ZA201209345B - Insulin derivatives containing additional disulfide bonds - Google Patents

Insulin derivatives containing additional disulfide bonds

Info

Publication number
ZA201209345B
ZA201209345B ZA2012/09345A ZA201209345A ZA201209345B ZA 201209345 B ZA201209345 B ZA 201209345B ZA 2012/09345 A ZA2012/09345 A ZA 2012/09345A ZA 201209345 A ZA201209345 A ZA 201209345A ZA 201209345 B ZA201209345 B ZA 201209345B
Authority
ZA
South Africa
Prior art keywords
disulfide bonds
derivatives containing
containing additional
insulin derivatives
additional disulfide
Prior art date
Application number
ZA2012/09345A
Other languages
English (en)
Inventor
Peter Madsen
Thomas Borglum Kjeldsen
Frantisek Hubalek
Svend Ludvigsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA201209345B publication Critical patent/ZA201209345B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA2012/09345A 2010-06-23 2012-12-10 Insulin derivatives containing additional disulfide bonds ZA201209345B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167046 2010-06-23
EP10167033 2010-06-23
US35915010P 2010-06-28 2010-06-28
US35950010P 2010-06-29 2010-06-29
PCT/EP2011/060383 WO2011161125A1 (en) 2010-06-23 2011-06-21 Insulin derivatives containing additional disulfide bonds

Publications (1)

Publication Number Publication Date
ZA201209345B true ZA201209345B (en) 2013-08-28

Family

ID=44508482

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/09345A ZA201209345B (en) 2010-06-23 2012-12-10 Insulin derivatives containing additional disulfide bonds

Country Status (13)

Country Link
US (2) US8853155B2 (enExample)
EP (1) EP2585485A1 (enExample)
JP (1) JP5931857B2 (enExample)
KR (1) KR20130036290A (enExample)
CN (2) CN102985440B (enExample)
AU (1) AU2011269000C1 (enExample)
BR (1) BR112012033107A2 (enExample)
CA (1) CA2802510A1 (enExample)
IL (1) IL223288A0 (enExample)
MX (1) MX337549B (enExample)
RU (1) RU2598273C2 (enExample)
WO (1) WO2011161125A1 (enExample)
ZA (1) ZA201209345B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
JP2014509603A (ja) * 2011-03-15 2014-04-21 ノヴォ ノルディスク アー／エス システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体
JP2015502971A (ja) * 2011-12-21 2015-01-29 ノヴォ ノルディスク アー／エス Ｎ末端修飾インスリン誘導体
EP2836508B1 (en) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulin formulations
EP2869830B1 (en) 2012-07-09 2016-10-12 Novo Nordisk A/S Novel use of insulin derivatives
JP6499184B2 (ja) 2013-10-07 2019-04-10 ノヴォ ノルディスク アー／エス インスリン類似体の新規な誘導体
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3250225A1 (en) * 2015-01-29 2017-12-06 Novo Nordisk A/S Pharmaceutical composition for oral insulin administration comprising a tablet core and a polyvinyl alcohol coating
US11583572B2 (en) * 2015-12-23 2023-02-21 Case Western Reserve University Encapsulation of ultra-stable insulin analogues with polymer melts
CN107436311B (zh) * 2016-05-25 2021-11-19 正大天晴药业集团股份有限公司 一种鉴别胰岛素单体或胰岛素多聚体的方法
EP3821905B1 (en) * 2016-12-16 2022-10-12 Novo Nordisk A/S Insulin containing pharmaceutical compositions
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
CN113121649B (zh) * 2019-12-26 2022-10-04 李瑛� 一种新型两亲性蛋白、其制备方法及用途
CN116789801B (zh) * 2023-08-21 2023-11-14 南京赛诺生物技术有限公司 新型胰岛素衍生物及其用途
US20250154220A1 (en) * 2023-11-15 2025-05-15 Ambio, Inc. Insulin analogs for the treatment of human metabolic disorder and disease

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
EA200000453A1 (ru) * 1997-10-24 2000-10-30 Эли Лилли Энд Компани Композиции нерастворимого инсулина
ATE409193T1 (de) 1999-03-17 2008-10-15 Novo Nordisk As Verfahren zur acylierung von peptiden und proteinen
HUP0203475A3 (en) 1999-12-29 2005-11-28 Novo Nordisk As Method for making insulin precursors and insulin precursor analogs
KR101131783B1 (ko) 2002-09-25 2012-03-30 노보 노르디스크 에이/에스 아실화된 펩타이드의 제조방법
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
CA2531988C (en) 2003-08-05 2016-06-28 Novo Nordisk A/S Novel insulin derivatives
EP1692168B1 (en) 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
JP2009527526A (ja) 2006-02-21 2009-07-30 ノボ・ノルデイスク・エー／エス 単鎖インスリンのアナログとその製薬的製剤
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
US9018161B2 (en) 2006-09-22 2015-04-28 Novo Nordisk A/S Protease resistant insulin analogues
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
AU2008288413B2 (en) * 2007-08-15 2013-09-26 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
JP5694779B2 (ja) 2008-01-09 2015-04-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体
ES2618073T3 (es) * 2008-03-14 2017-06-20 Novo Nordisk A/S Análogos de insulina estabilizados frente a proteasas
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
WO2010029159A1 (en) 2008-09-12 2010-03-18 Novo Nordisk A/S Method of acylating a peptide or protein
CN102245633A (zh) 2008-12-09 2011-11-16 诺沃—诺迪斯克有限公司 新的胰岛素类似物
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
JP5973427B2 (ja) 2010-06-23 2016-08-23 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン類似体
CN102933599A (zh) 2010-06-23 2013-02-13 诺沃—诺迪斯克有限公司 包含额外的二硫键的人胰岛素

Also Published As

Publication number Publication date
CN102985440B (zh) 2016-10-26
US20140371140A1 (en) 2014-12-18
AU2011269000C1 (en) 2015-10-08
JP2013530974A (ja) 2013-08-01
CN104693302A (zh) 2015-06-10
IL223288A0 (en) 2013-02-03
JP5931857B2 (ja) 2016-06-08
RU2598273C2 (ru) 2016-09-20
KR20130036290A (ko) 2013-04-11
MX337549B (es) 2016-03-10
CA2802510A1 (en) 2011-12-29
WO2011161125A1 (en) 2011-12-29
AU2011269000A1 (en) 2012-12-13
US9512195B2 (en) 2016-12-06
MX2012014641A (es) 2013-02-07
BR112012033107A2 (pt) 2016-10-11
US8853155B2 (en) 2014-10-07
RU2012157683A (ru) 2014-07-27
US20130157938A1 (en) 2013-06-20
EP2585485A1 (en) 2013-05-01
AU2011269000B2 (en) 2015-04-23
CN102985440A (zh) 2013-03-20

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