JP2017506065A5 - - Google Patents
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- Publication number
- JP2017506065A5 JP2017506065A5 JP2016547592A JP2016547592A JP2017506065A5 JP 2017506065 A5 JP2017506065 A5 JP 2017506065A5 JP 2016547592 A JP2016547592 A JP 2016547592A JP 2016547592 A JP2016547592 A JP 2016547592A JP 2017506065 A5 JP2017506065 A5 JP 2017506065A5
- Authority
- JP
- Japan
- Prior art keywords
- coli
- fucosyl lactose
- salt medium
- integrated
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940062827 2'-fucosyllactose Drugs 0.000 description 3
- HWHQUWQCBPAQQH-UHFFFAOYSA-N 2-O-alpha-L-Fucosyl-lactose Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC(C(O)CO)C(O)C(O)C=O HWHQUWQCBPAQQH-UHFFFAOYSA-N 0.000 description 3
- HWHQUWQCBPAQQH-BWRPKUOHSA-N 2-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O HWHQUWQCBPAQQH-BWRPKUOHSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- SNFSYLYCDAVZGP-UHFFFAOYSA-N UNPD26986 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(OC(O)C(O)C2O)CO)OC(CO)C(O)C1O SNFSYLYCDAVZGP-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 101100075927 Aspergillus aculeatus mndA gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241001198387 Escherichia coli BL21(DE3) Species 0.000 description 1
- 101100022282 Escherichia coli O157:H7 manC2 gene Proteins 0.000 description 1
- 102000006471 Fucosyltransferases Human genes 0.000 description 1
- 108010019236 Fucosyltransferases Proteins 0.000 description 1
- 101150102398 Galt gene Proteins 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 101100168102 Yersinia pseudotuberculosis colC gene Proteins 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 101150041441 fcl gene Proteins 0.000 description 1
- 101150002054 galE gene Proteins 0.000 description 1
- 101150045500 galK gene Proteins 0.000 description 1
- 101150054547 galM gene Proteins 0.000 description 1
- 101150106565 gmd gene Proteins 0.000 description 1
- 101150001899 lacY gene Proteins 0.000 description 1
- 101150088678 manB gene Proteins 0.000 description 1
- 101150032120 manC gene Proteins 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14151737.5 | 2014-01-20 | ||
| EP14151737.5A EP2896628B1 (en) | 2014-01-20 | 2014-01-20 | Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation |
| PCT/EP2014/079212 WO2015106943A1 (en) | 2014-01-20 | 2014-12-23 | PROCESS FOR EFFICIENT PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDES (HMOs) FROM MICROBIAL FERMENTATION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191254A Division JP7000396B2 (ja) | 2014-01-20 | 2019-10-18 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506065A JP2017506065A (ja) | 2017-03-02 |
| JP2017506065A5 true JP2017506065A5 (enExample) | 2018-02-01 |
| JP6901857B2 JP6901857B2 (ja) | 2021-07-14 |
Family
ID=49949589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547592A Active JP6901857B2 (ja) | 2014-01-20 | 2014-12-23 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
| JP2019191254A Active JP7000396B2 (ja) | 2014-01-20 | 2019-10-18 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191254A Active JP7000396B2 (ja) | 2014-01-20 | 2019-10-18 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US10377787B2 (enExample) |
| EP (5) | EP2896628B1 (enExample) |
| JP (2) | JP6901857B2 (enExample) |
| KR (1) | KR102137027B1 (enExample) |
| CN (1) | CN106132977B (enExample) |
| AT (2) | AT17271U1 (enExample) |
| AU (1) | AU2014377374B2 (enExample) |
| BR (1) | BR112016016705A8 (enExample) |
| CZ (2) | CZ35289U1 (enExample) |
| DE (2) | DE202014011358U1 (enExample) |
| DK (6) | DK2896628T3 (enExample) |
| ES (4) | ES2701163T3 (enExample) |
| FI (2) | FI3680249T3 (enExample) |
| MX (2) | MX369375B (enExample) |
| PH (2) | PH12016501421A1 (enExample) |
| PL (4) | PL2896628T3 (enExample) |
| RU (1) | RU2682445C2 (enExample) |
| WO (1) | WO2015106943A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2896628T3 (pl) | 2014-01-20 | 2019-03-29 | Jennewein Biotechnologie Gmbh | Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej |
| US10500221B2 (en) | 2014-12-05 | 2019-12-10 | Glycom A/S | Crystalline difucosyllactose |
| EP3141610A1 (en) | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
| EP3390652B1 (en) | 2015-12-18 | 2024-12-04 | Glycom A/S | Fermentative production of oligosaccharides |
| ES2991621T3 (es) | 2016-03-07 | 2024-12-04 | Glycom As | Separación de oligosacáridos de caldo de fermentación |
| WO2017182965A1 (en) | 2016-04-19 | 2017-10-26 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
| EP3645146A4 (en) | 2017-06-30 | 2021-05-05 | Glycom A/S | SYNTHESIS OF OLIGOSACCHARIDES |
| WO2019012461A1 (en) | 2017-07-12 | 2019-01-17 | Glycom A/S | AMORPHOUS MIXTURE COMPRISING A NEUTRAL MONO- OR OLIGOSACCHARIDE AND A NON-GLUCIDIC ACID COMPONENT |
| EP3450443A1 (en) * | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| CN111164090A (zh) * | 2017-09-29 | 2020-05-15 | 菲仕兰坎皮纳荷兰公司 | 用于从微生物发酵纯化中性母乳寡糖（hmo）的方法 |
| EP3486326A1 (en) | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| EP3494807A1 (en) | 2017-12-11 | 2019-06-12 | Jennewein Biotechnologie GmbH | Spray-dried sialyllactose |
| EP3494805B1 (en) | 2017-12-08 | 2025-08-13 | Chr. Hansen HMO GmbH | Spray-dried tetrasaccharides |
| AU2018380956B2 (en) * | 2017-12-08 | 2024-12-05 | Chr. Hansen HMO GmbH | Spray-dried mixture of human milk oligosacchrides |
| ES3040419T3 (en) | 2017-12-08 | 2025-10-30 | Chr Hansen Hmo Gmbh | Spray-dried lacto-n-fucopentaose |
| PL3494804T3 (pl) | 2017-12-08 | 2025-10-06 | Chr. Hansen HMO GmbH | Suszona rozpyłowo 3-fukozylolaktoza |
| DK3524067T3 (da) * | 2018-02-08 | 2025-05-19 | Chr Hansen Hmo Gmbh | Spraytørret blanding af modermælksoligosaccharider |
| EP3546060A1 (en) * | 2018-03-27 | 2019-10-02 | DuPont Nutrition Biosciences ApS | Process for spray drying fucosyllactose solutions and related product compositions |
| MX2020011875A (es) * | 2018-05-07 | 2021-01-20 | Jennewein Biotechnologie Gmbh | Un metodo sencillo para la purificacion de lacto-n-neotetraosa (lnnt) a partir de carbohidratos obtenidos por fermentacion microbiana. |
| JP2021524238A (ja) * | 2018-05-23 | 2021-09-13 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | オリゴ糖の生成 |
| ES2933959T3 (es) * | 2018-06-01 | 2023-02-15 | Chr Hansen Hmo Gmbh | Un método simple para la purificación de una sialil-lactosa |
| CN109111043B (zh) * | 2018-09-16 | 2021-11-09 | 苏州渭中科技发展有限公司 | 一种高盐高cod废水的处理方法 |
| KR20210104847A (ko) | 2018-12-19 | 2021-08-25 | 바스프 에스이 | 바이오매스 및 적어도 하나의 올리고당을 포함하는 용액으로부터 바이오매스를 분리하는 방법 |
| WO2020154217A1 (en) * | 2019-01-21 | 2020-07-30 | Dupont Nutrition Biosciences Aps | Process for making l-fucose |
| EP3686210A1 (en) * | 2019-01-24 | 2020-07-29 | DuPont Nutrition Biosciences ApS | Process for purifying a human milk oligosaccharide and related compositions |
| BE1027078A9 (nl) * | 2019-02-25 | 2020-09-28 | Nutribam Bvba | Samenstelling, voedingssupplement en werkwijze voor het ondersteunen en/of verbeteren van de darmgezondheid |
| WO2020174386A1 (en) | 2019-02-25 | 2020-09-03 | Nutribam Bvba | Composition, food supplement and method for supporting and/or improving intestinal health |
| EP3741770A1 (en) * | 2019-05-21 | 2020-11-25 | Jennewein Biotechnologie GmbH | Purification of oligosaccharides from a fermentation broth by using filtration |
| SI3979827T1 (sl) * | 2019-06-04 | 2023-11-30 | N. V. Nutricia | Hranilna sestava, ki vsebuje 2'fukozilaktozo in 3'galaktozilaktozo |
| EP3822282A1 (en) * | 2019-11-18 | 2021-05-19 | DuPont Nutrition Biosciences ApS | Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions |
| US20220330584A1 (en) * | 2019-09-04 | 2022-10-20 | Dupont Nutrition Biosciences Aps | Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions |
| KR20220066904A (ko) | 2019-09-24 | 2022-05-24 | 프롤랙타 바이오사이언스, 인코포레이티드 | 염증 및 면역 질환의 치료용 조성물 및 방법 |
| US20230074506A1 (en) * | 2020-01-29 | 2023-03-09 | Dsm Ip Assets B.V. | Process for recovering & purifying human milk oligosaccharides |
| CN111540125B (zh) * | 2020-04-20 | 2021-01-05 | 中国人民解放军火箭军工程设计研究院 | 一种充电桩的充电管理方法、设备及计算机可读存储介质 |
| CN116075517A (zh) * | 2020-06-12 | 2023-05-05 | 巴斯夫欧洲公司 | 改进的发酵液的脱矿化与诸如寡糖的精细化学品的纯化 |
| IL300573A (en) | 2020-08-14 | 2023-04-01 | Prolacta Bioscience Inc | Breast milk oligosaccharide compositions for use with bacteriotherapy |
| CN112568439A (zh) * | 2020-12-21 | 2021-03-30 | 湖北福星生物科技有限公司 | 一种从微生物发酵液中分离纯化母乳低聚糖的方法及其应用 |
| WO2022155201A1 (en) | 2021-01-12 | 2022-07-21 | Prolacta Bioscience, Inc. | Synbiotic treatment regimens |
| CN112920234B (zh) * | 2021-01-27 | 2022-03-29 | 南开大学 | 一种2′-岩藻糖基乳糖的富集纯化方法 |
| CN117355228A (zh) * | 2021-04-30 | 2024-01-05 | 帝斯曼知识产权资产管理有限公司 | 砷含量低的婴幼儿配方品 |
| DK181242B1 (en) | 2021-05-17 | 2023-05-30 | Dsm Ip Assets Bv | GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME |
| WO2022263425A1 (en) | 2021-06-15 | 2022-12-22 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| WO2022263406A1 (en) | 2021-06-15 | 2022-12-22 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| US20240286081A1 (en) | 2021-06-15 | 2024-08-29 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| EP4355465A1 (en) | 2021-06-15 | 2024-04-24 | DSM IP Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| WO2023066907A1 (en) | 2021-10-18 | 2023-04-27 | Dsm Ip Assets B.V. | A method for providing an amorphous hmo product by drying |
| CN114539433B (zh) * | 2021-12-29 | 2022-11-01 | 北京三元食品股份有限公司 | 一种乳低聚糖的制备方法及制备的低聚糖粉、食品 |
| EP4502168A1 (en) * | 2022-03-25 | 2025-02-05 | Kirin Holdings Kabushiki Kaisha | Production method for lactodifucotetraose (ldft) |
| CN117003803A (zh) * | 2022-05-07 | 2023-11-07 | 山东恒鲁生物科技有限公司 | 一种三糖的新晶型 |
| CN115873051B (zh) | 2022-05-17 | 2024-06-25 | 山东恒鲁生物科技有限公司 | 三糖的新晶型 |
| EP4539967A1 (en) | 2022-06-14 | 2025-04-23 | DSM IP Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| WO2024047096A1 (en) | 2022-08-30 | 2024-03-07 | Inbiose N.V. | Process for purification of an oligosaccharide |
| WO2024130119A2 (en) | 2022-12-16 | 2024-06-20 | Prolacta Bioscience, Inc. | Synbiotic compositions for short chain fatty acid production |
| CN115651039A (zh) * | 2022-12-27 | 2023-01-31 | 保龄宝生物股份有限公司 | 一种高密度2’-岩藻糖基乳糖的生产方法 |
| CN116425810B (zh) * | 2023-06-14 | 2023-08-11 | 山东合成远景生物科技有限公司 | 一种混合液中3-岩藻糖基乳糖的纯化方法 |
| CN117089503B (zh) * | 2023-10-17 | 2024-01-02 | 保龄宝生物股份有限公司 | 一种大肠杆菌k-12 mg1655 blbyzt6及其应用 |
| WO2025114343A2 (en) * | 2023-11-29 | 2025-06-05 | Frieslandcampina Nederland B.V. | Process for the production of human milk oligosaccharides |
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| JP6017133B2 (ja) * | 2011-12-12 | 2016-10-26 | Ｍｃフードスペシャリティーズ株式会社 | 風味改良剤 |
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| PL2896628T3 (pl) | 2014-01-20 | 2019-03-29 | Jennewein Biotechnologie Gmbh | Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej |
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| EP3141610A1 (en) | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
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2014
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