JP2013530974A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013530974A5 JP2013530974A5 JP2013515874A JP2013515874A JP2013530974A5 JP 2013530974 A5 JP2013530974 A5 JP 2013530974A5 JP 2013515874 A JP2013515874 A JP 2013515874A JP 2013515874 A JP2013515874 A JP 2013515874A JP 2013530974 A5 JP2013530974 A5 JP 2013530974A5
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- human insulin
- desb30 human
- amino acid
- cysteine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10167033.9 | 2010-06-23 | ||
| EP10167046 | 2010-06-23 | ||
| EP10167033 | 2010-06-23 | ||
| EP10167046.1 | 2010-06-23 | ||
| US35915010P | 2010-06-28 | 2010-06-28 | |
| US61/359,150 | 2010-06-28 | ||
| US35950010P | 2010-06-29 | 2010-06-29 | |
| US61/359,500 | 2010-06-29 | ||
| PCT/EP2011/060383 WO2011161125A1 (en) | 2010-06-23 | 2011-06-21 | Insulin derivatives containing additional disulfide bonds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013530974A JP2013530974A (ja) | 2013-08-01 |
| JP2013530974A5 true JP2013530974A5 (enExample) | 2014-07-10 |
| JP5931857B2 JP5931857B2 (ja) | 2016-06-08 |
Family
ID=44508482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515874A Expired - Fee Related JP5931857B2 (ja) | 2010-06-23 | 2011-06-21 | 追加のジスルフィド結合を含有するインスリン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8853155B2 (enExample) |
| EP (1) | EP2585485A1 (enExample) |
| JP (1) | JP5931857B2 (enExample) |
| KR (1) | KR20130036290A (enExample) |
| CN (2) | CN102985440B (enExample) |
| AU (1) | AU2011269000C1 (enExample) |
| BR (1) | BR112012033107A2 (enExample) |
| CA (1) | CA2802510A1 (enExample) |
| IL (1) | IL223288A0 (enExample) |
| MX (1) | MX337549B (enExample) |
| RU (1) | RU2598273C2 (enExample) |
| WO (1) | WO2011161125A1 (enExample) |
| ZA (1) | ZA201209345B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| WO2012123519A2 (en) * | 2011-03-15 | 2012-09-20 | Novo Nordisk A/S | Human insulin analogues and derivatives comprising cysteine substitutions |
| JP2015502971A (ja) * | 2011-12-21 | 2015-01-29 | ノヴォ ノルディスク アー／エス | Ｎ末端修飾インスリン誘導体 |
| KR20150002777A (ko) | 2012-04-11 | 2015-01-07 | 노보 노르디스크 에이/에스 | 인슐린 제제 |
| US20150111820A1 (en) | 2012-07-09 | 2015-04-23 | Novo Nordisk A/S | Novel use of insulin derivatives |
| AU2014333979B2 (en) | 2013-10-07 | 2018-02-15 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| US20180000742A1 (en) * | 2015-01-29 | 2018-01-04 | Novo Nordisk A/S | Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and a Polyvinyl Alcohol Coating |
| SG11201803911PA (en) * | 2015-12-23 | 2018-07-30 | Univ Case Western Reserve | Encapsulation of ultra-stable insulin analogues with polymer melts |
| CN107436311B (zh) * | 2016-05-25 | 2021-11-19 | 正大天晴药业集团股份有限公司 | 一种鉴别胰岛素单体或胰岛素多聚体的方法 |
| MA49116A (fr) * | 2016-12-16 | 2020-03-25 | Novo Nordisk As | Compositions pharmaceutiques contenant de l'insuline |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| CN113121649B (zh) * | 2019-12-26 | 2022-10-04 | 李瑛� | 一种新型两亲性蛋白、其制备方法及用途 |
| CN116789801B (zh) * | 2023-08-21 | 2023-11-14 | 南京赛诺生物技术有限公司 | 新型胰岛素衍生物及其用途 |
| US20250154220A1 (en) * | 2023-11-15 | 2025-05-15 | Ambio, Inc. | Insulin analogs for the treatment of human metabolic disorder and disease |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4343898A (en) | 1980-02-11 | 1982-08-10 | Novo Industri A/S | Process for preparing esters of human insulin |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK155690D0 (da) * | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| SV1998000125A (es) * | 1997-10-24 | 1999-05-24 | Lilly Co Eli | Composiciones de insulina insoluble ref. x-11232 |
| PL351326A1 (en) | 1999-03-17 | 2003-04-07 | Novo Nordisk As | Method for acylating peptides and novel acylating agents |
| HUP0203475A3 (en) | 1999-12-29 | 2005-11-28 | Novo Nordisk As | Method for making insulin precursors and insulin precursor analogs |
| DE60328112D1 (de) | 2002-09-25 | 2009-08-06 | Novo Nordisk As | Verfahren zur herstellung acylierter peptide |
| AU2003903124A0 (en) * | 2003-06-20 | 2003-07-10 | Mark Del Borgo | Analogues of heteromeric proteins |
| KR101159559B1 (ko) | 2003-08-05 | 2012-06-26 | 노보 노르디스크 에이/에스 | 신규의 인슐린 유도체 |
| JP5697831B2 (ja) | 2003-12-03 | 2015-04-08 | ノヴォ ノルディスク アー／エス | 単鎖インシュリン |
| WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| US8343914B2 (en) * | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
| US20090069216A1 (en) | 2006-02-21 | 2009-03-12 | Novo Nordisk A/S | Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof |
| WO2007135117A2 (en) * | 2006-05-24 | 2007-11-29 | Novo Nordisk A/S | Soluble, stable insulin-containing formulations |
| EP2404934A1 (en) * | 2006-09-22 | 2012-01-11 | Novo Nordisk A/S | Protease resistant insulin analogues |
| ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| KR20100053561A (ko) * | 2007-08-15 | 2010-05-20 | 노보 노르디스크 에이/에스 | 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체 |
| PL2229407T3 (pl) | 2008-01-09 | 2017-06-30 | Sanofi-Aventis Deutschland Gmbh | Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania |
| ES2618073T3 (es) * | 2008-03-14 | 2017-06-20 | Novo Nordisk A/S | Análogos de insulina estabilizados frente a proteasas |
| MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| CN106317164A (zh) | 2008-09-12 | 2017-01-11 | 诺沃—诺迪斯克有限公司 | 酰化肽或蛋白的方法 |
| CN102245633A (zh) | 2008-12-09 | 2011-11-16 | 诺沃—诺迪斯克有限公司 | 新的胰岛素类似物 |
| US20120184488A1 (en) | 2009-09-01 | 2012-07-19 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| EP2585484A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
| EP2585483A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Human insulin containing additional disulfide bonds |
-
2011
- 2011-06-21 WO PCT/EP2011/060383 patent/WO2011161125A1/en not_active Ceased
- 2011-06-21 US US13/805,774 patent/US8853155B2/en not_active Expired - Fee Related
- 2011-06-21 CA CA2802510A patent/CA2802510A1/en not_active Withdrawn
- 2011-06-21 AU AU2011269000A patent/AU2011269000C1/en not_active Ceased
- 2011-06-21 MX MX2012014641A patent/MX337549B/es active IP Right Grant
- 2011-06-21 BR BR112012033107A patent/BR112012033107A2/pt not_active IP Right Cessation
- 2011-06-21 RU RU2012157683/10A patent/RU2598273C2/ru not_active IP Right Cessation
- 2011-06-21 JP JP2013515874A patent/JP5931857B2/ja not_active Expired - Fee Related
- 2011-06-21 CN CN201180031021.4A patent/CN102985440B/zh not_active Expired - Fee Related
- 2011-06-21 EP EP11728615.3A patent/EP2585485A1/en not_active Withdrawn
- 2011-06-21 KR KR1020137001441A patent/KR20130036290A/ko not_active Withdrawn
- 2011-06-21 CN CN201510007033.3A patent/CN104693302A/zh active Pending
-
2012
- 2012-11-27 IL IL223288A patent/IL223288A0/en unknown
- 2012-12-10 ZA ZA2012/09345A patent/ZA201209345B/en unknown
-
2014
- 2014-08-28 US US14/471,258 patent/US9512195B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013530974A5 (enExample) | ||
| JP2013530702A5 (enExample) | ||
| RU2012157683A (ru) | Производные инсулина, содержащие дополнительные дисульфидные связи | |
| ES2949553T3 (es) | Composición para el tratamiento de la diabetes, que contiene conjugado de análogo de insulina de acción prolongada y conjugado de péptido de secreción de insulina de acción prolongada | |
| JP2014129355A5 (enExample) | ||
| KR102092025B1 (ko) | 페길화된 옥신토모둘린 변이체 | |
| JP2011526886A5 (enExample) | ||
| RU2012128547A (ru) | Дважды ацилированные производные glp-1 | |
| RU2016135543A (ru) | Новые производные инсулина и их применение в медицине | |
| AR071990A1 (es) | Compuesto de insulina lispro pegilada, su uso para la manufactura de un medicamento util para el tratamiento de hipoglicemia o diabetes , composicion farmaceutica que lo comprende y proceso para elaborar dicho compuesto | |
| JP2016523241A5 (enExample) | ||
| JP2014520798A5 (enExample) | ||
| JP7432361B2 (ja) | ヒトインスリンまたはそのアナログのアシル化誘導体 | |
| EP2433650A3 (en) | Administration of anti-CD3 antibodies in the treatment of autoimmune diseases | |
| CA2608311A1 (en) | Glp-1 pegylated compounds | |
| WO2008050101A3 (en) | Benzoyl amino heterocyclyl compounds useful in the treatment of a disease mediated through glk | |
| JP2013517307A5 (enExample) | ||
| JP2013523619A5 (enExample) | ||
| JP2015517459A5 (enExample) | ||
| JP2018505146A5 (enExample) | ||
| RU2013131913A (ru) | Твердые композиции, содержащие агонист glp и соль n-(2-гидроксибензоил)амино)каприловой кислоты | |
| JP2014534265A5 (enExample) | ||
| JP2016516076A5 (enExample) | ||
| JP2014510739A5 (enExample) | ||
| RU2013139651A (ru) | Новые соединения, влияющие на пищевое поведение |