JP2014530625A5 - - Google Patents
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- Publication number
- JP2014530625A5 JP2014530625A5 JP2014537289A JP2014537289A JP2014530625A5 JP 2014530625 A5 JP2014530625 A5 JP 2014530625A5 JP 2014537289 A JP2014537289 A JP 2014537289A JP 2014537289 A JP2014537289 A JP 2014537289A JP 2014530625 A5 JP2014530625 A5 JP 2014530625A5
- Authority
- JP
- Japan
- Prior art keywords
- bacterium
- strain
- gene
- bacterium according
- genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000894006 Bacteria Species 0.000 claims description 36
- 229920001184 polypeptide Polymers 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 101150067506 dinB gene Proteins 0.000 claims description 5
- 101150005648 polB gene Proteins 0.000 claims description 5
- 241000588724 Escherichia coli Species 0.000 claims description 4
- 241001646716 Escherichia coli K-12 Species 0.000 claims description 2
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 101100278439 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) pol gene Proteins 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549375P | 2011-10-20 | 2011-10-20 | |
| US61/549,375 | 2011-10-20 | ||
| PCT/US2012/061027 WO2013059595A1 (en) | 2011-10-20 | 2012-10-19 | Reduced genome bacteria with improved genetic stability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017103668A Division JP6539691B2 (ja) | 2011-10-20 | 2017-05-25 | 遺伝的安定性が向上したゲノム縮小化細菌 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530625A JP2014530625A (ja) | 2014-11-20 |
| JP2014530625A5 true JP2014530625A5 (enExample) | 2015-11-05 |
| JP6151704B2 JP6151704B2 (ja) | 2017-06-21 |
Family
ID=47178310
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537289A Expired - Fee Related JP6151704B2 (ja) | 2011-10-20 | 2012-10-19 | 遺伝的安定性が向上したゲノム縮小化細菌 |
| JP2017103668A Active JP6539691B2 (ja) | 2011-10-20 | 2017-05-25 | 遺伝的安定性が向上したゲノム縮小化細菌 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017103668A Active JP6539691B2 (ja) | 2011-10-20 | 2017-05-25 | 遺伝的安定性が向上したゲノム縮小化細菌 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9340791B2 (enExample) |
| EP (1) | EP2768943B1 (enExample) |
| JP (2) | JP6151704B2 (enExample) |
| KR (1) | KR102043891B1 (enExample) |
| CN (1) | CN104024398B (enExample) |
| AU (1) | AU2012325917B2 (enExample) |
| CA (1) | CA2850842C (enExample) |
| WO (1) | WO2013059595A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013059595A1 (en) * | 2011-10-20 | 2013-04-25 | Scarab Genomics, Llc | Reduced genome bacteria with improved genetic stability |
| JP6545676B2 (ja) * | 2013-11-14 | 2019-07-17 | スカラブ ゲノミクス， エルエルシー | 改善された代謝能力を有する細菌 |
| WO2015134402A1 (en) * | 2014-03-03 | 2015-09-11 | Scarab Genomics, Llc | Enhanced production of recombinant crm197 in e. coli |
| AU2016242996B2 (en) | 2015-04-02 | 2021-02-18 | Scarab Genomics, Llc | Materials and methods for extended continuous flow fermentation of reduced genome bacteria |
| CN108587992B (zh) * | 2018-04-10 | 2022-03-15 | 安徽大学 | 一种高效分泌表达抗VEGF-Fab抗体片段的高产菌株及其构建方法 |
| CN111019877B (zh) * | 2019-12-31 | 2022-04-19 | 浙江工业大学 | 一种产l-半胱氨酸的基因工程菌、构建方法及应用 |
| US20240309390A1 (en) * | 2021-06-01 | 2024-09-19 | University Of Virginia Patent Foundation | Minicells from highly genome reduced escherichia coli: cytoplasmic and surface expression of recombinant proteins and incorporation in the minicells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5578464A (en) | 1989-10-31 | 1996-11-26 | Schering Corporation | E. coli secretory strains |
| US5747662A (en) | 1995-03-01 | 1998-05-05 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US6022952A (en) | 1998-04-01 | 2000-02-08 | University Of Alberta | Compositions and methods for protein secretion |
| US8119365B2 (en) * | 2002-01-23 | 2012-02-21 | Wisconsin Alumni Research Foundation | Insertion sequence-free bacteria |
| US8039243B2 (en) | 2002-01-23 | 2011-10-18 | Wisconsin Alumni Research Foundation | Insertion sequence-free bacteria |
| US20060270043A1 (en) | 2002-01-23 | 2006-11-30 | Blattner Frederick R | Bacteria with reduced genome |
| US6989265B2 (en) * | 2002-01-23 | 2006-01-24 | Wisconsin Alumni Research Foundation | Bacteria with reduced genome |
| US7303906B2 (en) | 2002-09-06 | 2007-12-04 | Wisconsin Alumni Research Foundation | Competent bacteria |
| US8178339B2 (en) * | 2005-08-20 | 2012-05-15 | Scarab Genomics Llc | Reduced genome E. coli |
| JP2012517472A (ja) | 2009-02-12 | 2012-08-02 | スカラブ ジェノミクス リミティド ライアビリティ カンパニー | 縮小ゲノム細菌を含む敗血症治療用組成物 |
| WO2013059595A1 (en) * | 2011-10-20 | 2013-04-25 | Scarab Genomics, Llc | Reduced genome bacteria with improved genetic stability |
-
2012
- 2012-10-19 WO PCT/US2012/061027 patent/WO2013059595A1/en not_active Ceased
- 2012-10-19 CN CN201280050875.1A patent/CN104024398B/zh active Active
- 2012-10-19 US US14/351,756 patent/US9340791B2/en active Active
- 2012-10-19 KR KR1020147012964A patent/KR102043891B1/ko active Active
- 2012-10-19 JP JP2014537289A patent/JP6151704B2/ja not_active Expired - Fee Related
- 2012-10-19 AU AU2012325917A patent/AU2012325917B2/en active Active
- 2012-10-19 CA CA2850842A patent/CA2850842C/en active Active
- 2012-10-19 EP EP12784803.4A patent/EP2768943B1/en active Active
-
2017
- 2017-05-25 JP JP2017103668A patent/JP6539691B2/ja active Active
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