JP2017501977A5 - - Google Patents
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- Publication number
- JP2017501977A5 JP2017501977A5 JP2016533067A JP2016533067A JP2017501977A5 JP 2017501977 A5 JP2017501977 A5 JP 2017501977A5 JP 2016533067 A JP2016533067 A JP 2016533067A JP 2016533067 A JP2016533067 A JP 2016533067A JP 2017501977 A5 JP2017501977 A5 JP 2017501977A5
- Authority
- JP
- Japan
- Prior art keywords
- tgf
- ligand
- tgfbrii
- receptor
- capturer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233811A JP6952100B2 (ja) | 2013-11-21 | 2019-12-25 | 肺高血圧症を治療するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361907260P | 2013-11-21 | 2013-11-21 | |
| US61/907,260 | 2013-11-21 | ||
| PCT/US2014/066776 WO2015077540A2 (en) | 2013-11-21 | 2014-11-21 | Compositions and methods for treating pulmonary hypertension |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019233811A Division JP6952100B2 (ja) | 2013-11-21 | 2019-12-25 | 肺高血圧症を治療するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501977A JP2017501977A (ja) | 2017-01-19 |
| JP2017501977A5 true JP2017501977A5 (enExample) | 2018-04-05 |
| JP6640083B2 JP6640083B2 (ja) | 2020-02-05 |
Family
ID=53180397
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533067A Active JP6640083B2 (ja) | 2013-11-21 | 2014-11-21 | 肺高血圧症を治療するための組成物および方法 |
| JP2019233811A Active JP6952100B2 (ja) | 2013-11-21 | 2019-12-25 | 肺高血圧症を治療するための組成物および方法 |
| JP2021156343A Active JP7474729B2 (ja) | 2013-11-21 | 2021-09-27 | 肺高血圧症を治療するための組成物および方法 |
| JP2024065676A Pending JP2024096891A (ja) | 2013-11-21 | 2024-04-15 | 肺高血圧症を治療するための組成物および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019233811A Active JP6952100B2 (ja) | 2013-11-21 | 2019-12-25 | 肺高血圧症を治療するための組成物および方法 |
| JP2021156343A Active JP7474729B2 (ja) | 2013-11-21 | 2021-09-27 | 肺高血圧症を治療するための組成物および方法 |
| JP2024065676A Pending JP2024096891A (ja) | 2013-11-21 | 2024-04-15 | 肺高血圧症を治療するための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10682392B2 (enExample) |
| EP (4) | EP4417255A3 (enExample) |
| JP (4) | JP6640083B2 (enExample) |
| CN (2) | CN105934249A (enExample) |
| AU (3) | AU2014352843B2 (enExample) |
| CA (1) | CA2931309C (enExample) |
| DK (2) | DK3071215T3 (enExample) |
| ES (2) | ES2778201T3 (enExample) |
| WO (1) | WO2015077540A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014308751B2 (en) | 2013-08-22 | 2020-03-05 | Acceleron Pharma, Inc. | TGF-beta receptor type II variants and uses thereof |
| EP4417255A3 (en) * | 2013-11-21 | 2024-10-23 | The Brigham and Women's Hospital Inc. | Compositions and methods for treating pulmonary hypertension |
| JP6955443B2 (ja) * | 2014-08-01 | 2021-10-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 肺動脈性肺高血圧症の処置に関する方法および組成物 |
| CN116327952A (zh) | 2015-08-04 | 2023-06-27 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
| CA2996996A1 (en) * | 2015-08-31 | 2017-03-09 | National Research Council Of Canada | Tgf-.beta.-receptor ectodomain fusion molecules and uses thereof |
| CN116531490A (zh) | 2016-07-15 | 2023-08-04 | 阿塞勒隆制药公司 | 用于治疗肺高血压的组合物和方法 |
| AU2017336546C1 (en) * | 2016-09-27 | 2025-05-29 | Epicentrx, Inc. | Immunomodulatory fusion proteins |
| JP7231553B2 (ja) | 2017-03-02 | 2023-03-01 | ナショナル リサーチ カウンシル オブ カナダ | Ｔｇｆ－ｂ－受容体外部ドメイン融合分子及びその使用 |
| BR112019023071A2 (pt) | 2017-05-04 | 2020-06-09 | Acceleron Pharma Inc | proteínas de fusão do receptor tgf-beta do tipo ii e uso das mesmas |
| AU2018264455B2 (en) | 2017-05-12 | 2024-12-12 | Jiangsu Hengrui Medicine Co., Ltd. | Fusion protein containing TGF-beta receptor and medicinal uses thereof |
| KR102757384B1 (ko) | 2017-09-27 | 2025-01-20 | 에피센트알엑스, 인코포레이티드 | 면역조절 융합 단백질 |
| TWI823906B (zh) | 2018-03-09 | 2023-12-01 | 美商艾吉納斯公司 | 抗-cd73 抗體及其使用方法 |
| US11168138B2 (en) | 2018-03-26 | 2021-11-09 | Altor Bioscience, Llc | Anti-PDL1, IL-15 and TGF-beta receptor combination molecules |
| TWI829799B (zh) | 2018-11-09 | 2024-01-21 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種TGF-β受體融合蛋白醫藥組成物及其用途 |
| CN112239507A (zh) * | 2019-07-17 | 2021-01-19 | 鸿运华宁（杭州）生物医药有限公司 | ETA抗体与TGF-β Trap的融合蛋白质，以及其药物组合物和应用 |
| US20220362333A1 (en) * | 2019-07-26 | 2022-11-17 | Board Of Trustees Of Michigan State University | Methods Of Preventing Or Treating Fatty Degeneration Of Skeletal Muscle |
| US20210061871A1 (en) * | 2019-08-29 | 2021-03-04 | Nantbio, Inc. | Modified N-810 and Methods Therefor |
| TW202128763A (zh) * | 2019-11-12 | 2021-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 含有ＴＧＦ－β受體的融合蛋白及其醫藥用途 |
| EP4142769A4 (en) | 2020-04-28 | 2024-05-15 | Acceleron Pharma Inc. | ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION |
| US20250152670A1 (en) * | 2022-04-28 | 2025-05-15 | Wenzhou Prarucom Bio-Chemical Technology Co. | Method for alleviating pulmonary fibrosis using epidermal growth factor |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ES2289778T3 (es) | 1997-04-18 | 2008-02-01 | Biogen Idec Ma Inc. | Proteinas de fusion de la region constante de la inmunoglobulina/receptor tgf-beta tipo ii. |
| US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| AU4572899A (en) | 1998-06-16 | 2000-01-05 | Biogen, Inc. | Variant type ii tgf-beta receptor fusion proteins and methods |
| ES2146552B1 (es) | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
| CA2390820A1 (en) | 2002-06-17 | 2003-12-17 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
| US7919084B2 (en) | 2002-06-17 | 2011-04-05 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
| EP1554133B1 (fr) * | 2002-10-14 | 2008-05-21 | Société de Technologie Michelin | Pneumatique a mobilite etendue avec bourrelet a repartition d'effort symetrique |
| WO2005010049A2 (en) * | 2003-07-09 | 2005-02-03 | Eli Lilly And Company | Tgf-beta1 ligands |
| GB0514259D0 (en) | 2005-07-12 | 2005-08-17 | Renovo Ltd | Pharmaceutical compositions |
| US20080009500A1 (en) * | 2005-11-08 | 2008-01-10 | Michael Kahn | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders |
| EP2230252A1 (en) | 2006-03-13 | 2010-09-22 | The Johns Hopkins University | Augmentation of endothelial thromboresistance |
| JP2009539842A (ja) | 2006-06-05 | 2009-11-19 | ノバルティス アクチエンゲゼルシャフト | 副甲状腺関連障害の処置におけるＴＧＦ−βアンタゴニストの使用 |
| CN100588717C (zh) | 2007-03-21 | 2010-02-10 | 中国医学科学院阜外心血管病医院 | 生长分化因子15基因多态位点在预测高血压继发左心室肥厚中的用途 |
| WO2009026204A1 (en) | 2007-08-22 | 2009-02-26 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
| EP2037275A1 (en) | 2007-09-11 | 2009-03-18 | F. Hoffmann-La Roche AG | Differentiation of different causes of right heart failure |
| WO2010031168A1 (en) | 2008-09-17 | 2010-03-25 | National Research Council Of Canada | HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY |
| KR101008385B1 (ko) | 2008-08-01 | 2011-01-14 | 한국과학기술연구원 | 다환 방향족 탄화수소류 노출 여부 확인용 바이오마커 및이를 이용한 확인 방법 |
| EP2524038A4 (en) | 2010-01-12 | 2013-11-20 | Isis Pharmaceuticals Inc | MODULATION OF TRANSFORMING A GROWTH FACTOR BETA-1 EXPRESSION |
| EP2372364A1 (en) | 2010-03-31 | 2011-10-05 | Medizinische Hochschule Hannover | Biomarker for pulmonary hypertension |
| US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| US20130287688A1 (en) | 2010-11-18 | 2013-10-31 | Xtuit Pharmaceuticals, Inc. | Novel compositions and uses of anti-hypertension agents for cancer therapy |
| PE20140982A1 (es) * | 2011-01-06 | 2014-08-22 | Glaxo Group Ltd | Ligandos que se unen al receptor ii del factor de crecimiento transformante-beta |
| CN108178789B (zh) * | 2011-04-20 | 2021-11-02 | 阿塞勒隆制药公司 | 内皮糖蛋白多肽及其用途 |
| PH12013502489B1 (en) | 2011-06-03 | 2019-04-24 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
| US9468666B2 (en) * | 2011-08-01 | 2016-10-18 | Tufts Medical Center, Inc. | Treatment of heart failure and related conditions |
| CN102321173B (zh) | 2011-08-12 | 2013-04-03 | 中国医学科学院肿瘤研究所 | 人源化巨噬细胞抑制因子1单克隆抗体及其应用 |
| WO2013059879A1 (en) | 2011-10-26 | 2013-05-02 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| CA2915627A1 (en) | 2012-06-15 | 2013-12-19 | The General Hospital Corporation | Inhibitors of micrornas that regulate production of atrial natriuretic peptide (anp) as therapeutics and uses thereof |
| EP2597466A1 (en) | 2012-06-26 | 2013-05-29 | Roche Diagniostics GmbH | Means and methods for proSP-B based diagnosis of alveolar damage in pulmonary hypertension patients |
| PT2900263T (pt) | 2012-09-26 | 2019-07-29 | Univ Wuerzburg J Maximilians | Anticorpos monoclonais contra o factor de crescimento e diferenciaçao 15 (gdf-15) |
| CA2896076C (en) | 2012-12-21 | 2022-12-06 | Aveo Pharmaceuticals, Inc. | Anti-gdf15 antibodies |
| JP6809789B2 (ja) | 2013-01-17 | 2021-01-06 | メディツィーニシェ・ホーホシューレ・ハノーファーＭｅｄｉｚｉｎｉｓｃｈｅ Ｈｏｃｈｓｃｈｕｌｅ Ｈａｎｎｏｖｅｒ | 疾患の治療または予防に用いるためのファクター１およびファクター２タンパク質、およびその阻害剤 |
| KR101346132B1 (ko) | 2013-02-18 | 2013-12-31 | 강원대학교산학협력단 | Mic-1의 혈관신생유도 기능을 억제하는 항 mic-1 단일클론항체 mbm-14 |
| KR101346181B1 (ko) | 2013-02-18 | 2014-01-03 | 강원대학교산학협력단 | Mic-1의 혈관신생유도 기능을 억제하는 항 mic-1 단일클론항체 mbm-12 |
| AU2014308751B2 (en) * | 2013-08-22 | 2020-03-05 | Acceleron Pharma, Inc. | TGF-beta receptor type II variants and uses thereof |
| EP4417255A3 (en) * | 2013-11-21 | 2024-10-23 | The Brigham and Women's Hospital Inc. | Compositions and methods for treating pulmonary hypertension |
| US10624929B2 (en) | 2014-05-18 | 2020-04-21 | Children's Medical Center Corporation | Methods and compositions relating to exosomes |
| BR112016028833A2 (pt) | 2014-06-13 | 2017-08-22 | Novartis Ag | uso de serelaxinaa para reduzir gdf-15 |
| WO2015196142A1 (en) | 2014-06-20 | 2015-12-23 | Aveo Pharmaceuticals, Inc. | Treatment of congestive heart failure and other cardiac dysfunction using a gdf15 modulator |
| JP6955443B2 (ja) * | 2014-08-01 | 2021-10-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 肺動脈性肺高血圧症の処置に関する方法および組成物 |
| CN116327952A (zh) | 2015-08-04 | 2023-06-27 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
-
2014
- 2014-11-21 EP EP24166565.2A patent/EP4417255A3/en active Pending
- 2014-11-21 US US15/037,852 patent/US10682392B2/en active Active
- 2014-11-21 DK DK14864524.5T patent/DK3071215T3/da active
- 2014-11-21 CA CA2931309A patent/CA2931309C/en active Active
- 2014-11-21 AU AU2014352843A patent/AU2014352843B2/en active Active
- 2014-11-21 EP EP14864524.5A patent/EP3071215B1/en active Active
- 2014-11-21 ES ES14864524T patent/ES2778201T3/es active Active
- 2014-11-21 EP EP21190858.7A patent/EP4005585B1/en active Active
- 2014-11-21 JP JP2016533067A patent/JP6640083B2/ja active Active
- 2014-11-21 CN CN201480073820.1A patent/CN105934249A/zh active Pending
- 2014-11-21 DK DK20150385.1T patent/DK3685848T3/da active
- 2014-11-21 ES ES20150385T patent/ES2902533T3/es active Active
- 2014-11-21 CN CN202511199453.6A patent/CN120919282A/zh active Pending
- 2014-11-21 WO PCT/US2014/066776 patent/WO2015077540A2/en not_active Ceased
- 2014-11-21 EP EP20150385.1A patent/EP3685848B1/en active Active
-
2019
- 2019-12-25 JP JP2019233811A patent/JP6952100B2/ja active Active
-
2020
- 2020-04-17 US US16/851,287 patent/US11951156B2/en active Active
- 2020-05-12 AU AU2020203110A patent/AU2020203110A1/en not_active Abandoned
-
2021
- 2021-09-27 JP JP2021156343A patent/JP7474729B2/ja active Active
-
2023
- 2023-11-12 AU AU2023263573A patent/AU2023263573A1/en active Pending
-
2024
- 2024-03-01 US US18/593,002 patent/US20240366720A1/en active Pending
- 2024-04-15 JP JP2024065676A patent/JP2024096891A/ja active Pending
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