JP2014529629A5 - - Google Patents
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- JP2014529629A5 JP2014529629A5 JP2014528963A JP2014528963A JP2014529629A5 JP 2014529629 A5 JP2014529629 A5 JP 2014529629A5 JP 2014528963 A JP2014528963 A JP 2014528963A JP 2014528963 A JP2014528963 A JP 2014528963A JP 2014529629 A5 JP2014529629 A5 JP 2014529629A5
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- JP
- Japan
- Prior art keywords
- chem
- xaa
- lys
- linker
- derivative according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11180265 | 2011-09-06 | ||
| EP11180265.8 | 2011-09-06 | ||
| US201161532323P | 2011-09-08 | 2011-09-08 | |
| US61/532,323 | 2011-09-08 | ||
| PCT/EP2012/067364 WO2013037690A1 (en) | 2011-09-06 | 2012-09-06 | Glp-1 derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529629A JP2014529629A (ja) | 2014-11-13 |
| JP2014529629A5 true JP2014529629A5 (enExample) | 2015-10-01 |
| JP6126097B2 JP6126097B2 (ja) | 2017-05-10 |
Family
ID=47882647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528963A Active JP6126097B2 (ja) | 2011-09-06 | 2012-09-06 | Ｇｌｐ−１誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9758560B2 (enExample) |
| EP (1) | EP2753642B8 (enExample) |
| JP (1) | JP6126097B2 (enExample) |
| CN (2) | CN107266558A (enExample) |
| ES (1) | ES2626013T3 (enExample) |
| WO (1) | WO2013037690A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6366575B2 (ja) | 2012-05-08 | 2018-08-01 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| WO2013167454A1 (en) | 2012-05-08 | 2013-11-14 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| HUE057361T2 (hu) * | 2013-05-28 | 2022-05-28 | Takeda Pharmaceuticals Co | Peptid vegyület |
| CN106132985B (zh) * | 2014-04-07 | 2020-10-13 | 诺和诺德股份有限公司 | 双酰化glp-1化合物 |
| JP2018012644A (ja) * | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
| MX2018012700A (es) * | 2016-04-28 | 2019-01-30 | Novo Nordisk As | Semaglutida en afecciones cardiovasculares. |
| WO2017204219A1 (ja) | 2016-05-24 | 2017-11-30 | 武田薬品工業株式会社 | ペプチド化合物 |
| CN109248323B (zh) * | 2017-07-14 | 2023-09-08 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| EP3474820B1 (en) | 2017-08-24 | 2024-02-07 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
| PE20211417A1 (es) | 2018-04-05 | 2021-08-02 | Sun Pharmaceutical Ind Ltd | Analogos novedosos de glp-1 |
| CN113024660B (zh) * | 2018-04-19 | 2023-07-14 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| CN116925237A (zh) | 2019-12-31 | 2023-10-24 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| FI4097099T3 (fi) | 2020-02-07 | 2024-07-30 | Gasherbrum Bio Inc | Heterosyklisiä glp-1-agonisteja |
| PE20230819A1 (es) | 2020-02-18 | 2023-05-19 | Novo Nordisk As | Composiciones y usos de glp-1 |
| CN113292646B (zh) * | 2020-05-29 | 2022-05-13 | 东莞云璟生物技术有限公司 | Glp-1/胰高血糖素双重激动剂融合蛋白 |
| CR20230066A (es) | 2020-08-06 | 2023-05-29 | Gasherbrum Bio Inc | Agonistas del glp-1 heterocíclicos |
| JP2023545684A (ja) | 2020-09-30 | 2023-10-31 | ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド | ポリペプチドコンジュゲートおよび使用の方法 |
| CN114621339B (zh) * | 2021-12-28 | 2022-09-23 | 北京惠之衡生物科技有限公司 | 一种长效glp-1衍生物 |
| EP4490155A1 (en) | 2022-03-09 | 2025-01-15 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN114621340B (zh) * | 2022-03-11 | 2022-09-23 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
| EP4496797A1 (en) | 2022-03-21 | 2025-01-29 | Gasherbrum Bio, Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
| CA3252113A1 (en) | 2022-03-30 | 2023-10-05 | Beijing Ql Biopharmaceutical Co Ltd | Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use |
| CN114958883B (zh) * | 2022-04-12 | 2023-01-31 | 北京惠之衡生物科技有限公司 | 一种表达glp-1类似物的重组工程菌及其构建方法 |
| EP4508047A1 (en) | 2022-04-14 | 2025-02-19 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| WO2024112617A2 (en) * | 2022-11-21 | 2024-05-30 | Eli Lilly And Company | Process for preparing a gip/glp1 dual agonist |
| WO2024158668A1 (en) * | 2023-01-23 | 2024-08-02 | CrossChem Limited | Compounds for use in keratin treatment |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69233068T2 (de) | 1991-02-27 | 2004-01-22 | Micromet Ag | Serin-reiche peptidlinker |
| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| US5662907A (en) | 1992-08-07 | 1997-09-02 | Cytel Corporation | Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes |
| JPH08504209A (ja) * | 1992-12-04 | 1996-05-07 | アボツト・ラボラトリーズ | ６位修飾デカペプチドｌｈｒｈ拮抗薬 |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US5663907A (en) * | 1996-04-25 | 1997-09-02 | Bright Microelectronics, Inc. | Switch driver circuit for providing small sector sizes for negative gate erase flash EEPROMS using a standard twin-well CMOS process |
| ES2283025T3 (es) * | 1996-08-30 | 2007-10-16 | Novo Nordisk A/S | Derivados de glp-1.1. |
| ATE466027T1 (de) * | 1998-02-27 | 2010-05-15 | Novo Nordisk As | Abkömmlinge von glp-1 analogen |
| EP1950224A3 (en) | 1998-03-09 | 2008-12-17 | Zealand Pharma A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| DK1355942T3 (da) | 2000-12-07 | 2008-11-17 | Lilly Co Eli | GLP-1-fusionsproteiner |
| CN101665538A (zh) * | 2003-12-18 | 2010-03-10 | 诺沃挪第克公司 | 与白蛋白样物质相连的新glp-1类似物 |
| JP2008537873A (ja) | 2004-03-31 | 2008-10-02 | セントカー・インコーポレーテツド | ヒトｇｌｐ−１ミメティボディ、組成物、方法および用途 |
| JP4933455B2 (ja) | 2005-02-02 | 2012-05-16 | ノヴォ ノルディスク アー／エス | 新規のインスリン誘導体 |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| EP2514406A1 (en) | 2007-06-01 | 2012-10-24 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
| ES2550363T3 (es) | 2007-09-05 | 2015-11-06 | Novo Nordisk A/S | Derivados truncados de GLP-1 y su uso terapéutico |
| WO2009030738A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| JP6006118B2 (ja) | 2009-12-16 | 2016-10-12 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アナログ及び誘導体 |
| US9708383B2 (en) | 2010-11-09 | 2017-07-18 | Novo Nordisk A/S | Double-acylated GLP-1 derivatives |
| WO2013167454A1 (en) | 2012-05-08 | 2013-11-14 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| JP6366575B2 (ja) | 2012-05-08 | 2018-08-01 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
-
2012
- 2012-09-06 ES ES12805429.3T patent/ES2626013T3/es active Active
- 2012-09-06 CN CN201710403766.8A patent/CN107266558A/zh active Pending
- 2012-09-06 JP JP2014528963A patent/JP6126097B2/ja active Active
- 2012-09-06 US US14/343,152 patent/US9758560B2/en active Active
- 2012-09-06 CN CN201280054416.0A patent/CN104039822A/zh active Pending
- 2012-09-06 EP EP12805429.3A patent/EP2753642B8/en active Active
- 2012-09-06 WO PCT/EP2012/067364 patent/WO2013037690A1/en not_active Ceased
-
2017
- 2017-01-12 US US15/404,808 patent/US10308700B2/en active Active
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