ES2626013T3 - Derivados de GLP-1 - Google Patents
Derivados de GLP-1 Download PDFInfo
- Publication number
- ES2626013T3 ES2626013T3 ES12805429.3T ES12805429T ES2626013T3 ES 2626013 T3 ES2626013 T3 ES 2626013T3 ES 12805429 T ES12805429 T ES 12805429T ES 2626013 T3 ES2626013 T3 ES 2626013T3
- Authority
- ES
- Spain
- Prior art keywords
- amino
- hydroxypropanoyl
- acetyl
- glp
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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Landscapes
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- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11180265 | 2011-09-06 | ||
| EP11180265 | 2011-09-06 | ||
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| EP2846823B1 (en) | 2012-05-08 | 2019-12-04 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| JP6366575B2 (ja) * | 2012-05-08 | 2018-08-01 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| MX388826B (es) | 2013-05-28 | 2025-03-20 | Scohia Pharma Inc | Compuesto peptidico. |
| CN106132985B (zh) * | 2014-04-07 | 2020-10-13 | 诺和诺德股份有限公司 | 双酰化glp-1化合物 |
| JP2018012644A (ja) * | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
| BR112018072020A2 (pt) | 2016-04-28 | 2019-02-12 | Novo Nordisk A/S | semaglutida em condições cardiovasculares |
| CN109477094B (zh) | 2016-05-24 | 2022-04-26 | 武田药品工业株式会社 | 肽化合物 |
| CN109248323B (zh) * | 2017-07-14 | 2023-09-08 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| CN111050750B (zh) | 2017-08-24 | 2024-09-24 | 诺和诺德股份有限公司 | Glp-1组合物及其用途 |
| DK3774862T3 (da) | 2018-04-05 | 2022-09-05 | Sun Pharmaceutical Ind Ltd | Nye GLP-1-analoger |
| CN113214382B (zh) * | 2018-04-19 | 2024-01-19 | 杭州先为达生物科技股份有限公司 | 酰化的glp-1衍生物 |
| CN113597434B (zh) | 2019-12-31 | 2022-07-01 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| MD4097099T2 (ro) | 2020-02-07 | 2025-02-28 | Gasherbrum Bio Inc | Agonişti GKP-1 heterociclici |
| JP7761567B2 (ja) | 2020-02-18 | 2025-10-28 | ノヴォ ノルディスク アー／エス | 医薬製剤 |
| CN113292646B (zh) * | 2020-05-29 | 2022-05-13 | 东莞云璟生物技术有限公司 | Glp-1/胰高血糖素双重激动剂融合蛋白 |
| CR20230066A (es) | 2020-08-06 | 2023-05-29 | Gasherbrum Bio Inc | Agonistas del glp-1 heterocíclicos |
| EP4222176A4 (en) | 2020-09-30 | 2024-02-28 | Beijing QL Biopharmaceutical Co., Ltd. | POLYPEPTIDE CONJUGATES AND METHODS OF USE |
| CN114874314B (zh) * | 2021-12-28 | 2022-11-11 | 北京惠之衡生物科技有限公司 | 一种高表达glp-1类似物的重组工程菌及其构建方法 |
| WO2023169456A1 (en) | 2022-03-09 | 2023-09-14 | Gasherbrum Bio , Inc. | Heterocyclic glp-1 agonists |
| CN114891090B (zh) * | 2022-03-11 | 2022-10-25 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
| WO2023179542A1 (en) | 2022-03-21 | 2023-09-28 | Gasherbrum Bio , Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
| KR20240163717A (ko) | 2022-03-30 | 2024-11-19 | 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 | 폴리펩티드 접합체의 액체 약학 조성물 및 그의 사용 방법 |
| CN114716533B (zh) * | 2022-04-12 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
| JP2025513071A (ja) | 2022-04-14 | 2025-04-22 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| KR20250110330A (ko) * | 2022-11-21 | 2025-07-18 | 일라이 릴리 앤드 캄파니 | Gip/glp1 이중 효능제의 제조 방법 |
| EP4654954A1 (en) * | 2023-01-23 | 2025-12-03 | Crosschem Limited | Compounds for use in keratin treatment |
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| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| US5662907A (en) | 1992-08-07 | 1997-09-02 | Cytel Corporation | Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes |
| CA2136078A1 (en) * | 1992-12-04 | 1994-06-23 | Jonathan Greer | 6-position modified decapeptide lhrh antagonists |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US5663907A (en) * | 1996-04-25 | 1997-09-02 | Bright Microelectronics, Inc. | Switch driver circuit for providing small sector sizes for negative gate erase flash EEPROMS using a standard twin-well CMOS process |
| CA2264243C (en) * | 1996-08-30 | 2004-10-05 | Novo Nordisk A/S | Glp-1 derivatives |
| AU2610699A (en) * | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Derivatives of glp-1 analogs |
| EP1950223A3 (en) | 1998-03-09 | 2009-05-13 | Zealand Pharma A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| PT1355942E (pt) | 2000-12-07 | 2008-11-21 | Lilly Co Eli | Proteínas de fusão de glp-1 |
| CA2550050A1 (en) * | 2003-12-18 | 2005-06-30 | Novo Nordisk A/S | Novel glp-1 analogues linked to albumin-like agents |
| EA011583B1 (ru) | 2004-03-31 | 2009-04-28 | Сентокор, Инк. | Миметические антитела glp-1 человека, композиции, способы и применения |
| US8067362B2 (en) | 2005-02-02 | 2011-11-29 | Novo Nordisk As | Insulin derivatives |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー／エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
| EP2679597A1 (en) | 2007-09-05 | 2014-01-01 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| WO2009030774A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Truncated glp-1 derivatives and their therapeutical use |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| CN111560060A (zh) * | 2009-12-16 | 2020-08-21 | 诺沃—诺迪斯克有限公司 | 双酰化glp-1衍生物 |
| CN105601729A (zh) | 2010-11-09 | 2016-05-25 | 诺沃—诺迪斯克有限公司 | 双-酰化的glp-1衍生物 |
| JP6366575B2 (ja) | 2012-05-08 | 2018-08-01 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| EP2846823B1 (en) | 2012-05-08 | 2019-12-04 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
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| US9758560B2 (en) | 2017-09-12 |
| JP6126097B2 (ja) | 2017-05-10 |
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