylating peptides and novel acylating agents |
| RU2283846C2 (ru) | 1999-12-29 | 2006-09-20 | Ново Нордиск А/С | Предшественник инсулина, способ его получения и применение |
| JP4468174B2 (ja) | 2002-09-25 | 2010-05-26 | ノボ ノルディスク アクティーゼルスカブ | ペプチドをアシル化するための方法 |
| AU2003903124A0 (en) * | 2003-06-20 | 2003-07-10 | Mark Del Borgo | Analogues of heteromeric proteins |
| AU2004261353B2 (en) * | 2003-08-05 | 2009-12-10 | Novo Nordisk A/S | Novel insulin derivatives |
| ES2369895T3 (es) | 2003-12-03 | 2011-12-07 | Novo Nordisk A/S | Insulina monocatenaria. |
| WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| US8343914B2 (en) * | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
| WO2007096332A1 (en) | 2006-02-21 | 2007-08-30 | Novo Nordisk A/S | Single-chain insulin analogues and pharmaceutical formulations thereof |
| WO2007135117A2 (en) | 2006-05-24 | 2007-11-29 | Novo Nordisk A/S | Soluble, stable insulin-containing formulations |
| CN101541830A (zh) * | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
| EP2074140B8 (en) | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| AU2008288413B2 (en) * | 2007-08-15 | 2013-09-26 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| RU2524423C2 (ru) * | 2008-01-09 | 2014-07-27 | Санофи-Авентис Дойчланд Гмбх | Новые производные инсулина с чрезвычайно замедленным профилем время/действие |
| CN101970477B (zh) | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| CN102149411A (zh) | 2008-09-12 | 2011-08-10 | 诺沃—诺迪斯克有限公司 | 酰化肽或蛋白的方法 |
| EP2376531A1 (en) | 2008-12-09 | 2011-10-19 | Novo Nordisk A/S | Novel insulin analogues |
| US20120184488A1 (en) | 2009-09-01 | 2012-07-19 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| EP2585483A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Human insulin containing additional disulfide bonds |
| EP2585484A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
-
2011
- 2011-06-21 CA CA2802510A patent/CA2802510A1/en not_active Withdrawn
- 2011-06-21 AU AU2011269000A patent/AU2011269000C1/en not_active Ceased
- 2011-06-21 BR BR112012033107A patent/BR112012033107A2/pt not_active IP Right Cessation
- 2011-06-21 KR KR1020137001441A patent/KR20130036290A/ko not_active Withdrawn
- 2011-06-21 CN CN201180031021.4A patent/CN102985440B/zh not_active Expired - Fee Related
- 2011-06-21 JP JP2013515874A patent/JP5931857B2/ja not_active Expired - Fee Related
- 2011-06-21 CN CN201510007033.3A patent/CN104693302A/zh active Pending
- 2011-06-21 MX MX2012014641A patent/MX337549B/es active IP Right Grant
- 2011-06-21 US US13/805,774 patent/US8853155B2/en not_active Expired - Fee Related
- 2011-06-21 EP EP11728615.3A patent/EP2585485A1/en not_active Withdrawn
- 2011-06-21 WO PCT/EP2011/060383 patent/WO2011161125A1/en not_active Ceased
- 2011-06-21 RU RU2012157683/10A patent/RU2598273C2/ru not_active IP Right Cessation
-
2012
- 2012-11-27 IL IL223288A patent/IL223288A0/en unknown
- 2012-12-10 ZA ZA2012/09345A patent/ZA201209345B/en unknown
-
2014
- 2014-08-28 US US14/471,258 patent/US9512195B2/en not_active Expired - Fee Related
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