JP2017501977A5 - - Google Patents

Info

Publication number

JP2017501977A5

JP2017501977A5 JP2016533067A JP2016533067A JP2017501977A5 JP 2017501977 A5 JP2017501977 A5 JP 2017501977A5 JP 2016533067 A JP2016533067 A JP 2016533067A JP 2016533067 A JP2016533067 A JP 2016533067A JP 2017501977 A5 JP2017501977 A5 JP 2017501977A5

Authority

JP

Japan

Prior art keywords

tgf

ligand

tgfbrii

receptor

capturer

Prior art date

2014-11-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 78
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 78
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 78
• 239000003446 ligand Substances 0.000 claims 54
• 239000008194 pharmaceutical composition Substances 0.000 claims 42
• 108091006020 Fc-tagged proteins Proteins 0.000 claims 31
• 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 claims 31
• 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims 31
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 20
• 108020001756 ligand binding domains Proteins 0.000 claims 20
• 102000005962 receptors Human genes 0.000 claims 20
• 108020003175 receptors Proteins 0.000 claims 20
• 108060003951 Immunoglobulin Proteins 0.000 claims 13
• 102000018358 immunoglobulin Human genes 0.000 claims 13
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 7
• 239000002773 nucleotide Substances 0.000 claims 7
• 125000003729 nucleotide group Chemical group 0.000 claims 7
• 230000008602 contraction Effects 0.000 claims 6
• 239000002516 radical scavenger Substances 0.000 claims 6
• 208000002815 pulmonary hypertension Diseases 0.000 claims 4
• 230000011664 signaling Effects 0.000 claims 4
• 208000019693 Lung disease Diseases 0.000 claims 3
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 1
• 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 1
• 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 claims 1
• 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims 1
• 208000000924 Right ventricular hypertrophy Diseases 0.000 claims 1
• 208000032594 Vascular Remodeling Diseases 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 238000013270 controlled release Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1
• 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 238000013268 sustained release Methods 0.000 claims 1
• 239000012730 sustained-release form Substances 0.000 claims 1
• 230000035488 systolic blood pressure Effects 0.000 claims 1
• 230000002861 ventricular Effects 0.000 claims 1