ZA201209345B - Insulin derivatives containing additional disulfide bonds - Google Patents
Insulin derivatives containing additional disulfide bondsInfo
- Publication number
- ZA201209345B ZA201209345B ZA2012/09345A ZA201209345A ZA201209345B ZA 201209345 B ZA201209345 B ZA 201209345B ZA 2012/09345 A ZA2012/09345 A ZA 2012/09345A ZA 201209345 A ZA201209345 A ZA 201209345A ZA 201209345 B ZA201209345 B ZA 201209345B
- Authority
- ZA
- South Africa
- Prior art keywords
- disulfide bonds
- derivatives containing
- containing additional
- insulin derivatives
- additional disulfide
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10167046 | 2010-06-23 | ||
| EP10167033 | 2010-06-23 | ||
| US35915010P | 2010-06-28 | 2010-06-28 | |
| US35950010P | 2010-06-29 | 2010-06-29 | |
| PCT/EP2011/060383 WO2011161125A1 (en) | 2010-06-23 | 2011-06-21 | Insulin derivatives containing additional disulfide bonds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201209345B true ZA201209345B (en) | 2013-08-28 |
Family
ID=44508482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/09345A ZA201209345B (en) | 2010-06-23 | 2012-12-10 | Insulin derivatives containing additional disulfide bonds |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8853155B2 (enExample) |
| EP (1) | EP2585485A1 (enExample) |
| JP (1) | JP5931857B2 (enExample) |
| KR (1) | KR20130036290A (enExample) |
| CN (2) | CN102985440B (enExample) |
| AU (1) | AU2011269000C1 (enExample) |
| BR (1) | BR112012033107A2 (enExample) |
| CA (1) | CA2802510A1 (enExample) |
| IL (1) | IL223288A0 (enExample) |
| MX (1) | MX337549B (enExample) |
| RU (1) | RU2598273C2 (enExample) |
| WO (1) | WO2011161125A1 (enExample) |
| ZA (1) | ZA201209345B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110004366A (ko) | 2008-03-18 | 2011-01-13 | 노보 노르디스크 에이/에스 | 프로테아제 안정화되고, 아실화된 인슐린 유사체 |
| JP2014509603A (ja) * | 2011-03-15 | 2014-04-21 | ノヴォ ノルディスク アー／エス | システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体 |
| EP2794648A1 (en) * | 2011-12-21 | 2014-10-29 | Novo Nordisk A/S | N-terminally modified insulin derivatives |
| AU2013247047A1 (en) | 2012-04-11 | 2014-10-23 | Novo Nordisk A/S | Insulin formulations |
| US20150111820A1 (en) | 2012-07-09 | 2015-04-23 | Novo Nordisk A/S | Novel use of insulin derivatives |
| CN105636979B (zh) | 2013-10-07 | 2020-01-10 | 诺和诺德股份有限公司 | 胰岛素类似物的新衍生物 |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| CN107206059A (zh) * | 2015-01-29 | 2017-09-26 | 诺和诺德股份有限公司 | 包含片芯和聚乙烯醇包衣的用于口服胰岛素给药的药物组合物 |
| AU2016377786A1 (en) * | 2015-12-23 | 2018-06-14 | Case Western Reserve University | Encapsulation of ultra-stable insulin analogues with polymer melts |
| CN107436311B (zh) * | 2016-05-25 | 2021-11-19 | 正大天晴药业集团股份有限公司 | 一种鉴别胰岛素单体或胰岛素多聚体的方法 |
| BR112019011761A2 (pt) | 2016-12-16 | 2019-11-05 | Novo Nordisk As | composições farmacêuticas contendo insulina |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| CN113121649B (zh) * | 2019-12-26 | 2022-10-04 | 李瑛� | 一种新型两亲性蛋白、其制备方法及用途 |
| CN116789801B (zh) * | 2023-08-21 | 2023-11-14 | 南京赛诺生物技术有限公司 | 新型胰岛素衍生物及其用途 |
| US20250154220A1 (en) * | 2023-11-15 | 2025-05-15 | Ambio, Inc. | Insulin analogs for the treatment of human metabolic disorder and disease |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50892B1 (en) | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK155690D0 (da) * | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| US6268335B1 (en) * | 1997-10-24 | 2001-07-31 | Eli Lilly And Company | Insoluble insulin compositions |
| BR0009040A (pt) | 1999-03-17 | 2001-12-18 | Novo Nordisk As | Método para acilar um grupo amino de um peptìdeoou de uma proteìna, e, composto |
| JP4773023B2 (ja) | 1999-12-29 | 2011-09-14 | ノボ ノルディスク アクティーゼルスカブ | インスリン前駆体及びインスリン前駆体類似体の製造方法 |
| DE60328112D1 (de) | 2002-09-25 | 2009-08-06 | Novo Nordisk As | Verfahren zur herstellung acylierter peptide |
| AU2003903124A0 (en) * | 2003-06-20 | 2003-07-10 | Mark Del Borgo | Analogues of heteromeric proteins |
| JP4463814B2 (ja) | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
| EP1692168B1 (en) | 2003-12-03 | 2011-07-20 | Novo Nordisk A/S | Single-chain insulin |
| WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| WO2007081824A2 (en) * | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
| JP2009527526A (ja) | 2006-02-21 | 2009-07-30 | ノボ・ノルデイスク・エー／エス | 単鎖インスリンのアナログとその製薬的製剤 |
| WO2007135117A2 (en) * | 2006-05-24 | 2007-11-29 | Novo Nordisk A/S | Soluble, stable insulin-containing formulations |
| PL2074141T3 (pl) | 2006-09-22 | 2017-02-28 | Novo Nordisk A/S | Analogi insuliny oporne na proteazę |
| ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| WO2009022005A1 (en) * | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulin analogues with an acyl and alkylene glycol moiety |
| ES2613152T3 (es) | 2008-01-09 | 2017-05-22 | Sanofi-Aventis Deutschland Gmbh | Nuevos derivados de insulina con perfil tiempo/acción extremadamente retardado |
| CN101970477B (zh) * | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| KR20110004366A (ko) | 2008-03-18 | 2011-01-13 | 노보 노르디스크 에이/에스 | 프로테아제 안정화되고, 아실화된 인슐린 유사체 |
| JP5591243B2 (ja) | 2008-09-12 | 2014-09-17 | ノボ・ノルデイスク・エー／エス | ペプチド又はタンパク質のアシル化の方法 |
| WO2010066636A1 (en) | 2008-12-09 | 2010-06-17 | Novo Nordisk A/S | Novel insulin analogues |
| WO2011028813A2 (en) | 2009-09-01 | 2011-03-10 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| JP6013330B2 (ja) | 2010-06-23 | 2016-10-25 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するヒトインスリン |
| WO2011161124A1 (en) | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
-
2011
- 2011-06-21 JP JP2013515874A patent/JP5931857B2/ja not_active Expired - Fee Related
- 2011-06-21 AU AU2011269000A patent/AU2011269000C1/en not_active Ceased
- 2011-06-21 BR BR112012033107A patent/BR112012033107A2/pt not_active IP Right Cessation
- 2011-06-21 US US13/805,774 patent/US8853155B2/en not_active Expired - Fee Related
- 2011-06-21 CN CN201180031021.4A patent/CN102985440B/zh not_active Expired - Fee Related
- 2011-06-21 RU RU2012157683/10A patent/RU2598273C2/ru not_active IP Right Cessation
- 2011-06-21 CN CN201510007033.3A patent/CN104693302A/zh active Pending
- 2011-06-21 KR KR1020137001441A patent/KR20130036290A/ko not_active Withdrawn
- 2011-06-21 CA CA2802510A patent/CA2802510A1/en not_active Withdrawn
- 2011-06-21 EP EP11728615.3A patent/EP2585485A1/en not_active Withdrawn
- 2011-06-21 MX MX2012014641A patent/MX337549B/es active IP Right Grant
- 2011-06-21 WO PCT/EP2011/060383 patent/WO2011161125A1/en not_active Ceased
-
2012
- 2012-11-27 IL IL223288A patent/IL223288A0/en unknown
- 2012-12-10 ZA ZA2012/09345A patent/ZA201209345B/en unknown
-
2014
- 2014-08-28 US US14/471,258 patent/US9512195B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2012157683A (ru) | 2014-07-27 |
| US20130157938A1 (en) | 2013-06-20 |
| EP2585485A1 (en) | 2013-05-01 |
| CN104693302A (zh) | 2015-06-10 |
| JP5931857B2 (ja) | 2016-06-08 |
| US9512195B2 (en) | 2016-12-06 |
| WO2011161125A1 (en) | 2011-12-29 |
| AU2011269000C1 (en) | 2015-10-08 |
| CN102985440A (zh) | 2013-03-20 |
| IL223288A0 (en) | 2013-02-03 |
| CN102985440B (zh) | 2016-10-26 |
| US20140371140A1 (en) | 2014-12-18 |
| BR112012033107A2 (pt) | 2016-10-11 |
| AU2011269000B2 (en) | 2015-04-23 |
| JP2013530974A (ja) | 2013-08-01 |
| RU2598273C2 (ru) | 2016-09-20 |
| AU2011269000A1 (en) | 2012-12-13 |
| MX2012014641A (es) | 2013-02-07 |
| CA2802510A1 (en) | 2011-12-29 |
| US8853155B2 (en) | 2014-10-07 |
| MX337549B (es) | 2016-03-10 |
| KR20130036290A (ko) | 2013-04-11 |
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