JP5931857B2 - 追加のジスルフィド結合を含有するインスリン誘導体 - Google Patents
追加のジスルフィド結合を含有するインスリン誘導体 Download PDFInfo
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- JP5931857B2 JP5931857B2 JP2013515874A JP2013515874A JP5931857B2 JP 5931857 B2 JP5931857 B2 JP 5931857B2 JP 2013515874 A JP2013515874 A JP 2013515874A JP 2013515874 A JP2013515874 A JP 2013515874A JP 5931857 B2 JP5931857 B2 JP 5931857B2
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- human insulin
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10167046.1 | 2010-06-23 | ||
| EP10167033.9 | 2010-06-23 | ||
| EP10167046 | 2010-06-23 | ||
| EP10167033 | 2010-06-23 | ||
| US35915010P | 2010-06-28 | 2010-06-28 | |
| US61/359,150 | 2010-06-28 | ||
| US35950010P | 2010-06-29 | 2010-06-29 | |
| US61/359,500 | 2010-06-29 | ||
| PCT/EP2011/060383 WO2011161125A1 (en) | 2010-06-23 | 2011-06-21 | Insulin derivatives containing additional disulfide bonds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013530974A JP2013530974A (ja) | 2013-08-01 |
| JP2013530974A5 JP2013530974A5 (enExample) | 2014-07-10 |
| JP5931857B2 true JP5931857B2 (ja) | 2016-06-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515874A Expired - Fee Related JP5931857B2 (ja) | 2010-06-23 | 2011-06-21 | 追加のジスルフィド結合を含有するインスリン誘導体 |
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| EP (1) | EP2585485A1 (enExample) |
| JP (1) | JP5931857B2 (enExample) |
| KR (1) | KR20130036290A (enExample) |
| CN (2) | CN102985440B (enExample) |
| AU (1) | AU2011269000C1 (enExample) |
| BR (1) | BR112012033107A2 (enExample) |
| CA (1) | CA2802510A1 (enExample) |
| IL (1) | IL223288A0 (enExample) |
| MX (1) | MX337549B (enExample) |
| RU (1) | RU2598273C2 (enExample) |
| WO (1) | WO2011161125A1 (enExample) |
| ZA (1) | ZA201209345B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| JP2014509603A (ja) * | 2011-03-15 | 2014-04-21 | ノヴォ ノルディスク アー／エス | システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体 |
| JP2015502971A (ja) * | 2011-12-21 | 2015-01-29 | ノヴォ ノルディスク アー／エス | Ｎ末端修飾インスリン誘導体 |
| EP2836508B1 (en) | 2012-04-11 | 2016-06-29 | Novo Nordisk A/S | Insulin formulations |
| EP2869830B1 (en) | 2012-07-09 | 2016-10-12 | Novo Nordisk A/S | Novel use of insulin derivatives |
| JP6499184B2 (ja) | 2013-10-07 | 2019-04-10 | ノヴォ ノルディスク アー／エス | インスリン類似体の新規な誘導体 |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| EP3250225A1 (en) * | 2015-01-29 | 2017-12-06 | Novo Nordisk A/S | Pharmaceutical composition for oral insulin administration comprising a tablet core and a polyvinyl alcohol coating |
| US11583572B2 (en) * | 2015-12-23 | 2023-02-21 | Case Western Reserve University | Encapsulation of ultra-stable insulin analogues with polymer melts |
| CN107436311B (zh) * | 2016-05-25 | 2021-11-19 | 正大天晴药业集团股份有限公司 | 一种鉴别胰岛素单体或胰岛素多聚体的方法 |
| EP3821905B1 (en) * | 2016-12-16 | 2022-10-12 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| CN113121649B (zh) * | 2019-12-26 | 2022-10-04 | 李瑛� | 一种新型两亲性蛋白、其制备方法及用途 |
| CN116789801B (zh) * | 2023-08-21 | 2023-11-14 | 南京赛诺生物技术有限公司 | 新型胰岛素衍生物及其用途 |
| US20250154220A1 (en) * | 2023-11-15 | 2025-05-15 | Ambio, Inc. | Insulin analogs for the treatment of human metabolic disorder and disease |
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| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
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| EA200000453A1 (ru) * | 1997-10-24 | 2000-10-30 | Эли Лилли Энд Компани | Композиции нерастворимого инсулина |
| ATE409193T1 (de) | 1999-03-17 | 2008-10-15 | Novo Nordisk As | Verfahren zur acylierung von peptiden und proteinen |
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| AU2003903124A0 (en) * | 2003-06-20 | 2003-07-10 | Mark Del Borgo | Analogues of heteromeric proteins |
| CA2531988C (en) | 2003-08-05 | 2016-06-28 | Novo Nordisk A/S | Novel insulin derivatives |
| EP1692168B1 (en) | 2003-12-03 | 2011-07-20 | Novo Nordisk A/S | Single-chain insulin |
| WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
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| JP2009527526A (ja) | 2006-02-21 | 2009-07-30 | ノボ・ノルデイスク・エー／エス | 単鎖インスリンのアナログとその製薬的製剤 |
| WO2007135117A2 (en) * | 2006-05-24 | 2007-11-29 | Novo Nordisk A/S | Soluble, stable insulin-containing formulations |
| US9018161B2 (en) | 2006-09-22 | 2015-04-28 | Novo Nordisk A/S | Protease resistant insulin analogues |
| ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| AU2008288413B2 (en) * | 2007-08-15 | 2013-09-26 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| JP5694779B2 (ja) | 2008-01-09 | 2015-04-01 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体 |
| ES2618073T3 (es) * | 2008-03-14 | 2017-06-20 | Novo Nordisk A/S | Análogos de insulina estabilizados frente a proteasas |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| WO2010029159A1 (en) | 2008-09-12 | 2010-03-18 | Novo Nordisk A/S | Method of acylating a peptide or protein |
| CN102245633A (zh) | 2008-12-09 | 2011-11-16 | 诺沃—诺迪斯克有限公司 | 新的胰岛素类似物 |
| WO2011028813A2 (en) | 2009-09-01 | 2011-03-10 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| JP5973427B2 (ja) | 2010-06-23 | 2016-08-23 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するインスリン類似体 |
| CN102933599A (zh) | 2010-06-23 | 2013-02-13 | 诺沃—诺迪斯克有限公司 | 包含额外的二硫键的人胰岛素 |
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| US20140371140A1 (en) | 2014-12-18 |
| AU2011269000C1 (en) | 2015-10-08 |
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| CN104693302A (zh) | 2015-06-10 |
| IL223288A0 (en) | 2013-02-03 |
| RU2598273C2 (ru) | 2016-09-20 |
| KR20130036290A (ko) | 2013-04-11 |
| MX337549B (es) | 2016-03-10 |
| CA2802510A1 (en) | 2011-12-29 |
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| MX2012014641A (es) | 2013-02-07 |
| BR112012033107A2 (pt) | 2016-10-11 |
| US8853155B2 (en) | 2014-10-07 |
| RU2012157683A (ru) | 2014-07-27 |
| US20130157938A1 (en) | 2013-06-20 |
| EP2585485A1 (en) | 2013-05-01 |
| AU2011269000B2 (en) | 2015-04-23 |
| ZA201209345B (en) | 2013-08-28 |
| CN102985440A (zh) | 2013-03-20 |
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